LOCUS       NM_001013880            1881 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus inositol-3-phosphate synthase 1 (Isyna1), mRNA.
ACCESSION   NM_001013880 XM_214319
VERSION     NM_001013880.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1881)
  AUTHORS   Deranieh,R.M., He,Q., Caruso,J.A. and Greenberg,M.L.
  TITLE     Phosphorylation regulates myo-inositol-3-phosphate synthase: a
            novel regulatory mechanism of inositol biosynthesis
  JOURNAL   J Biol Chem 288 (37), 26822-26833 (2013)
   PUBMED   23902760
REFERENCE   2  (bases 1 to 1881)
  AUTHORS   Parthasarathy,R.N., Lakshmanan,J., Thangavel,M., Seelan,R.S.,
            Stagner,J.I., Janckila,A.J., Vadnal,R.E., Casanova,M.F. and
            Parthasarathy,L.K.
  TITLE     Rat brain myo-inositol 3-phosphate synthase is a phosphoprotein
  JOURNAL   Mol Cell Biochem 378 (1-2), 83-89 (2013)
   PUBMED   23504145
  REMARK    GeneRIF: Differential phosphorylation of IPS isoforms in brain,
            intestine and testis suggests novel functions in these tissues.
REFERENCE   3  (bases 1 to 1881)
  AUTHORS   Seelan,R.S., Pisano,M.M., Greene,R.M., Casanova,M.F. and
            Parthasarathy,R.N.
  TITLE     Differential methylation of the gene encoding myo-inositol
            3-phosphate synthase (Isyna1) in rat tissues
  JOURNAL   Epigenomics 3 (1), 111-124 (2011)
   PUBMED   21841945
  REMARK    GeneRIF: Isyna1 is regulated, in part, by DNA methylation and that
            significant alterations in methylation patterns during development
            could have a major impact on inositol phosphate synthase expression
            in later life.
REFERENCE   4  (bases 1 to 1881)
  AUTHORS   Seelan,R.S., Lakshmanan,J., Casanova,M.F. and Parthasarathy,R.N.
  TITLE     Identification of myo-inositol-3-phosphate synthase isoforms:
            characterization, expression, and putative role of a 16-kDa
            gamma(c) isoform
  JOURNAL   J Biol Chem 284 (14), 9443-9457 (2009)
   PUBMED   19188364
REFERENCE   5  (bases 1 to 1881)
  AUTHORS   Maeda,T. and Eisenberg,F. Jr.
  TITLE     Purification, structure, and catalytic properties of
            L-myo-inositol-1-phosphate synthase from rat testis
  JOURNAL   J Biol Chem 255 (18), 8458-8464 (1980)
   PUBMED   6773943
REFERENCE   6  (bases 1 to 1881)
  AUTHORS   Sherman,W.R., Rasheed,A., Mauck,L.A. and Wiecko,J.
  TITLE     Incubations of testis myo-inositol-1-phosphate synthase with
            D-(5-18O)glucose 6-phosphate and with H218O show no evidence of
            Schiff base formation
  JOURNAL   J Biol Chem 252 (16), 5672-5676 (1977)
   PUBMED   885873
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA333826.1, BP490872.1, CO388828.1 and BI285489.1.
            
            On May 29, 2008 this sequence version replaced NM_001013880.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-633               CA333826.1         1-633
            634-867             BP490872.1         95-328
            868-1388            CO388828.1         118-638
            1389-1881           BI285489.1         1-493               c
FEATURES             Location/Qualifiers
     source          1..1881
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..1881
                     /gene="Isyna1"
                     /note="inositol-3-phosphate synthase 1"
                     /db_xref="GeneID:290651"
                     /db_xref="RGD:1359423"
     exon            1..93
                     /gene="Isyna1"
                     /inference="alignment:Splign:2.1.0"
     exon            94..222
                     /gene="Isyna1"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1776
                     /gene="Isyna1"
                     /EC_number="5.5.1.4"
                     /note="MIP synthase; MI-1-P synthase;
                     myo-inositol-1-phosphate synthase; IPS 1; myo-inositol
                     1-phosphate synthase A1"
                     /codon_start=1
                     /product="inositol-3-phosphate synthase 1"
                     /protein_id="NP_001013902.2"
                     /db_xref="GeneID:290651"
