LOCUS       NM_032074               1969 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus insulin receptor substrate 3 (Irs3), mRNA.
ACCESSION   NM_032074
VERSION     NM_032074.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1969)
  AUTHORS   Kumar M, Nath S, Prasad HK, Sharma GD and Li Y.
  TITLE     MicroRNAs: a new ray of hope for diabetes mellitus
  JOURNAL   Protein Cell 3 (10), 726-738 (2012)
   PUBMED   23055040
  REMARK    Review article
REFERENCE   2  (bases 1 to 1969)
  AUTHORS   Hakuno F, Kurihara S, Watson RT, Pessin JE and Takahashi S.
  TITLE     53BP2S, interacting with insulin receptor substrates, modulates
            insulin signaling
  JOURNAL   J Biol Chem 282 (52), 37747-37758 (2007)
   PUBMED   17965023
  REMARK    GeneRIF: 53BP2S interacts and modulates the insulin signals
            mediated by insulin receptor substrates.
REFERENCE   3  (bases 1 to 1969)
  AUTHORS   Villar M, Serrano R, Gallardo N, Carrascosa JM, Martinez C and
            Andres A.
  TITLE     Altered subcellular distribution of IRS-1 and IRS-3 is associated
            with defective Akt activation and GLUT4 translocation in
            insulin-resistant old rat adipocytes
  JOURNAL   Biochim Biophys Acta 1763 (2), 197-206 (2006)
   PUBMED   16445997
REFERENCE   4  (bases 1 to 1969)
  AUTHORS   Zhao X, Zhuang S, Chen Y, Boss GR and Pilz RB.
  TITLE     Cyclic GMP-dependent protein kinase regulates CCAAT
            enhancer-binding protein beta functions through inhibition of
            glycogen synthase kinase-3
  JOURNAL   J Biol Chem 280 (38), 32683-32692 (2005)
   PUBMED   16055922
  REMARK    GeneRIF: Cyclic GMP-dependent protein kinase increases the DNA
            binding potential of C/EBPbeta by preventing the negative effects
            of GSK-3 phosphorylation
REFERENCE   5  (bases 1 to 1969)
  AUTHORS   Kaburagi Y, Yamashita R, Ito Y, Okochi H, Yamamoto-Honda R, Yasuda
            K, Sekihara H, Sasazuki T, Kadowaki T and Yazaki Y.
  TITLE     Insulin-induced cell cycle progression is impaired in chinese
            hamster ovary cells overexpressing insulin receptor substrate-3
  JOURNAL   Endocrinology 145 (12), 5862-5874 (2004)
   PUBMED   15331570
  REMARK    GeneRIF: IRS-3 may play a unique role in mitogenesis by inhibiting
            insulin-stimulated cell cycle progression via a decrease in cyclin
            D1 and p21 expressions as well as suppression of c-myc mRNA
            induction
REFERENCE   6  (bases 1 to 1969)
  AUTHORS   Lingohr MK, Dickson LM, Wrede CE, McCuaig JF, Myers MG Jr and
            Rhodes CJ.
  TITLE     IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells
  JOURNAL   Mol Cell Endocrinol 204 (1-2), 85-99 (2003)
   PUBMED   12850284
  REMARK    GeneRIF: IRS-3 expression blocked glucose/IGF-1 induced IRS-2
            translocation from the cytosol to the plasma membrane, dampening
            IRS-2/IGF-1R interaction and subsequent activation of the
            PI3K/PKB/GSK3 signaling pathway
REFERENCE   7  (bases 1 to 1969)
  AUTHORS   Kabuta T, Hakuno F, Asano T and Takahashi S.
  TITLE     Insulin receptor substrate-3 functions as transcriptional activator
            in the nucleus
  JOURNAL   J Biol Chem 277 (9), 6846-6851 (2002)
   PUBMED   11724774
  REMARK    GeneRIF: These results suggest that intracellular localization of
            IRS-3 is determined by a different mechanism from other IRS
            proteins, and that IRS-3 possesses a transcription-regulating
            activity
REFERENCE   8  (bases 1 to 1969)
  AUTHORS   Lavan BE, Lane WS and Lienhard GE.
