LOCUS       NP_110469               1135 aa            linear   ROD 14-APR-2024
DEFINITION  integrin alpha-7 isoform 4 precursor [Rattus norvegicus].
ACCESSION   NP_110469 XP_213831
VERSION     NP_110469.1
DBSOURCE    REFSEQ: accession NM_030842.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1135)
  AUTHORS   Heller,K.N., Montgomery,C.L., Janssen,P.M., Clark,K.R.,
            Mendell,J.R. and Rodino-Klapac,L.R.
  TITLE     AAV-mediated overexpression of human alpha7 integrin leads to
            histological and functional improvement in dystrophic mice
  JOURNAL   Mol Ther 21 (3), 520-525 (2013)
   PUBMED   23319059
REFERENCE   2  (residues 1 to 1135)
  AUTHORS   Brafman,D.A., Phung,C., Kumar,N. and Willert,K.
  TITLE     Regulation of endodermal differentiation of human embryonic stem
            cells through integrin-ECM interactions
  JOURNAL   Cell Death Differ 20 (3), 369-381 (2013)
   PUBMED   23154389
REFERENCE   3  (residues 1 to 1135)
  AUTHORS   de Rezende,F.F., Martins Lima,A., Niland,S., Wittig,I., Heide,H.,
            Schroder,K. and Eble,J.A.
  TITLE     Integrin alpha7beta1 is a redox-regulated target of hydrogen
            peroxide in vascular smooth muscle cell adhesion
  JOURNAL   Free Radic Biol Med 53 (3), 521-531 (2012)
   PUBMED   22659335
  REMARK    GeneRIF: The laminin-binding integrin alpha7beta1 is oxidized by
            hydrogen peroxide at specific sites and thereby redox regulated in
            its binding activity.
REFERENCE   4  (residues 1 to 1135)
  AUTHORS   Semon,J.A., Nagy,L.H., Llamas,C.B., Tucker,H.A., Lee,R.H. and
            Prockop,D.J.
  TITLE     Integrin expression and integrin-mediated adhesion in vitro of
            human multipotent stromal cells (MSCs) to endothelial cells from
            various blood vessels
  JOURNAL   Cell Tissue Res 341 (1), 147-158 (2010)
   PUBMED   20563599
REFERENCE   5  (residues 1 to 1135)
  AUTHORS   Wang,L., Zheng,J., Du,Y., Huang,Y., Li,J., Liu,B., Liu,C.J.,
            Zhu,Y., Gao,Y., Xu,Q., Kong,W. and Wang,X.
  TITLE     Cartilage oligomeric matrix protein maintains the contractile
            phenotype of vascular smooth muscle cells by interacting with
            alpha(7)beta(1) integrin
  JOURNAL   Circ Res 106 (3), 514-525 (2010)
   PUBMED   20019333
  REMARK    GeneRIF: Alpha(7)beta(1) integrin is a potential receptor for COMP.
            The protective effects of COMP are mainly mediated through
            interaction with alpha(7)beta(1) integrin.
REFERENCE   6  (residues 1 to 1135)
  AUTHORS   Yao,C.C., Ziober,B.L., Sutherland,A.E., Mendrick,D.L. and
            Kramer,R.H.
  TITLE     Laminins promote the locomotion of skeletal myoblasts via the alpha
            7 integrin receptor
  JOURNAL   J Cell Sci 109 (Pt 13), 3139-3150 (1996)
   PUBMED   9004048
REFERENCE   7  (residues 1 to 1135)
  AUTHORS   Martin,P.T., Kaufman,S.J., Kramer,R.H. and Sanes,J.R.
  TITLE     Synaptic integrins in developing, adult, and mutant muscle:
            selective association of alpha1, alpha7A, and alpha7B integrins
            with the neuromuscular junction
  JOURNAL   Dev Biol 174 (1), 125-139 (1996)
   PUBMED   8626012
REFERENCE   8  (residues 1 to 1135)
  AUTHORS   Song,W.K., Wang,W., Sato,H., Bielser,D.A. and Kaufman,S.J.
  TITLE     Expression of alpha 7 integrin cytoplasmic domains during skeletal
            muscle development: alternate forms, conformational change, and
            homologies with serine/threonine kinases and tyrosine phosphatases
  JOURNAL   J Cell Sci 106 (Pt 4), 1139-1152 (1993)
   PUBMED   8126096
REFERENCE   9  (residues 1 to 1135)
  AUTHORS   Song,W.K., Wang,W., Foster,R.F., Bielser,D.A. and Kaufman,S.J.
  TITLE     H36-alpha 7 is a novel integrin alpha chain that is developmentally
            regulated during skeletal myogenesis
  JOURNAL   J Cell Biol 117 (3), 643-657 (1992)
   PUBMED   1315319
  REMARK    Erratum:[J Cell Biol 1992 Jul;118(1):213]
REFERENCE   10 (residues 1 to 1135)
  AUTHORS   Kramer,R.H., Vu,M.P., Cheng,Y.F., Ramos,D.M., Timpl,R. and Waleh,N.
