LOCUS       NM_031768               3776 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus integrin subunit alpha E (Itgae), mRNA.
ACCESSION   NM_031768
VERSION     NM_031768.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3776)
  AUTHORS   Sun,J.K., Zhang,Q., Shen,X., Zhou,J., Wang,X., Zhou,S.M. and
            Mu,X.W.
  TITLE     Integrin alphaEbeta7 is involved in the intestinal barrier injury
            of sepsis
  JOURNAL   Aging (Albany NY) 14 (2), 780-788 (2022)
   PUBMED   35042191
  REMARK    GeneRIF: Integrin alphaEbeta7 is involved in the intestinal barrier
            injury of sepsis.
REFERENCE   2  (bases 1 to 3776)
  AUTHORS   Engel,I., Zhao,M., Kappes,D., Taniuchi,I. and Kronenberg,M.
  TITLE     The transcription factor Th-POK negatively regulates Th17
            differentiation in Valpha14i NKT cells
  JOURNAL   Blood 120 (23), 4524-4532 (2012)
   PUBMED   23034280
REFERENCE   3  (bases 1 to 3776)
  AUTHORS   Abe,J., Ueha,S., Suzuki,J., Tokano,Y., Matsushima,K. and
            Ishikawa,S.
  TITLE     Increased Foxp3(+) CD4(+) regulatory T cells with intact
            suppressive activity but altered cellular localization in murine
            lupus
  JOURNAL   Am J Pathol 173 (6), 1682-1692 (2008)
   PUBMED   19008373
REFERENCE   4  (bases 1 to 3776)
  AUTHORS   Takada,Y., Ye,X. and Simon,S.
  TITLE     The integrins
  JOURNAL   Genome Biol 8 (5), 215 (2007)
   PUBMED   17543136
  REMARK    Review article
REFERENCE   5  (bases 1 to 3776)
  AUTHORS   Chae,W.J., Henegariu,O., Lee,S.K. and Bothwell,A.L.
  TITLE     The mutant leucine-zipper domain impairs both dimerization and
            suppressive function of Foxp3 in T cells
  JOURNAL   Proc Natl Acad Sci U S A 103 (25), 9631-9636 (2006)
   PUBMED   16769892
REFERENCE   6  (bases 1 to 3776)
  AUTHORS   Degauque,N., Lair,D., Dupont,A., Moreau,A., Roussey,G., Moizant,F.,
            Hubert,F.X., Louvet,C., Hill,M., Haspot,F., Josien,R., Usal,C.,
            Vanhove,B., Soulillou,J.P. and Brouard,S.
  TITLE     Dominant tolerance to kidney allografts induced by anti-donor MHC
            class II antibodies: cooperation between T and non-T CD103+ cells
  JOURNAL   J Immunol 176 (7), 3915-3922 (2006)
   PUBMED   16547225
  REMARK    GeneRIF: transfer of tolerance requires the presence of both T
            cells and CD103(+) dendritic cells
REFERENCE   7  (bases 1 to 3776)
  AUTHORS   Fontenot,J.D., Rasmussen,J.P., Gavin,M.A. and Rudensky,A.Y.
  TITLE     A function for interleukin 2 in Foxp3-expressing regulatory T cells
  JOURNAL   Nat Immunol 6 (11), 1142-1151 (2005)
   PUBMED   16227984
  REMARK    Erratum:[Nat Immunol. 2006 Apr;7(4):427]
REFERENCE   8  (bases 1 to 3776)
  AUTHORS   Yan,H., Miyagi,T., Satoh,E., Sugiura,W., Yamamoto,N. and Kimura,H.
  TITLE     Phenotype and function of GM-CSF independent dendritic cells
            generated by long-term propagation of rat bone marrow cells
  JOURNAL   Cell Immunol 229 (2), 117-129 (2004)
   PUBMED   15474526
REFERENCE   9  (bases 1 to 3776)
  AUTHORS   Brenan,M. and Rees,D.J.
