LOCUS       NM_001039505            2635 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus iroquois homeobox 2 (Irx2), mRNA.
ACCESSION   NM_001039505 XM_225077
VERSION     NM_001039505.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2635)
  AUTHORS   Werner,S., Stamm,H., Pandjaitan,M., Kemming,D., Brors,B., Pantel,K.
            and Wikman,H.
  TITLE     Iroquois homeobox 2 suppresses cellular motility and chemokine
            expression in breast cancer cells
  JOURNAL   BMC Cancer 15, 896 (2015)
   PUBMED   26560478
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2635)
  AUTHORS   Jolma,A., Yan,J., Whitington,T., Toivonen,J., Nitta,K.R.,
            Rastas,P., Morgunova,E., Enge,M., Taipale,M., Wei,G., Palin,K.,
            Vaquerizas,J.M., Vincentelli,R., Luscombe,N.M., Hughes,T.R.,
            Lemaire,P., Ukkonen,E., Kivioja,T. and Taipale,J.
  TITLE     DNA-binding specificities of human transcription factors
  JOURNAL   Cell 152 (1-2), 327-339 (2013)
   PUBMED   23332764
REFERENCE   3  (bases 1 to 2635)
  AUTHORS   Reggiani,L., Raciti,D., Airik,R., Kispert,A. and Brandli,A.W.
  TITLE     The prepattern transcription factor Irx3 directs nephron segment
            identity
  JOURNAL   Genes Dev 21 (18), 2358-2370 (2007)
   PUBMED   17875669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001039505.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. There are no full-length rat transcripts
            supporting this RefSeq. The genomic coordinates and exon
            combination used for the transcript record were based on alignment
            to full-length mouse mRNA BC085291.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.413.1, SRR26643295.434.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-519               JAXUCZ010000001.1  32494412-32494930   c
            520-925             JAXUCZ010000001.1  32492758-32493163   c
            926-1639            JAXUCZ010000001.1  32491762-32492475   c
            1640-1715           JAXUCZ010000001.1  32491077-32491152   c
            1716-2635           JAXUCZ010000001.1  32489512-32490431   c
FEATURES             Location/Qualifiers
     source          1..2635
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..2635
                     /gene="Irx2"
                     /note="iroquois homeobox 2"
                     /db_xref="GeneID:306657"
                     /db_xref="RGD:1309834"
     exon            1..519
                     /gene="Irx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..1692
                     /gene="Irx2"
                     /note="Iroquois related homeobox 2; Iroquois related
                     homeobox 5"
                     /codon_start=1
                     /product="iroquois-class homeodomain protein IRX-2"
                     /protein_id="NP_001034594.1"
                     /db_xref="GeneID:306657"
                     /db_xref="RGD:1309834"
                     /translation="MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSA
                     FSPYPGSAAFTAQAATGFGSPLQYSADAAAAAAAGFPSYMGSPYDTHTTGMTGAISYH
                     PYGSAAYPYQLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLT
                     QVSTWFANARRRLKKENKMTWAPRNKSEDEDEDEGDASRSKEENPDKAQDGTETSAED
                     EGISLHVDSLTDHSCSAESDGEKLPCRAGDPLCESGSECKDKFEDLEDEEDDEDECER
                     DLVPPKPVTSSPLTGVEAPLLSPAPEAAPRGGSGGKTPLGSRTSPGAPPPASKPKLWS
                     LAEIATSDLKQPSLGPGCGPPGLPAAAAPASSGAPPGGSPYSASPLLGRHLYYTSPFY
                     GNYTNYGNLNAALQGQGLLRYNTAASSPGETLHAIPKAASDAGKAGSHSLESHYRPPG
                     GGYEPKKDASEGCAVVGAGVQPYL"
     exon            520..925
