LOCUS       NM_001106700             663 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus ISG15 ubiquitin-like modifier (Isg15), mRNA.
ACCESSION   NM_001106700 XM_001077878 XM_216605
VERSION     NM_001106700.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 663)
  AUTHORS   Hu Y, Hong XY, Yang XF, Ma RH, Wang X, Zhang JF, Feng Q, Li XG, Sun
            DS, Li X, Wan HL, Li T, Wang Q, Ke D, Wang JZ and Liu GP.
  TITLE     Inflammation-dependent ISG15 upregulation mediates MIA-induced
            dendrite damages and depression by disrupting NEDD4/Rap2A signaling
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (6), 1477-1489 (2019)
   PUBMED   30826466
  REMARK    GeneRIF: The data revealed that maternal immune activation impedes
            offspring's dendrite development and causes depressive like
            behaviors by upregulating ISG15 and suppressing NEDD4/Rap2A
            signaling.
REFERENCE   2  (bases 1 to 663)
  AUTHORS   Swaim CD, Scott AF, Canadeo LA and Huibregtse JM.
  TITLE     Extracellular ISG15 Signals Cytokine Secretion through the LFA-1
            Integrin Receptor
  JOURNAL   Mol Cell 68 (3), 581-590 (2017)
   PUBMED   29100055
REFERENCE   3  (bases 1 to 663)
  AUTHORS   Murakawa M, Asahina Y, Kawai-Kitahata F, Nakagawa M, Nitta S, Otani
            S, Nagata H, Kaneko S, Asano Y, Tsunoda T, Miyoshi M, Itsui Y,
            Azuma S, Kakinuma S, Tanaka Y, Iijima S, Tsuchiya K, Izumi N, Tohda
            S and Watanabe M.
  TITLE     Hepatic IFNL4 expression is associated with non-response to
            interferon-based therapy through the regulation of basal
            interferon-stimulated gene expression in chronic hepatitis C
            patients
  JOURNAL   J Med Virol 89 (7), 1241-1247 (2017)
   PUBMED   28036111
REFERENCE   4  (bases 1 to 663)
  AUTHORS   Archambaud C, Nahori MA, Soubigou G, Becavin C, Laval L, Lechat P,
            Smokvina T, Langella P, Lecuit M and Cossart P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   5  (bases 1 to 663)
  AUTHORS   Bogunovic D, Byun M, Durfee LA, Abhyankar A, Sanal O, Mansouri D,
            Salem S, Radovanovic I, Grant AV, Adimi P, Mansouri N, Okada S,
            Bryant VL, Kong XF, Kreins A, Velez MM, Boisson B, Khalilzadeh S,
            Ozcelik U, Darazam IA, Schoggins JW, Rice CM, Al-Muhsen S, Behr M,
            Vogt G, Puel A, Bustamante J, Gros P, Huibregtse JM, Abel L,
            Boisson-Dupuis S and Casanova JL.
  TITLE     Mycobacterial disease and impaired IFN-gamma immunity in humans
            with inherited ISG15 deficiency
  JOURNAL   Science 337 (6102), 1684-1688 (2012)
   PUBMED   22859821
REFERENCE   6  (bases 1 to 663)
  AUTHORS   Okumura A, Pitha PM and Harty RN.
  TITLE     ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent
            manner by blocking Nedd4 ligase activity
  JOURNAL   Proc Natl Acad Sci U S A 105 (10), 3974-3979 (2008)
   PUBMED   18305167
REFERENCE   7  (bases 1 to 663)
  AUTHORS   Lenschow DJ, Lai C, Frias-Staheli N, Giannakopoulos NV, Lutz A,
            Wolff T, Osiak A, Levine B, Schmidt RE, Garcia-Sastre A, Leib DA,
            Pekosz A, Knobeloch KP, Horak I and Virgin HW 4th.
