LOCUS       NM_001108292            4930 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus integrin subunit alpha 3 (Itga3), transcript
            variant 1, mRNA.
ACCESSION   NM_001108292 XM_001081309 XM_003750907 XM_003752369 XM_340884
VERSION     NM_001108292.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4930)
  AUTHORS   Takahashi,T., Friedmacher,F., Zimmer,J. and Puri,P.
  TITLE     Decreased Expression of Integrin Subunits alpha3, alpha6, and
            alpha8 in the Branching Airway Mesenchyme of Nitrofen-Induced
            Hypoplastic Lungs
  JOURNAL   Eur J Pediatr Surg 28 (1), 109-114 (2018)
   PUBMED   28701000
  REMARK    GeneRIF: Decreased expression of Itga3, Itga6, and Itga8 in the
            pulmonary mesenchyme may lead to disruptions in airway branching
            morphogenesis, thus contributing to pulmonary hypoplasia in the
            nitrofen-induced congenital diaphragmatic hernia model.
REFERENCE   2  (bases 1 to 4930)
  AUTHORS   Heintz,T.G., Eva,R. and Fawcett,J.W.
  TITLE     Regional Regulation of Purkinje Cell Dendritic Spines by Integrins
            and Eph/Ephrins
  JOURNAL   PLoS One 11 (8), e0158558 (2016)
   PUBMED   27518800
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4930)
  AUTHORS   Garrigues,H.J., DeMaster,L.K., Rubinchikova,Y.E. and Rose,T.M.
  TITLE     KSHV attachment and entry are dependent on alphaVbeta3 integrin
            localized to specific cell surface microdomains and do not
            correlate with the presence of heparan sulfate
  JOURNAL   Virology 464-465, 118-133 (2014)
   PUBMED   25063885
  REMARK    Erratum:[Virology. 2018 Feb;515:264-265. PMID: 29407075]
REFERENCE   4  (bases 1 to 4930)
  AUTHORS   Shukrun,R., Vivante,A., Pleniceanu,O., Vax,E., Anikster,Y.,
            Dekel,B. and Lotan,D.
  TITLE     A human integrin-alpha3 mutation confers major renal developmental
            defects
  JOURNAL   PLoS One 9 (3), e90879 (2014)
   PUBMED   24621570
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4930)
  AUTHORS   Yamada,M. and Sekiguchi,K.
  TITLE     Disease-associated single amino acid mutation in the calf-1 domain
            of integrin alpha3 leads to defects in its processing and cell
            surface expression
  JOURNAL   Biochem Biophys Res Commun 441 (4), 988-993 (2013)
   PUBMED   24220332
REFERENCE   6  (bases 1 to 4930)
  AUTHORS   Baudoin,C., Goumans,M.J., Mummery,C. and Sonnenberg,A.
  TITLE     Knockout and knockin of the beta1 exon D define distinct roles for
            integrin splice variants in heart function and embryonic
            development
  JOURNAL   Genes Dev 12 (8), 1202-1216 (1998)
   PUBMED   9553049
REFERENCE   7  (bases 1 to 4930)
  AUTHORS   DeFreitas,M.F., Yoshida,C.K., Frazier,W.A., Mendrick,D.L.,
            Kypta,R.M. and Reichardt,L.F.
  TITLE     Identification of integrin alpha 3 beta 1 as a neuronal
            thrombospondin receptor mediating neurite outgrowth
  JOURNAL   Neuron 15 (2), 333-343 (1995)
   PUBMED   7544141
REFERENCE   8  (bases 1 to 4930)
  AUTHORS   Stepp,M.A., Zhu,L., Sheppard,D. and Cranfill,R.L.
  TITLE     Localized distribution of alpha 9 integrin in the cornea and
            changes in expression during corneal epithelial cell
            differentiation
  JOURNAL   J Histochem Cytochem 43 (4), 353-362 (1995)
   PUBMED   7534781
REFERENCE   9  (bases 1 to 4930)
  AUTHORS   Terracio,L., Rubin,K., Gullberg,D., Balog,E., Carver,W., Jyring,R.
            and Borg,T.K.
