LOCUS       NM_001033998            4363 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus integrin subunit alpha L (Itgal), mRNA.
ACCESSION   NM_001033998 XM_219349
VERSION     NM_001033998.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4363)
  AUTHORS   Sanchez JJ, Sanchez JE, Noor S, Ruffaner-Hanson CD, Davies S,
            Wagner CR, Jantzie LL, Mellios N, Savage DD and Milligan ED.
  TITLE     Targeting the beta2-integrin LFA-1, reduces adverse neuroimmune
            actions in neuropathic susceptibility caused by prenatal alcohol
            exposure
  JOURNAL   Acta Neuropathol Commun 7 (1), 54 (2019)
   PUBMED   30961664
  REMARK    GeneRIF: Prenatal alcohol exposure (PAE) creates a risk for
            developing peripheral neuropathies, and LFA-1 may be a novel
            therapeutic target for controlling dysregulated neuroimmune actions
            as a consequence of PAE.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4363)
  AUTHORS   Roberts LL and Robinson CM.
  TITLE     Mycobacterium tuberculosis infection of human dendritic cells
            decreases integrin expression, adhesion and migration to chemokines
  JOURNAL   Immunology 141 (1), 39-51 (2014)
   PUBMED   23981064
REFERENCE   3  (bases 1 to 4363)
  AUTHORS   Liang Y, Cucchetti M, Roncagalli R, Yokosuka T, Malzac A, Bertosio
            E, Imbert J, Nijman IJ, Suchanek M, Saito T, Wulfing C, Malissen B
            and Malissen M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   4  (bases 1 to 4363)
  AUTHORS   Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and
            Stoorvogel W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 4363)
  AUTHORS   Briceno F, Arcaya JL, Carrizo E, Rincon J and Mosquera J.
  TITLE     Forced swimming test decreases chemotactic responsiveness and
            expression of CD11a in rat monocytes
  JOURNAL   Neuroimmunomodulation 17 (6), 369-378 (2010)
   PUBMED   20516718
  REMARK    GeneRIF: Downregulated expression of CD11a in an experimental model
            of depression could be an important mechanisms to induce impaired
            immune responses in experimental and clinical depression.
REFERENCE   6  (bases 1 to 4363)
  AUTHORS   Coombe DR, Watt SM and Parish CR.
  TITLE     Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic
            progenitor cells to stromal cell elements via recognition of
            stromal heparan sulfate
  JOURNAL   Blood 84 (3), 739-752 (1994)
   PUBMED   8043862
REFERENCE   7  (bases 1 to 4363)
  AUTHORS   Fawcett J, Holness CL, Needham LA, Turley H, Gatter KC, Mason DY
            and Simmons DL.
  TITLE     Molecular cloning of ICAM-3, a third ligand for LFA-1,
            constitutively expressed on resting leukocytes
  JOURNAL   Nature 360 (6403), 481-484 (1992)
   PUBMED   1448173
REFERENCE   8  (bases 1 to 4363)
  AUTHORS   Liu Y, Jones B, Aruffo A, Sullivan KM, Linsley PS and Janeway CA
            Jr.
  TITLE     Heat-stable antigen is a costimulatory molecule for CD4 T cell
            growth
  JOURNAL   J Exp Med 175 (2), 437-445 (1992)
   PUBMED   1346270
REFERENCE   9  (bases 1 to 4363)
  AUTHORS   Tamatani T, Kotani M and Miyasaka M.
  TITLE     Characterization of the rat leukocyte integrin, CD11/CD18, by the
            use of LFA-1 subunit-specific monoclonal antibodies
  JOURNAL   Eur J Immunol 21 (3), 627-633 (1991)
   PUBMED   1672643
REFERENCE   10 (bases 1 to 4363)
  AUTHORS   Dustin ML and Springer TA.
  TITLE     T-cell receptor cross-linking transiently stimulates adhesiveness
            through LFA-1
  JOURNAL   Nature 341 (6243), 619-624 (1989)
   PUBMED   2477710
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC101849.1, CV076006.1, DV727670.1 and CR471677.1.
