LOCUS       NM_012711               3938 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus integrin subunit alpha M (Itgam), mRNA.
ACCESSION   NM_012711
VERSION     NM_012711.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3938)
  AUTHORS   Wang,Y., Pi,Y., Hu,L., Peng,Z., Hu,H., Zhao,J., Zhou,Y. and Wang,D.
  TITLE     Proteomic analysis of foot ulcer tissue reveals novel potential
            therapeutic targets of wound healing in diabetic foot ulcers
  JOURNAL   Comput Biol Med 159, 106858 (2023)
   PUBMED   37087778
REFERENCE   2  (bases 1 to 3938)
  AUTHORS   Atcha,H., Meli,V.S., Davis,C.T., Brumm,K.T., Anis,S., Chin,J.,
            Jiang,K., Pathak,M.M. and Liu,W.F.
  TITLE     Crosstalk Between CD11b and Piezo1 Mediates Macrophage Responses to
            Mechanical Cues
  JOURNAL   Front Immunol 12, 689397 (2021)
   PUBMED   34630381
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3938)
  AUTHORS   Lokki,A.I., Teirila,L., Triebwasser,M., Daly,E., Bhattacharjee,A.,
            Uotila,L., Llort Asens,M., Kurki,M.I., Perola,M., Auro,K.,
            Salmon,J.E., Daly,M., Atkinson,J.P., Laivuori,H., Fagerholm,S. and
            Meri,S.
  CONSRTM   Finnpec
  TITLE     Dysfunction of complement receptors CR3 (CD11b/18) and CR4
            (CD11c/18) in pre-eclampsia: a genetic and functional study
  JOURNAL   BJOG 128 (8), 1282-1291 (2021)
   PUBMED   33539617
REFERENCE   4  (bases 1 to 3938)
  AUTHORS   Zhou,M., Wang,X., Shi,Y., Ding,Y., Li,X., Xie,T., Shi,Z. and Fu,W.
  TITLE     Deficiency of ITGAM Attenuates Experimental Abdominal Aortic
            Aneurysm in Mice
  JOURNAL   J Am Heart Assoc 10 (7), e019900 (2021)
   PUBMED   33749307
REFERENCE   5  (bases 1 to 3938)
  AUTHORS   Shi,F.J., Xie,H., Zhang,C.Y., Qin,H.F., Zeng,X.W., Lou,H.,
            Zhang,L., Xu,G.T., Zhang,J.F. and Xu,G.X.
  TITLE     Is Iba-1 protein expression a sensitive marker for microglia
            activation in experimental diabetic retinopathy?
  JOURNAL   Int J Ophthalmol 14 (2), 200-208 (2021)
   PUBMED   33614447
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3938)
  AUTHORS   Choi,M., Rabb,H., Arnaout,M.A. and Ehrlich,H.P.
  TITLE     Preventing the infiltration of leukocytes by monoclonal antibody
            blocks the development of progressive ischemia in rat burns
  JOURNAL   Plast Reconstr Surg 96 (5), 1177-85 (1995)
   PUBMED   7568496
REFERENCE   7  (bases 1 to 3938)
  AUTHORS   Coombe,D.R., Watt,S.M. and Parish,C.R.
  TITLE     Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic
            progenitor cells to stromal cell elements via recognition of
            stromal heparan sulfate
  JOURNAL   Blood 84 (3), 739-752 (1994)
   PUBMED   8043862
REFERENCE   8  (bases 1 to 3938)
  AUTHORS   Seekamp,A., Mulligan,M.S., Till,G.O., Smith,C.W., Miyasaka,M.,
            Tamatani,T., Todd,R.F. 3rd and Ward,P.A.
  TITLE     Role of beta 2 integrins and ICAM-1 in lung injury following
            ischemia-reperfusion of rat hind limbs
  JOURNAL   Am J Pathol 143 (2), 464-472 (1993)
   PUBMED   8102031
REFERENCE   9  (bases 1 to 3938)
  AUTHORS   Mulligan,M.S., Varani,J., Warren,J.S., Till,G.O., Smith,C.W.,
            Anderson,D.C., Todd,R.F. 3rd and Ward,P.A.
  TITLE     Roles of beta 2 integrins of rat neutrophils in complement- and
            oxygen radical-mediated acute inflammatory injury
  JOURNAL   J Immunol 148 (6), 1847-1857 (1992)
   PUBMED   1347308
REFERENCE   10 (bases 1 to 3938)
  AUTHORS   Tamatani,T., Kotani,M. and Miyasaka,M.
