LOCUS       NM_053725               5964 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus integrin subunit alpha 6 (Itga6), mRNA.
ACCESSION   NM_053725 XM_001059353 XM_001059408 XM_002729169 XM_215984
VERSION     NM_053725.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5964)
  AUTHORS   Fu,C., Zhang,Y., Xi,W.J., Xu,K., Meng,F., Ma,T., Li,W., Wu,L. and
            Chen,Z.
  TITLE     Dahuang Zhechong pill attenuates hepatic sinusoidal capillarization
            in liver cirrhosis and hepatocellular carcinoma rat model via the
            MK/integrin signaling pathway
  JOURNAL   J Ethnopharmacol 308, 116191 (2023)
   PUBMED   36731809
  REMARK    GeneRIF: Dahuang Zhechong pill attenuates hepatic sinusoidal
            capillarization in liver cirrhosis and hepatocellular carcinoma rat
            model via the MK/integrin signaling pathway.
REFERENCE   2  (bases 1 to 5964)
  AUTHORS   Xu,Z., Zheng,J., Zhang,Y., Wu,H., Sun,B., Zhang,K., Wang,J.,
            Zang,F., Zhang,X., Guo,L. and Wu,X.
  TITLE     Increased Expression of Integrin Alpha 6 in Nucleus Pulposus Cells
            in Response to High Oxygen Tension Protects against Intervertebral
            Disc Degeneration
  JOURNAL   Oxid Med Cell Longev 2021, 8632823 (2021)
   PUBMED   34707783
  REMARK    GeneRIF: Increased Expression of Integrin Alpha 6 in Nucleus
            Pulposus Cells in Response to High Oxygen Tension Protects against
            Intervertebral Disc Degeneration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5964)
  AUTHORS   Moldrup,A., Lindberg,M.N., Galsgaard,E.D., Henriksen,U.,
            Dalgaard,L.T. and Nielsen,J.H.
  TITLE     Regulation of integrin alpha6A by lactogenic hormones in rat
            pancreatic beta-cells: Implications for the physiological
            adaptation to pregnancy
  JOURNAL   Acta Physiol (Oxf) 229 (3), e13454 (2020)
   PUBMED   32056357
  REMARK    GeneRIF: Regulation of integrin alpha6A by lactogenic hormones in
            rat pancreatic beta-cells: Implications for the physiological
            adaptation to pregnancy.
REFERENCE   4  (bases 1 to 5964)
  AUTHORS   Chang,I.A., Kim,K.J. and Namgung,U.
  TITLE     alpha6 and beta1 Integrin Heterodimer Mediates Schwann Cell
            Interactions with Axons and Facilitates Axonal Regeneration after
            Peripheral Nerve Injury
  JOURNAL   Neuroscience 371, 49-59 (2018)
   PUBMED   29223350
  REMARK    GeneRIF: alpha6 and beta1 integrins are induced in Schwann cells in
            the sciatic nerve after a crush injury, and the blocking of
            integrin activity by siRNA expression and by treatment with
            anti-integrin antibodies attenuates Schwann cell contact with
            cultured neurons and decreases neurite outgrowth. After nerve
            transection, the levels of alpha6 and beta1 integrins in the distal
            nerve stump are lower than corresponding nerve area...
REFERENCE   5  (bases 1 to 5964)
  AUTHORS   Shin,H.C., Park,J.Y., Lim,H.D. and Namgung,U.
  TITLE     Induction of alpha6 and beta1 integrins by acupuncture stimulation
            in rats
  JOURNAL   Biochem Biophys Res Commun 491 (3), 629-635 (2017)
   PUBMED   28760342
  REMARK    GeneRIF: The present results provide a new evidence on
            acupuncture-specific tissue response in terms of integrin
            induction, and further suggest that integrin activation may be
            involved in transmitting mechanosensory signals from the acupoint
            to afferent nerve fiber.
REFERENCE   6  (bases 1 to 5964)
  AUTHORS   Kadmon,G., Imhof,B.A., Altevogt,P. and Schachner,M.
  TITLE     Adhesive hierarchy involving the cell adhesion molecules L1, CD24,
            and alpha 6 integrin in murine neuroblastoma N2A cells
  JOURNAL   Biochem Biophys Res Commun 214 (1), 94-101 (1995)
   PUBMED   7669058
REFERENCE   7  (bases 1 to 5964)
  AUTHORS   Ruiz,P., Wiles,M.V. and Imhof,B.A.
