LOCUS       NP_446177               1073 aa            linear   ROD 24-JUN-2024
DEFINITION  integrin alpha-6 precursor [Rattus norvegicus].
ACCESSION   NP_446177 XP_001059353 XP_001059408 XP_002729215 XP_215984
VERSION     NP_446177.2
DBSOURCE    REFSEQ: accession NM_053725.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1073)
  AUTHORS   Fu,C., Zhang,Y., Xi,W.J., Xu,K., Meng,F., Ma,T., Li,W., Wu,L. and
            Chen,Z.
  TITLE     Dahuang Zhechong pill attenuates hepatic sinusoidal capillarization
            in liver cirrhosis and hepatocellular carcinoma rat model via the
            MK/integrin signaling pathway
  JOURNAL   J Ethnopharmacol 308, 116191 (2023)
   PUBMED   36731809
  REMARK    GeneRIF: Dahuang Zhechong pill attenuates hepatic sinusoidal
            capillarization in liver cirrhosis and hepatocellular carcinoma rat
            model via the MK/integrin signaling pathway.
REFERENCE   2  (residues 1 to 1073)
  AUTHORS   Xu,Z., Zheng,J., Zhang,Y., Wu,H., Sun,B., Zhang,K., Wang,J.,
            Zang,F., Zhang,X., Guo,L. and Wu,X.
  TITLE     Increased Expression of Integrin Alpha 6 in Nucleus Pulposus Cells
            in Response to High Oxygen Tension Protects against Intervertebral
            Disc Degeneration
  JOURNAL   Oxid Med Cell Longev 2021, 8632823 (2021)
   PUBMED   34707783
  REMARK    GeneRIF: Increased Expression of Integrin Alpha 6 in Nucleus
            Pulposus Cells in Response to High Oxygen Tension Protects against
            Intervertebral Disc Degeneration.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1073)
  AUTHORS   Moldrup,A., Lindberg,M.N., Galsgaard,E.D., Henriksen,U.,
            Dalgaard,L.T. and Nielsen,J.H.
  TITLE     Regulation of integrin alpha6A by lactogenic hormones in rat
            pancreatic beta-cells: Implications for the physiological
            adaptation to pregnancy
  JOURNAL   Acta Physiol (Oxf) 229 (3), e13454 (2020)
   PUBMED   32056357
  REMARK    GeneRIF: Regulation of integrin alpha6A by lactogenic hormones in
            rat pancreatic beta-cells: Implications for the physiological
            adaptation to pregnancy.
REFERENCE   4  (residues 1 to 1073)
  AUTHORS   Chang,I.A., Kim,K.J. and Namgung,U.
  TITLE     alpha6 and beta1 Integrin Heterodimer Mediates Schwann Cell
            Interactions with Axons and Facilitates Axonal Regeneration after
            Peripheral Nerve Injury
  JOURNAL   Neuroscience 371, 49-59 (2018)
   PUBMED   29223350
  REMARK    GeneRIF: alpha6 and beta1 integrins are induced in Schwann cells in
            the sciatic nerve after a crush injury, and the blocking of
            integrin activity by siRNA expression and by treatment with
            anti-integrin antibodies attenuates Schwann cell contact with
            cultured neurons and decreases neurite outgrowth. After nerve
            transection, the levels of alpha6 and beta1 integrins in the distal
            nerve stump are lower than corresponding nerve area...
REFERENCE   5  (residues 1 to 1073)
  AUTHORS   Shin,H.C., Park,J.Y., Lim,H.D. and Namgung,U.
  TITLE     Induction of alpha6 and beta1 integrins by acupuncture stimulation
            in rats
  JOURNAL   Biochem Biophys Res Commun 491 (3), 629-635 (2017)
   PUBMED   28760342
  REMARK    GeneRIF: The present results provide a new evidence on
            acupuncture-specific tissue response in terms of integrin
            induction, and further suggest that integrin activation may be
            involved in transmitting mechanosensory signals from the acupoint
            to afferent nerve fiber.
REFERENCE   6  (residues 1 to 1073)
  AUTHORS   Kadmon,G., Imhof,B.A., Altevogt,P. and Schachner,M.
  TITLE     Adhesive hierarchy involving the cell adhesion molecules L1, CD24,
            and alpha 6 integrin in murine neuroblastoma N2A cells
  JOURNAL   Biochem Biophys Res Commun 214 (1), 94-101 (1995)
   PUBMED   7669058
REFERENCE   7  (residues 1 to 1073)
  AUTHORS   Ruiz,P., Wiles,M.V. and Imhof,B.A.