  TITLE     Sequence analysis of rat integrin alpha E1 and alpha E2 subunits:
            tissue expression reveals phenotypic similarities between
            intraepithelial lymphocytes and dendritic cells in lymph
  JOURNAL   Eur J Immunol 27 (11), 3070-3079 (1997)
   PUBMED   9394838
  REMARK    Erratum:[Eur J Immunol 1998 Nov;28(11):3891]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jan 14, 2022 this sequence version replaced NM_031768.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF020046.1, SRR26643292.41611.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN13663594
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                JAXUCZ010000010.1  58203368-58203452
            86-209              JAXUCZ010000010.1  58215434-58215557
            210-307             JAXUCZ010000010.1  58219903-58220000
            308-375             JAXUCZ010000010.1  58220742-58220809
            376-493             JAXUCZ010000010.1  58221134-58221251
            494-631             JAXUCZ010000010.1  58221465-58221602
            632-747             JAXUCZ010000010.1  58222375-58222490
            748-899             JAXUCZ010000010.1  58223011-58223162
            900-1053            JAXUCZ010000010.1  58224206-58224359
            1054-1204           JAXUCZ010000010.1  58224820-58224970
            1205-1272           JAXUCZ010000010.1  58225401-58225468
            1273-1411           JAXUCZ010000010.1  58226262-58226400
            1412-1554           JAXUCZ010000010.1  58227055-58227197
            1555-1695           JAXUCZ010000010.1  58227528-58227668
            1696-1920           JAXUCZ010000010.1  58228163-58228387
            1921-2051           JAXUCZ010000010.1  58229188-58229318
            2052-2182           JAXUCZ010000010.1  58230778-58230908
            2183-2346           JAXUCZ010000010.1  58232918-58233081
            2347-2475           JAXUCZ010000010.1  58234510-58234638
            2476-2549           JAXUCZ010000010.1  58237419-58237492
            2550-2682           JAXUCZ010000010.1  58240545-58240677
            2683-2781           JAXUCZ010000010.1  58242141-58242239
            2782-2861           JAXUCZ010000010.1  58243043-58243122
            2862-2936           JAXUCZ010000010.1  58243823-58243897
            2937-3000           JAXUCZ010000010.1  58244593-58244656
            3001-3108           JAXUCZ010000010.1  58244736-58244843
            3109-3165           JAXUCZ010000010.1  58249193-58249249
            3166-3261           JAXUCZ010000010.1  58249499-58249594
            3262-3357           JAXUCZ010000010.1  58251233-58251328
            3358-3468           JAXUCZ010000010.1  58261109-58261219
            3469-3776           JAXUCZ010000010.1  58262299-58262606
FEATURES             Location/Qualifiers
     source          1..3776
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..3776
                     /gene="Itgae"
                     /note="integrin subunit alpha E"
                     /db_xref="GeneID:83577"
                     /db_xref="RGD:621644"
     exon            1..85
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..3558
                     /gene="Itgae"
                     /note="integrin alpha E1, epithelial-associated; integrin,
                     alpha E, epithelial-associated"
                     /codon_start=1
                     /product="integrin alpha-E precursor"
                     /protein_id="NP_113956.2"
                     /db_xref="GeneID:83577"
                     /db_xref="RGD:621644"
                     /translation="MKWFFHALLCVASLKPLGAFNVDVDWSWVTALQPGAPSVLNSLL
                     HQDPSNNQTCLLVARRSSNRNSAVLYRCATSIIPDEIGCQPVEHILMPKGRYQGVTLV
                     RNHNGVLVCIQVQSRKPRSLNSELTGACSLLTPNLDLQAQAYFSDLEGVLDLGASVNS
                     GDYYGSKGGSTGEETKSARRLRRQAVEEEDEEEAGTEIAIVLDGSGSIEPSDFQKAKD
                     FISTMMRNFYEKCFECNFALVQYGGVIQTEFDLLDSRDINASLAKVQSIVQVKEVTKT