  TITLE     Alpha 6 integrins participate in pro-T cell homing to the thymus
  JOURNAL   Eur J Immunol 25 (7), 2034-2041 (1995)
   PUBMED   7621877
REFERENCE   8  (bases 1 to 5964)
  AUTHORS   Rosahl,T.W., Spillane,D., Missler,M., Herz,J., Selig,D.K.,
            Wolff,J.R., Hammer,R.E., Malenka,R.C. and Sudhof,T.C.
  TITLE     Essential functions of synapsins I and II in synaptic vesicle
            regulation
  JOURNAL   Nature 375 (6531), 488-493 (1995)
   PUBMED   7777057
REFERENCE   9  (bases 1 to 5964)
  AUTHORS   Sutherland,A.E., Calarco,P.G. and Damsky,C.H.
  TITLE     Developmental regulation of integrin expression at the time of
            implantation in the mouse embryo
  JOURNAL   Development 119 (4), 1175-1186 (1993)
   PUBMED   8306881
REFERENCE   10 (bases 1 to 5964)
  AUTHORS   Cooper,H.M., Tamura,R.N. and Quaranta,V.
  TITLE     The major laminin receptor of mouse embryonic stem cells is a novel
            isoform of the alpha 6 beta 1 integrin
  JOURNAL   J Cell Biol 115 (3), 843-850 (1991)
   PUBMED   1833411
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053725.1.
            
            Sequence Note: This RefSeq record was created from transcripts of
            different strains because no single transcript from the same strain
            was available for the full length of the gene. The extent of this
            transcript is supported by transcript alignments and orthologous
            data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.11844.1,
                                           SRR26360186.2399507.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-375               JAXUCZ010000003.1  77025203-77025577
            376-500             JAXUCZ010000003.1  77058082-77058206
            501-580             JAXUCZ010000003.1  77059922-77060001
            581-836             JAXUCZ010000003.1  77061369-77061624
            837-968             JAXUCZ010000003.1  77063889-77064020
            969-1179            JAXUCZ010000003.1  77067315-77067525
            1180-1373           JAXUCZ010000003.1  77068284-77068477
            1374-1462           JAXUCZ010000003.1  77068614-77068702
            1463-1581           JAXUCZ010000003.1  77069718-77069836
            1582-1680           JAXUCZ010000003.1  77074229-77074327
            1681-1742           JAXUCZ010000003.1  77074568-77074629
            1743-1903           JAXUCZ010000003.1  77078538-77078698
            1904-2047           JAXUCZ010000003.1  77078836-77078979
            2048-2163           JAXUCZ010000003.1  77080865-77080980
            2164-2353           JAXUCZ010000003.1  77081076-77081265
            2354-2437           JAXUCZ010000003.1  77081357-77081440
            2438-2517           JAXUCZ010000003.1  77081539-77081618
            2518-2595           JAXUCZ010000003.1  77081768-77081845
            2596-2698           JAXUCZ010000003.1  77081933-77082035
            2699-2872           JAXUCZ010000003.1  77083217-77083390
            2873-2971           JAXUCZ010000003.1  77085929-77086027
            2972-3082           JAXUCZ010000003.1  77086119-77086229
            3083-3181           JAXUCZ010000003.1  77086315-77086413
            3182-3307           JAXUCZ010000003.1  77088444-77088569
            3308-3437           JAXUCZ010000003.1  77092175-77092304
            3438-5964           JAXUCZ010000003.1  77094550-77097076
FEATURES             Location/Qualifiers
     source          1..5964
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q23"
     gene            1..5964
                     /gene="Itga6"
                     /note="integrin subunit alpha 6"
                     /db_xref="GeneID:114517"