            
            On May 3, 2007 this sequence version replaced NM_001033998.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760400,
                              SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3493              BC101849.1         1-3493
            3494-3987           CV076006.1         268-761
            3988-4358           DV727670.1         265-635
            4359-4363           CR471677.1         1-5                 c
FEATURES             Location/Qualifiers
     source          1..4363
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..4363
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /note="integrin subunit alpha L"
                     /db_xref="GeneID:308995"
                     /db_xref="RGD:631424"
     exon            1..132
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..3560
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /note="lymphocyte function-associated antigen-1; integrin,
                     alpha L"
                     /codon_start=1
                     /product="integrin alpha-L precursor"
                     /protein_id="NP_001029170.1"
                     /db_xref="GeneID:308995"
                     /db_xref="RGD:631424"
                     /translation="MSFRIPGPRLLLLGLQLFVNAWSYNLDTRHAQSFLTQAGRHFGY
                     QVLQFGDGVVVGAPGEGNSTGNLYHCHPSSGSCQPVHLGSNHTSKYLGMTMVTDAAKG
                     SLLACDPGLSRTCDQNPYLSGLCYLFSQSLGKPILQNRPAYQECMKGNVDLVFLFDGS
                     QSLDKKDFEKIVDFMKDVMRKLSNTSYQFAAVQFSTECKTEFTFLDYIKLNKNPDVLL
                     GNVTPMFLLTNTFRAINYVVTHVFKEESGARPDATKVLVIITDGEASDNGNIDAAQDI
                     TRYIIGIGKHFSTTQKQEKLHIFASKPVEEFVKILDTFEKLKDLFTDLQRKIYAIEGT
                     SKQDLASFNMELSSSGISADLSKGHAVVGAVGAKDWAGGFLDLHEDLEGATFVGQEPL
                     TSDERGGYLGYTVAWLTSRSSRPLLAAGAPRYQHVGQVLLFQAPEAGGHWNQTQKIEG
                     TQIGSYFGGELCSVDLHQDGETDLLLIGAPLFYGEQRGGRVSVYQRRRSLFEMVSELQ
                     GDPGYPLGRFGAAISALTDINGDGLTDVAVGAPLEEQGAVYIFNGKPGGFSSQSSQRI
                     PGTQVSPGVRWFGRSIHGVKDLGGDRLADVVVGAEGQVIVLSSRPVVDIVTELSFSPD
                     EIPVHEVECSYSASQEQKEGVKLKVCFQIRPLTSQFQGRLLANLSYTLQLDGHRTRSR
                     GLFPGGSRELGGNTFVTPDRSCMDFHFHFPICIQDLISPINVSLNFSLLEEEGSPRDQ
                     KGGRDMQPILRPSIHAVTKEIPFEKNCGEDKKCEADLALSPPARSGVLRLMSSASLAV
                     EWTLRNLGEDAYWVRLDLDFPRGLSFRKVEMLQPHSQIPVSCEELTEESSLLTKTLKC
                     NVSSPIFKAGKQMTLQVMFNTLLNSSWGDFVELNGTVHCENENSSLGKDNSATTRIPV
                     LYPVNILTEDQENSTLYISFTPKGPKTQQVQHIYKVRIQPSAYDHNMPALEALVEVPQ
                     PHSEGPIAHTWTVHTDPLVTCHCEDLKKPTREAEPCLPGVQFRCPIVFRQETFIRVAG
                     TVELSEKIKASSTLSLCSSLSVSFNSSKHFHLYGSKASKAQVLMKVDMIYEKEMLHLY
                     VLSGIGGLLLLSLIFLALYKVGFFKRKLKEKMEADGGVPNGSPGEDADPLAVPGEETK
                     DMGCLEPLRESDKD"
     exon            133..232
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            233..324
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..392
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..510
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..641
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..790
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..923
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1074
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1148
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1281
