LOCUS       NM_020471               1790 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus ISL LIM homeobox 2 (Isl2), mRNA.
ACCESSION   NM_020471
VERSION     NM_020471.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1790)
  AUTHORS   Serinagaoglu,Y., Pare,J., Giovannini,M. and Cao,X.
  TITLE     Nf2-Yap signaling controls the expansion of DRG progenitors and
            glia during DRG development
  JOURNAL   Dev Biol 398 (1), 97-109 (2015)
   PUBMED   25433207
REFERENCE   2  (bases 1 to 1790)
  AUTHORS   Song,M.R., Sun,Y., Bryson,A., Gill,G.N., Evans,S.M. and Pfaff,S.L.
  TITLE     Islet-to-LMO stoichiometries control the function of transcription
            complexes that specify motor neuron and V2a interneuron identity
  JOURNAL   Development 136 (17), 2923-2932 (2009)
   PUBMED   19666821
REFERENCE   3  (bases 1 to 1790)
  AUTHORS   Pak,W., Hindges,R., Lim,Y.S., Pfaff,S.L. and O'Leary,D.D.
  TITLE     Magnitude of binocular vision controlled by islet-2 repression of a
            genetic program that specifies laterality of retinal axon
            pathfinding
  JOURNAL   Cell 119 (4), 567-578 (2004)
   PUBMED   15537545
REFERENCE   4  (bases 1 to 1790)
  AUTHORS   Thaler,J.P., Koo,S.J., Kania,A., Lettieri,K., Andrews,S., Cox,C.,
            Jessell,T.M. and Pfaff,S.L.
  TITLE     A postmitotic role for Isl-class LIM homeodomain proteins in the
            assignment of visceral spinal motor neuron identity
  JOURNAL   Neuron 41 (3), 337-350 (2004)
   PUBMED   14766174
REFERENCE   5  (bases 1 to 1790)
  AUTHORS   Ippel,H., Larsson,G., Behravan,G., Zdunek,J., Lundqvist,M.,
            Schleucher,J., Lycksell,P.O. and Wijmenga,S.
  TITLE     The solution structure of the homeodomain of the rat insulin-gene
            enhancer protein isl-1. Comparison with other homeodomains
  JOURNAL   J Mol Biol 288 (4), 689-703 (1999)
   PUBMED   10329173
REFERENCE   6  (bases 1 to 1790)
  AUTHORS   Tsuchida,T., Ensini,M., Morton,S.B., Baldassare,M., Edlund,T.,
            Jessell,T.M. and Pfaff,S.L.
  TITLE     Topographic organization of embryonic motor neurons defined by
            expression of LIM homeobox genes
  JOURNAL   Cell 79 (6), 957-970 (1994)
   PUBMED   7528105
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 22, 2020 this sequence version replaced NM_020471.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L35571.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000008.1  64819879-64820005
            128-317             JAXUCZ010000008.1  64820791-64820980
            318-580             JAXUCZ010000008.1  64821088-64821350
            581-864             JAXUCZ010000008.1  64822790-64823073
            865-1032            JAXUCZ010000008.1  64823639-64823806
            1033-1790           JAXUCZ010000008.1  64824107-64824864
FEATURES             Location/Qualifiers
     source          1..1790
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1790
                     /gene="Isl2"
                     /note="ISL LIM homeobox 2"
                     /db_xref="GeneID:57233"
                     /db_xref="RGD:621849"
     exon            1..127
                     /gene="Isl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1149
                     /gene="Isl2"
                     /note="islet-2; insulin related protein 2 (islet 2)"
                     /codon_start=1
                     /product="insulin gene enhancer protein ISL-2"
