LOCUS       NM_031691               3842 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Rattus norvegicus integrin subunit alpha D (Itgad), mRNA.
ACCESSION   NM_031691
VERSION     NM_031691.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3842)
  AUTHORS   Hurtado,A., Marcillo,A., Frydel,B., Bunge,M.B., Bramlett,H.M. and
            Dietrich,W.D.
  TITLE     Anti-CD11d monoclonal antibody treatment for rat spinal cord
            compression injury
  JOURNAL   Exp Neurol 233 (2), 606-611 (2012)
   PUBMED   21145887
  REMARK    GeneRIF: An anti-CD11d monoclonal antibody improves motor
            performance, reduces pain and histopathological damage in animals
            following clip-compression injury.
REFERENCE   2  (bases 1 to 3842)
  AUTHORS   Thomas,A.P., Dunn,T.N., Oort,P.J., Grino,M. and Adams,S.H.
  TITLE     Inflammatory phenotyping identifies CD11d as a gene markedly
            induced in white adipose tissue in obese rodents and women
  JOURNAL   J Nutr 141 (6), 1172-1180 (2011)
   PUBMED   21508205
  REMARK    GeneRIF: CD11d expression increased in retroperitoneal white
            adipose tissue of Zucker obese rats.
REFERENCE   3  (bases 1 to 3842)
  AUTHORS   Zhou,C., Robertson,J., Wu,J., Bartkowiak,T., Parker,K., McMahon,J.
            and Lou,Y.H.
  TITLE     Natural recovery from antiglomerular basement membrane
            glomerulonephritis is associated with glomeruli-infiltrating
            CD8alpha+CD11c+MHC class II+ cells
  JOURNAL   Am J Nephrol 34 (6), 519-528 (2011)
   PUBMED   22068125
  REMARK    GeneRIF: Recovery from Antiglomerular Basement Membrane
            Glomerulonephritis Is Associated with Glomeruli-Infiltrating
            CD8alpha+CD11c+MHC Class II+ Cells
REFERENCE   4  (bases 1 to 3842)
  AUTHORS   Semon,J.A., Nagy,L.H., Llamas,C.B., Tucker,H.A., Lee,R.H. and
            Prockop,D.J.
  TITLE     Integrin expression and integrin-mediated adhesion in vitro of
            human multipotent stromal cells (MSCs) to endothelial cells from
            various blood vessels
  JOURNAL   Cell Tissue Res 341 (1), 147-158 (2010)
   PUBMED   20563599
REFERENCE   5  (bases 1 to 3842)
  AUTHORS   Takada,Y., Ye,X. and Simon,S.
  TITLE     The integrins
  JOURNAL   Genome Biol 8 (5), 215 (2007)
   PUBMED   17543136
  REMARK    Review article
REFERENCE   6  (bases 1 to 3842)
  AUTHORS   Wu,H., Rodgers,J.R., Perrard,X.Y., Perrard,J.L., Prince,J.E.,
            Abe,Y., Davis,B.K., Dietsch,G., Smith,C.W. and Ballantyne,C.M.
  TITLE     Deficiency of CD11b or CD11d results in reduced staphylococcal
            enterotoxin-induced T cell response and T cell phenotypic changes
  JOURNAL   J Immunol 173 (1), 297-306 (2004)
   PUBMED   15210787
REFERENCE   7  (bases 1 to 3842)
  AUTHORS   Hynes,R.O.
  TITLE     Integrins: bidirectional, allosteric signaling machines
  JOURNAL   Cell 110 (6), 673-687 (2002)
   PUBMED   12297042
  REMARK    Review article
REFERENCE   8  (bases 1 to 3842)
  AUTHORS   Shelley,C.S., Teodoridis,J.M., Park,H., Farokhzad,O.C.,
            Bottinger,E.P. and Arnaout,M.A.
  TITLE     During differentiation of the monocytic cell line U937, Pur alpha
            mediates induction of the CD11c beta 2 integrin gene promoter
  JOURNAL   J Immunol 168 (8), 3887-3893 (2002)
   PUBMED   11937543
REFERENCE   9  (bases 1 to 3842)
  AUTHORS   Tamatani,T., Kotani,M. and Miyasaka,M.
