LOCUS       NM_001108648            2235 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus integrin alpha FG-GAP repeat containing 2
            (Itfg2), mRNA.
ACCESSION   NM_001108648 XM_001066574 XM_006237409 XM_342762
VERSION     NM_001108648.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2235)
  AUTHORS   Wolfson,R.L., Chantranupong,L., Wyant,G.A., Gu,X., Orozco,J.M.,
            Shen,K., Condon,K.J., Petri,S., Kedir,J., Scaria,S.M.,
            Abu-Remaileh,M., Frankel,W.N. and Sabatini,D.M.
  TITLE     KICSTOR recruits GATOR1 to the lysosome and is necessary for
            nutrients to regulate mTORC1
  JOURNAL   Nature 543 (7645), 438-442 (2017)
   PUBMED   28199306
REFERENCE   2  (bases 1 to 2235)
  AUTHORS   Al-Shami,A., Crisostomo,J., Wilkins,C., Xu,N., Humphries,J.,
            Chang,W.C., Anderson,S.J. and Oravecz,T.
  TITLE     Integrin-alpha FG-GAP repeat-containing protein 2 is critical for
            normal B cell differentiation and controls disease development in a
            lupus model
  JOURNAL   J Immunol 191 (7), 3789-3798 (2013)
   PUBMED   23997217
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Dec 3, 2020 this sequence version replaced
            XM_006237409.3, NM_001108648.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.17544.1,
                                           SRR26643290.18137.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               JAXUCZ010000004.1  163384163-163384367 c
            206-301             JAXUCZ010000004.1  163378709-163378804 c
            302-343             JAXUCZ010000004.1  163377344-163377385 c
            344-512             JAXUCZ010000004.1  163377032-163377200 c
            513-652             JAXUCZ010000004.1  163375693-163375832 c
            653-801             JAXUCZ010000004.1  163375167-163375315 c
            802-899             JAXUCZ010000004.1  163374701-163374798 c
            900-953             JAXUCZ010000004.1  163374562-163374615 c
            954-1045            JAXUCZ010000004.1  163374348-163374439 c
            1046-1163           JAXUCZ010000004.1  163373167-163373284 c
            1164-1337           JAXUCZ010000004.1  163372097-163372270 c
            1338-2235           JAXUCZ010000004.1  163371125-163372022 c
FEATURES             Location/Qualifiers
     source          1..2235
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2235
                     /gene="Itfg2"
                     /gene_synonym="RGD1311944"
                     /note="integrin alpha FG-GAP repeat containing 2"
                     /db_xref="GeneID:362441"
                     /db_xref="RGD:1311944"
     exon            1..205
                     /gene="Itfg2"
                     /gene_synonym="RGD1311944"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1441
                     /gene="Itfg2"
                     /gene_synonym="RGD1311944"
                     /note="integrin-alpha FG-GAP repeat-containing protein 2"
                     /codon_start=1
                     /product="KICSTOR complex protein ITFG2"
                     /protein_id="NP_001102118.2"
                     /db_xref="GeneID:362441"
                     /db_xref="RGD:1311944"
                     /translation="MRSVSYVQRVALDFSGSLFPHAICLGDVDNDALNELVVGDTSGK
                     LYVYKSDDSRPWLTCACQGMLTCVGVGDVCNKGKNLVVAVSAEGWLHLFDLTPTKALD
                     ASGHHETLVEEQRPVFKQHIPANTKVMLISDIDGDGCYELVVGYTDRVVRAFRWEELT
                     EGPEHLAGQLVSLKKWMLEGQVDSLSVTPGPLGVPELVVSQPGCAYAVLLCTWNKDTG
                     SPPASEEATGDSRETPAARDVVLHQTSGRIHNKNVSTHLIGNIKQGHYPESGNAGLFA
                     LCTLDGTLKLMQEADKLLWSVQVDHQLFALEKLDVTGNGLEEVVACAWDGQTYIIDHN
                     RTVVRFQVDENIRAFCAGQYACKEGRNSPCLVYVTFNQKIYVYWEVQLERMESTNLLK
                     LLEAEPEYHSLLQELGVDPEDLPAVCTLLQQTLYHPDQPLQCTPSSFQDPT"
     exon            206..301
                     /gene="Itfg2"
                     /gene_synonym="RGD1311944"
                     /inference="alignment:Splign:2.1.0"
     exon            302..343
                     /gene="Itfg2"
                     /gene_synonym="RGD1311944"
                     /inference="alignment:Splign:2.1.0"
     exon            344..512