                     /protein_id="NP_065204.2"
                     /db_xref="GeneID:57233"
                     /db_xref="RGD:621849"
                     /translation="MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSP
                     DLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAQCQVGFSSSDLV
                     MRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGP
                     LPGARGLHLPDAGSGRQSSLRTHVHKQAEKTTRVRTVLNEKQLHTLRTCYAANPRPDA
                     LMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKASLQGLTGTPLV
                     AGSPIRHENAVQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLVSFSESGSLGNSS
                     GSDVTSLSSQLPDTPNSMVPSPVET"
     exon            128..317
                     /gene="Isl2"
                     /inference="alignment:Splign:2.1.0"
     exon            318..580
                     /gene="Isl2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..864
                     /gene="Isl2"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1032
                     /gene="Isl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1790
                     /gene="Isl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggaggctg ggcgcgcgac cctggtcctt ctgcccccgg ccgtacgctt tgctcacgtc
       61 tctctctgca tggtggatat tatttttcat tatccttttc tgggtgctat gggggatcat
      121 tccaagaaga agcccgggac ggccatgtgc gtgggctgcg ggagtcagat ccacgaccag
      181 tttatccttc gggtgtcgcc cgacctcgag tggcacgccg cctgcctcaa gtgcgctgag
      241 tgcagccagt atctggatga gacgtgcacg tgcttcgtga gagacgggaa aacgtactgc
      301 aagcgggact acgtcaggct gttcggcatc aagtgtgccc agtgtcaggt gggcttcagc
      361 agcagtgacc tggtgatgcg ggcgcgggac agcgtgtacc acatcgagtg cttccgctgc
      421 tccgtgtgca gccgccagct gctccctgga gacgagttct cgctgaggga gcacgagctg
      481 ctctgccgag ccgaccacgg cctcctgctg gagcgcgctg cggccggcag cccgcgcagc
      541 cctggcccgc tccccggcgc ccgcggcctg catctgccag acgccgggtc cggacgacag
      601 tcctcactgc gcacgcacgt gcacaagcag gcggagaaga caacccgggt gcggactgtg
      661 ctcaacgaga agcaactgca caccctgcgg acatgctacg ccgccaaccc gcggcccgac
      721 gcgctcatga aggagcagct ggtagagatg accggcttga gcccgcgggt catccgcgtg
      781 tggtttcaga acaagcgttg caaggacaag aagaagtcca ttctcatgaa gcagctacag
      841 cagcagcaac acagcgacaa ggcgagtctc cagggactaa ctgggacgcc tctggtggcg
      901 ggcagcccca tccgccatga gaacgccgtg cagggcagcg cagtcgaggt gcagacgtac
      961 cagccgccct ggaaagctct cagcgagttc gcactccaga gcgacctgga tcaacccgcc
     1021 tttcaacagc tggtctcctt ctccgagtca ggctccctag gcaactcctc tggtagcgac
     1081 gtgacctctc tgtcttcgca gctcccggac acccccaaca gtatggtacc tagtccggtg
     1141 gagacgtgag acaggaccct tccctgccag cccgcggacc tcgcatgctc cctgcatgag
     1201 actcacccat gctcaggcca ttccagctct gaaaaatctc cggcccttgt aattattgtt
     1261 gttatttaaa gcgagcgggc agaggcacgt gacagcgaca ggacggccag cagcgcgggg
     1321 acacttgcct gcctcgctga gactggagac tcctgcttca aggacttttc ggtttttctt
     1381 tttttcctca taactagaat ttgggacatt ctgggttggc tccgcccttg cctctccctc
     1441 gccgcgtggg gaactgccac tctgtctctg cgccccactc gcccgggaac ccacttggtg
     1501 gggtcctacg gggctctacc ggcgaggacg cctgctccga attcgcctgc gctgaccgag
     1561 gctttgctct ggacttggcg gcgaggacgg gacaaaaaca gacataatcc ccaaagcgca
     1621 tgactgccgg acagagtaga aacgagactg tcttttaaaa agtgttttaa attatcagtc
     1681 gacggaggac agtgagagcc tttgccgaac aaacgtaagt tattgttatt tattgtgagg
     1741 cgaatagtgg gacgaatatt ttgatcttaa taaaaaacaa cccgatgcca
//