  TITLE     Characterization of the rat leukocyte integrin, CD11/CD18, by the
            use of LFA-1 subunit-specific monoclonal antibodies
  JOURNAL   Eur J Immunol 21 (3), 627-633 (1991)
   PUBMED   1672643
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jun 3, 2021 this sequence version replaced NM_031691.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF021334.1, SRR26643292.4272.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                JAXUCZ010000001.1  192190204-192190263
            61-166              JAXUCZ010000001.1  192191931-192192036
            167-270             JAXUCZ010000001.1  192194197-192194300
            271-341             JAXUCZ010000001.1  192194429-192194499
            342-456             JAXUCZ010000001.1  192194633-192194747
            457-587             JAXUCZ010000001.1  192197767-192197897
            588-733             JAXUCZ010000001.1  192199645-192199790
            734-887             JAXUCZ010000001.1  192202292-192202445
            888-1038            JAXUCZ010000001.1  192202543-192202693
            1039-1112           JAXUCZ010000001.1  192202845-192202918
            1113-1242           JAXUCZ010000001.1  192204061-192204190
            1243-1385           JAXUCZ010000001.1  192204277-192204419
            1386-1526           JAXUCZ010000001.1  192204582-192204722
            1527-1736           JAXUCZ010000001.1  192204808-192205017
            1737-1867           JAXUCZ010000001.1  192205682-192205812
            1868-2025           JAXUCZ010000001.1  192205898-192206055
            2026-2180           JAXUCZ010000001.1  192207430-192207584
            2181-2309           JAXUCZ010000001.1  192207808-192207936
            2310-2383           JAXUCZ010000001.1  192208692-192208765
            2384-2525           JAXUCZ010000001.1  192208934-192209075
            2526-2639           JAXUCZ010000001.1  192212464-192212577
            2640-2719           JAXUCZ010000001.1  192212679-192212758
            2720-2803           JAXUCZ010000001.1  192212866-192212949
            2804-2882           JAXUCZ010000001.1  192216380-192216458
            2883-2990           JAXUCZ010000001.1  192216582-192216689
            2991-3068           JAXUCZ010000001.1  192216775-192216852
            3069-3182           JAXUCZ010000001.1  192217023-192217136
            3183-3284           JAXUCZ010000001.1  192217281-192217382
            3285-3395           JAXUCZ010000001.1  192217871-192217981
            3396-3842           JAXUCZ010000001.1  192218418-192218864
FEATURES             Location/Qualifiers
     source          1..3842
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..3842
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /note="integrin subunit alpha D"
                     /db_xref="GeneID:64350"
                     /db_xref="RGD:71075"
     exon            1..60
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..3509
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /note="integrin alpha-D; integrin alpha X (Cd11c)"
                     /codon_start=1
                     /product="integrin alpha-D precursor"
                     /protein_id="NP_113879.2"
                     /db_xref="GeneID:64350"
                     /db_xref="RGD:71075"
                     /translation="MAGGVVILLCGWVLASCHGSNLDVEEPIVFREDAASFGQTVVQF
                     GGSRLVVGAPLEAVAVNQTGRLYDCAPATGMCQPIVLRSPLEAVNMSLGLSLVTATNN
                     AQLLACGPTAQRACVKNMYAKGSCLLLGSSLQFIQAVPASMPECPRQEMDIAFLIDGS
                     GSINQRDFAQMKDFVKALMGEFASTSTLFSLMQYSNILKTHFTFTEFKNILDPQSLVD
                     PIVQLQGLTYTATGIRTVVEELFHSKNGSRKSAKKILLVITDGQKYRDPLEYSDVIPA
                     ADKAGIIRYAIGVGDAFQEPTALKELNTIGSAPPQDHVFKVGNFAALRSIQRQLQEKI
                     FAIEGTQSRSSSSFQHEMSQEGFSSALTSDGPVLGAVGSFSWSGGAFLYPPNTRPTFI
                     NMSQENVDMRDSYLGYSTAVAFWKGVHSLILGAPRHQHTGKVVIFTQEARHWRPKSEV
