LOCUS       NM_001173972            5896 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus integrin subunit alpha 8 (Itga8), mRNA.
ACCESSION   NM_001173972 XM_001072297 XM_344634
VERSION     NM_001173972.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5896)
  AUTHORS   Takahashi T, Friedmacher F, Zimmer J and Puri P.
  TITLE     Decreased Expression of Integrin Subunits alpha3, alpha6, and
            alpha8 in the Branching Airway Mesenchyme of Nitrofen-Induced
            Hypoplastic Lungs
  JOURNAL   Eur J Pediatr Surg 28 (1), 109-114 (2018)
   PUBMED   28701000
  REMARK    GeneRIF: Decreased expression of Itga3, Itga6, and Itga8 in the
            pulmonary mesenchyme may lead to disruptions in airway branching
            morphogenesis, thus contributing to pulmonary hypoplasia in the
            nitrofen-induced congenital diaphragmatic hernia model.
REFERENCE   2  (bases 1 to 5896)
  AUTHORS   Humbert C, Silbermann F, Morar B, Parisot M, Zarhrate M, Masson C,
            Tores F, Blanchet P, Perez MJ, Petrov Y, Khau Van Kien P, Roume J,
            Leroy B, Gribouval O, Kalaydjieva L, Heidet L, Salomon R, Antignac
            C, Benmerah A, Saunier S and Jeanpierre C.
  TITLE     Integrin alpha 8 recessive mutations are responsible for bilateral
            renal agenesis in humans
  JOURNAL   Am J Hum Genet 94 (2), 288-294 (2014)
   PUBMED   24439109
  REMARK    Erratum:[Am J Hum Genet. 2014 May 1;94(5):799]
REFERENCE   3  (bases 1 to 5896)
  AUTHORS   Marek I, Volkert G, Hilgers KF, Bieritz B, Rascher W, Reinhardt DP
            and Hartner A.
  TITLE     Fibrillin-1 and alpha8 integrin are co-expressed in the glomerulus
            and interact to convey adhesion of mesangial cells
  JOURNAL   Cell Adh Migr 8 (4), 389-395 (2014)
   PUBMED   25482639
  REMARK    GeneRIF: Fibrillin-1 and alpha8 integrin interact, and thus,
            regulate mesangial cell adhesion and migration.
REFERENCE   4  (bases 1 to 5896)
  AUTHORS   Brafman DA, Phung C, Kumar N and Willert K.
  TITLE     Regulation of endodermal differentiation of human embryonic stem
            cells through integrin-ECM interactions
  JOURNAL   Cell Death Differ 20 (3), 369-381 (2013)
   PUBMED   23154389
REFERENCE   5  (bases 1 to 5896)
  AUTHORS   Supriyanto I, Watanabe Y, Mouri K, Shiroiwa K, Ratta-Apha W,
            Yoshida M, Tamiya G, Sasada T, Eguchi N, Okazaki K, Shirakawa O,
            Someya T and Hishimoto A.
  TITLE     A missense mutation in the ITGA8 gene, a cell adhesion molecule
            gene, is associated with schizophrenia in Japanese female patients
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 40, 347-352 (2013)
   PUBMED   23153507
REFERENCE   6  (bases 1 to 5896)
  AUTHORS   Chan CS, Weeber EJ, Kurup S, Sweatt JD and Davis RL.
  TITLE     Integrin requirement for hippocampal synaptic plasticity and
            spatial memory
  JOURNAL   J Neurosci 23 (18), 7107-7116 (2003)
   PUBMED   12904471
REFERENCE   7  (bases 1 to 5896)
  AUTHORS   Littlewood Evans A and Muller U.
  TITLE     Stereocilia defects in the sensory hair cells of the inner ear in
            mice deficient in integrin alpha8beta1
  JOURNAL   Nat Genet 24 (4), 424-428 (2000)
   PUBMED   10742111
REFERENCE   8  (bases 1 to 5896)
  AUTHORS   Hartner A, Schocklmann H, Prols F, Muller U and Sterzel RB.
  TITLE     Alpha8 integrin in glomerular mesangial cells and in experimental
            glomerulonephritis
  JOURNAL   Kidney Int 56 (4), 1468-1480 (1999)
   PUBMED   10504498
REFERENCE   9  (bases 1 to 5896)
  AUTHORS   Muller U, Wang D, Denda S, Meneses JJ, Pedersen RA and Reichardt
            LF.
  TITLE     Integrin alpha8beta1 is critically important for
            epithelial-mesenchymal interactions during kidney morphogenesis
  JOURNAL   Cell 88 (5), 603-613 (1997)
   PUBMED   9054500
REFERENCE   10 (bases 1 to 5896)
  AUTHORS   Einheber S, Schnapp LM, Salzer JL, Cappiello ZB and Milner TA.