  TITLE     Expression of collagen binding integrins during cardiac development
            and hypertrophy
  JOURNAL   Circ Res 68 (3), 734-744 (1991)
   PUBMED   1835909
REFERENCE   10 (bases 1 to 4930)
  AUTHORS   Tomaselli,K.J., Hall,D.E., Flier,L.A., Gehlsen,K.R., Turner,D.C.,
            Carbonetto,S. and Reichardt,L.F.
  TITLE     A neuronal cell line (PC12) expresses two beta 1-class
            integrins-alpha 1 beta 1 and alpha 3 beta 1-that recognize
            different neurite outgrowth-promoting domains in laminin
  JOURNAL   Neuron 5 (5), 651-662 (1990)
   PUBMED   2223092
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1 and FQ134609.1.
            
            On or before Aug 24, 2019 this sequence version replaced
            XM_003750907.3, XM_003752369.3, NM_001108292.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB727941.1, SRR26643297.35580.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-632               JAXUCZ010000010.1  80518270-80518901   c
            633-760             JAXUCZ010000010.1  80510947-80511074   c
            761-840             JAXUCZ010000010.1  80510494-80510573   c
            841-1090            JAXUCZ010000010.1  80508409-80508658   c
            1091-1177           JAXUCZ010000010.1  80506011-80506097   c
            1178-1385           JAXUCZ010000010.1  80505412-80505619   c
            1386-1582           JAXUCZ010000010.1  80504762-80504958   c
            1583-1671           JAXUCZ010000010.1  80503277-80503365   c
            1672-1808           JAXUCZ010000010.1  80503039-80503175   c
            1809-1895           JAXUCZ010000010.1  80502790-80502876   c
            1896-1963           JAXUCZ010000010.1  80501802-80501869   c
            1964-2100           JAXUCZ010000010.1  80501578-80501714   c
            2101-2250           JAXUCZ010000010.1  80500889-80501038   c
            2251-2348           JAXUCZ010000010.1  80500704-80500801   c
            2349-2496           JAXUCZ010000010.1  80500313-80500460   c
            2497-2568           JAXUCZ010000010.1  80500037-80500108   c
            2569-2648           JAXUCZ010000010.1  80499461-80499540   c
            2649-2726           JAXUCZ010000010.1  80499300-80499377   c
            2727-2829           JAXUCZ010000010.1  80498139-80498241   c
            2830-3012           JAXUCZ010000010.1  80497795-80497977   c
            3013-3135           JAXUCZ010000010.1  80497492-80497614   c
            3136-3249           JAXUCZ010000010.1  80496719-80496832   c
            3250-3348           JAXUCZ010000010.1  80495429-80495527   c
            3349-3474           JAXUCZ010000010.1  80489417-80489542   c
            3475-3615           JAXUCZ010000010.1  80488942-80489082   c
            3616-4908           JAXUCZ010000010.1  80486999-80488291   c
            4909-4930           FQ134609.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..4930
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..4930
                     /gene="Itga3"
                     /note="integrin subunit alpha 3"
                     /db_xref="GeneID:360606"
                     /db_xref="RGD:1310333"
     exon            1..632