                     /db_xref="RGD:621633"
     exon            1..375
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..3415
                     /gene="Itga6"
                     /note="integrin, alpha 6"
                     /codon_start=1
                     /product="integrin alpha-6 precursor"
                     /protein_id="NP_446177.2"
                     /db_xref="GeneID:114517"
                     /db_xref="RGD:621633"
                     /translation="MAVAGQLCLLYLSAGLLARLSTAFNLDTREDNVIRKSGDPGSLF
                     GFSLAMHWQLQPEDKRLLLVGAPRAEALPLQKANRTGGLYSCDITSRGPCTRIVFDND
                     ADPMSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQN
                     LRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVR
                     VEQKNNTFFDMNIFEDGPYEVGGETDHDESLVPVPANSYLGFSLDSGKGIVSKDDITF
                     VSGAPRANHSGAVVLLKRDMKSAHLLLEYIFDGEGLASSFGYDVAVVDLNADGWQDIV
                     IGAPQYFDRDGEVGGAVYVYINQQGRWSNVKPVRLNGTKDSMFGIAVKNIGDINQDGY
                     PDIAVGAPYDDLGKVFIYHGSPTGIITKPTQVLEGTTPFFGYSIAGNMDLDRNSYPDV
                     AVGSLSDSVTIFRSRPVINILKTITVTPSRIDLRQKSMCGSPSGICLKVKACFEYTAK
                     PSGYNPPISILGILEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLNRQKQRACMEET
                     LWLQENIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSNEAKTVQTDVHFLKE
                     GCGDDNVCNSNLKLEYKFGTREGNQDKFSYLPIQKGIPELVLKDQKDIALEITVTNGP
                     SDPRNPRKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELG
                     NPFKRNSSVTFYLILSTTEVTFDTTDLDINLKLETTSNQDNLAPITAKAKVVIELLLS
                     VSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLKNLGTATLNIQWP
                     KEISNGKWLLYLMKVESKGLEQVVCEPHNEINFLKLKESHNSRKKRELPEKQIDDSRK
                     FSLFSERKYQTLNCSVNVRCVNIRCPLRGLDSKASLVLRSRLWNSTFLEEYSKLNYLD
                     ILVRASIDVTAAAQNIKLPHAGTQVRVTVFPSKTVAQYSGIAWWIILLAVLAGILMLA
                     LLVFLLWKCGFFKRNKKDHYDATYHKAEIHTQPSDKERLTSDA"
     exon            376..500
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            501..580
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            581..836
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            837..968
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1179
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1373
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1462
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1581
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1680
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1742
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1903
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2047
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2163
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2353
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2437
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2517
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2595
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2698
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2872
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..2971
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3082
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3181
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3307
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            3308..3437
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
     exon            3438..5964
                     /gene="Itga6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgagcggct gctagctacc ggcgtggggg agctgccgga cagagagcgc gagccggccg
       61 ggggtggggc cgcgcgcagg ggcgacccag gccaagtggc cacagcggcg cgccagggag
