LOCUS       NM_030842               3922 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus integrin subunit alpha 7 (Itga7), mRNA.
ACCESSION   NM_030842 XM_213831
VERSION     NM_030842.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3922)
  AUTHORS   Heller,K.N., Montgomery,C.L., Janssen,P.M., Clark,K.R.,
            Mendell,J.R. and Rodino-Klapac,L.R.
  TITLE     AAV-mediated overexpression of human alpha7 integrin leads to
            histological and functional improvement in dystrophic mice
  JOURNAL   Mol Ther 21 (3), 520-525 (2013)
   PUBMED   23319059
REFERENCE   2  (bases 1 to 3922)
  AUTHORS   Brafman,D.A., Phung,C., Kumar,N. and Willert,K.
  TITLE     Regulation of endodermal differentiation of human embryonic stem
            cells through integrin-ECM interactions
  JOURNAL   Cell Death Differ 20 (3), 369-381 (2013)
   PUBMED   23154389
REFERENCE   3  (bases 1 to 3922)
  AUTHORS   de Rezende,F.F., Martins Lima,A., Niland,S., Wittig,I., Heide,H.,
            Schroder,K. and Eble,J.A.
  TITLE     Integrin alpha7beta1 is a redox-regulated target of hydrogen
            peroxide in vascular smooth muscle cell adhesion
  JOURNAL   Free Radic Biol Med 53 (3), 521-531 (2012)
   PUBMED   22659335
  REMARK    GeneRIF: The laminin-binding integrin alpha7beta1 is oxidized by
            hydrogen peroxide at specific sites and thereby redox regulated in
            its binding activity.
REFERENCE   4  (bases 1 to 3922)
  AUTHORS   Semon,J.A., Nagy,L.H., Llamas,C.B., Tucker,H.A., Lee,R.H. and
            Prockop,D.J.
  TITLE     Integrin expression and integrin-mediated adhesion in vitro of
            human multipotent stromal cells (MSCs) to endothelial cells from
            various blood vessels
  JOURNAL   Cell Tissue Res 341 (1), 147-158 (2010)
   PUBMED   20563599
REFERENCE   5  (bases 1 to 3922)
  AUTHORS   Wang,L., Zheng,J., Du,Y., Huang,Y., Li,J., Liu,B., Liu,C.J.,
            Zhu,Y., Gao,Y., Xu,Q., Kong,W. and Wang,X.
  TITLE     Cartilage oligomeric matrix protein maintains the contractile
            phenotype of vascular smooth muscle cells by interacting with
            alpha(7)beta(1) integrin
  JOURNAL   Circ Res 106 (3), 514-525 (2010)
   PUBMED   20019333
  REMARK    GeneRIF: Alpha(7)beta(1) integrin is a potential receptor for COMP.
            The protective effects of COMP are mainly mediated through
            interaction with alpha(7)beta(1) integrin.
REFERENCE   6  (bases 1 to 3922)
  AUTHORS   Yao,C.C., Ziober,B.L., Sutherland,A.E., Mendrick,D.L. and
            Kramer,R.H.
  TITLE     Laminins promote the locomotion of skeletal myoblasts via the alpha
            7 integrin receptor
  JOURNAL   J Cell Sci 109 (Pt 13), 3139-3150 (1996)
   PUBMED   9004048
REFERENCE   7  (bases 1 to 3922)
  AUTHORS   Martin,P.T., Kaufman,S.J., Kramer,R.H. and Sanes,J.R.
  TITLE     Synaptic integrins in developing, adult, and mutant muscle:
            selective association of alpha1, alpha7A, and alpha7B integrins
            with the neuromuscular junction
  JOURNAL   Dev Biol 174 (1), 125-139 (1996)
   PUBMED   8626012
REFERENCE   8  (bases 1 to 3922)
  AUTHORS   Song,W.K., Wang,W., Sato,H., Bielser,D.A. and Kaufman,S.J.
