LOCUS       NP_113956               1169 aa            linear   ROD 30-MAR-2024
DEFINITION  integrin alpha-E precursor [Rattus norvegicus].
ACCESSION   NP_113956
VERSION     NP_113956.2
DBSOURCE    REFSEQ: accession NM_031768.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1169)
  AUTHORS   Sun,J.K., Zhang,Q., Shen,X., Zhou,J., Wang,X., Zhou,S.M. and
            Mu,X.W.
  TITLE     Integrin alphaEbeta7 is involved in the intestinal barrier injury
            of sepsis
  JOURNAL   Aging (Albany NY) 14 (2), 780-788 (2022)
   PUBMED   35042191
  REMARK    GeneRIF: Integrin alphaEbeta7 is involved in the intestinal barrier
            injury of sepsis.
REFERENCE   2  (residues 1 to 1169)
  AUTHORS   Engel,I., Zhao,M., Kappes,D., Taniuchi,I. and Kronenberg,M.
  TITLE     The transcription factor Th-POK negatively regulates Th17
            differentiation in Valpha14i NKT cells
  JOURNAL   Blood 120 (23), 4524-4532 (2012)
   PUBMED   23034280
REFERENCE   3  (residues 1 to 1169)
  AUTHORS   Abe,J., Ueha,S., Suzuki,J., Tokano,Y., Matsushima,K. and
            Ishikawa,S.
  TITLE     Increased Foxp3(+) CD4(+) regulatory T cells with intact
            suppressive activity but altered cellular localization in murine
            lupus
  JOURNAL   Am J Pathol 173 (6), 1682-1692 (2008)
   PUBMED   19008373
REFERENCE   4  (residues 1 to 1169)
  AUTHORS   Takada,Y., Ye,X. and Simon,S.
  TITLE     The integrins
  JOURNAL   Genome Biol 8 (5), 215 (2007)
   PUBMED   17543136
  REMARK    Review article
REFERENCE   5  (residues 1 to 1169)
  AUTHORS   Chae,W.J., Henegariu,O., Lee,S.K. and Bothwell,A.L.
  TITLE     The mutant leucine-zipper domain impairs both dimerization and
            suppressive function of Foxp3 in T cells
  JOURNAL   Proc Natl Acad Sci U S A 103 (25), 9631-9636 (2006)
   PUBMED   16769892
REFERENCE   6  (residues 1 to 1169)
  AUTHORS   Degauque,N., Lair,D., Dupont,A., Moreau,A., Roussey,G., Moizant,F.,
            Hubert,F.X., Louvet,C., Hill,M., Haspot,F., Josien,R., Usal,C.,
            Vanhove,B., Soulillou,J.P. and Brouard,S.
  TITLE     Dominant tolerance to kidney allografts induced by anti-donor MHC
            class II antibodies: cooperation between T and non-T CD103+ cells
  JOURNAL   J Immunol 176 (7), 3915-3922 (2006)
   PUBMED   16547225
  REMARK    GeneRIF: transfer of tolerance requires the presence of both T
            cells and CD103(+) dendritic cells
REFERENCE   7  (residues 1 to 1169)
  AUTHORS   Fontenot,J.D., Rasmussen,J.P., Gavin,M.A. and Rudensky,A.Y.
  TITLE     A function for interleukin 2 in Foxp3-expressing regulatory T cells
  JOURNAL   Nat Immunol 6 (11), 1142-1151 (2005)
   PUBMED   16227984
  REMARK    Erratum:[Nat Immunol. 2006 Apr;7(4):427]
REFERENCE   8  (residues 1 to 1169)
  AUTHORS   Yan,H., Miyagi,T., Satoh,E., Sugiura,W., Yamamoto,N. and Kimura,H.
  TITLE     Phenotype and function of GM-CSF independent dendritic cells
            generated by long-term propagation of rat bone marrow cells
  JOURNAL   Cell Immunol 229 (2), 117-129 (2004)
   PUBMED   15474526
REFERENCE   9  (residues 1 to 1169)
  AUTHORS   Brenan,M. and Rees,D.J.
