LOCUS       NM_001108118            4395 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus integrin subunit alpha 5 (Itga5), mRNA.
ACCESSION   NM_001108118 XM_001070203 XM_235707
VERSION     NM_001108118.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4395)
  AUTHORS   Kanda,Y., Yurube,T., Morita,Y., Takeoka,Y., Kurakawa,T.,
            Tsujimoto,R., Miyazaki,K., Kakiuchi,Y., Miyazaki,S., Zhang,Z.,
            Takada,T., Hoshino,Y., Masuda,K., Kuroda,R. and Kakutani,K.
  TITLE     Delayed notochordal cell disappearance through integrin alpha5beta1
            mechanotransduction during ex-vivo dynamic loading-induced
            intervertebral disc degeneration
  JOURNAL   J Orthop Res 39 (9), 1933-1944 (2021)
   PUBMED   33049071
  REMARK    GeneRIF: Delayed notochordal cell disappearance through integrin
            alpha5beta1 mechanotransduction during ex-vivo dynamic
            loading-induced intervertebral disc degeneration.
REFERENCE   2  (bases 1 to 4395)
  AUTHORS   Li,L., Rongfang,Z., Junhai,Z., Changqin,C. and Jing,Y.
  TITLE     Integrin alphanubeta3 modulates lipopolysaccharide-induced
            hyperpermeability in cardiac microvascular endothelial cells
  JOURNAL   Biosci Biotechnol Biochem 84 (8), 1614-1620 (2020)
   PUBMED   32351169
  REMARK    GeneRIF: Integrin alphanubeta3 modulates lipopolysaccharide-induced
            hyperpermeability in cardiac microvascular endothelial cells.
REFERENCE   3  (bases 1 to 4395)
  AUTHORS   Lopes,H.B., Freitas,G.P., Fantacini,D.M.C., Picanco-Castro,V.,
            Covas,D.T., Rosa,A.L. and Beloti,M.M.
  TITLE     Titanium with nanotopography induces osteoblast differentiation
            through regulation of integrin alphaV
  JOURNAL   J Cell Biochem 120 (10), 16723-16732 (2019)
   PUBMED   31090958
  REMARK    GeneRIF: Titanium with nanotopography induces osteoblast
            differentiation through regulation of integrin alphaV.
REFERENCE   4  (bases 1 to 4395)
  AUTHORS   Takada,Y.K., Yu,J., Shimoda,M. and Takada,Y.
  TITLE     Integrin Binding to the Trimeric Interface of CD40L Plays a
            Critical Role in CD40/CD40L Signaling
  JOURNAL   J Immunol 203 (5), 1383-1391 (2019)
   PUBMED   31331973
REFERENCE   5  (bases 1 to 4395)
  AUTHORS   Chen,H.Y., Pan,L., Yang,H.L., Xia,P., Yu,W.C., Tang,W.Q.,
            Zhang,Y.X., Chen,S.F., Xue,Y.Z. and Wang,L.X.
  TITLE     Integrin alpha5beta1 suppresses rBMSCs anoikis and promotes nitric
            oxide production
  JOURNAL   Biomed Pharmacother 99, 1-8 (2018)
   PUBMED   29324307
  REMARK    GeneRIF: Transduction of rat bone marrow mesenchymal stem cells
            with ITGA5B1 lentivirus could prevent cell anoikis and increase
            nitric oxide production.
REFERENCE   6  (bases 1 to 4395)
  AUTHORS   Soldi,R., Mitola,S., Strasly,M., Defilippi,P., Tarone,G. and
            Bussolino,F.
  TITLE     Role of alphavbeta3 integrin in the activation of vascular
            endothelial growth factor receptor-2
  JOURNAL   EMBO J 18 (4), 882-892 (1999)
   PUBMED   10022831
REFERENCE   7  (bases 1 to 4395)
  AUTHORS   Baudoin,C., Goumans,M.J., Mummery,C. and Sonnenberg,A.
  TITLE     Knockout and knockin of the beta1 exon D define distinct roles for
            integrin splice variants in heart function and embryonic
            development
  JOURNAL   Genes Dev 12 (8), 1202-1216 (1998)
   PUBMED   9553049
REFERENCE   8  (bases 1 to 4395)
  AUTHORS   Wada,J., Kumar,A., Liu,Z., Ruoslahti,E., Reichardt,L., Marvaldi,J.
            and Kanwar,Y.S.