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     CDS             427..3585
                     /gene="Itga3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; integrin, alpha 3"
                     /codon_start=1
                     /product="integrin alpha-3 isoform 1 precursor"
                     /protein_id="NP_001101762.2"
                     /db_xref="GeneID:360606"
                     /db_xref="RGD:1310333"
                     /translation="MGPGPRRVPRDPGWMLRALALMVAASGRVAFAFNLDTKFLVVKE
                     AVNPGSLFGYSVALHRQTERQQRYLLLAGAPRDLAVDDDYTNRTGAVYLCPLTALKND
                     CERMDISEKSDPDHHIIEDMWLGVTVASQGPAGRVLVCAHRYTKVLWSGLEDQRRMVG
                     KCYVRGNDLQLDPGDDWQTYHNEMCNSNTDYLQTGMCQLGTSGGFTQNTVYFGAPGAY
                     NWKGNSYMIQRKDWDLSEYSYRGSEDQGNLYIGYTMQVGSAILHPSEITLVTGAPRHQ
                     HMGAVFLLKQESGGDLQRRQVLKGTQVGAYFGSAIALADLNNDGWQDLLVGAPYYFER
                     KEEVGGAVYVFMNQAGTSFPDQPSLLLHGPSRSAFGISVASIGDINQDGFQDIAVGAP
                     FEGLGKVYIYHSSSGGLLKQPQQIIHGETLGLPGLATFGYSLSGKMDVDENLYPDLLV
                     GSLSDHIVLLRARPVINILHRTLVARPAVLDPSLCTVTSCVQVELCFAYNQSAGNPNY
                     RRNITLAYTVEADRDRRPPRLRFARSQSSVFHGFFSMPETHCQTLELLLMDNVRDKLR
                     PIVITMNYSLPLRMPDRLKLGLRSLDAYPVLNQAQAMENHTEVHFQKECGPDNKCDSN
                     LQMRAAFVSEQLQPLSRLQYSRDTKKLFLSINVTNSPSRQRAGEDAHEALLTLEVSSA
                     LLLSSVRPAGTCQANETNTVCELGNPFKRNQRMELLIAFEVTGVTLHTRDLRAHLQLS
                     TSSHQDNLQPMFLTLQVDYTLQASLSLMNHRLQSFFSGTVMGEAAMKTVKDVGSPLKY
                     EFQVSPVGDGLAALGTLVLGLEWPYEVTNGKWLLYPTEITIHSNGSWPCQPHGNLVNP
                     LNLTLSDPGVKPLSPQRRRRQLDPGGDQGPPPVTLAAAKKAKSETVLTCSNGRARCVW
                     LECPLPDASNITNVTVKARVWNSTFIEDYKDFDRVRVDGWATLFLRTSIPTINMENKT
                     TWFSVDIDSELVEELPAEIELWLVLVAVGAGLLLLGLIIILLWKCGFFKRARTRALYE
                     AKRQKAEMRSQPSETERLTDDY"
     exon            633..760
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            761..840
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1090
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1177
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1385
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1582
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1671
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1808
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1895
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..1963
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2100
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2250
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2348
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2496
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2568
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2648
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2726
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2829
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..3012
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3135
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3249
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3348
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3474