                     /db_xref="RGD:1359423"
                     /translation="MEPAAEILVDSPDVIFGPEAIEARYEYRTTRVSREGGVLRVRPT
                     ATRFTFRTARQVPRLGVMLVGWGGNNGSTLTAAVLANRLRLTWPTRTGRKEANYYGSL
                     TQAGTVNLGLDGDGREVFVPFSALLPMVAPNDLVFDGWDISSLNLAEAMRRAQVLDCG
                     LQEQLWPHMESLRPRPSVYIPEFIAANQTARADNLIPGTRAQQLEQIRKDIRDFRSSA
                     GLDKVIVLWTANTERFCEVVPGRNDTAENLLRTIQLGLEVSPSTLFAVASILEGCAFL
                     NGSPQNTLVPGALELASQRHVFVGGDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNH
                     LGNNDGQNLSAPLQFRSKEVTKSSVVDDMVQSNRVLYAPGEEPDHCVVIKYVPYVGDS
                     KRALDEYTSELMLGGTNTLVLHNTCEDSLLAAPIMLDLVLLTELCQRVSFCTDSDPEP
                     QGFHPVLSVLSFLFKAPLVPPGSPVVNALFRQRSCIENIFRACVGLPPQNHMLLEHKM
                     ERPFPGIKPEEVKATSPLPCKKESTPATNGCTGDANGHTQAPTPELSTA"
     exon            223..384
                     /gene="Isyna1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..517
                     /gene="Isyna1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..711
                     /gene="Isyna1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..861
                     /gene="Isyna1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1077
                     /gene="Isyna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1242
                     /gene="Isyna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1356
                     /gene="Isyna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1574
                     /gene="Isyna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1865
                     /gene="Isyna1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtggccgg gcgtggcctc agcgcttttc ttcgctgccc cgggcctagg gcccacgctg
       61 tcggctgccg cagtctgacc caactcttag tcgctcgccg cgatggagcc tgccgccgag
      121 atcctggtgg acagcccgga cgtgatcttc ggccccgaag ccatcgaggc gcgctacgag
      181 taccggacaa cgcgcgtcag ccgcgagggc ggcgtgctgc gggtgcggcc cacggctacg
      241 cgtttcacct tccgcacagc ccggcaggtg ccccggcttg gggtcatgtt agtcggctgg
      301 ggcgggaaca acggctccac gctcactgcg gctgttctgg ccaaccggct acgcctgacc
      361 tggcccacgc gcactggtcg caaggaggca aactattatg gctcgttgac ccaggcgggc
      421 accgtgaact tgggtctgga tggggacggc cgggaggtgt ttgtgccctt cagtgcgctg
      481 ctacccatgg tggcacccaa cgacctggtg tttgacggct gggatatctc gtcgctgaac
      541 ctggcggagg cgatgcggcg cgcgcaggtc ctggactgcg gtctgcagga gcagctgtgg
      601 ccccacatgg agagcctgcg tccacggccc tcagtctaca ttcctgagtt catcgctgcc
      661 aaccagacag cacgtgcgga caacctcatc cctggcacac gcgcccaaca gttggagcag
      721 atccgaaagg atattagaga cttccgatcc agtgcgggat tggacaaggt catcgtgctg
      781 tggaccgcca atacagagcg cttctgtgaa gtggtcccgg gtcgcaatga cacagctgaa
      841 aacttgctgc gtactatcca gcttggcctg gaggtttcac catccacact ttttgctgtg
      901 gccagcatcc tggagggctg cgccttcctc aacgggtccc cacagaacac actggtaccc
      961 ggagccctgg agctggcttc gcagcgccat gtgttcgtag gtggcgatga cttcaagtca
     1021 gggcagacta aggtcaaatc tgttctggtc gacttcctca ttggctctgg cctcaagacc
     1081 atgtccatcg tgagctataa ccacttgggc aacaacgatg ggcagaacct gtctgcacca
     1141 ctgcagttcc gctccaagga agtgacaaag agcagtgtgg tggatgacat ggttcagagc
     1201 aaccgtgtgc tctacgcgcc tggagaggag ccagatcact gtgtggtgat caaatatgta
     1261 ccctatgttg gcgacagcaa gcgtgccctg gatgagtaca cctcagagct gatgctgggt
     1321 gggacaaaca ctttggtgct ccataacacc tgcgaggact cgctgctggc cgcacccatc
     1381 atgctggacc tagtgctgct cacagagctg tgtcagcgtg tgagcttctg cacagactcg
     1441 gacccagagc ctcagggctt ccacccagtg ctgtcggtgc tcagcttcct ctttaaggca
     1501 ccacttgtgc cccctggcag ccctgtggtg aatgccctct tccgccagcg cagctgtatt
     1561 gagaatattt tcagggcttg cgtggggctc ccaccccaga accacatgct gttagagcac
     1621 aagatggagc gccctttccc aggcatcaag ccagaagagg tgaaggccac cagcccactg
     1681 ccttgcaaga aagagtccac accggccacc aatggctgca ccggtgatgc caatgggcac
     1741 acacaggcac caacaccaga gctgtccacc gcttaaacca agtgcccaga ccctcctacc
     1801 ccaatgcctc caaccactgt acttcagacc ttgccaaaga caataaaggg tcccccacca
     1861 agcaaaaaaa aaaaaaaaaa a
//