  TITLE     Cloning of mouse integrin alphaV cDNA and role of the
            alphaV-related matrix receptors in metanephric development
  JOURNAL   J Cell Biol 132 (6), 1161-1176 (1996)
   PUBMED   8601592
REFERENCE   9  (bases 1 to 4395)
  AUTHORS   Ruppert,M., Aigner,S., Hubbe,M., Yagita,H. and Altevogt,P.
  TITLE     The L1 adhesion molecule is a cellular ligand for VLA-5
  JOURNAL   J Cell Biol 131 (6 Pt 2), 1881-1891 (1995)
   PUBMED   8557754
REFERENCE   10 (bases 1 to 4395)
  AUTHORS   Sutherland,A.E., Calarco,P.G. and Damsky,C.H.
  TITLE     Developmental regulation of integrin expression at the time of
            implantation in the mouse embryo
  JOURNAL   Development 119 (4), 1175-1186 (1993)
   PUBMED   8306881
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474035.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001070203.1, XM_235707.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4395
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..4395
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /note="integrin subunit alpha 5"
                     /db_xref="GeneID:315346"
                     /db_xref="RGD:2925"
     exon            1..497
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..3423
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /note="integrin alpha 5 (fibronectin receptor alpha);
                     integrin, alpha 5 (fibronectin receptor, alpha
                     polypeptide)"
                     /codon_start=1
                     /product="integrin alpha-5"
                     /protein_id="NP_001101588.1"
                     /db_xref="GeneID:315346"
                     /db_xref="RGD:2925"
                     /translation="MPPRQPTRRPGGGPSRELGKLLPALSHSPLGGLGSGSGSVAPGQ
                     GRTGAMGSWTPRSPRSPLHAVLLRWGPRRLPPLLPLLLLLWPPPLQVGGFNLDAEAPA
                     VLSGPPGSLFGFSVEFYRPGRDGVSVLVGAPKANTSQPGVLQGGAVYVCPWGTSPIQC
                     STIQFDSKGSRILESSLYSEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRTEKDPQ
                     NDPVGTCYLSTENFTRILEYAPCRSDFGSAAGQGYCQGGFSAEFTKTGRVVLGGPGSY
                     FWQGQILSATQEQISESYYPQYLINPVQGQLQTRQASSVYDDSYLGYSVAVGEFSGDD
                     TEDFVAGVPKGNLTYGYVTVLNGSDIHSLYNVSGEQMASYFGYAVAATDTNGDGLDDL
                     LVGAPLLMERTADGRPQEVGRVYIYLQHPEGIEPTPSLTLTGQDEFGRFGSSLTPLGD
                     LDQDGYNDVAIGAPFGGEAQQGVVFIFPGGPGGLNTKPSQVLQPLWAAGHTPDFFGSA
                     LRGGRDLDGNGYPDLIVGSFGVDKALVYRGRPIISASASLTIFPSMFNPEERSCSLEG
                     NPVSCINLSFCLNASGKHVPNSIGFEVELQLDWQKQKGGVRRALFLASKQATLTQTLL
                     IQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSLDPKAPMDSHGLRPVLHYQSKS
                     RIEDKAQILLDCGEDNICVPDLQLAVYGEKKHVYLGDKNALNLTFLAQNLGEGGAYEA
                     ELRVTAPLEAEYSGLVRHPGNFSSLSCDYFAVNQSRQLVCDLGNPMKAGTSIWGGLRF
                     TVPHLQDTKKTIQFDFQILSKNLNNSQSNMVSFPLSVEAQAQVSLNGVSKPEAVIFPV
                     SDWNPQDQPQKEGDLGPAVHHVYELINQGPSSISQGVLEISCPQALEGQQLLYVTKVT
                     GLNNCTSNYTPNSQGLELDPEVSPHHLQRREAPGRSSTTSGTQVLKCPEAKCFRLRCE
                     FGPLHRQESRSLQLHFRVWAKTFLQQEYQPFSLQCEALYEALKMPYQILPRQLPQKKL
                     QVATAVQWTKAEGSNGVPLWIIILAILFGLLLLGLLIYVLYKLGFFKRSLPYGTAMEK
                     AQLKPPATSDA"
     exon            498..628
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            629..732
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            733..853
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            854..915
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            916..961