  TITLE     IFN-stimulated gene 15 functions as a critical antiviral molecule
            against influenza, herpes, and Sindbis viruses
  JOURNAL   Proc Natl Acad Sci U S A 104 (4), 1371-1376 (2007)
   PUBMED   17227866
REFERENCE   8  (bases 1 to 663)
  AUTHORS   Giannakopoulos NV, Luo JK, Papov V, Zou W, Lenschow DJ, Jacobs BS,
            Borden EC, Li J, Virgin HW and Zhang DE.
  TITLE     Proteomic identification of proteins conjugated to ISG15 in mouse
            and human cells
  JOURNAL   Biochem Biophys Res Commun 336 (2), 496-506 (2005)
   PUBMED   16139798
REFERENCE   9  (bases 1 to 663)
  AUTHORS   Zou W, Papov V, Malakhova O, Kim KI, Dao C, Li J and Zhang DE.
  TITLE     ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to
            form thioester bond with ubiquitin
  JOURNAL   Biochem Biophys Res Commun 336 (1), 61-68 (2005)
   PUBMED   16122702
REFERENCE   10 (bases 1 to 663)
  AUTHORS   Kim KI, Giannakopoulos NV, Virgin HW and Zhang DE.
  TITLE     Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme
            for protein ISGylation
  JOURNAL   Mol Cell Biol 24 (21), 9592-9600 (2004)
   PUBMED   15485925
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_216605.3, XM_001077878.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB790136.1, CB774823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06680424
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..663
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..663
                     /gene="Isg15"
                     /gene_synonym="G1p2"
                     /note="ISG15 ubiquitin-like modifier"
                     /db_xref="GeneID:298693"
                     /db_xref="RGD:1310312"
     exon            1..141
                     /gene="Isg15"
                     /gene_synonym="G1p2"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..624
                     /gene="Isg15"
                     /gene_synonym="G1p2"
                     /note="interferon, alpha-inducible protein (clone
                     IFI-15K)"
                     /codon_start=1
                     /product="ubiquitin-like protein ISG15"
                     /protein_id="NP_001100170.1"
                     /db_xref="GeneID:298693"
                     /db_xref="RGD:1310312"
                     /translation="MTWNLKVKMLGGKEFLVSMTNSMMLSELKKQVAQKSGVPAFQQR
                     LAHQSGEMLQDGVALIRQGLSSGSTVMLMVENCSHPLSILVRNERGRSNVYEVQLTQT
                     VEVLMRQVSQHEQVSQDQFWLSFNGRPMEDKEPLGEYGLTPHCTVIMNLRLRGGGDYY
                     F"
     exon            142..663
                     /gene="Isg15"
                     /gene_synonym="G1p2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatccacag ctcagacttt aagagagctg acccagtgag tctctctctg actgtgagag
       61 ccagcagcca gaagctgaga gaagcagaga gaagcagact ccttagtttc aggggaccta
      121 gtgctaaagc ctacagccat gacctggaac ctaaaggtga agatgctggg gggcaaggag
      181 ttcctggtgt ccatgacaaa ctccatgatg ctgtcagaac tgaagaagca ggttgctcag
      241 aagagtggtg tgccagcttt ccagcagcgc ctggcccacc aaagcggtga aatgctacag
      301 gatggtgttg cccttatcag gcagggcctt agttctggca gcacagtcat gctgatggta
      361 gagaactgca gccatcctct gagcatcctg gtgaggaatg aaaggggccg cagcaatgtc
      421 tatgaggtcc agctgacaca gactgtggaa gtgcttatga ggcaggtgtc ccagcacgag
      481 caagtctccc aagaccaatt ctggctgagc ttcaacggaa ggcccatgga ggacaaagag
      541 ccactggggg agtatggcct aacaccccac tgcacagtga tcatgaattt gcgcctgagg
      601 gggggagggg actactattt ctaaggcccc tatccagagc caatgtaggt aataaaagac
      661 aat
//