                     RGTQIGSYFGASLCSVDVDRDGSTDLVLIGAPHYYEQTRGGQVSVCPVPGVRGRWQCE
                     ATLHGEQGHPWGRFGVALTVLGDVNGDNLADVAIGAPGEEESRGAVYIFHGASRLEIM
                     PSPSQRVTGSQLSLRLQYFGQSLSGGQDLTQDGLVDLAVGAQGHVLLLRSLPLLKVEL
                     SIRFAPMEVAKAVYQCWERTPTVLEAGEATVCLTVHKGSPDLLGNVQGSVRYDLALDP
                     GRLISRAIFDETKNCTLTGRKTLGLGDHCETVKLLLPDCVEDAVSPIILRLNFSLVRD
                     SASPRNLHPVLAVGSQDHITASLPFEKNCKQELLCEGDLGISFNFSGLQVLVVGGSPE
                     LTVTVTVWNEGEDSYGTLVKFYYPAGLSYRRVTGTQQPHQYPLRLACEAEPAAQEDLR
                     SSSCSINHPIFREGAKTTFMITFDVSYKAFLGDRLLLRAKASSENNKPDTNKTAFQLE
                     LPVKYTVYTLISRQEDSTNHVNFSSSHGGRRQEAAHRYRVNNLSPLKLAVRVNFWVPV
                     LLNGVAVWDVTLSSPAQGVSCVSQMKPPQNPDFLTQIQRRSVLDCSIADCLHFRCDIP
                     SLGIQDELDFILRGNLSFGWVSQTLQEKVLLVSEAEITFDTSVYSQLPGQEAFLRAQV
                     ETTLEEYVVYEPIFLVAGSSVGGLLLLALITVVLYKLGFFKRQYKEMLDGKAADPVTA
                     GQADFGCETPPYLVS"
     exon            61..166
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            167..270
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            271..341
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            342..456
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            457..587
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            588..733
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            734..887
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1038
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1112
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1242
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1385
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1526
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1736
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1867
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2025
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2180
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2309
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2383
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2525
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2639
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2719
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2803
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2882
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..2990
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3068
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            3069..3182
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3284
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3395
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3842
                     /gene="Itgad"
                     /gene_synonym="Itgax"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttctcagt gcactgctca gtgatggccg gtggagttgt gatcctcctg tgtggctggg
       61 tcctggcttc ctgtcatggg tctaacctgg atgtggagga acccatcgtg ttcagagagg
      121 atgcagccag ctttggacag actgtggtgc agtttggtgg atctcgactc gtggtgggag
      181 cccctctgga ggcggtggca gtcaaccaaa caggacggtt gtatgactgt gcacctgcca
      241 ctggcatgtg ccagcccatc gtactgcgca gtcccctaga ggcagtgaac atgtccctgg
      301 gcctgtctct ggtgactgcc accaataacg cccagttgct ggcttgtggt ccaactgcac
      361 agagagcttg tgtgaagaac atgtatgcga aaggttcctg cctccttctc ggctccagct
      421 tgcagttcat ccaggcagtc cctgcctcca tgccagagtg tccaagacaa gagatggaca
      481 ttgctttcct gattgatggt tctggcagca ttaaccaaag ggactttgcc cagatgaagg
      541 actttgtcaa agctttgatg ggagagtttg cgagcaccag caccttgttc tccctgatgc
      601 aatactcgaa catcctgaag acccatttta ccttcactga attcaagaac atcctggacc
      661 ctcagagcct ggtggatccc attgtccagc tgcaaggcct gacctacaca gccacaggca
      721 tccggacagt ggtggaagag ctatttcata gcaagaatgg gtcccgtaaa agtgccaaga