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1087
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1132
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1176
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1233
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1286
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1495
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1687
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1733
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1835
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1891
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2046
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2184
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2252
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2403
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2496
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2576
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2657
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2763
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2916
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3000
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3114
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3216
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3339
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..4395
                     /gene="Itga5"
                     /gene_synonym="Itga5_retired"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccagtctga gccaggccag accaccggcc tccagctggg gccggagcca ggggtgcaga
       61 ggtgcggccc cccacgcccc ttcggggtgc ggggcgcggc ctcagcgtcc ctgggaccca
      121 ggaatgcccc cccgccagcc gacccggcgg ccggggggag ggcccagccg ggagttgggc
      181 aaactcctcc ccgcgttgag tcattcgcct ctgggaggtt taggaagcgg ctccgggtcg
      241 gtggccccag gacagggaag aacgggcgct atggggagct ggacgccacg gtcgccacga
      301 tctcctctcc atgcggtgct gctgcgctgg gggccccgac gcctaccgcc gctgctgccg
      361 ctgctgctgc tactgtggcc gccaccactc caggttgggg gcttcaacct agacgcggag
      421 gccccggcgg tgctctccgg gccccccggc tccctctttg gcttctccgt ggagttttac
      481 cggccgggaa gggacggagt cagtgtgctg gttggggcac ccaaggctaa cactagccaa
      541 ccaggagtac tacaaggtgg cgctgtctat gtgtgtccct ggggcaccag tcctatccag
      601 tgcagcacca ttcaatttga cagcaaaggc tcccgcatcc tggagtcttc attgtatagt
      661 gaggaacctg tggagtacaa gtccttgcag tggttcgggg caacggttcg ggcccacggc
      721 tcctccatct tggcatgcgc tccactgtat agctggcgca cagaaaagga cccacagaat
      781 gacccagtgg gcacctgcta cctctccaca gaaaacttca cccggattct ggagtatgca
      841 ccttgccgct cagattttgg cagtgcagca gggcagggtt actgccaagg gggcttcagt
      901 gccgagttca ccaagactgg ccgcgtggtc ctaggaggac ctgggagcta cttctggcaa
      961 ggccagatcc tgtcggccac tcaagagcag atctcggagt cctattaccc acagtacctc
     1021 atcaaccctg ttcaggggca gctgcagacc cgccaggcca gctccgtcta tgatgacagc
     1081 tacttgggat actctgtggc tgtaggtgaa ttcagtggtg atgacacaga agactttgtt
     1141 gctggcgtgc ccaaaggaaa cctcacctat ggctatgtca ctgtccttaa tggctcagac
     1201 atccactccc tctacaacgt ctcaggagaa cagatggcct cctattttgg ctatgccgta
     1261 gctgccactg ataccaatgg agatgggcta gatgacctgc tggtaggggc acccctactc
     1321 atggagcgga cagctgacgg gagacctcag gaggtgggca gggtctacat ctatctgcag
     1381 cacccagagg gtatagagcc tacgccctcc ctcaccctca ctggccaaga tgagttcggc
     1441 cgattcggca gctccttgac acccctgggg gacctggacc aagacggcta caatgatgtc
     1501 gccattgggg ctccgtttgg tggggaggcc cagcaaggag ttgtatttat attcccggga
