LOCUS       NM_030994               3963 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus integrin subunit alpha 1 (Itga1), mRNA.
ACCESSION   NM_030994
VERSION     NM_030994.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3963)
  AUTHORS   Gao,G., He,J., Nong,L., Xie,H., Huang,Y., Xu,N. and Zhou,D.
  TITLE     Periodic mechanical stress induces the extracellular matrix
            expression and migration of rat nucleus pulposus cells by
            upregulating the expression of intergrin alpha1 and phosphorylation
            of downstream phospholipase Cgamma1
  JOURNAL   Mol Med Rep 14 (3), 2457-2464 (2016)
   PUBMED   27484337
  REMARK    GeneRIF: periodic mechanical stress induced ECM expression and the
            migration of NP cells via upregulating the expression of integrin
            alpha1 and the phosphorylation of downstream PLCgamma1. These
            findings provide novel information to aid the understanding of the
            pathogenesis and development of IDD.
REFERENCE   2  (bases 1 to 3963)
  AUTHORS   Zhao,C.M., Chen,Q., Zhang,W.J., Huang,A.B., Zhang,W., Yang,H.L. and
            Zhang,Z.M.
  TITLE     17beta-Estradiol Protects Rat Annulus Fibrosus Cells Against
            Apoptosis via alpha1 Integrin-Mediated Adhesion to Type I Collagen:
            An In-vitro Study
  JOURNAL   Med Sci Monit 22, 1375-1383 (2016)
   PUBMED   27108411
  REMARK    GeneRIF: This study shows that E2 protects against apoptosis in a
            time-dependent manner, and alpha1 integrin-mediated adhesion to
            collagen II is essential for estrogen-dependent anti-apoptosis in
            rat annulus fibrosus cells in vitro.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3963)
  AUTHORS   Moraes,J.A., Frony,A.C., Dias,A.M., Renovato-Martins,M.,
            Rodrigues,G., Marcinkiewicz,C., Assreuy,J. and Barja-Fidalgo,C.
  TITLE     Alpha1beta1 and integrin-linked kinase interact and modulate
            angiotensin II effects in vascular smooth muscle cells
  JOURNAL   Atherosclerosis 243 (2), 477-485 (2015)
   PUBMED   26520903
  REMARK    GeneRIF: Alpha1beta1 and integrin-linked kinase interact and
            modulate angiotensin II effects on vascular smooth muscle cell
            proliferation/migration.
REFERENCE   4  (bases 1 to 3963)
  AUTHORS   Sipila,K., Haag,S., Denessiouk,K., Kapyla,J., Peters,E.C.,
            Denesyuk,A., Hansen,U., Konttinen,Y., Johnson,M.S., Holmdahl,R. and
            Heino,J.
  TITLE     Citrullination of collagen II affects integrin-mediated cell
            adhesion in a receptor-specific manner
  JOURNAL   FASEB J 28 (8), 3758-3768 (2014)
   PUBMED   24823363
REFERENCE   5  (bases 1 to 3963)
  AUTHORS   Soteriou,D., Iskender,B., Byron,A., Humphries,J.D.,
            Borg-Bartolo,S., Haddock,M.C., Baxter,M.A., Knight,D.,
            Humphries,M.J. and Kimber,S.J.
  TITLE     Comparative proteomic analysis of supportive and unsupportive
            extracellular matrix substrates for human embryonic stem cell
            maintenance
  JOURNAL   J Biol Chem 288 (26), 18716-18731 (2013)
   PUBMED   23658023
REFERENCE   6  (bases 1 to 3963)
  AUTHORS   Szpirer,C., Szpirer,J., Van Vooren,P., Tissir,F., Simon,J.S.,
            Koike,G., Jacob,H.J., Lander,E.S., Helou,K., Klinga-Levan,K. and
            Levan,G.
  TITLE     Gene-based anchoring of the rat genetic linkage and cytogenetic
            maps: new regional localizations, orientation of the linkage
            groups, and insights into mammalian chromosome evolution
  JOURNAL   Mamm Genome 9 (9), 721-734 (1998)
   PUBMED   9716657
REFERENCE   7  (bases 1 to 3963)
  AUTHORS   Baudoin,C., Goumans,M.J., Mummery,C. and Sonnenberg,A.