  TITLE     Expression of alpha 7 integrin cytoplasmic domains during skeletal
            muscle development: alternate forms, conformational change, and
            homologies with serine/threonine kinases and tyrosine phosphatases
  JOURNAL   J Cell Sci 106 (Pt 4), 1139-1152 (1993)
   PUBMED   8126096
REFERENCE   9  (bases 1 to 3922)
  AUTHORS   Song,W.K., Wang,W., Foster,R.F., Bielser,D.A. and Kaufman,S.J.
  TITLE     H36-alpha 7 is a novel integrin alpha chain that is developmentally
            regulated during skeletal myogenesis
  JOURNAL   J Cell Biol 117 (3), 643-657 (1992)
   PUBMED   1315319
  REMARK    Erratum:[J Cell Biol 1992 Jul;118(1):213]
REFERENCE   10 (bases 1 to 3922)
  AUTHORS   Kramer,R.H., Vu,M.P., Cheng,Y.F., Ramos,D.M., Timpl,R. and Waleh,N.
  TITLE     Laminin-binding integrin alpha 7 beta 1: functional
            characterization and expression in normal and malignant melanocytes
  JOURNAL   Cell Regul 2 (10), 805-817 (1991)
   PUBMED   1839357
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088846.1.
            
            [WARNING] On Apr 11, 2024 this sequence was replaced by
            NM_030842.2.
            
            On Jan 18, 2005 this sequence version replaced XM_213831.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088846.1, SRR8487231.168907.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3922
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..3922
                     /gene="Itga7"
                     /note="integrin subunit alpha 7"
                     /db_xref="GeneID:81008"
                     /db_xref="RGD:71022"
     exon            1..249
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..3451
                     /gene="Itga7"
                     /note="integrin alpha-7; H36-alpha7; alpha 7A integrin"
                     /codon_start=1
                     /product="integrin alpha-7 precursor"
                     /protein_id="NP_110469.1"
                     /db_xref="GeneID:81008"
                     /db_xref="RGD:71022"
                     /translation="MARIPRCDFLGLPGICYLLSFLLAGLLLPRASAFNLDVMGAIRK
                     EGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETD
                     CYRVDIDRGANVQKESKENQWLGVSVRSQGAGGKVVTCAHRYESRQRVDQVLETRDVI
                     GRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAATFSPDSHYLIFGAPG
                     TYNWKGLLFVTNIDSSDPDQLVYKTLDPADRLTGPAGDLTLNSYLGFSIDSGKGLMRS
                     EELSFVAGAPRANHKGAVVILRKDSASRLIPEVVLSGERLTSGFGYSLAVTDLNSDGW
                     ADLIVGAPYFFERQEELGGAVYVYMNQGGHWADISPLRLCGSPDSMFGISLAVLGDLN
                     QDGFPDIAVGAPFDGDGKVFIYHGSSLGVVTKPSQVLEGEAVGIKSFGYSLSGGLDVD
                     GNHYPDLLVGSLADTAALFRARPVLHVSQEIFIDPRAIDLEQPNCADGRLVCVHVKVC
                     FSYVAVPSSYSPIVVLDYVLDGDTDRRLRGQAPRVTFPGRGPDDLKHQSSGTVSLKHQ
                     HDRVCGDTVFQLQENVKDKLRAIVVTLSYGLQTPRLRRQAPDQGLPLVAPILNAHQPS
                     TQRTEIHFLKQGCGDDKICQSNLQLAQAQFCSRISDTEFQALPMDLDGTALFALSGQP
                     FIGLELTVTNLPSDPARPQADGDDAHEAQLLATLPASLRYSGVRTLDSVEKPLCLSNE
                     NASHVECELGNPMKRGTQVTFYLILSTSGITIETTELKVELLLATISEQDLHPVSVRA
                     HVFIELPLSISGVATPQQLFFSGKVKGESAMRSERDVGSKVKYEVTVSNQGQSLNTLG
                     SAFLNIMWPHEIANGKWLLYPMRVELEGGQGPEKKGICSPRPNILHLDVDSRDRRRRE