  TITLE     Characterization of the rat leukocyte integrin, CD11/CD18, by the
            use of LFA-1 subunit-specific monoclonal antibodies
  JOURNAL   Eur J Immunol 21 (3), 627-633 (1991)
   PUBMED   1672643
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 13, 2022 this sequence version replaced NM_012711.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF268593.1, SRR26643298.5540.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                JAXUCZ010000001.1  192089592-192089651
            61-166              JAXUCZ010000001.1  192091693-192091798
            167-270             JAXUCZ010000001.1  192097657-192097760
            271-341             JAXUCZ010000001.1  192099374-192099444
            342-459             JAXUCZ010000001.1  192099581-192099698
            460-590             JAXUCZ010000001.1  192104302-192104432
            591-736             JAXUCZ010000001.1  192104802-192104947
            737-890             JAXUCZ010000001.1  192106160-192106313
            891-1041            JAXUCZ010000001.1  192107792-192107942
            1042-1115           JAXUCZ010000001.1  192108629-192108702
            1116-1245           JAXUCZ010000001.1  192109163-192109292
            1246-1388           JAXUCZ010000001.1  192109545-192109687
            1389-1529           JAXUCZ010000001.1  192117910-192118050
            1530-1739           JAXUCZ010000001.1  192118131-192118340
            1740-1870           JAXUCZ010000001.1  192123450-192123580
            1871-2034           JAXUCZ010000001.1  192123664-192123827
            2035-2189           JAXUCZ010000001.1  192134382-192134536
            2190-2321           JAXUCZ010000001.1  192134629-192134760
            2322-2395           JAXUCZ010000001.1  192134911-192134984
            2396-2537           JAXUCZ010000001.1  192135210-192135351
            2538-2657           JAXUCZ010000001.1  192135438-192135557
            2658-2737           JAXUCZ010000001.1  192136108-192136187
            2738-2821           JAXUCZ010000001.1  192136947-192137030
            2822-2897           JAXUCZ010000001.1  192137369-192137444
            2898-3005           JAXUCZ010000001.1  192137919-192138026
            3006-3089           JAXUCZ010000001.1  192138136-192138219
            3090-3203           JAXUCZ010000001.1  192138323-192138436
            3204-3305           JAXUCZ010000001.1  192138518-192138619
            3306-3416           JAXUCZ010000001.1  192138837-192138947
            3417-3938           JAXUCZ010000001.1  192139422-192139943
FEATURES             Location/Qualifiers
     source          1..3938
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..3938
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="integrin subunit alpha M"
                     /db_xref="GeneID:25021"
                     /db_xref="RGD:2926"
     exon            1..60
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..3488
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /note="Integrin alpha-M; integrin, alpha M"
                     /codon_start=1
                     /product="integrin alpha-M precursor"
                     /protein_id="NP_036843.2"
                     /db_xref="GeneID:25021"
                     /db_xref="RGD:2926"
                     /translation="MTLKFLLVTVLTLCHGFNLDTENPMTFQENARGFGQSVIQLGET
                     RVVVAAPQEVKAVNQTGALYQCDYSTNRCDPIPLQVPPEAVNMSLGLSLAATTVPPQL
                     LACGPTVHQNCKENTYVNGLCYLFGSNLLRKPQQFPEALRGCPQQESDIAFLIDGSGS
                     INSIDFQKMKEFVSTVMDQFQKSKTLFSLMQYSDEFRTHFTFNDFKRNPDPKSHVRPI
                     RQLNGRTKTASGIRKVVRELFQKINGARDNAAKILVVITDGEKFGDPLNYEDVIPEAE
                     EAGIIRYVIGVGNAFHKPQSRRELDTIASKPAGDHVFQVDNFEALNTIRNQLQEKIFA
                     IEGTQTGSTSSFEHEMSQEGFSAAITSNGPLLGSVGSFDWAGGAFLYPSKDKATFINT
                     TRIDSDMNDAYLGYASAVISRNRVQSLVLGAPRYQHIGLVVMFKQNFGAWEPHTDIKG