  TITLE     Regional and ultrastructural distribution of the alpha 8 integrin
            subunit in developing and adult rat brain suggests a role in
            synaptic function
  JOURNAL   J Comp Neurol 370 (1), 105-134 (1996)
   PUBMED   8797161
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168655.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_344634.4, XM_001072297.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168655.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5896
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..5896
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /note="integrin subunit alpha 8"
                     /db_xref="GeneID:364786"
                     /db_xref="RGD:621634"
     exon            1..354
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..3337
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /note="integrin, alpha 8"
                     /codon_start=1
                     /product="integrin alpha-8"
                     /protein_id="NP_001167443.1"
                     /db_xref="GeneID:364786"
                     /db_xref="RGD:621634"
                     /translation="MSARTHRGPPENWAPPFACLCCVSAVLGMLWSPVSLAFNLDVDK
                     LTVYSGPEGSYFGYSLDFYIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPAERS
                     AQCKQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVRAHKGKVVACAPLYHWRTLKP
                     NPAKDPVGTCYVAIQNFSAYAEHSPCRNSNVDPEGQGYCQAGFSLDFYKNGDLIVGGP
                     GSFYWQGQVITVSVADIIANYSFKDILRKLAAEKQTDVAPASYDDSYLGYSVAAGEFT
                     GDSLQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNNDGM
                     DDILVGAPLFMEREFESNPREVGQVYLYLQVSALLFQDPQVLTGTETFGRFGSSVAHL
                     GDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNARGLHSKPSQVLQGIWGSQTIPSGFG
                     FSLRGDADIDKNDYPDLLVGAFGEGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQI
                     PEFPTPVACFSLRVCASIAGQSISNTVALMAEVQLDFLKQKGAIKRTLFLHNHQSHLI
                     FPFVMRQQKSLHCQDFMVYLRDETEFRDKLSPINVSLNYSLDDSTFEDGLEVKPILNH
                     YRENVVTEQAHILVDCGEDNLCVPDLRLSARPDKQEIIIGDENHLMLIINARNEGEGA
                     YEAELFVMIPEEADYVGIERNNKGLRLLSCEYKMENVTRMVVCDLGNPMVTGTNFSLG
                     LRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSVQINVTAVAQVEIRGVSHPPQIV
                     LPIHNWEPAEEPHKEEEVGPLVEHIYELHNIGPSTISDSILEVGWPFSAREEFLLYVF
                     HLQTLGPLQCQTNPEINPQDIKPAASPEDTPELSAFLRNATIPHLVRKRDVPVVQPHR
                     QSPAKILNCTNIDCLQISCAVGRLGGGESAVLKVRSRLWAHTFLQRKNDPYALASLVS
                     FEVKKIPYKEQPAKLPAGSTAIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTL
                     ALWKCGFFDRARPPQDEMTDREQLTSDKTPEA"
     exon            355..488
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            489..589
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            590..713
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            714..775
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            776..821
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            822..947
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            948..992
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1036
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1093
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1146
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1352
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1544
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1590
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1698
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1754
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1909
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2047
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2115
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2263
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2356
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2436
