LOCUS       NM_001107330            2567 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus iroquois homeobox 4 (Irx4), mRNA.
ACCESSION   NM_001107330 XM_001057125 XM_001057181 XM_001057247 XM_225068
VERSION     NM_001107330.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2567)
  AUTHORS   He,W., Jia,Y. and Takimoto,K.
  TITLE     Interaction between transcription factors Iroquois proteins 4 and 5
            controls cardiac potassium channel Kv4.2 gene transcription
  JOURNAL   Cardiovasc Res 81 (1), 64-71 (2009)
   PUBMED   18815185
  REMARK    GeneRIF: Interaction between transcription factors Iroquois
            proteins 4 and 5 controls cardiac potassium channel Kv4.2 gene
            transcription across the left ventricular wall of rodent hearts.
REFERENCE   2  (bases 1 to 2567)
  AUTHORS   Bruneau,B.G., Bao,Z.Z., Fatkin,D., Xavier-Neto,J.,
            Georgakopoulos,D., Maguire,C.T., Berul,C.I., Kass,D.A., Kuroski-de
            Bold,M.L., de Bold,A.J., Conner,D.A., Rosenthal,N., Cepko,C.L.,
            Seidman,C.E. and Seidman,J.G.
  TITLE     Cardiomyopathy in Irx4-deficient mice is preceded by abnormal
            ventricular gene expression
  JOURNAL   Mol Cell Biol 21 (5), 1730-1736 (2001)
   PUBMED   11238910
REFERENCE   3  (bases 1 to 2567)
  AUTHORS   Christoffels,V.M., Habets,P.E., Franco,D., Campione,M., de Jong,F.,
            Lamers,W.H., Bao,Z.Z., Palmer,S., Biben,C., Harvey,R.P. and
            Moorman,A.F.
  TITLE     Chamber formation and morphogenesis in the developing mammalian
            heart
  JOURNAL   Dev Biol 223 (2), 266-278 (2000)
   PUBMED   10882515
  REMARK    Erratum:[Dev Biol 2000 Sep 1;225(1):266]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001107330.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               JAXUCZ010000001.1  31867720-31868089   c
            371-492             JAXUCZ010000001.1  31863622-31863743   c
            493-744             JAXUCZ010000001.1  31862901-31863152   c
            745-857             JAXUCZ010000001.1  31861981-31862093   c
            858-1186            JAXUCZ010000001.1  31860881-31861209   c
            1187-2567           JAXUCZ010000001.1  31859101-31860481   c
FEATURES             Location/Qualifiers
     source          1..2567
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..2567
                     /gene="Irx4"
                     /note="iroquois homeobox 4"
                     /db_xref="GeneID:306655"
                     /db_xref="RGD:1309309"
     exon            1..370
                     /gene="Irx4"
                     /inference="alignment:Splign:2.1.0"
     exon            371..492
                     /gene="Irx4"
                     /inference="alignment:Splign:2.1.0"
     CDS             448..1995
                     /gene="Irx4"
                     /note="Iroquois related homeobox 4"
                     /codon_start=1
                     /product="iroquois-class homeodomain protein IRX-4"
                     /protein_id="NP_001100800.1"
                     /db_xref="GeneID:306655"
                     /db_xref="RGD:1309309"
                     /translation="MSYPQFGYPYSSAPQFLMTTNSLSTCCESGGRTLADSGPAASAQ
                     APVYCPVYESRLLATARHELNSAAALGVYGSPYSSSQGYGNYVTYGSEASAFYSLNSF
                     ESKDGTGSSHAGLPPTAAAAYYPYEPTLGQYPYDRYGTVDSGTRRKNATRETTSTLKA
                     WLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADE
                     KRPYGEGEEEEAGEEESREEPLKSVKSEGPAGKEDKELELSDLEDFDPLDTETSECEL
                     KTPFQPLDSVPERIPPSSDGPGTGKEAPVTLRMPLGTADGAVMDGDLERARNCLRSTV
                     VAPDSGAEGGPQACEAKLTFAPAGAPPNLETKPRIWSLAHTATAAAATALSQTEFPSC
                     MLKRQGSTGASAVTPASSPAVPAASGTLDRHQDSPVTSLRNWVDGVFHDPILRHSTLN