  TITLE     Laminin-binding integrin alpha 7 beta 1: functional
            characterization and expression in normal and malignant melanocytes
  JOURNAL   Cell Regul 2 (10), 805-817 (1991)
   PUBMED   1839357
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jan 18, 2005 this sequence version replaced XP_213831.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088846.1, SRR26643298.37705.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1135
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     Protein         1..1135
                     /product="integrin alpha-7 isoform 4 precursor"
                     /note="integrin alpha-7; H36-alpha7; alpha 7A integrin"
                     /calculated_mol_wt=120651
     sig_peptide     1..33
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3562
     mat_peptide     34..1135
                     /product="Integrin alpha-7. /id=PRO_0000293124"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63258.2)"
                     /calculated_mol_wt=120651
     Region          38..103
                     /region_name="FG-GAP 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63258.2)"
     Region          48..109
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Site            86
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q63258.2)"
     Region          110..165
                     /region_name="FG-GAP 2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63258.2)"
     Region          185..238
                     /region_name="FG-GAP 3.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63258.2)"
     Region          248..305
                     /region_name="FG-GAP 4.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63258.2)"
     Region          260..311
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          306..367
                     /region_name="FG-GAP 5.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63258.2)"
     Region          318..371
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          368..423
                     /region_name="FG-GAP 6.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63258.2)"
     Region          377..429
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          427..486
                     /region_name="FG-GAP 7.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00803"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63258.2)"
     Region          439..>479
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          472..960
                     /region_name="Integrin_alpha2"
                     /note="Integrin alpha; pfam08441"
                     /db_xref="CDD:462478"
     Site            603..604
                     /site_type="cleavage"
                     /note="Cleavage, by urokinase; propagated from
                     UniProtKB/Swiss-Prot (Q63258.2)"
     Site            741
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q63258.2)"
     Region          905..933
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63258.2)"
     Site            943
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q63258.2)"
     Site            979
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q63258.2)"
     Site            999
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q63258.2)"
     Site            1037..1057
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63258.2)"
     Region          1061..1065
                     /region_name="GFFKR motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63258.2)"
     Region          1111..1130
                     /region_name="3 X 4 AA repeats of D-X-H-P"
                     /note="propagated from UniProtKB/Swiss-Prot (Q63258.2)"
     CDS             1..1135
                     /gene="Itga7"
                     /coded_by="NM_030842.2:182..3589"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4"
                     /db_xref="GeneID:81008"
                     /db_xref="RGD:71022"
ORIGIN      
        1 mariprcdfl glpgicylls fllaglllpr asafnldvmg airkegepgs lfgfsvalhr
       61 qlqprpqswl lvgapqalal pgqqanrtgg lfacplslee tdcyrvdidr ganvqkeske
      121 nqwlgvsvrs qgaggkvvtc ahryesrqrv dqvletrdvi grcfvlsqdl airdeldgge
      181 wkfcegrpqg heqfgfcqqg taatfspdsh ylifgapgty nwkgllfvtn idssdpdqlv
      241 yktldpadrl tgpagdltln sylgfsidsg kglmrseels fvagapranh kgavvilrkd
      301 sasrlipevv lsgerltsgf gyslavtdln sdgwadlivg apyfferqee lggavyvymn
      361 qgghwadisp lrlcgspdsm fgislavlgd lnqdgfpdia vgapfdgdgk vfiyhgsslg
      421 vvtkpsqvle geavgiksfg yslsggldvd gnhypdllvg sladtaalfr arpvlhvsqe
      481 ifidpraidl eqpncadgrl vcvhvkvcfs yvavpssysp ivvldyvldg dtdrrlrgqa
      541 prvtfpgrgp ddlkhqssgt vslkhqhdrv cgdtvfqlqe nvkdklraiv vtlsyglqtp
      601 rlrrqapdqg lplvapilna hqpstqrtei hflkqgcgdd kicqsnlqla qaqfcsrisd
      661 tefqalpmdl dgtalfalsg qpfigleltv tnlpsdparp qadgddahea qllatlpasl
      721 rysgvrtlds vekplclsne nashvecelg npmkrgtqvt fylilstsgi tiettelkve
      781 lllatiseqd lhpvsvrahv fielplsisg vatpqqlffs gkvkgesamr serdvgskvk
      841 yevtvsnqgq slntlgsafl nimwpheian gkwllypmrv eleggqgpek kgicsprpni
      901 lhldvdsrdr rrrelgqpep qeppekveps tswwpvssae krnvtldcaq gtakcvvfsc
      961 plysfdraav lhvwgrlwns tfleeymsvk slevivrani tvkssiknll lrdastvipv
     1021 mvyldpvavv aegvpwwvil lavlagllvl allvlllwkl gffkrakhpe atvpqyhavk
     1081 ilredrqqfk eektgtiqrs nwgnsqwegs dahpilaadw hpelgpdghp vsvta
//