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2517
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2623
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2782
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2911
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3025
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3127
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            3128..3250
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
     exon            3251..5861
                     /gene="Itga8"
                     /gene_synonym="RGD1564327"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttggcgggc cgcacaggag aggactgtca ctgtggactc accgagctca ctgacccggg
       61 acaccggcct ctggggaaca tcagggctcc tcctcctctg gctccacggc tcccgatcct
      121 gggtgagcag cgtttggggc agaggacgat gtctgcgaga acccaccggg gtcccccgga
      181 gaactgggca cctccgttcg cttgtctctg ttgcgtctcg gccgtgctgg ggatgctgtg
      241 gtcccccgtg tctctggcgt tcaacttgga cgtagacaag ctcacggtgt acagtggccc
      301 cgagggcagc tacttcggct actcgctgga cttctacata cctgatgcgc gcacagccag
      361 tgtcttggtg ggggcgccca aagccaacac tagccagccg gatatcgtag aagggggagc
      421 tgtctactac tgtccctggc ctgcagagag gtctgcacag tgcaagcaga taccctttga
      481 caccaccaac aacaggaaaa tcagagttaa tggaaccaaa gagcctatag aatttaaatc
      541 aaaccaatgg tttggagcca cagtgagagc tcacaaagga aaagttgtgg cttgtgcccc
      601 tttatatcac tggagaactc tgaagcctaa tccagcaaag gacccggttg gcacatgcta
      661 tgtagcaatt cagaacttca gtgcttacgc tgagcactca ccctgtcgga acagcaacgt
      721 tgatcctgaa ggccaaggtt actgccaagc cggcttcagt ctagacttct ataagaatgg
      781 agaccttata gtgggaggac ctggaagctt ttactggcaa ggtcaggtga tcacggtcag
      841 tgtagcagac atcattgcaa attactcatt caaagacatt cttcgaaaac tggcagcaga
      901 aaagcagaca gatgtggctc cagcttccta tgatgacagc taccttggat attcagttgc
      961 tgctggagaa ttcactgggg actctctgca agaattggtt gctggaattc caagaggagc
     1021 acagaacttt ggatatgtct ccatcattaa ctccacagat atgaccttca ttcagaattt
     1081 tactggtgag cagatggcat cttatttcgg atatactgtt gtggtatcag atgttaacaa
     1141 tgatggcatg gatgacatat tggtcggggc acctctcttt atggagcgag aatttgaaag
     1201 taaccctaga gaagtgggtc aggtctacct gtacctacaa gtgagcgccc tcctcttcca
     1261 agacccacag gtccttacgg gcacagagac ttttgggaga ttcggtagtt ctgtggccca
     1321 cttgggggac ctgaaccaag atggatacaa tgatattgcc atcggtgtgc cctttgcagg
     1381 caaggatcaa agaggtaaag tcctcattta caacggaaac gccagaggct tgcacagcaa
     1441 gccttcccaa gttctgcaag gaatatgggg gtcacagacc atcccttctg gattcggctt
     1501 ttctctaaga ggagacgcag acatagacaa gaatgattac ccagatttac ttgtcggggc
     1561 atttggagaa gggaaagtgg ccgtgtacag agcaaggcca gttgtaacag tggatgccca
     1621 gcttctgctg cacccaatga ttatcaacct tgaaaataaa acttgccaga ttccagaatt
     1681 cccgactcct gtggcctgct tttctttaag agtctgtgca tctatagcag gccagagcat
     1741 ttcaaataca gtagccctga tggccgaggt gcagttagat ttcctgaagc aaaaaggagc
     1801 catcaaacgg accctcttcc tccacaacca ccagtcccac ctcatcttcc ccttcgtgat
     1861 gaggcagcaa aaatccctcc actgccagga ttttatggtt taccttcgag atgaaactga
     1921 attccgagat aaactgtctc caatcaacgt tagcctgaac tacagtttgg atgattccac
     1981 ctttgaagat ggcctggaag tgaagccgat tttgaaccac tacagggaga atgtcgttac
     2041 tgagcaggct cacatcctgg tggactgtgg agaagacaac ctctgtgttc ctgacttgag
     2101 gctgtcagct agaccagata agcaggagat aattattggg gatgaaaatc acctaatgct
     2161 cataatcaat gcaaggaatg aaggagaagg agcttacgaa gctgaactct tcgtcatgat
     2221 tcccgaagaa gcagattacg ttgggatcga gcgcaacaac aagggactga ggctcctgag
     2281 ttgtgagtac aagatggaaa acgtaaccag gatggtggtg tgtgaccttg ggaacccgat
     2341 ggtgactgga acgaattttt ctctgggcct ccgatttgct gttcctcgtc ttgagaaaac
     2401 aaacatgagt attaacttcg atctccaaat cagaagctcc aacaaggaca atcctgacag
     2461 caatttcgtg agcgtgcaaa tcaacgtcac tgccgtggct caggtggaaa tcagaggagt
     2521 gtcccaccct ccccaaattg ttctgcccat ccacaactgg gagccagcag aggagcccca
     2581 caaagaggag gaagtcggtc ccctggttga acatatttat gagctgcaca atattggacc
     2641 cagcaccatc agtgacagca ttctcgaagt gggctggcca ttctctgcac gggaggagtt