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1433
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1571
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1769
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1900
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2061
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2213
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2303
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2357
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2428
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2570
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2681
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2761
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..2848
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..2924
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..3038
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3039..3095
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3096..3194
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..3290
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3291..3401
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3402..4361
                     /gene="Itgal"
                     /gene_synonym="LFA-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccgggtct aggttgccag caaatctcaa gagctctcta agatccagtc tggaccatag
       61 gtccctccta ggcgcagatg agtttccgga tccctggccc cagacttctg ctattggggc
      121 tccagctgtt tgtgaatgcc tggagctaca acctggacac gcggcatgcg cagagcttct
      181 tgacacaagc tggaagacat tttgggtacc aggtcttgca gtttggagat ggggttgtcg
      241 tgggagctcc aggagagggg aacagcacag gaaacctcta tcactgtcac ccaagcagcg
      301 gctcctgcca gccagtccac ctaggttcta accatacctc caaatacttg ggaatgacca
      361 tggtgacaga tgctgccaag ggaagccttt tggcctgtga tcctggactg tctcggacct
      421 gtgatcagaa cccctacctc agtgggctgt gctacttatt ttcccagagc ctggggaaac
      481 ctatattaca aaatcgtcct gcttatcagg aatgtatgaa gggcaatgtc gacctagtgt
      541 ttctgttcga tggctcacag agcttggata aaaaggactt tgaaaaaatc gtggacttca
      601 tgaaggatgt gatgaggaaa ctcagcaaca cttcctacca gtttgctgct gttcagtttt
      661 ccacagagtg caaaacagaa tttactttct tggactacat caagctaaac aagaatcctg
      721 atgttctgct aggcaacgtg acgcccatgt tcttgctgac caataccttc cgtgccatca
      781 actacgtggt gacacacgtg ttcaaagaag agtctggtgc caggccagat gctaccaagg
      841 tgcttgtcat cattacagac ggggaagcaa gtgacaatgg caacatcgat gcagcccaag
      901 acataacccg ctatatcatc gggattggca agcatttttc aaccacacaa aagcaggaga
      961 aactccacat atttgcctca aaacctgtag aggaatttgt caagattctg gacacatttg
     1021 agaagctgaa ggatctgttt actgatctgc agaggaagat ttatgccatt gagggcacaa
     1081 gcaaacagga cctggcatcc tttaatatgg aactctcctc cagcgggatc agcgcagacc
     1141 tcagcaaggg ccatgcggtt gttggagccg ttggggctaa ggattgggct gggggctttc
     1201 tggacctgca tgaagacctg gagggtgcca catttgttgg gcaggaaccg ctgacctcag
     1261 atgagagagg aggttatctg ggttacactg tggcctggct gacctcccgg agctctagac
     1321 cactgctggc agcaggagct ccgcggtacc agcatgtggg acaagtgctg cttttccaag
     1381 ccccagaagc tggaggacat tggaaccaga ctcagaagat agaagggact cagatcggat
     1441 cttactttgg tggggagcta tgtagcgttg acctgcacca agatggcgag acagatctgc
     1501 tgctgattgg agcgcccctc ttctacgggg agcagagagg aggccgagtg tccgtttacc
     1561 agagaagacg gtcactgttc gaaatggtct cagagctgca gggtgaccca ggctacccgc
     1621 ttggtcggtt tggagctgcc ataagtgccc tgacagacat caatggggat gggctgactg
