LOCUS       NM_001107331            2345 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus iroquois homeobox 1 (Irx1), mRNA.
ACCESSION   NM_001107331 XM_001057357 XM_001057410 XM_225101
VERSION     NM_001107331.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2345)
  AUTHORS   Zeng,L., Gu,N., Chen,J., Jin,G. and Zheng,Y.
  TITLE     IRX1 hypermethylation promotes heart failure by inhibiting CXCL14
            expression
  JOURNAL   Cell Cycle 18 (23), 3251-3262 (2019)
   PUBMED   31640472
REFERENCE   2  (bases 1 to 2345)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 2345)
  AUTHORS   Guo,C., Wang,Q., Wang,Y., Yang,L., Luo,H., Cao,X.F., An,L., Qiu,Y.,
            Du,M., Ma,X., Li,H. and Lu,C.
  TITLE     Exome sequencing reveals novel IRXI mutation in congenital heart
            disease
  JOURNAL   Mol Med Rep 15 (5), 3193-3197 (2017)
   PUBMED   28358424
REFERENCE   4  (bases 1 to 2345)
  AUTHORS   Guo,X., Liu,W., Pan,Y., Ni,P., Ji,J., Guo,L., Zhang,J., Wu,J.,
            Jiang,J., Chen,X., Cai,Q., Li,J., Zhang,J., Gu,Q., Liu,B., Zhu,Z.
            and Yu,Y.
  TITLE     Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma
  JOURNAL   Oncogene 29 (27), 3908-3920 (2010)
   PUBMED   20440264
REFERENCE   5  (bases 1 to 2345)
  AUTHORS   Reggiani,L., Raciti,D., Airik,R., Kispert,A. and Brandli,A.W.
  TITLE     The prepattern transcription factor Irx3 directs nephron segment
            identity
  JOURNAL   Genes Dev 21 (18), 2358-2370 (2007)
   PUBMED   17875669
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001107331.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.309.1, SRR26643286.277.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               JAXUCZ010000001.1  33123122-33123624
            504-1539            JAXUCZ010000001.1  33126584-33127619
            1540-1612           JAXUCZ010000001.1  33127911-33127983
            1613-2345           JAXUCZ010000001.1  33128219-33128951
FEATURES             Location/Qualifiers
     source          1..2345
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..2345
                     /gene="Irx1"
                     /note="iroquois homeobox 1"
                     /db_xref="GeneID:306659"
                     /db_xref="RGD:1309060"
     exon            1..503
                     /gene="Irx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1670
                     /gene="Irx1"
                     /note="Iroquois related homeobox 1"
                     /codon_start=1
                     /product="iroquois-class homeodomain protein IRX-1"
                     /protein_id="NP_001100801.1"
                     /db_xref="GeneID:306659"
                     /db_xref="RGD:1309060"
                     /translation="MSFPQLGYPQYLSAAGPGAYGGERPGMLAAAAAAAAAASSGRPG
                     TAELGAGAGAAAVTSVLGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNP
                     GVHPATFAAHTTPAYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEK
                     IMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEGDPEKAE
                     DDEEIDLESIDIDQIDERDGDQSNEDEEDKVEAPRARVAPPAPARDQSSPLSAAETLK
                     SQDSPLGLAKEVSEPGSTRLLSPGAAAVGLQGAPHSKPKIWSLAETATSPDGAPKASP
                     PPPSSHASAHGPPSGSPLQHPAFLPSHGLYTCHIGKFSNWTNGAFLAQGSLLNMRSFL
                     GVSAPHAAPHGPHVTAPPPPQLPVQVATGVLHGEKASASSSPALPERDLVTRPDSPPQ