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3615
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
     exon            3616..4909
                     /gene="Itga3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctaggcg gtggggaggc ggggcgcgcg ccggggagga tccctccctc ctgccttcct
       61 agcgatcgcg gatttgcctt tctagatcct ccacctagcc gagatctaaa gagctaacac
      121 ctccaagggg gcgcggcccg gaccatctag ggtgcagggt gcccggagcc cggatcggtg
      181 accggtccat cggaccaacc ggagagtaga tacacggatc tggaaaaaag actggagaag
      241 caccaacccg gagcagacgt gagactgacc tggactaggg caaaaaaatt gccggagtcc
      301 cggcgcagcg gctctgcggg ctcgggtgtc ctctggcggc gcctggagca ggtgaaccgt
      361 tcatcacttc ccggtgctga gccctctagc gatttcgccg ggctcggttc agcccggccc
      421 gcagccatgg gccctggccc gcgccgcgtg ccccgcgacc ctggctggat gctccgcgcc
      481 ctggctttga tggtggcggc tagtggccgg gtcgccttcg ctttcaacct ggacaccaaa
      541 ttcctggtgg tgaaggaggc ggtgaaccct ggtagcctct ttggctactc cgtcgccctc
      601 catcggcaga ctgagcgaca gcagcgctac ctccttctgg ccggtgcacc ccgagacctc
      661 gcagtggatg atgactacac caaccggact ggtgctgtgt acctgtgtcc cctcactgcc
      721 ctcaagaacg attgtgaacg catggacatt tcagagaaga gtgaccctga ccatcacatt
      781 attgaggaca tgtggcttgg agtgactgtg gccagccagg gccctgcagg tagagtcctg
      841 gtctgtgccc atcggtacac caaggtgctg tggtctgggc tggaagacca gcggcgcatg
      901 gtgggcaagt gctacgtgcg tggcaacgac ctacagctcg accctggcga tgattggcag
      961 acataccaca acgagatgtg taacagcaac actgactact tgcagactgg catgtgccag
     1021 ctgggcacca gtggcggctt cacccagaac actgtatact tcggcgcccc tggtgcctac
     1081 aactggaaag gaaacagcta catgattcag cggaaagact gggatttatc tgaatacagc
     1141 tacaggggct cagaggacca gggaaacctc tatattgggt acacgatgca ggtaggcagt
     1201 gccatcctac atccctcgga gatcactctt gtgacgggtg ccccacggca ccaacatatg
     1261 ggcgctgtct tcttgctgaa acaagagtcg ggtggagacc tgcagaggag gcaggtgctg
     1321 aagggcacgc aggtgggcgc ttattttggc agtgccattg ccctggcaga cctgaacaat
     1381 gatgggtggc aggacctcct ggtgggtgct ccctactact tcgaacggaa agaggaggta
     1441 gggggtgccg tctatgtctt catgaaccag gcgggaacgt ccttccctga tcagccttcc
     1501 ctcctgctcc atggccccag tcgctctgcc tttggcatct ctgtagccag cattggtgac
     1561 atcaaccagg atggattcca ggacattgct gtgggagctc catttgaggg cttgggcaaa
     1621 gtatacatct accacagcag ctccgggggg ctcctcaagc agcctcagca gataatccac
     1681 ggagagacac taggactgcc tggcttggcc accttcggct actctctgag tgggaagatg
     1741 gatgtggatg aaaacttata cccagacctg ctagtaggga gcctgtcgga ccacattgtg
     1801 ctgctgcggg cccgacctgt catcaatatc ctccacagga ccttggtggc caggccagct
     1861 gtgttggacc cctcgctttg tacggttact tcctgtgttc aggtggagct gtgctttgcc
     1921 tacaaccaga gtgccgggaa ccccaactac aggcggaaca tcaccctggc ttacacagtg
     1981 gaggctgaca gggaccgacg cccacccagg ctccgattcg cccgtagcca gtcgtcggtc
     2041 ttccatggct tcttctccat gccagagaca cattgccaga cattggagtt actgctgatg
     2101 gacaatgttc gtgataaact ccgtcctatc gtcatcacca tgaactactc cttacctttg
     2161 cgcatgcccg atcgcctcaa gctgggctta cggtccctgg atgcctaccc ggtcctcaac
     2221 caggcacagg ctatggagaa tcacaccgag gtccacttcc agaaagagtg cgggccagac
     2281 aacaagtgcg acagcaacct gcagatgcga gccgccttcg tgtctgagca gctgcagcct
     2341 ctaagcaggc tccagtacag cagagacact aagaaactgt tcttgagcat caatgtgacc
