LOCUS       NM_001134552            2492 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus isthmin 1 (Ism1), mRNA.
ACCESSION   NM_001134552 XM_231010
VERSION     NM_001134552.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2492)
  AUTHORS   Xiang,W., Ke,Z., Zhang,Y., Cheng,G.H., Irwan,I.D., Sulochana,K.N.,
            Potturi,P., Wang,Z., Yang,H., Wang,J., Zhuo,L., Kini,R.M. and Ge,R.
  TITLE     Isthmin is a novel secreted angiogenesis inhibitor that inhibits
            tumour growth in mice
  JOURNAL   J Cell Mol Med 15 (2), 359-374 (2011)
   PUBMED   19874420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 4, 2022 this sequence version replaced NM_001134552.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.13143.1,
                                           SRR26643295.15552.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JAXUCZ010000003.1  147476983-147477146
            165-395             JAXUCZ010000003.1  147527417-147527647
            396-660             JAXUCZ010000003.1  147536042-147536306
            661-804             JAXUCZ010000003.1  147542139-147542282
            805-894             JAXUCZ010000003.1  147547262-147547351
            895-2492            JAXUCZ010000003.1  147554303-147555900
FEATURES             Location/Qualifiers
     source          1..2492
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2492
                     /gene="Ism1"
                     /gene_synonym="RGD1562551"
                     /note="isthmin 1"
                     /db_xref="GeneID:311760"
                     /db_xref="RGD:1562551"
     exon            1..164
                     /gene="Ism1"
                     /gene_synonym="RGD1562551"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1412
                     /gene="Ism1"
                     /gene_synonym="RGD1562551"
                     /note="isthmin 1 homolog; isthmin 1, angiogenesis
                     inhibitor"
                     /codon_start=1
                     /product="isthmin-1"
                     /protein_id="NP_001128024.1"
                     /db_xref="GeneID:311760"
                     /db_xref="RGD:1562551"
                     /translation="MVRLAAELLLLLGLLLLTLHITVLRGSGAADRQDAAASNVSGSQ
                     LQNNLNLESDSTSETSFPLSKEAPEEHQVVHQPFPRQRFPQETGHPSLQRDGPRSFLL
                     DLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEAEKDQHPENKPSWSLPAPDWRAWWQ
                     RSLSLARTNSGDQDDKYDSTSDDSNFLSVPRGWDRPAPGHRTFETKEQPEYDSTDGEG
                     DWSLWSVCSVTCGNGNQKRTRSCGYACIATESRTCDRPNCPGIEDTFRTAATEVSLLA
                     GSEEFNATKLFEVDMDSCERWMSCKSEFLKKYMHKVINDLPSCPCSYPTEVAYSTADI
                     FDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLIT
                     RGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDED
                     YIKQFQEAREY"
     exon            165..395
                     /gene="Ism1"
                     /gene_synonym="RGD1562551"
                     /inference="alignment:Splign:2.1.0"
     exon            396..660
                     /gene="Ism1"
                     /gene_synonym="RGD1562551"
                     /inference="alignment:Splign:2.1.0"
     exon            661..804
                     /gene="Ism1"
                     /gene_synonym="RGD1562551"
                     /inference="alignment:Splign:2.1.0"
     exon            805..894
                     /gene="Ism1"