  TITLE     Alpha 6 integrins participate in pro-T cell homing to the thymus
  JOURNAL   Eur J Immunol 25 (7), 2034-2041 (1995)
   PUBMED   7621877
REFERENCE   8  (residues 1 to 1073)
  AUTHORS   Rosahl,T.W., Spillane,D., Missler,M., Herz,J., Selig,D.K.,
            Wolff,J.R., Hammer,R.E., Malenka,R.C. and Sudhof,T.C.
  TITLE     Essential functions of synapsins I and II in synaptic vesicle
            regulation
  JOURNAL   Nature 375 (6531), 488-493 (1995)
   PUBMED   7777057
REFERENCE   9  (residues 1 to 1073)
  AUTHORS   Sutherland,A.E., Calarco,P.G. and Damsky,C.H.
  TITLE     Developmental regulation of integrin expression at the time of
            implantation in the mouse embryo
  JOURNAL   Development 119 (4), 1175-1186 (1993)
   PUBMED   8306881
REFERENCE   10 (residues 1 to 1073)
  AUTHORS   Cooper,H.M., Tamura,R.N. and Quaranta,V.
  TITLE     The major laminin receptor of mouse embryonic stem cells is a novel
            isoform of the alpha 6 beta 1 integrin
  JOURNAL   J Cell Biol 115 (3), 843-850 (1991)
   PUBMED   1833411
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NP_446177.1.
            
            Sequence Note: This RefSeq record was created from transcripts of
            different strains because no single transcript from the same strain
            was available for the full length of the gene. The extent of this
            transcript is supported by transcript alignments and orthologous
            data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.11844.1,
                                           SRR26360186.2399507.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1073
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q23"
     Protein         1..1073
                     /product="integrin alpha-6 precursor"
                     /note="integrin, alpha 6"
                     /calculated_mol_wt=117162
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2336
     Region          40..100
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          254..>292
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          316..354
                     /region_name="FG-GAP"
                     /note="FG-GAP repeat; pfam01839"
                     /db_xref="CDD:460357"
     Region          374..425
                     /region_name="Int_alpha"
                     /note="Integrin alpha (beta-propellor repeats);
                     smart00191"
                     /db_xref="CDD:214549"
     Region          465..939
                     /region_name="Integrin_alpha2"
                     /note="Integrin alpha; pfam08441"
                     /db_xref="CDD:462478"
     Region          1038..1052
                     /region_name="Integrin_alpha"
                     /note="Integrin alpha cytoplasmic region; pfam00357"
                     /db_xref="CDD:459778"
     CDS             1..1073
                     /gene="Itga6"
                     /coded_by="NM_053725.2:194..3415"
                     /db_xref="GeneID:114517"
                     /db_xref="RGD:621633"
ORIGIN      
        1 mavagqlcll ylsagllarl stafnldtre dnvirksgdp gslfgfslam hwqlqpedkr
       61 lllvgaprae alplqkanrt gglyscdits rgpctrivfd ndadpmsesk edqwmgvtvq
      121 sqgpggkvvt cahryekrqh vntkqesrdi fgrcyvlsqn lrieddmdgg dwsfcdgrlr
      181 ghekfgscqq gvaatftkdf hyivfgapgt ynwkgivrve qknntffdmn ifedgpyevg
      241 getdhdeslv pvpansylgf sldsgkgivs kdditfvsga pranhsgavv llkrdmksah
      301 llleyifdge glassfgydv avvdlnadgw qdivigapqy fdrdgevgga vyvyinqqgr
      361 wsnvkpvrln gtkdsmfgia vknigdinqd gypdiavgap yddlgkvfiy hgsptgiitk
      421 ptqvlegttp ffgysiagnm dldrnsypdv avgslsdsvt ifrsrpvini lktitvtpsr
      481 idlrqksmcg spsgiclkvk acfeytakps gynppisilg ileaekerrk sglssrvqfr
      541 nqgsepkytq eltlnrqkqr acmeetlwlq enirdklrpi pitasveiqe pssrrrvnsl
      601 pevlpilnsn eaktvqtdvh flkegcgddn vcnsnlkley kfgtregnqd kfsylpiqkg
      661 ipelvlkdqk dialeitvtn gpsdprnprk dgddaheakl iatfpdtlty sayrelrafp
      721 ekqlscvanq ngsqadcelg npfkrnssvt fylilsttev tfdttdldin lklettsnqd
      781 nlapitakak vvielllsvs gvakpsqvyf ggtvvgeqam ksedevgsli eyefrvinlg
      841 kplknlgtat lniqwpkeis ngkwllylmk veskgleqvv cephneinfl klkeshnsrk
      901 krelpekqid dsrkfslfse rkyqtlncsv nvrcvnircp lrgldskasl vlrsrlwnst
      961 fleeysklny ldilvrasid vtaaaqnikl phagtqvrvt vfpsktvaqy sgiawwiill
     1021 avlagilmla llvfllwkcg ffkrnkkdhy datyhkaeih tqpsdkerlt sda
//