  TITLE     Sequence analysis of rat integrin alpha E1 and alpha E2 subunits:
            tissue expression reveals phenotypic similarities between
            intraepithelial lymphocytes and dendritic cells in lymph
  JOURNAL   Eur J Immunol 27 (11), 3070-3079 (1997)
   PUBMED   9394838
  REMARK    Erratum:[Eur J Immunol 1998 Nov;28(11):3891]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On May 9, 2012 this sequence version replaced NP_113956.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF020046.1, SRR26643292.41611.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN13663594
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1169
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     Protein         1..1169
                     /product="integrin alpha-E precursor"
                     /note="integrin alpha E1, epithelial-associated; integrin,
                     alpha E, epithelial-associated"
                     /calculated_mol_wt=126913
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2133
     Region          196..373
                     /region_name="vWA_integrins_alpha_subunit"
                     /note="Integrins are a class of adhesion receptors that
                     link the extracellular matrix to the cytoskeleton and
                     cooperate with growth factor receptors to promote celll
                     survival, cell cycle progression and cell migration.
                     Integrins consist of an alpha and a beta...; cd01469"
                     /db_xref="CDD:238746"
     Site            order(196,198,219,301,303,332,362)
                     /site_type="active"
                     /note="integrin inhibitor binding pocket [active]"
                     /db_xref="CDD:238746"
     Site            order(203,205,207,274,307)
                     /site_type="other"
                     /note="metal ion-dependent adhesion site (MIDAS)"
                     /db_xref="CDD:238746"
     Site            order(205..207,209,274)
                     /site_type="active"
                     /note="integrin-collagen binding site [active]"
                     /db_xref="CDD:238746"
     Region          503..559
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          568..626
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          670..>941
                     /region_name="Integrin_alpha2"
                     /note="Integrin alpha; pfam08441"
                     /db_xref="CDD:462478"
     CDS             1..1169
                     /gene="Itgae"
                     /coded_by="NM_031768.3:49..3558"
                     /db_xref="GeneID:83577"
                     /db_xref="RGD:621644"
ORIGIN      
        1 mkwffhallc vaslkplgaf nvdvdwswvt alqpgapsvl nsllhqdpsn nqtcllvarr
       61 ssnrnsavly rcatsiipde igcqpvehil mpkgryqgvt lvrnhngvlv ciqvqsrkpr
      121 slnseltgac slltpnldlq aqayfsdleg vldlgasvns gdyygskggs tgeetksarr
      181 lrrqaveeed eeeagteiai vldgsgsiep sdfqkakdfi stmmrnfyek cfecnfalvq
      241 yggviqtefd lldsrdinas lakvqsivqv kevtktasam qhvldnifip srgsrkkalk
      301 vmvvltdgdi frdplnlttv issskmqgvv rfaigvgnaf ennntyrelk liasdpkaah
      361 tfkvtnysal dgllsklqqr iihmegtvgd tlqyqlaqtg fsaqildkgq vllgtvgafn
      421 wsggallynt qngrgrflnq takedfraaq ysylgysvaa lhkahgvsyv agaprhklrg
      481 avfelqkedg eetfmrrieg eqmgsyfgsv lcpvdinmdg itdfllvaap fyhirgeegr
      541 vyvyrvheqd apfslvytls gypgltssrf gfamaavgdi nqdkftdvai gaplegfgag
      601 dgasygsvyi ynghsgglha spsqqirass valglyyfgm svsggldfsg ddladitvgs
      661 qdvavvlrsr pvvdltvsmt ftpdalpmaf kdkmdvelcf kvdssavpse pglrgmslnf
      721 tvdvdvtkqk qrlqcadrsc cqsclmkwsg gsslcehfgl isteeelced dcfsnitikv
      781 syefqtseer rnhpnpildh ykepsaifql pyekdcknkv fciaeiqltt aisqqdlvvg
      841 itkevtmnis ltnsgedsym tnmalnyprn lqfkkiqkpl spdiqcddpk pvasvlvmnc
      901 kighpilkrs svnvsvtwql eesifpnrta ditvtisnsn ekslareths lqfrhafiav
      961 lsrpsvmymn tsqsssdhke fffnvhgenh fgavfqlqic vpitlrdlqi irvkhltktq
     1021 ahtectqsqe ptcgsdpvqn veewhsvica itsnkenvtv aaeismghtk qllrdiselq
     1081 ilgeisfnks lyeglnaenh rtkitviflk eekphslpli igssiggllv lvviiailfk
     1141 cgffkrkykq lnlesvrkaq lksdslled
//
