LOCUS       NM_001008510             817 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus interferon stimulated exonuclease gene 20
            (Isg20), mRNA.
ACCESSION   NM_001008510 XM_214981
VERSION     NM_001008510.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 817)
  AUTHORS   Zhou Z, Wang N, Woodson SE, Dong Q, Wang J, Liang Y, Rijnbrand R,
            Wei L, Nichols JE, Guo JT, Holbrook MR, Lemon SM and Li K.
  TITLE     Antiviral activities of ISG20 in positive-strand RNA virus
            infections
  JOURNAL   Virology 409 (2), 175-188 (2011)
   PUBMED   21036379
REFERENCE   2  (bases 1 to 817)
  AUTHORS   Espert L, Eldin P, Gongora C, Bayard B, Harper F, Chelbi-Alix MK,
            Bertrand E, Degols G and Mechti N.
  TITLE     The exonuclease ISG20 mainly localizes in the nucleolus and the
            Cajal (Coiled) bodies and is associated with nuclear SMN
            protein-containing complexes
  JOURNAL   J Cell Biochem 98 (5), 1320-1333 (2006)
   PUBMED   16514659
REFERENCE   3  (bases 1 to 817)
  AUTHORS   Espert L, Degols G, Gongora C, Blondel D, Williams BR, Silverman RH
            and Mechti N.
  TITLE     ISG20, a new interferon-induced RNase specific for single-stranded
            RNA, defines an alternative antiviral pathway against RNA genomic
            viruses
  JOURNAL   J Biol Chem 278 (18), 16151-16158 (2003)
   PUBMED   12594219
REFERENCE   4  (bases 1 to 817)
  AUTHORS   Nguyen LH, Espert L, Mechti N and Wilson DM 3rd.
  TITLE     The human interferon- and estrogen-regulated ISG20/HEM45 gene
            product degrades single-stranded RNA and DNA in vitro
  JOURNAL   Biochemistry 40 (24), 7174-7179 (2001)
   PUBMED   11401564
REFERENCE   5  (bases 1 to 817)
  AUTHORS   Gongora C, David G, Pintard L, Tissot C, Hua TD, Dejean A and
            Mechti N.
  TITLE     Molecular cloning of a new interferon-induced PML nuclear
            body-associated protein
  JOURNAL   J Biol Chem 272 (31), 19457-19463 (1997)
   PUBMED   9235947
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086557.1.
            
            On Dec 16, 2004 this sequence version replaced XM_214981.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086557.1, FQ234031.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..817
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..817
                     /gene="Isg20"
                     /note="interferon stimulated exonuclease gene 20"
                     /db_xref="GeneID:293052"
                     /db_xref="RGD:1306407"
     exon            1..14
                     /gene="Isg20"
                     /inference="alignment:Splign:2.1.0"
     exon            15..265
                     /gene="Isg20"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..583
                     /gene="Isg20"
                     /EC_number="3.1.13.1"
                     /note="interferon-stimulated protein; interferon
                     stimulated exonuclease 20; interferon stimulated gene
                     20kDa"
                     /codon_start=1
                     /product="interferon-stimulated gene 20 kDa protein"
                     /protein_id="NP_001008510.1"
                     /db_xref="GeneID:293052"
                     /db_xref="RGD:1306407"
                     /translation="MADSPEVVAMDCEMVGLGPQRVSGLARCSIVNVHSAVLYDKYIQ
                     PEGEITDYRTQVSGITPQHMARATPFAEARLEILQLLKGKLVVGHDLKHDFSALKEDM
                     RKYTIYDTSTDMLLWHEAKLHCYSRVSLRLLCKRLLHKSIQNNWRGHCSVEDARATME
                     LYKISQRLRAQRGLPCLGTSA"
     exon            266..466
                     /gene="Isg20"
                     /inference="alignment:Splign:2.1.0"
     exon            467..794
                     /gene="Isg20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcactggg acaggacttc ctgagggtct gaggagcatg gcagacagcc cagaggtggt
       61 agccatggac tgtgagatgg tggggctcgg gcctcaaagg gtgagtggcc tcgcccgctg
      121 cagcattgtg aacgtccaca gcgcagtcct ctatgacaag tacatccagc ctgagggaga
      181 gatcacggac tacagaaccc aagtcagcgg gatcacgcct cagcacatgg cgagggccac
      241 gccatttgct gaagccaggc tagagatcct gcagcttctg aaaggcaagc tggtggtggg
      301 ccatgacctg aagcatgact tcagtgccct gaaggaggac atgagaaaat acaccatcta
      361 cgacacgtcc acagacatgc tgctgtggca cgaggccaag ctgcactgct acagccgtgt
      421 gtccctgagg ctgctgtgca agcgcctgct gcacaagagc atccagaaca actggcgggg
      481 ccactgctct gtagaagatg ccagggccac aatggagctc tacaaaatct ctcagcgact
      541 cagagcccag cgagggctgc cctgcctggg aacatcagcc tgaacttcat cctcatccag
      601 gatcagaagc agctactcct tgaaggacca tagttttcca tgaatgagac ctgtttctag
      661 ctacaacaac aacagcaaca accacaaaat gcaaaagcaa gaacactccg ccattacagc
      721 aattctcttg ctttggagca aagaaaaaaa aaaccaaact ttagtaataa atgactttga
      781 ttttgtctaa tcaaaaaaaa aaaaaaaaaa aaaaaaa
//