                     ASAMQHVLDNIFIPSRGSRKKALKVMVVLTDGDIFRDPLNLTTVISSSKMQGVVRFAI
                     GVGNAFENNNTYRELKLIASDPKAAHTFKVTNYSALDGLLSKLQQRIIHMEGTVGDTL
                     QYQLAQTGFSAQILDKGQVLLGTVGAFNWSGGALLYNTQNGRGRFLNQTAKEDFRAAQ
                     YSYLGYSVAALHKAHGVSYVAGAPRHKLRGAVFELQKEDGEETFMRRIEGEQMGSYFG
                     SVLCPVDINMDGITDFLLVAAPFYHIRGEEGRVYVYRVHEQDAPFSLVYTLSGYPGLT
                     SSRFGFAMAAVGDINQDKFTDVAIGAPLEGFGAGDGASYGSVYIYNGHSGGLHASPSQ
                     QIRASSVALGLYYFGMSVSGGLDFSGDDLADITVGSQDVAVVLRSRPVVDLTVSMTFT
                     PDALPMAFKDKMDVELCFKVDSSAVPSEPGLRGMSLNFTVDVDVTKQKQRLQCADRSC
                     CQSCLMKWSGGSSLCEHFGLISTEEELCEDDCFSNITIKVSYEFQTSEERRNHPNPIL
                     DHYKEPSAIFQLPYEKDCKNKVFCIAEIQLTTAISQQDLVVGITKEVTMNISLTNSGE
                     DSYMTNMALNYPRNLQFKKIQKPLSPDIQCDDPKPVASVLVMNCKIGHPILKRSSVNV
                     SVTWQLEESIFPNRTADITVTISNSNEKSLARETHSLQFRHAFIAVLSRPSVMYMNTS
                     QSSSDHKEFFFNVHGENHFGAVFQLQICVPITLRDLQIIRVKHLTKTQAHTECTQSQE
                     PTCGSDPVQNVEEWHSVICAITSNKENVTVAAEISMGHTKQLLRDISELQILGEISFN
                     KSLYEGLNAENHRTKITVIFLKEEKPHSLPLIIGSSIGGLLVLVVIIAILFKCGFFKR
                     KYKQLNLESVRKAQLKSDSLLED"
     exon            86..209
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            210..307
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            308..375
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            376..493
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            494..631
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            632..747
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            748..899
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1053
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1204
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1272
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1411
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1554
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1695
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1920
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2051
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2182
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2346
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2475
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2549
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2682
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2781
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2861
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..2936
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3000
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3108
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3165
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3261
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3357
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..3468
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
     exon            3469..3776
                     /gene="Itgae"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttctctgtgt cgccccactc agctcacacg gttgcgtctg ctccagctat gaagtggttc
       61 ttccatgccc ttctctgcgt ggccagcctg aagcccttgg gagccttcaa tgtggatgtg
      121 gactggtcct gggtcacagc actccagcca ggtgcgcctt ccgtgctcaa ctcccttctg
      181 catcaagacc ccagcaacaa ccagacctgc ctcctggtag ccagacgcag ctccaacagg
      241 aattcagcag tcctgtatcg atgtgctaca tccatcattc cagatgaaat tggttgccag
      301 ccagtagagc acatccttat gccaaagggc aggtaccagg gagtgacatt ggtcaggaac
      361 cacaatggtg ttttggtatg cattcaggta cagtcccgga agccccgcag ccttaactcg
      421 gagctcaccg gtgcctgcag cctacttacc cccaacttgg acctccaggc gcaagcctac
      481 ttctctgacc ttgaaggagt cctggatctg ggtgcatctg tgaactctgg tgactactac
      541 ggaagcaaag gaggcagcac aggggaggag acgaaatcag ccaggagact ccgacgacag
      601 gcagtggagg aggaagacga ggaggaagct ggcaccgaaa tcgctattgt tctggatggc