     2701 cctcctctat gtctttcatc ttcaaactct gggacctcta caatgtcaaa caaatcctga
     2761 gatcaacccg caggatataa agcctgctgc ctccccagag gatacccctg agctcagcgc
     2821 cttcttaaga aatgctacaa ttccccatct tgtcaggaag agggatgtgc cagtggtcca
     2881 gccccacaga cagagcccgg caaaaatact gaactgtacc aacattgact gcttgcaaat
     2941 ctcgtgtgca gtgggtcgcc tgggaggagg agaaagtgca gttctgaagg tcagatcgag
     3001 attgtgggcg cacacattcc tccagagaaa gaacgaccct tatgctcttg catccctggt
     3061 gtcctttgaa gtcaagaaga taccttataa agagcagcca gcaaaactgc cagccgggag
     3121 cacagcgatt aagacatcgg ttatttgggc cactccaaat gtctccttct caattccact
     3181 gtgggtcata atactagcga tccttcttgg cttgctggtt ctggccatct taactttagc
     3241 tttatggaag tgtggattct ttgatagagc aagacctcct caggatgaaa tgacagacag
     3301 ggaacaactg accagtgaca agaccccgga ggcttgactt ggaaccatga acacctaaaa
     3361 ttcaagcact ggtcctgttc aaagaaagaa agaaagaaca caagggttga atgatcatag
     3421 ccttccacac ctgccaatga cccagggaat ggaagagtcc ctaatctgtg taacgcattg
     3481 gcagggacta cagagaaccc caccggaaaa gaaacacagc caccaacact gtaggaacaa
     3541 tccacagcca tgaagatttc ctttgctctc accctttcac atctggccaa tattctggaa
     3601 cagctgtagg aactcaaaca actgtccaga tcagcccaat gtgactcaca aaaacacagt
     3661 tcctacagag acgagatgga ccaagatcga acactactgt aatccgatgg cgtctcggac
     3721 acccccctat ggaagagaac cctttctaag gatgtgatgg ctcagggaga aaagcagata
     3781 caacgttggg actgtgaaag tgcttgcaga actacaaaga tgatttcact aaggaaggac
     3841 caaaaatgta tttatttatg tttcgtttct ctaggtagaa aattgggcca tctagaggat
     3901 ttggagagga cgatttggtt agctagattt catcagcact caacttactc cctcttaaga
     3961 taactgttct gtgcagatag cgtgtttaat tgggcttctt caggtgttag atgatgttac
     4021 acatggtttg gcattagggc tcttttgtgc ttaatttcct gctgcctgga gtgacattcc
     4081 ttcatgttct ccgggaactc atgtctgcat aattcaactt tacaaaatct tatatttata
     4141 gttcatttta tatgtgtgaa aaatctattt ccactgactt ctttaaagca ttcatttcaa
     4201 ggtactcact accctgatgc tgttgaaaac tactagcaca atttgtagag tccatataaa
     4261 aaaacaattt aactatatgg gtgaatatta tcttgatagc tattgtaaac accaacattt
     4321 accttgaaat ttacacactt gttttcattg taatacctca cattcatgta aaagagaaaa
     4381 gtgtgttgag cataaataag atagaaatat ataaagtcat acaagtatga gccaggcaga
     4441 cacacactct taaggaccta acaatgttta ttacagcttt attagccact ctttatggtt
     4501 aatctgtcct agcaagtaat cttggagaat aatcttttat atttaagcta ttttaccatc
     4561 atctttactt aaacgttgct taaagcgctt gtaaataatt catagtaatt cgtaatgtta
     4621 tgattttgaa gtactattga acagccaaat tcataagatt acctgcacac ttttatatcc
     4681 tttttataat aatgaaaaat gctacggaga aatgctgaac aaaatgttat gtgcaatatt
     4741 ttatagaact atgtatctga ggcatgttta cactggcatt agtttctttt tttttaatta
     4801 atatcctgaa tactaagtct gatataacaa gctgaccaaa cgtttacaaa gcagttggga
     4861 aaatctgtgt ctcagtttca ccaatgacac tctttttgaa agacgatcca aactcacaga
     4921 cagtaaacat gatgtggtgc cttaacctgg aaaggagcca tttggcttca gttgcctgga
     4981 aagcaaatga aatgcagagt cgaagatcac tgctgttcac cttgccctgc ttgtcagtta
     5041 acctgtcctg atagctgctt tatgtctatc aggaaatcaa atatggttcc ccgtcgatat
     5101 ggctagtgcc tagggaacac tacactggcc tcagagagtc acacaccagc ctctggggtt
     5161 gtctttactg ttagtctttt ctgtaagaca tttcataagc agaacgctat ctatatgcta
     5221 tcatttgagg gatgacaaac agctcactct acacttttaa cgcttgtgat ttctgaggtg
     5281 agaccaatac aaactcttca gaagtttaga atgcatctct gatcttaaaa gaactcagag
     5341 aactcttagg gcaaagcaca ggaactgtgg gagacagcca tgtgggaaaa actaaagatg
     5401 tcagggacca acacagaagg tatggggata tcaaatccaa ctatggcttc ccatggtctc
     5461 aactgtggaa gcgcaggggg ccgccataca catgcacaca gaaaaccaag gtcaggtgac
     5521 ctctcctggg acatgttcct cacagagaac actgagaata cagcagtgct catggcgtcg
     5581 ctgactcttg tgacccattc tgtattggta ttcacgggga ttctatctat atttctcttc
     5641 aacaagttct atcctaattc tcacagctgt ttttataaga cacagggaaa tgagcagatt
     5701 ttataatctt ggagattttt atacactaaa gcgttctagt tgtcactgaa atacaaatct
     5761 tagaattctt gtctcattta aatacttgta tagagacagc gtagattttc atatacctat
     5821 ttacattgtc accaataaaa ttaaaaatta aagatggaaa aaaaaaaaaa aaaaaaaaaa
     5881 aaaaaaaaaa aaaaaa
//