  TITLE     Knockout and knockin of the beta1 exon D define distinct roles for
            integrin splice variants in heart function and embryonic
            development
  JOURNAL   Genes Dev 12 (8), 1202-1216 (1998)
   PUBMED   9553049
REFERENCE   8  (bases 1 to 3963)
  AUTHORS   Giebel,J., Loster,K. and Rune,G.M.
  TITLE     Localization of integrin beta 1, alpha 1, alpha 5 and alpha 9
            subunits in the rat testis
  JOURNAL   Int J Androl 20 (1), 3-9 (1997)
   PUBMED   9202984
REFERENCE   9  (bases 1 to 3963)
  AUTHORS   Damjanovich,L., Fulop,B., Adany,R. and Nemes,Z.
  TITLE     Integrin expression on normal and neoplastic human breast
            epithelium
  JOURNAL   Acta Chir Hung 36 (1-4), 69-71 (1997)
   PUBMED   9408292
REFERENCE   10 (bases 1 to 3963)
  AUTHORS   Ignatius,M.J., Large,T.H., Houde,M., Tawil,J.W., Barton,A.,
            Esch,F., Carbonetto,S. and Reichardt,L.F.
  TITLE     Molecular cloning of the rat integrin alpha 1-subunit: a receptor
            for laminin and collagen
  JOURNAL   J Cell Biol 111 (2), 709-720 (1990)
   PUBMED   2380249
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X52140.1.
            
            On Apr 19, 2007 this sequence version replaced NM_030994.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X52140.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3963              X52140.1           25-3987
FEATURES             Location/Qualifiers
     source          1..3963
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..3963
                     /gene="Itga1"
                     /note="integrin subunit alpha 1"
                     /db_xref="GeneID:25118"
                     /db_xref="RGD:2923"
     exon            1..456
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..3938
                     /gene="Itga1"
                     /note="integrin alpha-1; VLA-1; laminin and collagen
                     receptor; CD49 antigen-like family member A"
                     /codon_start=1
                     /product="integrin alpha-1 precursor"
                     /protein_id="NP_112256.1"
                     /db_xref="GeneID:25118"
                     /db_xref="RGD:2923"
                     /translation="MVPRRPASLEVTVACIWLLTVILGFCVSFNVDVKNSMSFSGPVE
                     DMFGYTVQQYENEEGKWVLIGSPLVGQPKARTGDVYKCPVGRERAMPCVKLDLPVNTS
                     IPNVTEIKENMTFGSTLVTNPNGGFLACGPLYAYRCGHLHYTTGICSDVSPTFQVVNS
                     FAPVQECSTQLDIVIVLDGSNSIYPWESVIAFLNDLLKRMDIGPKQTQVGIVQYGENV
                     THEFNLNKYSSTEEVLVAANKIGRQGGLQTMTALGIDTARKEAFTEARGARRGVKKVM
                     VIVTDGESHDNYRLKQVIQDCEDENIQRFSIAILGHYNRGNLSTEKFVEEIKSIASEP
                     TEKHFFNVSDELALVTIVKALGERIFALEATADQSAASFEMEMSQTGFSAHYSQDWVM
                     LGAVGAYDWNGTVVMQKANQMVIPHNTTFQTEPAKMNEPLASYLGYTVNSATIPGDVL
                     YIAGQPRYNHTGQVVIYKMEDGNINILQTLGGEQIGSYFGSVLTTIDIDKDSYTDLLL
                     VGAPMYMGTEKEEQGKVYVYAVNQTRFEYQMSLEPIRQTCCSSLKDNSCTKENKNEPC
                     GARFGTAIAAVKDLNVDGFNDVVIGAPLEDDHAGAVYIYHGSGKTIREAYAQRIPSGG
                     DGKTLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAALFWARDVAVVKVTMNFEPNKVNI
                     QKKNCRVEGKETVCINATMCFHVKLKSKEDSIYEADLQYRVTLDSLRQISRSFFSGTQ
                     ERKIQRNITVRESECIRHSFYMLDKHDFQDSVRVTLDFNLTDPENGPVLDDALPNSVH
                     EHIPFAKDCGNKERCISDLTLNVSTTEKSLLIVKSQHDKFNVSLTVKNKGDSAYNTRT
                     VVQHSPNLIFSGIEEIQKDSCESNQNITCRVGYPFLRAGETVTFKIIFQFNTSHLSEN
                     AIIHLSATSDSEEPLESLNDNEVNISIPVKYEVGLQFYSSASEHHISVAANETIPEFI