                     SQIGSYFGASLCSVDMDADGNTNLILIGAPHHYEKTRGGQVSVCPLPRGRARWQCEAI
                     LHGDQGHPWGRFGAALTVLGDVNGDKLTDVAIGAPGEQENQGAVYIFHGASVASISTP
                     HSQRIAGARFSPGLQYFGQSLSGGKDLTMDGLMDLAVGAQGRLLLIRAQPVLRLEATM
                     EFSPKNLARSVFACQEEVVKNKDAGEVRVCLHVRKNTKDRLREGDIQSTVTYDLALDP
                     GRSVVRAFFDETKNGILRRIRVFGLTQKCETLKLILPDCVDNSVSPIILRLNYTLVGE
                     PLRSSRDLRPVLAMEAQRIFTAMFPFEKNCGNDTICQDDLSITVSSIRVNTLVVGDSR
                     DFDVSVTLRNDGEDSYGTKVTCYYPSGLSYRKVSASQNQFSKKPWRVIAEPSSSEGQG
                     VLKSTIWDINHPIFPANSEVTFNVTFDVDSDASLGNKLLLKVVVTSENNVSRTDKTES
                     QLELPVKYAIYMVVTSGESSIKYLNFTASEMTSKVIQHQYQFNNLGQRSFPVSVVFWI
                     PVQINKVTIWDPPQVTFSQNLSSVCRTEQKSPSHSKFQDELERTPVLNCSVAVCKRIQ
                     CDIPSFNSKEIFNVTLQGNLLFDWYIETSHDHLLLVSTAEILFNDSAFALLPGQETFV
                     KAQTETKVEPYKVHNPVPLIVGSSVGGLVLLALITAGLYKLGFFKRQYKDMMNEAAPQ
                     DGPPQ"
     exon            61..166
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            167..270
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            271..341
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            342..459
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            460..590
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            591..736
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            737..890
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1041
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1115
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1245
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1388
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1529
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1739
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1870
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2034
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2189
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2321
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2395
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2537
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2657
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2737
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2821
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2897
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3005
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3089
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3203
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3305
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            3306..3416
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
     exon            3417..3938
                     /gene="Itgam"
                     /gene_synonym="Cd11b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacatctcc tagggttttg ttcctttcag tcatgactct taaatttctt ctggtgacag
       61 tcctaacctt gtgtcatggc ttcaatttgg acactgaaaa tcccatgacc ttccaagaga
      121 atgcaagagg cttcgggcag agtgtgatcc agcttggtga aacccgagtg gttgttgcag
      181 ccccccagga ggtaaaggcg gttaaccaga caggtgccct ctaccagtgt gactacagca
      241 caaaccggtg cgaccccatt cccctgcaag tacctccaga ggctgtgaat atgtccttgg
      301 gcctgtccct ggctgctact accgtccctc cacagctgct ggcttgtggc cccacagtac
      361 accagaactg caaggagaac acttacgtca atggattgtg ctacctattc ggctccaacc
      421 tgctgaggaa gccccagcag ttcccagagg ctctcagagg atgtcctcag caggagagcg
      481 acattgcctt cttgattgac ggctccggta gcatcaacag catcgacttt cagaagatga
      541 aggaatttgt ctcaactgtg atggaccagt tccaaaagtc taaaaccttg ttctctttga
      601 tgcagtactc tgatgaattc cggactcact tcaccttcaa tgatttcaag agaaaccctg
      661 acccaaaatc acatgtgaga cccataaggc agctgaatgg aaggacaaaa actgcctcag
      721 ggatccgtaa agtagtgaga gaactgtttc agaaaatcaa tggggcccgg gacaatgccg
      781 cgaagatcct agttgtcatc acagacggag aaaagtttgg tgacccccta aattatgagg
