LOCUS       NP_001095883             443 aa            linear   ROD 26-OCT-2024
DEFINITION  iroquois-class homeodomain protein IRX-6 isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_001095883 XP_001064772 XP_226359
VERSION     NP_001095883.1
DBSOURCE    REFSEQ: accession NM_001102413.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 443)
  AUTHORS   Star,E.N., Zhu,M., Shi,Z., Liu,H., Pashmforoush,M., Sauve,Y.,
            Bruneau,B.G. and Chow,R.L.
  TITLE     Regulation of retinal interneuron subtype identity by the Iroquois
            homeobox gene Irx6
  JOURNAL   Development 139 (24), 4644-4655 (2012)
   PUBMED   23172916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On or before Aug 24, 2007 this sequence version replaced
            XP_226359.4, XP_001064772.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1163183.1,
                                           SRR26360190.3260949.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984041 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..443
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     Protein         1..443
                     /product="iroquois-class homeodomain protein IRX-6 isoform
                     1"
                     /note="Iroquois related homeobox 6; iroquois-class
                     homeodomain protein IRX-6"
                     /calculated_mol_wt=47284
     Region          <142..222
                     /region_name="COG5576"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]"
                     /db_xref="CDD:227863"
     Site            order(146..148,150,170,176,189,191..192,195..196,198..200,
                     202..203)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            order(146,149,192,195..196,199)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     Region          162..200
                     /region_name="Homeobox_KN"
                     /note="Homeobox KN domain; pfam05920"
                     /db_xref="CDD:428673"
     CDS             1..443
                     /gene="Irx6"
                     /gene_synonym="RGD1564830"
                     /coded_by="NM_001102413.2:741..2072"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:307715"
                     /db_xref="RGD:1564830"
ORIGIN      
        1 mafppfghpy ggasqflvsa sssatcceta prsvsdvasa stsastlcca pydsrllgsa
       61 rpelgaalgi ygapyaaaqs ypgyltygpe pptlcgalnp qyefkdaags ftpsltqpga
      121 yypyettlgq yqydryggve lssagrrkna trestsalka wlhehrknpy ptkgekimla
      181 iitkmtltqv stwfanarrr lkkenkmtwv pknkggeerk adgggedalg clngdtkdat
      241 asqeaqglql sdledleeee eeeeeeeaek eeaavsaarr lvgfpksaqp lpapcaaaqe
      301 gclestecgl avprfsftea pqsgeadfit aepsgptmiv hypsghkpri wslahtaass
      361 avkgapstpp rgqspechmi prqpssvrrl lvprfsggee nspavkafgn stfalqglpl
      421 ncapcprrre pevrfqypsg aeg
//
