LOCUS       NM_181626               1875 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Rattus norvegicus iron-sulfur cluster assembly 1 (Isca1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_181626
VERSION     NM_181626.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1875)
  AUTHORS   Sheng,H., Lu,D., Qi,X., Ling,Y., Li,J., Zhang,X., Dong,W., Chen,W.,
            Gao,S., Gao,X., Zhang,L. and Zhang,L.
  TITLE     A neuron-specific Isca1 knockout rat developments multiple
            mitochondrial dysfunction syndromes
  JOURNAL   Animal Model Exp Med 6 (2), 155-167 (2023)
   PUBMED   37140997
  REMARK    GeneRIF: A neuron-specific Isca1 knockout rat developments multiple
            mitochondrial dysfunction syndromes.
REFERENCE   2  (bases 1 to 1875)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1875)
  AUTHORS   Yang,X., Lu,D., Zhang,X., Chen,W., Gao,S., Dong,W., Ma,Y. and
            Zhang,L.
  TITLE     Knockout of ISCA1 causes early embryonic death in rats
  JOURNAL   Animal Model Exp Med 2 (1), 18-24 (2019)
   PUBMED   31016283
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1875)
  AUTHORS   Maio,N. and Rouault,T.A.
  TITLE     Iron-sulfur cluster biogenesis in mammalian cells: New insights
            into the molecular mechanisms of cluster delivery
  JOURNAL   Biochim Biophys Acta 1853 (6), 1493-1512 (2015)
   PUBMED   25245479
  REMARK    Review article
REFERENCE   5  (bases 1 to 1875)
  AUTHORS   Cozar-Castellano,I., del Valle Machargo,M., Trujillo,E.,
            Arteaga,M.F., Gonzalez,T., Martin-Vasallo,P. and Avila,J.
  TITLE     hIscA: a protein implicated in the biogenesis of iron-sulfur
            clusters
  JOURNAL   Biochim Biophys Acta 1700 (2), 179-188 (2004)
   PUBMED   15262227
REFERENCE   6  (bases 1 to 1875)
  AUTHORS   Serizawa,N.
  TITLE     [Initial characterization of a new miniature animal model in the
            rat: studies on anatomy, pituitary hormones and GH mRNA in
            miniature rat Ishikawa]
  JOURNAL   Nihon Naibunpi Gakkai Zasshi 69 (1), 33-45 (1993)
   PUBMED   8449243
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070929.1.
            
            On May 24, 2004 this sequence version replaced NM_181626.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070929.1, BC078677.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1875
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1875
                     /gene="Isca1"
                     /gene_synonym="Hbld2; hIscA"
                     /note="iron-sulfur cluster assembly 1"
                     /db_xref="GeneID:290985"
                     /db_xref="RGD:727792"
     exon            1..139
                     /gene="Isca1"
                     /gene_synonym="Hbld2; hIscA"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..448
                     /gene="Isca1"
                     /gene_synonym="Hbld2; hIscA"
                     /EC_number="2.7.7.52"
                     /note="iron-sulfur cluster assembly 1 homolog,
                     mitochondrial; HESB-like domain-containing protein 2;
                     iron-sulfur assembly protein IscA; HESB like domain
                     containing 2; HesB protein"
                     /codon_start=1
                     /product="iron-sulfur cluster assembly 1 homolog,