                     QLKSPFQPVRDNSLAPQEGTPRILAALSSA"
     exon            504..1539
                     /gene="Irx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1612
                     /gene="Irx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..2345
                     /gene="Irx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcggaggg cggccgccgc agtcggcgcg cgatctcgga tccgggcgca gccgggcgcc
       61 gccaaccagc actgggctga ggaacagcga gcggcccccg cccccgggcc ggccggagcg
      121 cgcccggccc gccgcccgca gccccagagc cgcgcctcct cggatcgaca gccagtctct
      181 ttgcccgcgc agttagggtg ccctccacca ccgccaagcc cgcggacatg tccttcccgc
      241 agctgggcta cccgcaatac ctaagcgccg cgggcccggg cgcctacggt ggagagcgcc
      301 ctgggatgct ggctgcggcc gcggctgctg cagccgccgc ctcgtcgggt cggccgggga
      361 ctgcagagct gggagcgggc gccggagcgg ccgcggtcac ctcggtgctg ggcatgtatg
      421 ccgcggcggg accgtacgcg ggcgcaccca actacagcgc ctttctgccc tatgccgcgg
      481 acctcagcct cttctcacag atgggctctc agtatgaact caaggacaac cccggggtac
      541 acccagctac cttcgcagcc cacacaacgc ctgcttatta tccctatggc cagttccaat
      601 acggggatcc cggacggccc aagaacgcca cgcgcgagag cacaagcaca ctgaaagcct
      661 ggctcaacga acaccgcaag aatccgtacc ccaccaaagg agagaagatc atgctggcca
      721 ttattaccaa gatgaccctc acacaggtct ccacctggtt cgccaacgcg cgccggcgcc
      781 tcaagaagga aaacaaggtg acttgggggg cgcgcagcaa ggaccaggaa gacggcgccc
      841 tctttggcag cgacaccgag ggcgaccccg agaaggccga ggacgacgag gagatcgacc
      901 tggagagcat tgacatcgat cagattgacg aacgtgatgg cgaccagagc aacgaagacg
      961 aggaggacaa ggtggaggct cctagggcgc gcgtagcccc tcccgcccca gctcgggacc
     1021 agagctcccc gttgtcggcc gccgagacac tcaagtccca agattcgccc ttgggcctgg
     1081 ctaaggaggt ctcagagccg ggcagcacgc gccttctgag tcccggagcc gcggcggtcg
     1141 gcctgcaggg cgcgcctcac agcaagccca agatctggtc actggctgag acagccacta
     1201 gccccgacgg tgcgcctaag gcgtccccac cgccaccctc cagccacgcc agcgcacacg
     1261 ggccgcccag cggctcgccc ctgcaacacc cggcctttct acccagccac ggactgtaca
     1321 cctgccacat aggcaagttt tccaactgga ccaacggcgc gttcctagca cagggctcgc
     1381 tgttgaacat gcgatctttc ctgggagtca gtgcaccgca tgcagcacct catggcccac
     1441 acgtgaccgc accgccacct ccgcagctgc ctgtccaggt tgccacaggg gtgctccatg
     1501 gtgagaaggc ctcggcgagt agcagtcctg cgcttccaga gagagaccta gtcaccaggc
     1561 cggattcgcc cccacagcag ctaaagtcgc ccttccagcc ggtgcgcgac aactcgctgg
     1621 ccccgcagga gggaacgcct cggatcctcg cagccctctc gtctgcctga ttaagggggg
     1681 tcgtctttta cttttgcggg gagaggggag gggggagggg ttggggggag gagacgaggg
     1741 aagaattaag acaaatattt gagacttgtg taaaggacaa acgtgaccgc agcgtcagtg
     1801 attctcacac atcgctctct gcagaaaggg gctcatcctg cctaagagct tggggagggg
     1861 ggagtaaggc tcagcctgcc gctcgggttg gttatccgat tcggtaaatg cctccccctc
     1921 cgtgtttgtg tcttctttgt ttcttttccc ccctttctgt atatagcgtg atttcagatt
     1981 gtaaatagcg cgtcagcgaa cttgtttaaa tcatatattt ttgtctaata aactaaatga
     2041 aacgatgtgc acgcggctgt agctgtttgt ccttgtgctc ctgcgttttg ggggaggcaa
     2101 tgatatatgc gatcttgaaa tcctgggcac agtccaaggg gctgtggtta caccagagac
     2161 tcctttggga gaagggtctt ggaacagtgt ttccaccgag caaaaccact gtgtcaggcg
     2221 cacagtcttt ccgtggtgat agtggtcgaa tttgttcgtt ttgctcttag gccagcttct
     2281 tgttggcagt ttaaatcgtt gccacgctta gacaagcgtt tatctggagc agcctttctc
     2341 agtac
//