                     /gene_synonym="RGD1562551"
                     /inference="alignment:Splign:2.1.0"
     exon            895..2492
                     /gene="Ism1"
                     /gene_synonym="RGD1562551"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctaaagc cgcgcgactc aaaaggatgg tgcgcctggc cgcggaactg ctcctgctgc
       61 tggggctgct gctgctcact ctgcacatca ccgttctgcg cggatccgga gccgccgacc
      121 ggcaggacgc ggccgccagc aacgtcagcg ggtcccagct gcagaataac ctcaacctgg
      181 agagtgactc cacatcagaa accagctttc ctctgtccaa agaagcccca gaggagcacc
      241 aggttgtcca ccaacccttc cccagacaac gattccctca ggagactggg catccttcac
      301 tgcaaagaga cggccccaga tcctttctcc ttgacctacc aaactttcca gatctttcca
      361 aagctgatat caatgggcag aatccaaata ttcaggtcac catagaggtg gttgatggcc
      421 ctgactctga agcagaaaaa gatcagcatc cagagaacaa acccagctgg tcactcccag
      481 ctcccgactg gcgggcctgg tggcagaggt ccttgtcctt ggccaggaca aacagtgggg
      541 accaggatga caagtatgac agtacctcag atgacagcaa cttcctcagt gttcctagag
      601 gatgggaccg tccagcccca ggacaccgga cttttgaaac caaagagcag ccagagtatg
      661 attccacaga cggtgagggt gattggagtc tctggtctgt ctgcagcgtc acctgtggaa
      721 atggcaatca gaaaaggacc cgttcctgtg gctatgcatg cattgccaca gaatccagga
      781 cctgtgaccg tccaaactgc ccaggaattg aagacacttt caggacagca gccactgaag
      841 tgagtctact tgcgggaagc gaggagttta atgccaccaa gttgtttgaa gttgacatgg
      901 acagctgtga gcgatggatg agctgcaaaa gtgagttctt aaagaagtac atgcacaagg
      961 tgatcaatga cctgcccagt tgcccctgct cctaccccac tgaggtagcc tacagcacag
     1021 ctgacatctt cgaccgcatc aagcgcaagg acttccgatg gaaggatgct agcgggccca
     1081 aagagaaact agagatctac aagcctactg ctcgatactg catccgctct atgttgtccc
     1141 tagagagtac cacactggct gcccagcact gttgctatgg tgacaacatg cagctcatca
     1201 ccaggggcaa aggggcaggc acacccaatc tcatcagcac cgagttctct gctgagctcc
     1261 actacaaagt ggacgttctg ccctggatta tctgtaaggg tgactggagc agatataatg
     1321 aggccaggcc tcccaataat ggacagaagt gcacagagag cccttctgat gaggactaca
     1381 ttaaacagtt ccaagaagcc agggagtact aaagcaccac tgctttggag acacaaatgc
     1441 actgcactga tctgccaact gtcacctggt tctttccaca tttttgtata tctgtatatt
     1501 ccacatgaat atttttgtaa gtatagtagg gctatgcacc aggtctgcgg gactgctatg
     1561 cccagtacct acataccatg gtggaagtcc tcctaatggc tgtgtgggca gaaagtggca
     1621 cctaggagct atagtgggta tgagtctgtt cccacctccg ttcagtgcat aggaacacag
     1681 agactgaggt tgtaaacatt ataagcagtt tttttatata tatataactt atttaataca
     1741 aatgtgactt aagcttaacc ttttctctgg agttgtcctt ataaaacaat tatttaattg
     1801 cttctgaaag agttcaaaag gaaaaggaca caggggaatt acgagaaaag gaattttgca
     1861 ttggaaatgc atcagagcag taaaacaccc accttacacc agtgttcttt agtcatgggt
     1921 ttcttactgg tgtcacggat tccaacgctt ccttgcctca gacgaggcaa ggggtgggta
     1981 gtaagtgaat gtgtagaatc taaggcacgg gttttaaatg gttttaaagt aagggaccag
     2041 cataactgta ctgaagagcc ccagcagtag catttctgtt ctgtcttaac aggctcagaa
     2101 gactgaagga agttcagccg taaagccagg agtggcactt tccaaagaaa aagcaaaaca
     2161 agttgaaaaa taatacgtgc ctcgctttgt ctattttatc ttaatagagc aacttttctc
     2221 tgccaataaa tattattccc agtaaataaa tataaaaggg ggtcatggga gctgaagtct
     2281 aggaaatcct aattttttat gttttaagaa aaaactgcct tatttttgta aagtatttat
     2341 tgagtcattg gctattgtac atcgtgcagt tatgagatga tccacttttg tgggatagaa
     2401 cttgaggaca gatgaagagt tggttcttat gcaacctttt acttgcaaaa ctccagggaa
     2461 agagatatat aataaaatca taataaaatg tg
//