      121 cccggccccg gccccgagcc cgcgcgcaca gaggccgtag cagctccgcg ggtccctccc
      181 accgcgcgcg cccatggcgg tcgccggcca gttgtgcttg ctctacctgt ccgcagggct
      241 tctggcccgg ctgagcacag ctttcaacct ggatacccgc gaggacaacg tgatccggaa
      301 atcgggggat cccgggagcc tcttcggctt ctcgctcgcc atgcactggc agttgcagcc
      361 ggaggacaag cggctgttgc ttgtgggggc acctcgggca gaagcacttc ccctgcagaa
      421 ggcgaacaga acagggggcc tgtacagctg tgacatcacc tcccggggac cttgcacacg
      481 aattgtattt gataatgatg ctgatcctat gtcagaaagc aaggaagacc agtggatggg
      541 agtcactgtc cagagtcaag gtccaggggg caaagtggtg acgtgtgcgc atcgatacga
      601 gaaacggcag cacgttaaca cgaagcagga gtcccgggac atcttcggaa ggtgttacgt
      661 cctgagtcag aatctcagaa ttgaagatga tatggatgga ggagactgga gtttctgtga
      721 tggccgattg aggggccatg aaaaatttgg ctcttgtcag caaggagtag cggctacttt
      781 cactaaagac tttcattaca ttgtttttgg agccccaggg acttacaact ggaaagggat
      841 cgttcgtgta gaacaaaaga ataacacttt ttttgacatg aacatctttg aagatgggcc
      901 ctatgaagtt ggtggagaga ctgatcatga cgaaagtctc gtgcccgttc ctgctaacag
      961 ttatctaggc ttttctctgg actcagggaa gggtattgtt tctaaagatg acatcacttt
     1021 tgtatctggt gctccaagag ccaatcacag tggggctgta gttttgctaa aaagagacat
     1081 gaagtcagca catcttctcc ttgagtatat atttgatggt gaaggcctgg cttcttcgtt
     1141 tggctatgac gtggcggtgg tggacctcaa tgcagatggg tggcaagaca tcgttatcgg
     1201 agcgccacag tactttgaca gggatggcga agtcgggggt gcggtgtacg tctacattaa
     1261 ccagcaaggc agatggagta atgtgaagcc agttcgtcta aatgggacca aagactcgat
     1321 gtttggaatc gcagtgaaaa atatcggcga tattaatcaa gatggctatc cggatattgc
     1381 tgttggagct ccctatgacg atctggggaa ggtttttatc tatcatggat ccccgactgg
     1441 cataattacc aagccaacac aggttcttga gggtacaacg cctttcttcg gctactcaat
     1501 cgctgggaac atggacctgg acaggaattc ctaccctgac gttgctgtgg gttccctctc
     1561 agactcagta actattttca gatcccggcc agtgattaac attctgaaaa ccatcacagt
     1621 gactcctagc agaattgacc tccgccagaa atccatgtgt gggtcaccta gcgggatatg
     1681 cctcaaggtt aaagcctgtt ttgaatatac tgcgaagccc tccggttata accctccaat
     1741 atcaattttg ggtattcttg aagctgaaaa agaaagaaga aagtcagggt tgtcgtcaag
     1801 agttcagttt cgaaaccaag gttctgagcc aaagtatact caggagctga ccctgaacag
     1861 gcagaagcag cgggcatgca tggaggagac gctctggctg caggaaaaca tcagagacaa
     1921 gctgcgcccc atccccatca cggcttctgt ggagatccag gagcccagct ctcgacggcg
     1981 ggtgaattca cttccagaag ttcttcccat cttgaattca aatgaagcca aaacagtgca
     2041 gacagatgtc cacttcttaa aggaaggatg tggagacgac aatgtctgta acagcaacct
     2101 taagctagag tataaatttg gtacccgaga aggaaatcaa gacaaattct cttaccttcc
     2161 aattcagaaa ggcatcccag aattagtcct aaaagatcag aaagatatag ctctggaaat
     2221 aacggtgacc aacggccctt ctgatccaag gaatccccgg aaagatggtg acgatgccca
     2281 cgaagccaaa ctcatcgcaa cgtttccaga caccctgaca tattccgcct acagagagct
     2341 gagggctttc cctgagaagc agctgagctg tgttgccaac cagaatggct cccaagctga
     2401 ctgtgagctc ggaaatcctt tcaagagaaa ttccagtgtt actttttatc tgattttaag
     2461 taccaccgag gtcacctttg acaccacaga tctggatatt aatctgaagt tggaaacaac
     2521 aagcaatcag gataatttgg ctccaattac agcgaaagca aaagtggtta ttgaattgct
     2581 tttatcggtc tctggagtcg ctaagccttc gcaggtgtat tttggaggta cagttgttgg
     2641 tgagcaggcc atgaagtctg aagatgaagt aggaagttta atagagtatg aattcagggt
     2701 gattaacttg ggtaaacctc ttaaaaacct cggcacggca accctgaata tccagtggcc
     2761 caaggagatt agcaatggca aatggttgct ttatttgatg aaggtcgaat ccaaaggttt
     2821 ggagcaggtt gtctgtgagc cacacaatga aataaacttc ctcaagctga aggagtctca
     2881 caactcaaga aagaagcggg aacttcctga aaaacagata gacgacagca ggaagttttc
     2941 tctattttcc gaaagaaaat accagaccct caactgcagc gtcaacgtga ggtgtgtgaa
     3001 catcaggtgt ccactgcgag ggctggacag caaggcctct ctcgttctac gctccaggct