                     LGQPEPQEPPEKVEPSTSWWPVSSAEKRNVTLDCAQGTAKCVVFSCPLYSFDRAAVLH
                     VWGRLWNSTFLEEYMSVKSLEVIVRANITVKSSIKNLLLRDASTVIPVMVYLDPVAVV
                     AEGVPWWVILLAVLAGLLVLALLVLLLWKLGFFKRAKHPEATVPQYHAVKILREDRQQ
                     FKEEKTGTIQRSNWGNSQWEGSDAHPILAADWHPELGPDGHPVSVTA"
     exon            250..377
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            378..457
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            458..713
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            714..833
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1041
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1235
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1324
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1452
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1548
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1610
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1780
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1930
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2046
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2236
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2317
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2397
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2472
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2575
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2752
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2881
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..2995
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3094
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3220
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3887
                     /gene="Itga7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgatttcctc gcattagcag agagagcgcg gagcgttggt cccatggcca ggattccgag
       61 gtgcgatttc ctcgggctcc ccggaatttg ctaccttctt agtttcttgc ttgccggact
      121 gctcttacca cgggctagcg ccttcaatct ggatgtgatg ggtgccatac gcaaggaggg
      181 agaacctggc agcttattcg gcttttcggt ggccctacac cgacaattac agccccgacc
      241 ccagagctgg ctgctggtgg gtgcccccca ggccctggct cttcccggac agcaggcaaa
      301 tcgcacggga ggcctctttg cttgtcccct gagcctagag gagacagact gctacagagt
      361 ggacatcgac aggggagcta atgtgcagaa ggaaagcaag gagaaccagt ggctgggagt
      421 cagcgtgcgg agccagggag ccgggggcaa ggttgttacc tgtgcacacc gatatgagtc
      481 tcgacagaga gtggaccagg ttttggagac tcgggatgtg attggtcgtt gctttgtgct
      541 gagccaggac ctggccatcc gtgatgagtt ggatggtggg gagtggaagt tctgtgaagg
      601 gcgcccccag ggccacgaac aatttgggtt ctgccagcag ggcacagctg ccaccttctc
      661 ccccgacagc cactacctca tttttggggc tccaggaacc tataactgga aggggttgct
      721 ttttgtgacc aacattgata gctcagaccc cgaccagctg gtgtataaaa ctttggaccc
      781 cgctgaccgg ctcacaggac cagccggaga cttgaccttg aatagctatt taggtttctc
      841 cattgattct gggaagggtc tcatgcgctc agaagagctg agttttgtgg caggggcccc
      901 acgtgccaac cacaaagggg ctgtggtcat tctgcgcaag gatagtgcca gccgcctgat
      961 tcctgaggtt gtgctgtctg gggagcgcct gacctctggc tttggctact ccctggctgt
     1021 gactgacctc aacagtgatg gctgggcaga cctgattgtg ggtgctccct acttctttga
     1081 acgccaagaa gaacttggag gtgccgtgta tgtgtacatg aaccagggtg gccattgggc
     1141 agatatctct cctctccgac tctgtggctc ccctgactcc atgtttggga tcagtttggc
     1201 tgtactgggg gacctcaatc aagatggctt tccagacatt gctgtaggag ctccctttga
