LOCUS       NM_001014188            1507 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ISY1 splicing factor homolog (Isy1), mRNA.
ACCESSION   NM_001014188 XM_342719
VERSION     NM_001014188.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1507)
  AUTHORS   Zhan,X., Yan,C., Zhang,X., Lei,J. and Shi,Y.
  TITLE     Structure of a human catalytic step I spliceosome
  JOURNAL   Science 359 (6375), 537-545 (2018)
   PUBMED   29301961
REFERENCE   2  (bases 1 to 1507)
  AUTHORS   Chanarat,S. and Strasser,K.
  TITLE     Splicing and beyond: the many faces of the Prp19 complex
  JOURNAL   Biochim Biophys Acta 1833 (10), 2126-2134 (2013)
   PUBMED   23742842
  REMARK    Review article
REFERENCE   3  (bases 1 to 1507)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1507)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079119.1.
            
            On Apr 20, 2005 this sequence version replaced XM_342719.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079119.1, SRR8487227.137578.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1507
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1507
                     /gene="Isy1"
                     /gene_synonym="Isy1-rab43; RGD1307688"
                     /note="ISY1 splicing factor homolog"
                     /db_xref="GeneID:362394"
                     /db_xref="RGD:1307688"
     exon            1..84
                     /gene="Isy1"
                     /gene_synonym="Isy1-rab43; RGD1307688"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..936
                     /gene="Isy1"
                     /gene_synonym="Isy1-rab43; RGD1307688"
                     /note="ISY1-RAB43 readthrough"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor ISY1 homolog"
                     /protein_id="NP_001014210.1"
                     /db_xref="GeneID:362394"
                     /db_xref="RGD:1307688"
                     /translation="MARNAEKAMTALARFRQAQLEEGKVKERRPFLASECTELPKAEK
                     WRRQIIGEISKKVAQIQNAGLGEFRIRDLNDEINKLLREKGHWEVRIKELGGPDYGKV
                     GPKMLDHEGKEVPGNRGYKYFGAAKDLPGVRELFEKEPLPPPRKTRAELMKAIDFEYY
                     GYLDEDDGVIVPLEQEYEKRLRAELVEKWKAEREARLARGEKEEEEEEEEINIYAVTE
                     EESDEEGSQEKAGEDGQQKFIAHVPVPSQQEIEEALVRRKKMELLQKYASETLQAQSE
                     EAKRLLGY"
     exon            85..107
                     /gene="Isy1"
                     /gene_synonym="Isy1-rab43; RGD1307688"
                     /inference="alignment:Splign:2.1.0"
     exon            108..159
                     /gene="Isy1"
                     /gene_synonym="Isy1-rab43; RGD1307688"
                     /inference="alignment:Splign:2.1.0"
     exon            160..225
                     /gene="Isy1"
                     /gene_synonym="Isy1-rab43; RGD1307688"
                     /inference="alignment:Splign:2.1.0"
     exon            226..268
                     /gene="Isy1"
                     /gene_synonym="Isy1-rab43; RGD1307688"
                     /inference="alignment:Splign:2.1.0"
     exon            269..381
                     /gene="Isy1"
                     /gene_synonym="Isy1-rab43; RGD1307688"
                     /inference="alignment:Splign:2.1.0"
     exon            382..499
                     /gene="Isy1"
                     /gene_synonym="Isy1-rab43; RGD1307688"
                     /inference="alignment:Splign:2.1.0"
     exon            500..622
                     /gene="Isy1"
                     /gene_synonym="Isy1-rab43; RGD1307688"
                     /inference="alignment:Splign:2.1.0"
     exon            623..741
                     /gene="Isy1"
                     /gene_synonym="Isy1-rab43; RGD1307688"
                     /inference="alignment:Splign:2.1.0"
     exon            742..828
                     /gene="Isy1"
                     /gene_synonym="Isy1-rab43; RGD1307688"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1480
                     /gene="Isy1"
                     /gene_synonym="Isy1-rab43; RGD1307688"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcccgcgc ctgcctgcct cgttccgggc gcctaagcac gttgtgtagc ggcgcggcgc
       61 cggggcgccc tcgccggcac catggcccga aatgcagaaa aagccatgac tgccctagcg
      121 agattccggc aagctcagct ggaagaggga aaggtcaagg aacggagacc tttccttgct
      181 tccgagtgca cagaactgcc aaaagcagag aagtggagac ggcagatcat tggagagatc
      241 tcaaaaaaag ttgctcagat tcagaatgct ggtttagggg aattccgaat ccgagacctg
      301 aatgatgaaa ttaacaagct gctgagggag aaaggacact gggaggtccg gatcaaggag
      361 ctgggcggcc ctgactatgg aaaagttggc cccaagatgc tggatcacga aggtaaagaa
      421 gtcccaggaa accgaggtta caagtacttt ggggcagcga aagatttgcc tggtgtcaga
      481 gagctattcg agaaagagcc ccttcctcct cccagaaaga cacgtgctga gctcatgaag
      541 gcaatcgatt ttgagtacta tggttacctg gatgaagatg atggagtgat tgtgcccttg
      601 gagcaagagt acgagaagag actcagggct gagctggtgg aaaaatggaa agcagagaga
      661 gaggctcggc tggcaagggg agaaaaggaa gaggaggagg aggaagagga gatcaacatc
      721 tatgccgtca ccgaggagga gtctgatgag gaaggcagcc aggagaaggc aggggaagac
      781 ggtcagcaga agttcattgc tcatgttccg gtgccgtcac agcaggagat tgaggaggcg
      841 cttgtacgga ggaagaaaat ggaactgctc cagaaatacg caagcgagac tctgcaggca
      901 cagagtgaag aggccaagcg gctcctgggg tactaggcca gagccctcac tcctgggata
      961 cgaggccaag ccagagccct tactcctggg gtactaggcc aagccagagc cctcactcct
     1021 ggggtactag actgtaggcc gagccagagc cctcactcct ggggtactag gccgagccag
     1081 agccctcact cctggggtac taggccaagc cagagccctt actctggtgg gtgtgctcgg
     1141 tacgccatgg ccgccatcct catagctgcc ctgggctgtg gctaggctgg ctggctctgg
     1201 gatgccctgg gcctttctca cccttgatct tgcctcctct ctggacatgt gagctggcct
     1261 gatggtaggg cctgtccctt cccagtaagc tgccagggaa ctgaatgcat tagtaaccat
     1321 catttcgtac agatgctttt gataccatat ggatccattt atttttattt tggaatgtgt
     1381 aaaatctgtt ctgaaaattt attctgtact atgattttgg gaattgagaa ggatcaatta
     1441 gtagccagtt tttaaaaata catgattttt attcaaatca aaaaaaaaaa aaaaaaaaaa
     1501 aaaaaaa
//
