LOCUS       NM_001107737            3736 bp    mRNA    linear   ROD 30-OCT-2023
DEFINITION  Rattus norvegicus integrin subunit alpha 4 (Itga4), mRNA.
ACCESSION   NM_001107737 XM_001067316 XM_230033
VERSION     NM_001107737.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3736)
  AUTHORS   Fu C, Zhang Y, Xi WJ, Xu K, Meng F, Ma T, Li W, Wu L and Chen Z.
  TITLE     Dahuang Zhechong pill attenuates hepatic sinusoidal capillarization
            in liver cirrhosis and hepatocellular carcinoma rat model via the
            MK/integrin signaling pathway
  JOURNAL   J Ethnopharmacol 308, 116191 (2023)
   PUBMED   36731809
  REMARK    GeneRIF: Dahuang Zhechong pill attenuates hepatic sinusoidal
            capillarization in liver cirrhosis and hepatocellular carcinoma rat
            model via the MK/integrin signaling pathway.
REFERENCE   2  (bases 1 to 3736)
  AUTHORS   Ran Y, Dong Y, Li Y, Xie J, Zeng S, Liang C, Dai W, Tang W, Wu Y
            and Yu S.
  TITLE     Mesenchymal stem cell aggregation mediated by integrin
            alpha4/VCAM-1 after intrathecal transplantation in MCAO rats
  JOURNAL   Stem Cell Res Ther 13 (1), 507 (2022)
   PUBMED   36273220
  REMARK    GeneRIF: Mesenchymal stem cell aggregation mediated by integrin
            alpha4/VCAM-1 after intrathecal transplantation in MCAO rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3736)
  AUTHORS   Ma F, Li T, Zhang H and Wu G.
  TITLE     MiR-30s Family Inhibit the Proliferation and Apoptosis in Human
            Coronary Artery Endothelial Cells Through Targeting the 3'UTR
            Region of ITGA4 and PLCG1
  JOURNAL   J Cardiovasc Pharmacol 68 (5), 327-333 (2016)
   PUBMED   27464494
REFERENCE   4  (bases 1 to 3736)
  AUTHORS   Zhang K, Pan Y, Qi J, Yue J, Zhang M, Xu C, Li G and Chen J.
  TITLE     Disruption of disulfide restriction at integrin knees induces
            activation and ligand-independent signaling of alphabeta
  JOURNAL   J Cell Sci 126 (Pt 21), 5030-5041 (2013)
   PUBMED   23986478
REFERENCE   5  (bases 1 to 3736)
  AUTHORS   Kim SV, Xiang WV, Kwak C, Yang Y, Lin XW, Ota M, Sarpel U, Rifkin
            DB, Xu R and Littman DR.
  TITLE     GPR15-mediated homing controls immune homeostasis in the large
            intestine mucosa
  JOURNAL   Science 340 (6139), 1456-1459 (2013)
   PUBMED   23661644
REFERENCE   6  (bases 1 to 3736)
  AUTHORS   Yang JT, Rayburn H and Hynes RO.
  TITLE     Cell adhesion events mediated by alpha 4 integrins are essential in
            placental and cardiac development
  JOURNAL   Development 121 (2), 549-560 (1995)
   PUBMED   7539359
REFERENCE   7  (bases 1 to 3736)
  AUTHORS   Yang XD, Michie SA, Tisch R, Karin N, Steinman L and McDevitt HO.
  TITLE     A predominant role of integrin alpha 4 in the spontaneous
            development of autoimmune diabetes in nonobese diabetic mice
  JOURNAL   Proc Natl Acad Sci U S A 91 (26), 12604-12608 (1994)
   PUBMED   7528925
REFERENCE   8  (bases 1 to 3736)
  AUTHORS   Turunen JP, Ustinov J and Renkonen R.
  TITLE     Adhesion molecules involved in protein kinase A- and C-dependent
            lymphocyte adherence to microvascular endothelial cells
  JOURNAL   Scand J Immunol 37 (3), 282-288 (1993)
   PUBMED   7680140
REFERENCE   9  (bases 1 to 3736)
  AUTHORS   Mulligan MS, Johnson KJ, Todd RF 3rd, Issekutz TB, Miyasaka M,
            Tamatani T, Smith CW, Anderson DC and Ward PA.
  TITLE     Requirements for leukocyte adhesion molecules in nephrotoxic
            nephritis
  JOURNAL   J Clin Invest 91 (2), 577-587 (1993)
   PUBMED   7679412
REFERENCE   10 (bases 1 to 3736)
  AUTHORS   Ryan DH, Nuccie BL, Abboud CN and Winslow JM.