      661 tcaggaagca ttgaaccctc agacttccag aaggccaaag atttcatctc tacgatgatg
      721 aggaacttct atgaaaagtg ttttgagtgc aactttgccc tggtgcagta tgggggcgtg
      781 atccagactg agtttgatct tctagacagc cgggacatca acgcctccct tgccaaagtt
      841 cagagcatcg ttcaagtgaa ggaagtcact aagaccgcct cagccatgca gcatgtccta
      901 gataatatct tcattccaag tcgtggctcc agaaagaaag cattgaaggt tatggtggtg
      961 cttactgatg gtgacatatt tagggaccct ctcaacctta cgactgtcat cagttcctca
     1021 aagatgcagg gtgttgtgcg ctttgccatt ggggtaggca atgcattcga gaataataac
     1081 acttacagag aactgaagct gattgcctca gaccctaaag cggcccacac tttcaaggtg
     1141 accaactact cggctctgga tgggctgctg agcaagctac agcagaggat catccacatg
     1201 gaaggcacag ttggagacac ccttcaatat caactcgcac agactggctt cagtgctcag
     1261 atcctggaca aggggcaggt gttgcttggc actgtggggg cctttaactg gtctgggggc
     1321 gcgctgctct acaacacaca gaatggtcgg ggccgcttcc taaaccagac agccaaggag
     1381 gacttcaggg ctgcacagta cagctacctc ggttattcag ttgcagcgct acacaaggcc
     1441 catggtgtct cctacgtggc aggggctcca aggcacaagc tccgtggggc tgtgtttgag
     1501 ctccagaagg aggacggaga ggaaaccttc atgcgacgga tagaaggaga gcagatgggg
     1561 tcctattttg gctctgtgct gtgccctgtg gatatcaaca tggatggaat cacagatttt
     1621 ctgctggtgg cagctccatt ttaccacatc cgtggagaag aaggcagagt ctatgtgtac
     1681 cgcgtgcacg agcaggatgc tcccttctcc ttggtataca cactgagtgg gtaccctggg
     1741 ctcaccagta gccgcttcgg ctttgccatg gcagctgtgg gggatatcaa tcaagataaa
     1801 ttcacagatg tggccattgg ggcccctctg gagggctttg gggcaggcga tggggcaagc
     1861 tatggcagcg tgtacatcta caatggacac tcaggtggcc tgcatgccag tccctcccag
     1921 cagatcagag cctcctctgt ggccttggga ctctactact ttggcatgtc tgtgtctggt
     1981 ggtttagatt tcagtggcga tgaccttgcc gacatcacag ttggctctca ggacgtggca
     2041 gttgtgctcc gctcacgacc tgtggtggac ctgactgtgt ctatgacctt tacccctgat
     2101 gcgctgccca tggccttcaa ggacaagatg gatgtagaac tgtgcttcaa agttgactct
     2161 tcagctgtac cttctgaacc aggccttaga gggatgtcac taaactttac cgtggatgtg
     2221 gatgtgacca agcagaagca gaggctgcag tgtgcagacc ggagttgttg tcaaagctgc
     2281 cttatgaagt ggagcggagg atcctctctg tgtgaacact tcgggctcat ctccacagag
     2341 gaggagcttt gtgaggatga ctgcttctcc aacatcacca tcaaggtcag ttatgagttc
     2401 cagacatccg aggaaaggag gaaccacccc aaccccatcc tggaccacta caaggaaccc
     2461 tctgccatct tccagctgcc ctatgagaag gactgcaaga acaaagtgtt ctgcatcgct
     2521 gagatccagc tgaccaccgc catctctcag caagacctgg tggtgggtat cacaaaggag
     2581 gtgaccatga acatcagcct gactaactct ggggaagatt cttacatgac aaacatggct
     2641 ctgaattatc ccagaaactt acagtttaag aagatacaaa agccactctc tccagatatt
     2701 cagtgtgatg accccaagcc agtcgcttct gtcctggtca tgaactgcaa gattggtcac
     2761 cccatactca agagatcatc tgtaaatgtc tcagtgactt ggcagctaga ggagagtatc
     2821 tttccaaata ggacagcaga tatcactgtg accatctcca attccaatga gaagtctttg
     2881 gccagagaga cccacagcct tcaattcagg catgccttca ttgcagttct ttccagaccg
     2941 tcagtgatgt acatgaacac gagccaaagc tcttctgacc acaaagaatt cttcttcaac
     3001 gtgcacgggg agaatcactt tggagctgta ttccagttgc aaatttgtgt ccccatcaca
     3061 ttacgagatt tacagattat aagagtgaag catctgacaa agactcaggc ccacactgag
     3121 tgcacccaga gtcaagagcc cacgtgtgga agcgatcctg ttcagaatgt ggaagaatgg
     3181 cattcagtga tctgcgctat cacatctaat aaagaaaatg taaccgtggc cgcagagatc
     3241 tccatgggcc acactaagca gttactaaga gatataagtg aactgcagat ccttggtgaa
     3301 atatctttca acaaatctct ctatgagggc ctgaatgcag agaaccacag gacaaagatc
     3361 acagtcatct tcctgaagga ggagaagcca cactccctgc ctctaatcat tggcagcagt
     3421 atcggaggcc tcctggtcct ggtcgtgatt atagccattc tgttcaagtg tggctttttc
     3481 aaaagaaaat ataaacagct gaacttggag agcgtaagga aggcacagct gaagtctgac
     3541 agtctgctcg aagattagcc cctgcttcct cacctgaagg agggagcttg aggcagtctg
     3601 gaagaagccc ggataccccc tgtcggggct ccttactctc tttaggacaa tctagcaaca
     3661 tcaaacaaac tgtagagtgt tgttcgtagc cacacattat ctccacagtg tctgtgaatt
     3721 gtgaaaaaag ggaaacttgg gacatgcggt aataaataaa tttaccttta cagtga
//