                     mitochondrial precursor"
                     /protein_id="NP_853657.1"
                     /db_xref="GeneID:290985"
                     /db_xref="RGD:727792"
                     /translation="MSASLVRATVRAVSKRKLQPTRAALTLTPSAVNKIKQLLKDKPE
                     HVGLKVGVRTRGCNGLSYSLEYTKTKGDADEEVIQDGVRVFIEKKAQLTLLGTEMDYV
                     EDKLSSEFVFNNPNIKGTCGCGESFNV"
     exon            140..193
                     /gene="Isca1"
                     /gene_synonym="Hbld2; hIscA"
                     /inference="alignment:Splign:2.1.0"
     exon            194..299
                     /gene="Isca1"
                     /gene_synonym="Hbld2; hIscA"
                     /inference="alignment:Splign:2.1.0"
     exon            300..1854
                     /gene="Isca1"
                     /gene_synonym="Hbld2; hIscA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggagagaag ctgaggtccc acgctccagc ccgaggctgc gggcgctgcg acgtggacat
       61 gtcggcgtcg ttggtccgcg ccaccgtgcg ggccgtgagc aagagaaaac tgcaacccac
      121 gcgggcggcg ctcacgctga ccccctctgc tgtgaacaag ataaaacaac ttcttaaaga
      181 caagcctgag catgtgggtc tgaaagtggg tgtgcggacc aggggctgta acggcctctc
      241 ttacagcctg gagtatacaa agacaaaagg agatgctgat gaagaagtta ttcaagacgg
      301 agtccgagtg ttcatcgaga agaaagccca gctaaccctg ttaggcacag agatggacta
      361 tgtggaagac aaactgtcca gtgagtttgt gttcaacaac cccaacatca agggaacctg
      421 tggctgcggt gaaagcttta acgtctgaaa gctgaggact gcaaactcca ggagagctgg
      481 gtctgccttg gagcacaccg aagaaatcat gtgatgtccc gtgtcggaag ttagtgtgtg
      541 gctgcctcgt ggttgagaat aaagtgaagc attgaaaatc aagccagcgt gttagagttc
      601 caaaaacatg gtgtctgttc tctgtaagac acaaatggag agaacatggt gtctgttctc
      661 tggaggacac aaactgagaa actgttgagt cctctgtcct gtacagaaaa ctcctaccct
      721 gcccttacgc tgtagcctgc tctgtgctag aaccagcttc gtgaccattg ctttgctggg
      781 aattgaggaa tgggataacg ggtgtgcacc tgggtcacag aatggcttga gactgtctcc
      841 tggccctgtc tcacctcagg cagggcagct gtgggagcag cagctgtggg agcggtgagg
      901 ggacctggtt tccctcacct gtggcgtggc ccgttgcatc tttaccacgt gcctgttgtc
      961 agatacctca tttgccagcc tccagcaagc tcagctctga gtgccagtct caggaggtag
     1021 ggatcacggg cctggtgtca gtctgtcctc tggggcgtgc ttcatgcggt ttgcttagac
     1081 ctttcagtta gaagcgcttg tgatgagcag ccaggtagac ctgctgagag cgtggttctc
     1141 agagcttctg cccagccctc ctcacaggtc acagcagaca gtgctgtctg agacactcgg
     1201 tgaggagaca tcctgcctgg ccagtgctct taccagttta gagactgcat tagttttctc
     1261 ttgaatggaa gccttgtgta aacccttttg tctgaatggc catcctgttt agagctttga
     1321 accagtagtg tcttccttca gaagatctgc agcagagggg tccctctcag cacggcacct
     1381 ggggggcaga acatgcacac acttacagtt gccagggtgc agatgctccc tgcttcccag
     1441 aggaagcttc taagtttctt taatgtggtc atcaccagtt ttttgagcca tggttttgct
     1501 gtatactaca ggccagcctt gaacccacaa caatcctcct gcttccacgt tcagaggcat
     1561 gtgctaccac acctgacctg gatcccaagt ttctctttaa gtggtcttga tggacttggg
     1621 tcggacatct tagtgacctg tgaattcttc tgtggaggct gagtctcacg tagccgagtt
     1681 taatatctgt gctatttact aaagtatctg ccaccaaatt gtaccaactc atagttttat
     1741 atgaatgttg atgagtctgt atcataaata gaattgttga tacatcctta atttgtgcaa
     1801 tattgtatga agaagattgt tatcaattaa aaccacgcct ctttatgatc ctaaaaaaaa
     1861 aaaaaaaaaa aaaaa
//