                     QAWATAKGALLDPGPLGRNLGAGTNVLTTPLACSFRPTVPQDVSPAGASRELLATPKA
                     SGKPFCT"
     exon            493..744
                     /gene="Irx4"
                     /inference="alignment:Splign:2.1.0"
     exon            745..857
                     /gene="Irx4"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1186
                     /gene="Irx4"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..2567
                     /gene="Irx4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcgccta gggacgccgg cgcgctccgc tctccaggtg ctccgcctgg aaatgtctcc
       61 attagttgtc gcttgctccc cgccggagcg cgcgcgccca gcggccgcgc agagccctag
      121 cgggcagtca ggagtggccc ggcgccaccg caggtaggca aggtccccgc gcccgccccc
      181 tcccggagtt ccgagacccc tccccccctt tcgaggaggc ggaggaggca gaggctccgc
      241 gcggccgccg aggggcgcgg gcggccgagg cgacagcggc ggcggcgact ccccggtgcg
      301 tcccgggctg cgcgcagctc ccggaggccc tggcgcccaa gcggcgcggg ccggctcttt
      361 cctagcgcag agcctaggat cctacagctc ggagcagtgc ccacgccgcg cacaggaccc
      421 caaggacctt cttaggctgc gcccgccatg tcctacccgc agtttggata cccctattcc
      481 tccgctcctc agttcctgat gaccaccaac tccctgagca cgtgctgcga gtcgggcggc
      541 cgcacactgg ctgactccgg gcctgcagcc tcggcccagg cgcccgtcta ctgccctgtc
      601 tacgagagcc ggctgctggc cactgcacgc cacgaactca attctgccgc cgcgctcggt
      661 gtctatggga gcccctacag cagctcgcaa ggctatggca attacgtgac ctatggttct
      721 gaggcatctg ctttctactc gctgaacagc ttcgagtcca aggatggcac aggatcttcg
      781 cacgccggcc taccacccac tgcagctgca gcctactacc cttatgagcc aactctgggc
      841 cagtaccctt atgacaggta cggaaccgtg gacagcggca cgcggcgcaa gaatgccacc
      901 cgggagacca ccagcacact taaggcctgg ctgcaggagc atcgaaagaa cccgtacccc
      961 accaaaggag agaagatcat gctggccatc atcaccaaga tgaccctcac acaggtctcc
     1021 acctggttcg ccaatgcacg ccggcgcctc aagaaggaga acaagatgac ctggccacct
     1081 agaaataaat gtgcagatga gaagaggcca tatggggagg gtgaggagga ggaagctgga
     1141 gaggaggagt cacgggagga gcctctcaag agtgtcaaga gcgaaggtcc tgctggcaaa
     1201 gaggacaagg aactagaact cagtgacttg gaagacttcg accctctaga tacagaaacc
     1261 tcagagtgtg agctgaagac gcccttccag cccctggata gtgtaccaga gaggattcct
     1321 ccttcatctg acggtcctgg caccggcaag gaggcccctg tcacactccg gatgcccctg
     1381 ggcactgctg atggagctgt tatggatggg gatctggaga gggcacggaa ctgcctccgg
     1441 agcacagtgg tagctcctga ctctggcgct gagggcggcc cacaagcctg cgaagctaaa
     1501 ctgacttttg ctccggccgg agcgccgcca aatctggaga ccaagccccg catctggtcc
     1561 ttggcgcaca cagctactgc tgctgcagcc accgctctga gccagactga gtttccctcc
     1621 tgcatgctga aacgccaagg ttcaacgggt gcatccgcgg tgacgcctgc gtcctcacct
     1681 gcagtcccgg ccgcttctgg aactctggat aggcaccaag actccccagt aactagcctc
     1741 agaaactggg tggatggtgt atttcatgat cccatcctta gacacagcac tttgaaccag
     1801 gcctgggcca ccgctaaggg cgcacttctg gatcccggcc ctctaggacg caatctgggg
     1861 gcgggtacca acgtactgac gacgcccctg gcttgctcct tccgacctac ggtgccccaa
     1921 gacgtctcac ctgcaggggc ctcccgggag ctgctggcta cgcccaaggc cagtggcaaa
     1981 cccttctgca cttaacatcc acctgcatag tggagaaggg aactggttct caggctgcgg
     2041 acgctgactc tggactgttt ttaatgggtt tccaaaagaa gaaggaattc caagtcaagg
     2101 ataccaatcc acctgaatca gagaatctga actcaacctc cagggctatg gagggacgtt
     2161 ttatcaccag gtttcaactg gtcttgcgtc cacctgagcc atccctgaac tccaggaaga
     2221 tgggaagatg ggagagtaca ggggagggga ggccccctga agcataaagt ttacgtccaa
     2281 agtttacaag gagaaggcat ttgggttctg aagcttgttt tgtgttgctg tctccttctg
     2341 ggttttaggc atactggtgt tcccgtgaag gaactcctcg gcctgttttt cttcggactt
     2401 cttcctcagc acgtaaaaaa actcaccgcc aacacttcca ccgagtttac actgttgctc
     2461 actcttgact cgacaaaatt atgttttcta aaatgtatat tcacaccagt aattgcctgt
     2521 ttcagagcga ggctaataca acaaaactaa taaattctcg tgtttgc
//