      781 agatcctcct tgtcatcaca gatgggcaga aatacagaga ccccctggag tatagtgatg
      841 tcattcccgc cgcagacaaa gctggcatca ttcgttatgc tattggggtg ggagatgcct
      901 tccaggagcc cactgccctg aaggagctga acaccattgg ctcagctccc ccacaggacc
      961 acgtgttcaa ggtaggcaac tttgcagcac ttcgcagcat ccagaggcaa cttcaggaga
     1021 aaatcttcgc cattgaggga actcaatcaa ggtcaagtag ttcctttcag cacgagatgt
     1081 cacaagaagg tttcagttca gctctcacat cggatggacc cgttctgggg gccgtgggaa
     1141 gcttcagctg gtccggaggt gccttcttat atcccccaaa tacgagaccc acctttatca
     1201 acatgtctca ggagaatgtg gacatgagag actcctacct gggttactcc accgcagtgg
     1261 ccttttggaa gggggttcac agcctgatcc tgggggcccc gcgtcaccag cacacgggga
     1321 aggttgtcat ctttacccag gaagccaggc attggaggcc caagtctgaa gtcagaggga
     1381 cacagatcgg ctcctacttc ggggcctctc tctgttctgt ggacgtggat agagatggca
     1441 gcactgacct ggtcctgatc ggagcccccc attactatga gcagacccga ggggggcagg
     1501 tctcagtgtg ccccgtgccc ggtgtgaggg gcaggtggca gtgtgaggcc accctccacg
     1561 gggagcaggg ccatccttgg ggccgctttg gggtggctct gacagtgctg ggggacgtaa
     1621 acggggacaa tctggcagac gtggctattg gtgcccctgg agaggaggag agcagaggtg
     1681 ctgtctacat atttcatgga gcctcgagac tggagatcat gccctcaccc agccagcggg
     1741 tcactggctc ccagctctcc ctgagactgc agtattttgg gcagtcattg agtgggggtc
     1801 aggaccttac acaggatggc ctggtggacc tggccgtggg agcccagggg cacgtactgc
     1861 tgctcaggag tctgcctctg ctgaaagtgg agctctccat aagattcgcc cccatggagg
     1921 tggcaaaggc tgtgtaccag tgctgggaaa ggactcccac tgtcctcgaa gctggagagg
     1981 ccactgtctg tctcactgtc cacaaaggct cacctgacct gttaggtaat gtccaaggct
     2041 ctgtcaggta tgatctggcg ttagatccgg gccgcctgat ttctcgtgcc atttttgatg
     2101 agactaagaa ctgcactttg acgggaagga agactctggg gcttggtgat cactgcgaaa
     2161 cagtgaagct gcttttgccg gactgtgtgg aagatgcagt gagccctatc atcctgcgcc
     2221 tcaacttttc cctggtgaga gactctgctt cacccaggaa cctgcatcct gtgctggctg
     2281 tgggctcaca agaccacata actgcttctc tgccgtttga gaagaactgt aagcaagaac
     2341 tcctgtgtga gggggacctg ggcatcagct ttaacttctc aggcctgcag gtcttggtgg
     2401 tgggaggctc cccagagctc actgtgacag tcactgtgtg gaatgagggt gaggacagct
     2461 atggaacttt agtcaagttc tactacccag cagggctatc ttaccgacgg gtaacaggga
     2521 ctcagcaacc tcatcagtac ccactacgct tggcctgtga ggctgagccc gctgcccagg
     2581 aggacctgag gagcagcagc tgtagcatta atcaccccat cttccgagaa ggtgcaaaga
     2641 ccaccttcat gatcacattc gatgtctcct acaaggcctt cctaggagac aggttgcttc
     2701 tgagggccaa agccagcagt gagaataata agcctgatac caacaagact gccttccagc
     2761 tggagctccc agtgaagtac accgtctata ccctgatcag taggcaagaa gattccacca
     2821 accatgtcaa cttttcatct tcccacgggg ggagaaggca agaagccgca catcgctatc
     2881 gtgtgaataa cctgagtcca ctgaagctgg ccgtcagagt taacttctgg gtccctgtcc
     2941 ttctgaacgg tgtggctgtg tgggacgtga ctctgagcag cccagcacag ggtgtctcct
     3001 gcgtgtccca gatgaaacct cctcagaatc ccgactttct gacccagatt cagagacgtt
     3061 ctgtgctgga ctgctccatt gctgactgcc tgcacttccg ctgtgacatc ccctccttgg
     3121 gcatccagga tgaacttgac ttcattctga ggggcaacct cagcttcggc tgggtcagtc
     3181 agacattgca ggaaaaggtg ttgcttgtga gtgaggctga aatcactttc gacacatctg
     3241 tgtactccca gctgccagga caggaggcat ttctgagagc ccaggtggag acaacgttag
     3301 aagaatacgt ggtctatgag cccatcttcc tcgtggcggg cagctcggtg ggaggtctgc
     3361 tgttactggc tctcatcaca gtggtactgt acaagcttgg cttcttcaaa cgtcagtaca
     3421 aagaaatgct ggacggcaag gctgcagatc ctgtcacagc cggccaggca gatttcggct
     3481 gtgagactcc tccatatctc gtgagctagg aatccactct cctgcctatc tctgcaatga
     3541 agattggtcc tgcctatgag tctactggca tgggaacgag ttccctacag ctctggacta
     3601 gcctggggaa cgtcccaggc gtgatgtcat acctcctgag atgggagatt tttatgcttt
     3661 tgccgaagtg tcagacttca gtgctgatcc actttttttt gcaagagcag ggatggggtc
     3721 agcataaatt tacatatgga gaagatttag cacccaatat agactgacag gagtatgctc
     3781 agtatccaat gtgttgcttg tatgtatttt ttaaaaaata aatatgaaaa tgcaggggga
     3841 aa
//