                     NSTEDIGNEINVFYTIRKRGHFPMPELQLSISFPNLTADGYPVLYPIGWSSSDNVNCR
                     PRSLEDPFGINSGKKMTISKSEVLKRGTIQDCSSTCGVATITCSLLPSDLSQVNVSLL
                     LWKPTFIRAHFSSLNLTLRGELKSENSSLTLSSSNRKRELAIQISKDGLPGRVPLWVI
                     LLSAFAGLLLLMLLILALWKIGFFKRPLKKKMEK"
     exon            457..577
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..690
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..779
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..891
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1019
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1168
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1319
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1485
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1559
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1704
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1847
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1991
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2249
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2380
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2547
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2684
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2795
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..3005
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3086
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3163
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            3164..3253
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3356
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3470
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            3471..3575
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            3576..3683
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            3684..3776
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            3777..3893
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
     exon            3894..3953
                     /gene="Itga1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggcagatg tccctttaag gtttgctttg ctgctgcccg tggactttag cctaaacagg
       61 gtcccgcgaa gttggcttta tttgtccatg tctcggacac agcctgggta gctgccagtg
      121 agatttcagg gacggagcgc gcaaaggggg gggaaatgtg gcaatccatc tgggatgtga
      181 gacgcgtgga gagggcttag cagcatttga ccaaaacaca ggaaatcact cctccacagc
      241 tcctgggcgc agcagcggct ggggccactg ccggacaccc tcggagacca cacgagtgac
      301 ccagagcgca agtcgccagc gtcccggttc tgcctgttcc tgccagctcc tgcccacgaa
      361 ccggcacgta gctggttcca gcagccgctc cagcaatggt ccccaggcgt cctgccagcc
      421 tagaggtcac tgtagcctgc atatggcttc tcacggtcat cctaggcttc tgcgtctcct
      481 tcaatgttga tgtgaaaaac tcaatgagtt tcagtggccc agtagaggac atgtttggat
      541 acactgttca acaatatgaa aacgaagaag gcaaatgggt tcttattggt tctcctttag
      601 ttggccaacc caaagcaaga actggagatg tctataagtg tccggttggg agagagagag
      661 caatgccttg cgtgaagttg gacttgccag ttaacacatc gatccccaat gtcacagaaa
      721 taaaggaaaa catgacattt ggatcaactt tagtcaccaa cccgaatgga ggatttctgg
      781 catgtgggcc cttgtatgcc tatagatgtg gacatttgca ttatacaact ggaatatgtt
      841 ctgatgtcag tcctacattt caagttgtga actcctttgc ccctgtacaa gaatgcagca
      901 cccagctgga catagtcatc gtcctggatg gctccaacag catctacccc tgggaaagtg
      961 tcatcgcctt tttaaacgac cttcttaaga ggatggatat tggccctaag cagacacagg
     1021 tcgggattgt acagtatgga gagaatgtaa cccatgagtt caacctcaat aagtattcat
     1081 ccacagaaga ggtccttgtc gcagcaaaca aaataggccg acagggaggc ctccaaacga