  TITLE     Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate
            adhesion of human B cell precursors to cultured bone marrow
            adherent cells
  JOURNAL   J Clin Invest 88 (3), 995-1004 (1991)
   PUBMED   1715889
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_230033.4, XM_001067316.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3736
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..3736
                     /gene="Itga4"
                     /note="integrin subunit alpha 4"
                     /db_xref="GeneID:311144"
                     /db_xref="RGD:1593249"
     exon            1..444
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..3346
                     /gene="Itga4"
                     /note="integrin, alpha 4"
                     /codon_start=1
                     /product="integrin alpha-4"
                     /protein_id="NP_001101207.1"
                     /db_xref="GeneID:311144"
                     /db_xref="RGD:1593249"
                     /translation="MAAEAMCRPRPRGVALQEAVMLLLYFGVHFRVPTGHSYNLDPES
                     ALLYQGPSGTLFGYSVVLHSHGTKRWLIVGAPTASWLANASVVNPGAIYRCRIGKNPN
                     QICEQLQLGSPSGEPCGKTCLEERDNQWLGVTISRQPGENGSIVTCGHRWKNIFYMKN
                     NNKLPTGVCYGMPSDLRTELSKRMAPCYQDFVRKFGENFASCQAGISSFYTQDLIVMG
                     APGSSYWTGSVFVYNITTNKYKAFVDRQNQVKFGSYLGYSVGAGHFRNPHTTEVVGGA
                     PQHEQIGKAYIFSIDESELTIVYEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQ
                     STIREEGRVFVYINSGMGAVMVEMERVLVGSDKYAARFGESMANLGDIDNDGFEDIAI
                     GAPQEDDLRGAVYIYNGRVDGISSTYSQRIEGRQISQSLRMFGQSISGQIDADNNGYV
                     DVAVGAFQSDSAVLLRTRPVVIVEASLSHPESVNRTKFDCTENGLLSVCVDLKLCFSY
                     KGKEVPGYIVLFYNVSLDVHRKAESPSRFYFFSNGTSDMITRSIRVSSSGEKCRTHQA
                     FMRKDVRDILTPIQVEATYHLGHHVITKRNTEEFPPLQPILQQKKEKDIIRKTINFAR
                     FCAYENCSADLQVSAKVGFLKPYENKTYLAVGSMKTIMLNVSLFNAGDDAYETTLNVQ
                     LPTGLYFIKILDLEEKQINCDVTESSGVVKLACSLGYIYVDRLSRIDISFLLDVSSLS
                     RAHEDLSINVHASCENEGKLDQVKDNRVTLVIPLRYEVMLAVHGFVTPTSFVYGSSEE
                     NEPEMCMAEKLNLTFHVINTGISMAPNVSVKIMVPNSFLPRNDKLFNVLDVQATMGQC
                     QFEHYGRECALAQQKGIAGTLTDLVKFLSKTDKRLLYCMKADRHCLDFLCNFGKMESG
                     KEASVHIQLEGRPSVLEMDETSSLKFEIKATAFPEPHPKVIELNKDENIAHVYLEGLH
                     HQRPKRHFTIVIVTISLLLGLIVLLLISCVMWKAGFFKRQYKSILQEENRRDSWSYVN
                     SKSNDD"
     exon            445..566
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            567..673
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            674..803
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            804..871
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1001
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1087
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1150
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1288
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1400
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1495
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1586
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1632
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1787
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1942
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2092
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2169
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2320
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2416
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2496
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2586
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2677
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2785
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2911
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3031
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3130
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3250
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
     exon            3251..3736
                     /gene="Itga4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaacgggg cgtgggccag agcctgaggc attcctggcc accaggatcg ctccgcctgt
       61 ggccaccaat tcccctcctc ttctggcgtt cctctctccg cccctgtcgc ctgccagcac
      121 cggacacgct gctgcacttc atctcttggg gcgctcttcg ctttggccaa ccgtcgcgtc
      181 ctgtgcaact ctggtcagtg gccgttttgt gttgaatgtt ccccaccaag agtgcatggc