     1681 atgtggccgt gggagcccct ctggaggagc agggggctgt gtatatcttc aatgggaagc
     1741 ctggtgggtt cagttcccag tcaagtcagc gtataccagg aacccaggtg tccccgggag
     1801 tccggtggtt tggacgctcc atccatgggg tgaaggacct tggaggggac aggctggcag
     1861 atgtggttgt aggagctgag ggccaggtga ttgtgctgag ctcgaggccg gtggtggata
     1921 ttgtcactga gctgtccttc tccccagacg aaatcccagt gcatgaggtg gagtgctcct
     1981 actcagccag tcaggagcag aaggaaggcg tcaagctcaa ggtgtgcttc cagatccgcc
     2041 cccttacgtc tcagtttcaa ggtcgcctgc ttgccaacct cagctacacc ctgcagctgg
     2101 acggccatcg gacgaggagc cgaggtctgt tcccaggagg aagccgtgag ctcggcggaa
     2161 acacatttgt caccccagat aggtcctgca tggacttcca cttccacttc ccaatctgca
     2221 ttcaagacct catctcccct atcaatgtct ctctgaattt ctctcttttg gaggaagaag
     2281 gatcaccaag ggaccaaaag gggggcaggg acatgcagcc catcctgaga ccttcgatcc
     2341 atgcagtcac taaggagatc ccctttgaga agaactgtgg tgaggataag aagtgtgagg
     2401 cagacctggc cctgtcacct cctgccagat ccggagtcct gcgtctgatg tcctctgcca
     2461 gccttgctgt ggagtggaca ctgaggaact tgggagaaga cgcttactgg gtgcgactgg
     2521 acctggactt cccccggggc ctctccttcc gaaaagtgga gatgcttcag ccacacagcc
     2581 aaatacctgt gagctgcgag gagctcaccg aggagtcgag tctcctgact aagaccctga
     2641 aatgcaatgt gagctctccc atcttcaaag caggcaaaca gatgaccctc caggtgatgt
     2701 ttaacacgct actcaacagt tcctggggag attttgtcga gctgaacggc actgtgcact
     2761 gtgagaacga gaactcaagc ctcgggaagg acaactcagc caccacccgc attcctgtcc
     2821 tgtaccctgt caacatcctt actgaggacc aggagaactc cacactctat atcagtttca
     2881 cccctaaagg tcccaagact caacaagtcc agcatatcta caaggtgagg attcagcctt
     2941 ctgcctatga ccacaacatg cccgcactgg aggccttggt tgaggtgccg cagcctcaca
     3001 gcgagggccc catcgcacac acatggactg tgcatacgga tccccttgtc acttgccact
     3061 gtgaggacct gaagaagcca accagggaag ctgagccctg tctgcctgga gtccagttcc
     3121 gctgcccaat tgtcttcagg caagagacct tcatccgagt ggccgggact gtggaactct
     3181 cagagaaaat caaggcctcc tccacactca gcctctgcag ctcgctctca gtctccttca
     3241 acagcagcaa gcatttccat ttgtatggta gcaaggcctc caaggcccag gtcctcatga
     3301 aggttgacat gatctatgag aaggagatgc ttcacctgta cgtgctcagc ggcattgggg
     3361 ggctattgct actgtccctg attttcctag cgctctacaa ggttggtttc ttcaaacgga
     3421 agctgaagga gaagatggag gcggatggag gtgttccaaa tggaagccct ggcgaagacg
     3481 ctgaccctct ggcagtacct ggggaagaga ccaaagatat gggctgtcta gagcccctcc
     3541 gtgagagtga caaggactaa gctctgatac acggctggcc cagggacaga cttgggagcc
     3601 ctggcagtga ccagcttcag ctccatgtca ctagccgatc cttggcttgt catggctgct
     3661 cctagttttc agcttccctg tcctgagcat agagcttgtt cttacgttat ctacaggtaa
     3721 ggctgagggc agccaagagg gccatcggtg aagcctgtct tctgctagcc taccttgttg
     3781 tccctctgag agaatcttca aaatagactt ggagaaactg ttatctcagg acccggtaat
     3841 actccaaccc tcccaactgc ccttgggctg tcccgacctc ctggatgtgc cccacgctct
     3901 ctcctgccgg gactctgctg ccatctgtgt cccgtgggac acacgtctgc atggctgcta
     3961 cagatgcctt cttgagtgag tcagagacga cattctttga agagccttag aaggccttat
     4021 gaagtcaggc cccagtggcc cccagcctct gctgaggatg actcacctct ctctcccagg
     4081 ctgcagttat cacagccttt cccggagttt gtctcctttc tataggctgc atttgagctc
     4141 atgccctcct cccccaggga tgcttctgcc ccctcctgtt ctggctaagg agggctccac
     4201 actgcacctc acaccagcct gttctcgcct cagtctgcca ggttatattt attctctctt
     4261 tgatgattta atttctacct ctccttgagc tccttgaggt tagggcatgc gttttctgtt
     4321 gctacaataa agcaccccaa agaaaacaac atacgtggaa aaa
//