     1141 tgacagccct tggaatagac acagccagga aagaggcatt cactgaagct cggggtgcca
     1201 ggaggggagt taaaaaagtc atggttattg tgaccgacgg agaatcgcat gacaactatc
     1261 gcctgaaaca ggtcatccaa gactgcgagg acgaaaacat tcagcgattt tccatagcta
     1321 tccttggcca ctataacagg gggaacttaa gcactgaaaa atttgtggag gaaataaaat
     1381 cgatcgcaag cgagcccacg gaaaagcact tcttcaatgt ctcggatgag ttggccctgg
     1441 tcactattgt taaagctctg ggagaaagga tattcgcttt ggaagcgaca gctgaccagt
     1501 cagcagcttc atttgagatg gaaatgtctc agactggctt cagtgctcac tactcccagg
     1561 actgggtcat gcttggagcg gtgggagcct atgactggaa cggaactgtg gtcatgcaga
     1621 aggctaacca gatggtcatc cctcataaca ccacctttca aactgagccc gccaagatga
     1681 acgagcctct ggcttcttat ttaggttaca cagtgaactc ggccaccatc cctggagatg
     1741 tgctctacat cgctgggcag cctcggtaca atcatacggg ccaggtcgtc atctacaaga
     1801 tggaggatgg gaacatcaac attctgcaga cactcggcgg agagcagatt ggttcctact
     1861 ttggtagtgt cttaacaaca attgacatcg acaaagattc ttatactgat ctgcttctcg
     1921 tcggggcccc catgtacatg gggacagaga aagaggaaca gggcaaggtg tacgtgtacg
     1981 ctgtgaatca gacaaggttt gaatatcaaa tgagcctgga accaattagg cagacctgct
     2041 gctcatccct gaaggataat tcatgcacga aagaaaacaa gaatgagccc tgcggggccc
     2101 gcttcggaac agcaattgct gctgtaaaag acctcaacgt ggatggattt aatgacgtcg
     2161 tgattggagc tccgctggaa gatgaccacg caggagctgt gtacatttat catggcagtg
     2221 gcaagaccat aagggaggcg tatgcacaac gcattccatc aggtggggat ggcaagaccc
     2281 tgaaattttt cggccagtct atccacggag agatggattt aaatggtgac ggtctgactg
     2341 acgtgaccat tggaggcctt ggtggagcag ccctcttctg ggccagagat gtggctgtag
     2401 ttaaagtgac catgaatttt gaacccaata aagtgaatat tcaaaagaaa aactgccgtg
     2461 tggagggcaa agaaacagtg tgcataaatg ctacaatgtg ttttcatgtg aaattaaagt
     2521 ctaaagagga ctcaatttac gaggctgatc tgcagtaccg tgtcaccctt gattcactga
     2581 ggcagatatc acggagcttt ttttctggaa ctcaggaaag gaagattcaa agaaatatca
     2641 ccgttcgaga atcagaatgc atcaggcact ccttctacat gttggacaaa catgactttc
     2701 aggactctgt gagagtgact ctggatttta atctcactga tccagaaaat ggtcctgtac
     2761 ttgatgacgc tctgccaaac tcagtccacg aacacattcc ctttgccaaa gactgtggaa
     2821 acaaggaaag atgcatttca gacctcactc tgaatgtgtc caccacagaa aagagcctgc
     2881 tgatcgtcaa gtcccagcat gacaagttca acgttagcct caccgtcaaa aacaaaggag
     2941 acagtgcgta caacaccagg acagtggtgc agcattcacc aaatctgatt ttttcgggaa
     3001 ttgaggagat ccaaaaagat agctgtgaat ctaatcaaaa tatcacttgc agagttggat
     3061 atcctttcct aagagcagga gaaacggtta ccttcaaaat aatattccag tttaacacat
     3121 cccatctctc ggaaaatgca atcattcact taagtgcaac aagtgacagt gaggagcccc
     3181 tggaatctct taatgataat gaagtaaata tttccatccc agtaaaatat gaagttggac
     3241 tgcagtttta cagttctgcg agtgaacatc acatttcagt cgctgccaat gagacgatcc
     3301 ctgagtttat taactccact gaggacattg ggaatgaaat taatgtcttc tatacgatta
     3361 gaaagagggg gcatttccca atgccagaac ttcagctgtc aatttcattc cccaatttga
     3421 cggcagatgg ttatcctgta ctgtacccaa ttggatggtc atcttcagat aatgtgaact
     3481 gtagaccccg gagccttgag gacccctttg gcatcaactc tgggaagaaa atgacaatat
     3541 cgaagtctga ggttctcaaa agaggcacaa tccaggactg cagtagtacg tgtggagttg
     3601 ccaccatcac gtgtagcctc cttccttccg acctgagtca agtgaatgtc tcgctcctcc
     3661 tgtggaaacc gactttcata agagcacatt tttccagctt aaaccttact ctaagaggag
     3721 aacttaagag tgaaaattca tcgctgactt taagtagcag caaccggaag cgagagctgg
     3781 ctattcagat atccaaagac gggctcccag gcagagtgcc gctgtgggtt atcctcctga
     3841 gcgccttcgc ggggctactg ctgctaatgc tccttatatt ggctctgtgg aagattggat
     3901 tcttcaaaag gccactgaag aagaaaatgg agaaatgaaa ggtttcatag aaaaaaaaaa
     3961 aaa
//