      841 atgtcattcc tgaggcagag gaagcaggga tcattcgcta cgttattggg gtgggaaacg
      901 ccttccacaa accacagtcc cgcagagagc ttgacaccat cgcgtctaag ccagctggtg
      961 atcacgtgtt ccaagtggac aactttgaag ctctgaatac cattcggaac cagctccagg
     1021 aaaagatctt tgcaattgag ggcacccaga caggaagtac cagctccttt gagcatgaga
     1081 tgtctcaaga aggctttagc gctgccatta cctctaacgg tcccttgctg ggctccgtgg
     1141 ggagctttga ctgggcaggt ggagccttcc tgtatccatc aaaggataaa gccactttca
     1201 tcaacacaac cagaatagat tcagacatga acgatgctta cttgggttat gcttctgcag
     1261 tcatctcgag gaaccgcgtc caaagcttgg ttttaggggc acctcgatat cagcatatcg
     1321 gcctggtggt gatgttcaag cagaatttcg gtgcctggga gccccacact gatatcaagg
     1381 gcagccagat cggctcttat tttggggcct ccctctgttc tgtggacatg gacgctgatg
     1441 gcaataccaa cttgatcctc attggggccc ctcatcacta tgagaagacc cgagggggcc
     1501 aggtgtcagt gtgccccttg cctaggggga gagcacggtg gcagtgtgaa gctattctcc
     1561 atggcgatca gggccatcca tggggtcgct ttggggcagc attgacagtg ctgggagatg
     1621 tgaatggaga caaactgaca gatgtggcca ttggggcccc aggagagcag gagaatcagg
     1681 gtgctgtcta catttttcat ggagcatcag tagccagcat cagtacccct cacagccagc
     1741 ggatcgcagg cgcccgcttc tcccccgggc tccagtactt tgggcagtct ctgagtgggg
     1801 gcaaggatct cacaatggac ggcctgatgg acttggctgt gggggcgcag gggcgtcttc
     1861 tgctgatcag agcccagcct gtgctgagac tggaggcaac catggaattc agccccaaga
     1921 atctagcaag gagtgtgttt gcgtgtcaag aagaagtagt caaaaacaag gatgctgggg
     1981 aggtcagagt ctgcctccat gtccgcaaga acaccaagga caggctgcga gaaggagaca
     2041 tccagagcac tgtcacttat gacctggctt tagaccccgg ccgctcagtt gtccgagcct
     2101 tctttgatga aacaaagaac ggcatactca ggcgcatccg ggtctttgga ttgacacaga
     2161 aatgtgaaac cctgaagcta attttaccgg actgtgtgga caactcagtg agtcccatca
     2221 tcctgcgcct taattacaca ctggttgggg agcccttgcg gtcctctagg gaccttcggc
     2281 cagttctggc tatggaggct cagaggatct tcacagctat gtttcccttt gagaagaatt
     2341 gtggcaatga caccatttgc caggatgatc tcagcatcac cgtgagttcc atacgcgtga
     2401 acactttggt ggtgggagac tcccgggact ttgacgtgag tgtgactctg agaaatgatg
     2461 gcgaggattc ctatgggacc aaggttacct gttattaccc atctggcttg tcttaccgga
     2521 aggtgtcagc aagccagaac cagttctcca agaagccttg gcgtgtgata gctgagccca
     2581 gttcttctga agggcaaggg gttctgaaga gcaccatctg ggatataaac catcccatct
     2641 ttcccgctaa ttctgaggtc acgtttaatg tcacatttga tgtggactct gatgcctccc
     2701 ttgggaacaa actgctcctc aaggtcgttg tgaccagcga gaacaacgtg tccaggaccg
     2761 acaaaactga gtctcagttg gagctgcctg tgaagtacgc catctacatg gtcgtcacca
     2821 gtggtgagag ttctatcaaa tatctcaact tcacagcttc agagatgacc agtaaggtca
     2881 tacagcatca gtaccagttc aacaacctgg gccagaggag cttccctgtc agcgtggtct
     2941 tctggatccc tgtccagatc aacaaggtga ccatatggga tcctccccag gtcaccttct
     3001 cccagaacct ctcaagtgtc tgtcgcactg agcagaaatc cccctctcac tccaagttcc
     3061 aggatgagct tgaaaggacc ccagtgctga actgctctgt tgcagtctgc aagagaatcc
     3121 agtgtgacat cccttccttc aacagtaaag aaatattcaa cgtcaccctc cagggcaatc
     3181 tgctatttga ctggtacatc gagacttctc acgaccacct cctgcttgtg agcactgccg
     3241 agatcctctt taacgactcc gcatttgccc tacttccggg gcaggagacg tttgtgaagg
     3301 ctcagacaga gaccaaagtg gagccatata aagttcacaa ccctgtacca ctcattgtgg
     3361 gcagctccgt cggaggcctg gtgctcttgg ctctcatcac tgctggcctg tacaagcttg
     3421 gctttttcaa acgacagtac aaggacatga tgaatgaagc cgctccccaa gatggccccc
     3481 ctcagtaatg gcctttgttc catggagtga cctctccaac aacaagcagg tctagacggt
     3541 cagaccaaca gcgaggctgg tggacagaca tgtcctttag aagactgttg ccgtgacgtc
     3601 ttatacagaa atggagtttc tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgttggaa
     3661 gtcagaacag caaagaacag cacgcgcgcg cacacacaca cacacacaca cacacacaca
     3721 cggttttaaa caagtggtag cactttttta ctgttatgca tattgtcttt ttattaatat
     3781 gctcaaataa ttttatataa gttataaagt agctcagagt attcccttgt gatttaacat
     3841 atttaacatt taatgtaatc tcctttggac atattatttc cagccatttg ctattgtgaa
     3901 caatgctgaa ttaataaatt gggtatatct aattttta
//