     1261 cggagatggg aaagtcttta tctaccatgg gagcagcctg ggggtggtca ccaaaccttc
     1321 acaggtgctg gagggtgagg ctgtgggtat caagagcttt ggttactccc tgtctggtgg
     1381 cctggatgtg gacggaaatc actacccgga cctgcttgtg ggctccctgg ctgatactgc
     1441 tgctctgttc agggccagac ctgttctaca tgtctcccaa gaaatcttca ttgatccaag
     1501 agccatcgat ctggaacagc ccaactgtgc cgacggacgc ttggtctgcg tgcacgtaaa
     1561 ggtctgtttc agttatgttg ctgtgcccag cagctacagc cctattgtgg tcctagatta
     1621 tgtgttagat ggggacacag accggaggct ccggggccag gctccacgtg tgactttccc
     1681 gggccgaggc ccggatgatc tcaagcatca gtcctcgggc accgtgtcgt tgaagcacca
     1741 acatgacaga gtctgtggag acactgtgtt ccagctgcag gaaaacgtca aagacaagct
     1801 acgggccatt gtggtgaccc tgtcatatgg tctccaaacc cctcgattaa ggaggcaagc
     1861 gcctgaccag gggctccccc ttgtggctcc catcctcaac gctcaccagc ccagtacaca
     1921 gaggactgag atccacttcc tgaagcaagg ctgtggtgac gataagatct gtcagagcaa
     1981 cctccagctt gcgcaggccc agttctgttc ccggatcagc gacacagagt tccaggctct
     2041 gcccatggat ctggatggga ccgccctgtt tgcgctgagc gggcagccat tcataggcct
     2101 ggagctgaca gtcaccaacc tgccctctga cccagcccgg cctcaggcag atggggatga
     2161 tgctcatgaa gcccagctcc tggccaccct cccagcctct cttcgatact cgggagtccg
     2221 cactctggac tctgtggaga agccgctctg cctgtccaac gagaatgcct ctcatgtcga
     2281 gtgtgagctc gggaacccta tgaagagagg cactcaggtc accttctacc tcatcctcag
     2341 cacctctgga atcaccattg agaccacaga gctgaaggtg gaattgctct tagccacgat
     2401 cagtgagcag gacctgcatc cggtctccgt tcgggctcat gtcttcattg aattgccgct
     2461 gtccatttca ggggtggcca ctcctcagca actcttcttc tctggcaagg tgaaggggga
     2521 gagcgccatg cggtctgaga gggacgtggg cagcaaggtc aagtacgagg tcacggtctc
     2581 caatcaaggc cagtcactca atactctggg ctctgccttc ctcaacatca tgtggcccca
     2641 tgagatcgcc aatgggaaat ggctgttgta ccccatgcgg gtggagctgg agggtggaca
     2701 ggggcctgag aagaaaggga tctgctcccc aagacccaac atcctccacc tggatgtgga
     2761 cagcagggat aggaggcggc gagagctggg gcagccggag cctcaggagc ctccagagaa
     2821 ggtggaacct agcacatctt ggtggccagt gtcctccgct gagaagagaa acgtgactct
     2881 ggactgtgcc cagggcacgg ccaagtgtgt ggtattcagc tgcccactct acagctttga
     2941 ccgtgcagcc gtgcttcatg tctggggccg cctctggaac agcacctttc tggaggagta
     3001 catgtccgtg aagtccctgg aggtgatcgt ccgagccaac atcacagtga aatcctccat
     3061 taagaacttg ctgctcagag atgcatccac agtgatccca gtgatggtat acttggaccc
     3121 ggtggctgtg gttgcagaag gagtcccctg gtgggtcatc ctcctggcgg tgctggctgg
     3181 gctgctagta ctggccctgc tggtgctgct gctgtggaag ctgggattct tcaagcgggc
     3241 gaagcaccct gaggccactg taccccagta ccacgcagtg aagatccttc gggaagaccg
     3301 gcagcagttc aaggaggaga agacaggcac cattcagagg agtaactggg gcaattccca
     3361 gtgggagggc tccgacgcac accctatcct ggctgccgac tggcaccctg agttgggtcc
     3421 tgatggacat cctgtgtcag tcactgccta acttctcctg tcccaagccc agcctctggg
     3481 ttccttccac cctttcccaa gatggctctt tgggggtgga gatagtggag taggttgctg
     3541 gcttcatgtt gaaataaggc aggttctgct ttctcagggg cacagatctt tcccaccgtg
     3601 agaaccaccc cttcccatct tctccgtaca atgctgtgag acacggggca tggctggaag
     3661 gacaggcatg acctggtgca ggatggagaa gaaggggtac tgagctgcct ctctcaccca
     3721 ccctgtaaga ccgtcttccc caaagtgcct tagacagagg gtcagggaag agatcgtgtc
     3781 actgtctcag gggcccttcc ctcctaagtc tttcctgtgc tctggcctta gtgtgctgta
     3841 ccagcccagc ggatcttgtc tatttattaa aaagtatttg acaataaaaa aaaaaaaaaa
     3901 aaaaaaaaaa aaaaaaaaaa gg
//