      241 tgcggaagcg atgtgcagac cgaggccccg aggggtcgcc ctccaggaag cggtgatgct
      301 gttgctgtac ttcggggtac acttcagggt accaaccggg cactcctaca acctggaccc
      361 ggagagtgca ctgctgtacc agggcccctc cggcacgctg tttggctact cggtggtgct
      421 gcacagccac gggacgaagc gctggctcat tgtgggggcg cccactgcca gctggctcgc
      481 caatgcctcg gtggtcaatc ctggggcgat ttacagatgc aggatcggaa agaatccaaa
      541 ccagatctgc gaacagctcc agctgggaag ccccagtgga gaaccctgtg ggaagacgtg
      601 cttggaagag agagataatc agtggctggg agtgacaatt tccagacagc caggagaaaa
      661 tggatctatc gtgacttgtg ggcacaggtg gaaaaatata ttttacatga agaacaataa
      721 taaactcccc actggtgttt gctatggcat gccttctgat ttgcggacag aactaagtaa
      781 aaggatggcc ccctgttacc aagattttgt gagaaaattt ggagaaaatt ttgcatcgtg
      841 tcaagctgga atatctagtt tttacacaca ggatttgatt gtgatggggg ccccgggatc
      901 atcgtactgg accggctccg tctttgtcta caacataact acgaacaaat acaaggcatt
      961 tgtagacaga cagaatcaag taaaatttgg aagctactta ggctactcag taggagctgg
     1021 tcatttccga aatccacata ctaccgaagt cgtgggagga gcccctcaac acgaacagat
     1081 aggaaaagca tatatattca gcattgatga aagcgaactg accatcgtat atgaaatgaa
     1141 aggtaaaaag cttggctctt actttggagc ttctgtctgt gcggtggacc tcaatgcaga
     1201 tggcttctca gatctccttg ttggagcgcc tatgcagagc accatcaggg aggaaggaag
     1261 agtgttcgtg tacatcaact ctggcatggg agctgtgatg gttgaaatgg aaagagtgct
     1321 cgtcggaagt gacaaatatg ctgccaggtt tggggaatcc atggcaaatc ttggcgacat
     1381 tgacaatgat ggctttgaag atattgctat tggcgcacca caagaagatg acttgcgagg
     1441 cgctgtctac atttacaatg gccgagtaga tggcatctcc tctacatact cacagagaat
     1501 cgaaggacgt caaatcagcc agtcactaag gatgtttgga cagtctatct caggacaaat
     1561 tgatgcagac aacaatggat atgttgatgt agcggttggt gcatttcagt ctgattctgc
     1621 agtgttgcta aggacacggc ctgtagtgat tgttgaagca tctttaagcc atcctgagtc
     1681 agtaaataga acaaaatttg actgtactga aaatggactt ctgtctgtgt gcgtggatct
     1741 taaactgtgt ttctcatata agggcaaaga ggtcccaggc tacatcgttt tgttttacaa
     1801 tgtgagcttg gatgtgcaca ggaaggccga gtctccgtca agattttatt tcttctccaa
     1861 tgggacttct gacatgatta caagaagcat acgagtttca agcagtggag agaaatgtag
     1921 gacacaccag gcattcatgc ggaaagacgt gcgagacatc ctcactccca ttcaggttga
     1981 ggccacatac caccttgggc atcatgtgat caccaaacga aacacagagg aattcccacc
     2041 cctccagccg atccttcagc agaagaaaga aaaagacatt attagaaaaa cgataaactt
     2101 cgcaaggttt tgtgcctatg aaaattgttc tgctgatctg caggtttctg caaaagttgg
     2161 gtttttgaag ccatatgaaa ataaaaccta tcttgctgtt gggagcatga agaccataat
     2221 gctaaatgtg tccttgttca atgctggaga tgatgcttat gaaactactc tgaatgtcca
     2281 actccccaca ggcctttatt tcattaagat cttagacctg gaagagaaac aaataaactg
     2341 cgacgtgaca gagagctcag gcgtagttaa gcttgcctgc agcctcggtt acatatacgt
     2401 ggatcgtctc tcaaggatag acattagctt tctcctggat gtgagctcac tcagcagggc
     2461 ccatgaggac ctcagcatca acgtgcatgc ctcctgtgaa aatgagggta aattggacca
     2521 agtgaaagac aacagagtga ccttagtgat acctctaagg tatgaagtta tgctggctgt
     2581 tcacgggttt gtgaccccaa cttcgtttgt gtatggatcc agtgaagaaa acgagccaga
     2641 aatgtgcatg gcagagaaat tgaacctcac tttccatgtt ataaacactg gcattagcat
     2701 ggctccaaat gttagtgtga aaataatggt accaaattct tttctccctc gaaatgataa
     2761 gttgttcaac gttttggatg tccaggcaac tatggggcag tgccaatttg aacactatgg
     2821 acgagagtgt gcattagcac agcaaaaagg catagcgggg accttgaccg atttggtcaa
     2881 atttctatca aagactgata agagactcct gtattgcatg aaagctgatc gacactgttt
     2941 agatttctta tgtaatttcg ggaaaatgga aagtgggaag gaagccagcg ttcacattca
     3001 gctggaaggc aggccatccg tcttggaaat ggatgagacc tcatcgctca aatttgaaat
     3061 aaaagcaaca gcttttccag agccacaccc aaaagttatt gagctcaata aggatgagaa
     3121 cattgcccat gtttacttgg aagggctcca tcatcaaaga cccaaacggc atttcaccat
     3181 cgtgattgtc accatcagct tgctccttgg acttattgta cttttattaa tttcatgtgt
     3241 tatgtggaag gctggatttt ttaaaaggca gtacaaatct atcctacaag aagaaaacag
     3301 gagagacagc tggagttatg tcaacagcaa aagcaatgat gactgaagac ttaaattgag
     3361 agaattgaaa aaggtctcag gttaagatct ctccaggaga tctgtgataa tttctctttt
     3421 ccatgcactt atggttttgt gacccactct gtcttagtgc tggggaagtc tgcaaggaag
     3481 aaaatacaca aagatggctt gacagcagtc agtgaataag tggagcaaaa cactaaagct
     3541 ctggacacac ccagaacttc cgaagccaat ttaaagggac agtaactcca gatttagctg
     3601 gaccgactta aaaggaatga tctttcaagg aaatattact gattaggtgg gctcacctca
     3661 gcaaaatgga tgccatgata tggaagggta ttggtttcaa atatactttt gatttatctt
     3721 cagactatga ccatga
//