                     /gene="Irx2"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1639
                     /gene="Irx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1715
                     /gene="Irx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..2635
                     /gene="Irx2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgctcct tcctcaactc ctcactcctg actgcagact cccccaaatc ccgaccgccg
       61 gcctggcgcg cggctgcgcc caccggctcc gctctgctgc cgccgccgcc gccccaccga
      121 tccgccagcc ccgcgcccag ctagcgccct ccagtccagc ctgccccgac ccacggcccc
      181 ggtgcgcccc ggccgggcgt ggatggaggg cgccgcgcgc gctgcccgct gctccgtgtg
      241 acgcgggccc tgcgcccggc gcccaccatg tcctacccgc agggctacct gtaccaagcg
      301 cccggctcgc tggcgctcta ctcgtgcccc gcgtacggcg cgtccgcgct ggcggcgccg
      361 cgcagcgaag agctggcgcg ctcggcttcg ggctccgcgt tcagtccgta ccccggctca
      421 gcggccttca cagcgcaggc ggccaccggc ttcggcagcc cgctgcagta ctcggccgac
      481 gctgccgccg ccgccgctgc cggcttcccg tcctacatgg gctcgccata cgacacgcac
      541 accaccggaa tgactggcgc catcagttat cacccatatg gcagcgcggc ctacccatac
      601 cagcttaacg accccgcgta ccgcaagaac gccacgcggg acgccactgc cacactgaaa
      661 gcctggctca acgaacaccg caagaacccg taccccacca agggagagaa gatcatgctg
      721 gccatcatca ccaagatgac cctcacgcag gtttccacct ggttcgccaa cgcgcgccgg
      781 cgcctcaaga aggagaacaa aatgacctgg gccccgagga acaaaagcga agacgaggac
      841 gaggacgagg gagatgcttc cagaagcaag gaggagaatc cagacaaggc acaggacggc
      901 acagagacct ccgcggagga cgaagggatc agtctacacg tcgactcgct caccgaccac
      961 tcgtgctcgg cggagtcaga tggggagaaa ttgccctgcc gcgccgggga tcccttgtgc
     1021 gaatcgggct ctgagtgtaa ggacaagttt gaggacctgg aggatgagga ggacgatgaa
     1081 gacgagtgcg agcgggatct ggtgccgccc aagcccgtaa cctcctcgcc cctcaccggc
     1141 gtggaggcac ccctgctgag cccggcgccc gaagccgcgc cgcgcggtgg tagcggtggc
     1201 aagacgcccc taggcagccg gacgtcgcct ggagcgccgc cgcctgccag caagcccaag
     1261 ctgtggtcgc tggccgagat agccacgtcg gacctcaagc aaccaagctt gggcccaggg
     1321 tgcgggcctc cgggtctgcc cgctgccgcc gcgcctgcct cgtctggggc ccctccggga
     1381 ggctcgccct actctgcttc gccgctgctg ggccgccacc tctattacac gtcccctttc
     1441 tatggcaact acacaaacta cgggaactta aacgcagcgc tccaaggcca gggccttctg
     1501 cggtacaata ccgcggcctc ctcaccaggc gagacactgc acgccatccc aaaggcggcc
     1561 agcgacgcgg gcaaggcggg ctcgcattcg ctggagtccc actacaggcc tccgggcggc
     1621 ggctacgagc ccaagaaaga tgccagtgag ggctgtgcag ttgttggtgc aggcgtccag
     1681 ccctacctat aggagggcca agctcagcag tgcaagtagg tgtcacaatt gctttggaaa
     1741 aaaaaagtca ggaggccatt ctcccttccc aagctcataa atacacagat acaaacccca
     1801 gatgtggaaa tgcggaccac attttgtgcc actgtataga ggatgcagac tgcactgcca
     1861 acccacagac tctaaggact ggacacacgt tgtttgggca tatgagaact cgttggcata
     1921 gtatagcttc cctatgtttg tgtgactttt ggaaacaatc tgttttttct caggatatct
     1981 tcacttcatt gccacggtat atattctata ggtgtgatag aacttgctgt aaaatttatt
     2041 tgtaaaaaaa aatgtacacg gtagaactaa tgtgattgaa gaacttgggt ccttcagaag
     2101 tggaaacaaa tttgatattt atttttataa tgacataaag cttctagtaa tttatgcaag
     2161 ttgtattgca atgaaatcta aaacttttgt aaataaattc tgcctggttt ttatttgaac
     2221 attgctggtt atacaatctc tgttggttgt ttaacatgaa ttctctacta atttatatct
     2281 aaaactgtaa ataaaaacag atgagcctac aagaaaatgg tgttcggggc tcatttttcc
     2341 tggagagcca ttctggtagg agctacagtg ttgaccctgg ttcctgcccc aaaggtgatc
     2401 ctagctcacc ttttaagtga agagcccagt gaaataaact tccttctcaa gcttatttga
     2461 aaattgcaga cctgagagag attaatgtgc aacagggaaa atacctatgc tttagtttat
     2521 ttacaggcaa atgtgtctcg agaaagtaat tcaggttttt gttctctgaa tatgcaaatc
     2581 ccttcttagt gtaaatttct aaaacatgaa aaaaaataaa aggatatgtc acctc
//