     3061 gtggaacagc acgtttctag aggaatattc caaactgaac tacttggaca tcctcgtgag
     3121 ggcgtccata gatgtgaccg ccgccgctca gaatatcaag ctccctcatg cgggcactca
     3181 ggttcgagtg acggtgtttc cctcaaagac ggtagctcag tattcaggga tagcgtggtg
     3241 gatcatcctc ctggctgtgc ttgccgggat tttgatgctg gctctattag tgtttttact
     3301 gtggaagtgt ggtttcttca agagaaataa gaaagatcat tacgatgcca cctaccacaa
     3361 ggctgagatc cacactcagc cgtctgataa agagaggctt acttccgatg catagtattg
     3421 atctacttcc ctaattgtgt ggattcttta agcgctctag gtacgatgac agtgttcccc
     3481 gataccatgc ggtgcggatt cggaaagaag agcgagagat caacgacgag aaacacactg
     3541 ataaccccga aaaaaagtgg cccccgaagt ggaatgaaaa cgaaagttac tcatagagga
     3601 gggtgtagga aagaaagcct cactgcccaa agcccccctt atttttccca gctcagaaat
     3661 ccaggtgact tcaaagcctg ctcagcgccc cgtatatgag actgactaca cccaggacgg
     3721 acctacagtt tcaactgtgg atattgttac acctcaggct cctgttttgc acagccaagt
     3781 ttaagactag tagagtggat ttttctttaa ctgccttaat ttaactttcc ggattgcctt
     3841 ggtttttgat gtggctgatt tccacacact ggggcagggc ctgcccatct gcattcccgg
     3901 gacgttctct ccccgccatc atctgtgcta acagagtggc cattccagcc tgctcccaca
     3961 gcatccttct cataagactg gagaacctgc aagatgatgt ttcttggctc aagactctgc
     4021 caatggatag ctttgcctct attgaaagtt ctgtcttaaa ttaaatatgc agtagaaggt
     4081 gttgttaccc tttggccttc tctctccatt tcctagaagt gaggaccctt gctgatgcca
     4141 aatgcacaca ggttcctgtc tcccttgtca ctaaggcaca ggttcgacag acttgaatgc
     4201 tagttacact tgtttgtata tgatatttat tttttcttca agccatcttg ctgttgacta
     4261 gtaggccaaa gatgcttcag gttgattaag caatgagaag agaacctggg aggtcgtttt
     4321 tttttgttct gaccttaact atttactgca aaaagaaaaa gttctttatt aacatgcaag
     4381 ggttgtttga ataacttaaa ctcacctgta aatgatacca tctcctttct ggcaggccct
     4441 ccccccaacc cagaaagtct gacgaagcgg ggttgactgt aggacgtttc gtccttcccc
     4501 agcgttgggt atatggtttt gagccctgtg tggaacttct gaacttcgtg ctgtaacttt
     4561 cagaactctt agaggtgagc gtgctcaccg aactctaggg tctgtgtgct caatgctgcc
     4621 aacactgtgt attcaggacc tgacgtgagt acccatgtgg atccagacca atccagtgtg
     4681 agactactga agagcatctg tcgccaaaac agccgtacca gacagacaga atgccacgca
     4741 cggcacctag cttcttaaat atcattggac tcattcaacc agcaagcccc atgtttgctt
     4801 tttttcctaa tcgttcaccg aatctaaatt cctccaggtg acttgtgact actacgataa
     4861 gacttttagg cctggagcag gaggtttagc tcattgcaaa cgtgcttgcc tagcgtgcct
     4921 gggcccgcct tggttggttg gttgtaaaaa tgataggagg gggaaaacaa ttattttttt
     4981 ttatatatag tcaacagaga ttgaatatat tatcaaaact ttttttaaat tgtgttttac
     5041 aatcattaag ttatatggaa ggcaaccgag agctggtgct aattggtttg gataagcagt
     5101 tctcgatctt attttaaaac ttggtctcaa gtaacccagg ctggccttga actccttatg
     5161 tggcttggga tagttttgaa cttctgatcc ccatacctcc ccaccccagg gctgtgattg
     5221 caggtgtgtg cttgggattg aaccccagac tttgtgcatg ccaggccagc actctgtggc
     5281 aaccaagcta gatcccagcc acttctccat cttttaaaag aacaaaacat tgctaaatgt
     5341 gacaccgttg ctttgagttt taattctttt ttttttcctt tcataaaaca ttacaacctt
     5401 aagatattaa agactttcat tctggtccta cttctgcttt ttcactcaaa aaatggtctt
     5461 acaaatgatg ccttgtttac aaaagttctc taccacaggt tctagtagtg tgtaaagtgt
     5521 cagtttcttg cttgggtatc ttggagccta gcacactggc tttaaaggac acagccagga
     5581 agctgatatc ttgacagtgt ttgtagacct ttgttataaa aaaaaatgaa tgtcctggta
     5641 agggttagga gggagttcaa caacgaggaa acaagaatgt tgtgctgttt gagtttagag
     5701 ttgtttaaaa tgtcatctca agtcaagtca ctggtctgtt tgcatttgat aggtttttat
     5761 actaactagc attgtaaaat tatttcataa ttagaaaaca cctgtggata tttgtataaa
     5821 agtgtgaaat aaattttttt atgaaagtgc tcatcgcttg ttaacacagc actatgtatg
     5881 tgaaaccaca atctaagatt atacatgaca acccgagtta cctttctttg tatttcagca
     5941 gccaaagtaa agctttcaat gttt
//