     1561 ggcccaggag gactgaacac taagccttcc caggttttgc agcctctgtg ggcagctggc
     1621 cataccccag acttctttgg ctctgccctc cgaggaggac gagatctgga cggcaatgga
     1681 taccctgatc taatcgttgg atcctttggt gtggacaagg ctctggtata caggggtcgg
     1741 cccatcatat ctgccagtgc gtctctcacc atcttcccct ccatgttcaa cccagaggag
     1801 cgcagctgca gcctggaagg aaaccctgta tcctgcatca accttagctt ctgcctcaac
     1861 gcctctggaa aacatgtacc caactctata ggcttcgagg tggaactcca actggactgg
     1921 cagaagcaga agggaggggt ccggagggca ctgttcctgg cttccaagca ggccaccctt
     1981 acccagaccc tgcttatcca gaatggggct cgggaggact gcagggagat gaagatctac
     2041 ctcaggaatg aatcagaatt cagagacaaa ctctccccaa ttcacattgc cctcaacttc
     2101 tccttggacc ccaaagcccc catggacagc catggcctcc ggccagtcct acactaccag
     2161 agcaagagcc ggatagagga caaggcccag atcttgctag actgtggtga agacaacatc
     2221 tgtgtgcctg acctgcagct ggctgtgtat ggggagaaga aacatgtgta cctgggtgac
     2281 aagaacgccc tgaacctgac attcctcgcc cagaatctgg gcgagggtgg ggcctatgaa
     2341 gccgagctgc gggtcacagc ccccctggag gctgagtact cggggcttgt cagacaccca
     2401 gggaacttct ccagcctgag ctgtgactac ttcgcggtga accagagccg ccagctggtg
     2461 tgtgacctgg gcaaccccat gaaggcaggc accagtatct ggggtggcct tcggttcact
     2521 gttcctcatc ttcaagacac aaagaaaacc atccaatttg acttccagat cctcagcaag
     2581 aacctgaaca actcacaaag caacatggtc tccttcccac tctcggtgga ggctcaagcc
     2641 caagtctccc ttaacggtgt ctccaagcct gaagccgtga ttttcccagt cagcgactgg
     2701 aatcctcaag accagcctca gaaggaggga gatttgggcc ctgctgtcca ccatgtctat
     2761 gagctcatta accaggggcc cagctccatc agccagggtg tgctggagat cagctgtccc
     2821 caggctctgg aaggccaaca gctcctctat gtgaccaagg tgacgggact caacaactgc
     2881 acctccaact acacccccaa ctcacagggc ctggagttgg atccagaggt ttctccacat
     2941 cacctgcaga ggcgagaggc tccagggagg agttctacca cctcaggaac acaagtcctg
     3001 aaatgccctg aagccaagtg tttcaggctg cgctgtgagt ttgggccact gcatcgccaa
     3061 gagagccgga gtctgcagct gcatttccga gtctgggcca agaccttctt gcagcaggaa
     3121 taccagccgt tcagccttca gtgtgaggct ctatatgaag ccctgaagat gccctaccaa
     3181 atcctgcctc ggcagctgcc ccaaaagaaa ctccaggtgg ccacagccgt gcagtggacc
     3241 aaggcagaag gcagcaatgg cgtcccactg tggatcatca tcctcgccat cctttttggc
     3301 ctcctgctcc taggtctgct catctatgtc ctctacaagc tcggcttctt caaacgctcc
     3361 ctcccctacg gcacagccat ggaaaaagct cagctcaagc ctccagccac ctcagatgcc
     3421 tgagccctcc tgatctcaga atcctgattc tgaagagcca gtccgctatc ttccggtagg
     3481 gagggactag gcacttcctg aaggtgctga gggctgggga gaagcacttc tccctagccc
     3541 aaatacatac ttgaagggcc agagctgggg ggcaagaagc ttgtggatcc ttccccccac
     3601 gcactgtgat ggaccctcgt ttacacatgc cctctcacgg atgggggcct caggtccagg
     3661 gacagaagcc ccagccttcc ttcagccttt gaattttaga gacttttctg aaatcaactt
     3721 ggagctgtaa ttagggaatc tagtcatggt tctctgggcc gggcatgcca ccaggacttc
     3781 ctgtctgact cccgcctgca aagattcatc tttggccttg ccagagaact aaaggaagcc
     3841 tgcagcgaag agcctgagac ttggggaccg agacctggca acttcaacag cccctatcct
     3901 ggaaggccaa taaagaacac taagcatgga cagtgctgca ggaccagctc aggacaaatc
     3961 ccaaacaaag gtcaatgctg gcccagaccc agatccatgg aagtcagcgt gagaatggag
     4021 ccagacccag tctggggcct ggggttgatc tggaacccaa tctcagattc taagaaccta
     4081 tgctcgcaga cccaggatga catttgggtc agctgcagac ctgggcctag gaccctattt
     4141 atccctgact tagggcaagt cgggaattac ccaggacaca gtggcaaaca gacctggaac
     4201 ctcagcctga ccaaacaggc tcactcattc cccagagaac gggaagcccc aggcctgtac
     4261 gacctgggtt ctgcccacca gctgcactga cgctgcccct ctctccctag ccaaccctcc
     4321 cctctcctcc aaccccccca acttatttaa actctgttgc aagtgcaata aaccccactc
     4381 actgccccac tgacc
//