                     /gene="Itfg2"
                     /gene_synonym="RGD1311944"
                     /inference="alignment:Splign:2.1.0"
     exon            513..652
                     /gene="Itfg2"
                     /gene_synonym="RGD1311944"
                     /inference="alignment:Splign:2.1.0"
     exon            653..801
                     /gene="Itfg2"
                     /gene_synonym="RGD1311944"
                     /inference="alignment:Splign:2.1.0"
     exon            802..899
                     /gene="Itfg2"
                     /gene_synonym="RGD1311944"
                     /inference="alignment:Splign:2.1.0"
     exon            900..953
                     /gene="Itfg2"
                     /gene_synonym="RGD1311944"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1045
                     /gene="Itfg2"
                     /gene_synonym="RGD1311944"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1163
                     /gene="Itfg2"
                     /gene_synonym="RGD1311944"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1337
                     /gene="Itfg2"
                     /gene_synonym="RGD1311944"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..2235
                     /gene="Itfg2"
                     /gene_synonym="RGD1311944"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggtgacgta gacttccggt tcggtggcct gacactggcg cacggctgtc gacagggctc
       61 gagggtcgtt ttggtgcggt ggctcggcac ctcagccctc cagagtgcca tgaggtcggt
      121 tagctatgtg cagcgcgtgg cgctggactt cagcgggagt ctcttcccgc acgccatctg
      181 cctcggagac gtcgataacg acgcgttaaa tgagctggta gtaggagaca ccagcggaaa
      241 actgtacgtg tataagagtg atgacagccg gccgtggctt acctgtgcat gccagggaat
      301 gttgacttgc gttggggtcg gagatgtctg caataaaggg aagaacctgg tggtagcagt
      361 cagcgcagaa ggctggcttc acttgtttga cctgacaccc accaaggctc tggatgcttc
      421 tgggcaccat gagacacttg tcgaggagca gcgacctgtc ttcaagcagc acatccctgc
      481 caacacaaag gtcatgctga tcagcgacat cgatggagat gggtgttatg agctggtggt
      541 aggatacaca gaccgtgtgg tgcgggcctt ccgctgggaa gagctgactg aggggcctga
      601 acacctggca gggcagttgg tgtccctcaa gaagtggatg ctggagggtc aggtagacag
      661 tctctctgtg accccaggac ccctgggtgt gcctgagctg gttgtgtcac agccagggtg
      721 tgcttatgca gttctcctgt gcacctggaa caaggacact ggctcccctc ctgcctctga
      781 ggaggccaca ggagacagta gggagacccc agctgcccga gatgtggtac tgcaccagac
      841 ctctggccgg atccacaaca agaacgtttc cactcaccta attggcaaca tcaaacaagg
      901 tcattaccct gaaagtggta acgcaggcct ctttgccctg tgtaccttag atggaacact
      961 gaagctgatg caggaagcag ataagttgct gtggtctgtg caggtggatc accagctctt
     1021 tgccctggaa aagctggatg tcacgggcaa tgggcttgag gaggtggtag cctgtgcctg
     1081 ggatggacag acatatatca tcgatcacaa ccgcactgtt gtgcgcttcc aagtggatga
     1141 aaatatccgt gccttctgtg caggccagta cgcctgcaaa gagggccgca atagtccctg
     1201 cttggtctat gtcactttca atcagaagat ctatgtgtac tgggaagtgc agctggaacg
     1261 catggagtcc actaatcttc tgaagctgct ggaggccgag cctgagtacc acagcctact
     1321 gcaggagctg ggtgtggatc ctgaggatct tcctgcagtc tgtaccctgc ttcagcagac
     1381 tctctaccat ccggatcagc cactacaatg taccccgtca agcttccagg accccaccta
     1441 actaggcttg atcacttagc tggtgaagga tccttctgag tccccaaccc taccccaaag
     1501 tgatcttggc aggatgggga atgtatatta cagaggagca agacttggtt ctcagcatgg
     1561 atggatggtg gaccccagag agcttttgat gaagagatgg gttgcctctt tgcttgttgc
     1621 cccatggtcc ccttcccgtg ctccctgctc tgattgtttg tgagacaagg cagcaaacct
     1681 ttgccatgat ccaacacctg aaaggcttca ggcctgaggg agcatggagg tgaccccgag
     1741 accctctgct gagcaccgac tttcatagct ctaggcagct gacacagtag ttatcacagg
     1801 aatggcagag tttgttcagg gcatctttta ggatattttc ctgtctcctc atcttcctgt
     1861 gtttccattt actgaagcaa ttaggtcagg gctttccgtt ttgtcataat ctctctctct
     1921 ctctctctct ctctctggtt ttgttttggg gttttgtttg ttgttttcta tgtctgtgtg
     1981 tgcacagagg tggaacccag ggcctttcac aggctagcca agcactctgc tatcagctgc
     2041 atcccagaac tgccacactc tgaggtagcg actgcctgta gtagacgctc agagtttgcc
     2101 tctgtcttac atgatggtgc accagtgtaa tcccagttct gggaggaaga tcatgagtct
     2161 aaagccagcc atttgagacc agcgtgggtc acatttggag atcttacctc aaataaacaa
     2221 gacaaaacaa aaaga
//