     2401 aattcgccga gccgccaacg ggctggggaa gatgcccatg aggcactgct cactctagag
     2461 gtgtcatccg ctctgcttct gtcctccgtg cgcccggctg ggacctgcca agctaacgag
     2521 accaacaccg tgtgtgagct aggaaacccc ttcaaacgga accagaggat ggagctgctc
     2581 atcgcctttg aggtcaccgg ggtaactttg cacacgaggg accttagggc acatctacag
     2641 ctgtccacgt caagtcacca ggacaacttg cagcccatgt tcctgacttt gcaggtggac
     2701 tacaccctcc aggcctcgct cagtttgatg aatcatcgac tgcagagctt ctttagtggg
     2761 acagtgatgg gcgaggctgc catgaagact gtgaaggatg tgggaagccc cctgaaatat
     2821 gaattccagg tgagcccagt gggagacggg ctggcagcct tgggcacact ggttctaggt
     2881 ctggagtggc cgtatgaagt taccaatggc aagtggctgc tgtaccctac ggagatcacc
     2941 atccacagca atgggtcctg gccctgccag ccacatggaa accttgtcaa ccctctcaac
     3001 cttactctct ctgaccctgg agtcaagcca ctgtccccac agcgccggcg gagacaacta
     3061 gatccagggg gagaccaggg tcctccacct gtcacgctag ctgctgccaa aaaagccaag
     3121 tctgagaccg tgttgacctg ttccaatggc cgcgcccgct gtgtgtggct ggagtgcccc
     3181 cttccagatg cctccaacat taccaatgtg accgtgaagg cacgggtgtg gaacagcacc
     3241 ttcattgagg actacaaaga ctttgacaga gtccgagtag atggctgggc taccctgttc
     3301 ctgagaacca gtatccctac catcaacatg gagaataaga ccacatggtt ctccgtggac
     3361 atcgactctg agctggtgga ggagctgccc gctgagatcg agctgtggtt ggtgcttgtg
     3421 gccgtgggtg ctgggttgct gctactgggc ctcatcatca tcctgctgtg gaagtgcggc
     3481 ttcttcaagc gagcccgcac tcgtgccctg tatgaagcta agagacagaa ggctgagatg
     3541 aggagccagc catcagagac agaaaggctg accgacgact actgaggggg cagccccccg
     3601 ccccggccca cccggtgtga cttctttaag ccaacccgct actaccggat tatgcccaag
     3661 taccacgcag tgcgtatccg ggaggaagac cgctacccac ctccagggag cacactaccc
     3721 accaagaagc actgggtcac tagctggcag attcgggacc gatactactg attgccctcc
     3781 ccaacaaacc acccagcacc cccttccttc ctatttatca taaattatga ctccgacagt
     3841 ccaaaagggg ccacgagtgt ggctggcact ggcaggctca ggcatctatc cccctcttca
     3901 gtgcaggcat gttttctggg gtcgtggaat ctccttcaag accttgaaat gctgagcaca
     3961 gcatggccct gcatactggc cacacacaga actactagtg gcctgttctg atacaccctg
     4021 gtgggtgcca tgtccaagtc tctgtgccaa aaccaagcca aagcgcctcc accgggagac
     4081 aggaggaaaa ggtccctgat gtggtaacac ctctcctcca cactggatcc cccttgagcc
     4141 actgtcactg ggcagagttt actgtccaga ataaaactac tgacaaggag gagacagtca
     4201 ggcccagccg caattcctgg caggcactgg agcacagggc cacactaaag gctacccagg
     4261 ggatgttctt atgacctgtg tgctcagacc caagagcagt gaactagaaa acaggtcccc
     4321 ggaatgggtt ttatgagtgg ctctctaaaa ttgtggctac agagagagtt ggcaagaaat
     4381 gcagccccaa gggacaaaga gaaaccgtgg gcagcctgga cacactatgc tgggactgac
     4441 ctggagcacg gtgacatcct tcagagagtg gagtcctggc acagccgaca ctagtaggac
     4501 gaagaggaga gacttctgac ccatcctgac cacctcagcc tgggcaaggc ctggagttcc
     4561 ccacaaggcc atgtggggtg tgatacttga atgtagggca gaggggggcc cagcccctgc
     4621 cccagttggc cagacttgat tctgctccct tgaccacaga gatatattct gagctgcctg
     4681 tggctttctg agaaacctgg ccctccccct ccccgtcccc taggagctgc atccccattc
     4741 cagcagtgga ggccaatctc tcaggacctc tccccatccc tgcccacagg caggcccact
     4801 ccccagctct gtcccctcca ccccatggta ctataacagc ttcctccatc ctgtgccttc
     4861 tttgtatatg ggcgtctcac taaaataaat aaacagtccc cagtttgtaa aaaaaaaaaa
     4921 aaaaaaaaaa
//