  TITLE     The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is
            a new member of the insulin receptor substrate family
  JOURNAL   J Biol Chem 272 (17), 11439-11443 (1997)
   PUBMED   9111055
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U93880.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U93880.1, BC161840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132271
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1969
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..1969
                     /gene="Irs3"
                     /note="insulin receptor substrate 3"
                     /db_xref="GeneID:84021"
                     /db_xref="RGD:69317"
     exon            1..618
                     /gene="Irs3"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1673
                     /gene="Irs3"
                     /codon_start=1
                     /product="insulin receptor substrate 3"
                     /protein_id="NP_114463.1"
                     /db_xref="GeneID:84021"
                     /db_xref="RGD:69317"
                     /translation="MKPAGTGPTVSSGGESTDVSLGPPFPWPCPPDVRLCGHLRKQKS
                     QRRRFFVLRADPPRLECYESEKKFLASGCRPPRPRRTVSLEGACTISKRADARQRHLI
                     VIYTSDSSLGVAAASEAEQQTWYSALLEVRATAAAAAATAMGFSPQEAPESWIFAPFQ
                     DVWPVTLRSKGLGRAPGLSSGSYRLCLGSGALSLLRKPGSKGSRDSRATPPPVLRLSL
                     LSVRRCGHADSFFFLELGRSAPIGPGELWLQAPDAVVAQSIHETVLAAMKRLGSSAAS
                     GKAEAPLGDSPKGASAVPAPAPYEIPALALAAQARSPGERAKQDYVNPLERMGSAPSY
                     RGPDLGGDYIAMGMRNDYVHMGGKAAEYMWMAPPGLPPPTPPRVDPRKEPEDCESTEY
                     MPMNRFLPGPLYYEFKAREPEHGHSSAQCSIRDRWRPMVAQPRSSQGSELSGDYMYIP
                     DYPSARLGSLDSCLNYVDLDLVPPLEVPGAAPGNSPHSYASIKF"
     exon            619..1969
                     /gene="Irs3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggacacacg caccctgtac aggctccttg cccactccaa gtcaggagag ggcgtggaga
       61 gatgcagggc agctaggccg gttgcaatct tcccaagatt gcaacttgtc ccaagccggt
      121 ggtagctcag gggacaggac ccattcaaat tagtccttct gaggacagtt tactgccttt
      181 ggctggagat gaagcctgca ggtacgggcc ccacagtctc ctctgggggc gagtccaccg
      241 acgtgtccct cggcccgccg tttccttggc cctgcccgcc cgacgtgcgg ctctgtggcc
      301 atctgaggaa gcagaagtcc cagcgccgcc gctttttcgt gctgcgtgct gacccaccac
      361 ggctggagtg ctatgagagc gagaagaagt tcttggccag cggctgccgc ccacctcgac
      421 cccggcgtac cgttagcctg gaaggtgcct gcactattag caagcgcgcg gatgcccgtc
      481 agcgccacct gatcgtcatc tataccagcg acagcagcct gggcgtggcg gcggccagtg
      541 aagcagagca gcaaacatgg tacagcgcct tgctcgaggt gcgcgccacc gccgctgcag
      601 ctgctgccac cgctatgggt ttcagccccc aagaggcccc tgagtcttgg atcttcgccc
      661 cgttccagga cgtctggcct gtgacactgc ggtccaaggg gctggggaga gcaccaggcc
      721 tgagcagcgg cagctatcgc ctgtgcctgg gttctggggc cctgagcctc ctgcggaagc
      781 cgggaagcaa aggctccaga gacagccggg caacgccacc accagtcctg cgcttgtcct
      841 tgcttagtgt gcgccgctgc ggccacgcag attccttttt cttcctggaa ctcgggcgct
      901 cagcgcccat aggtcctggt gagctgtggc tgcaggcccc tgatgcagtg gtggcccaaa
      961 gcattcatga gaccgtcctg gctgccatga agagactggg gagcagtgca gccagtggca
     1021 aagctgaggc accgctggga gattctccaa agggggcttc tgcagtccct gccccagcac
     1081 catatgagat ccctgctttg gcactggcag cacaagcgag aagtccgggt gagagagcga
     1141 agcaggacta cgtcaatcca ctggaaagga tggggtcagc accctcctac agggggccag
     1201 atctgggtgg ggactacatc gccatgggaa tgaggaatga ctatgtgcac atggggggga
     1261 aagctgctga gtacatgtgg atggcgcccc caggtctccc tccccccacc cctcccaggg
     1321 tagatcccag aaaggagcct gaggattgtg agagcacaga gtatatgccc atgaacagat
     1381 ttttaccggg gcctctttac tacgagttca aggccaggga gcctgaacat gggcattcta
     1441 gtgcccagtg tagcattagg gacagatgga gacccatggt ggctcagccc cgctcttccc
     1501 aagggtcaga gctctctggg gactacatgt acatccctga ctatcccagt gctaggctgg
     1561 ggtctctgga cagctgcctc aactatgtgg acctggacct agtccctccc ctggaggttc
     1621 ctggagcggc cccagggaat agtccacata gctatgccag catcaagttc tagaactttc
     1681 agaagatagg ggaggagaac caagcattgg ttagggaaga gaggaaaaga agagaaaacc
     1741 ttagcactgt tcagctcagc ttctgcacat aggagccagg gactctgagg ccttgtgagg
     1801 tgctatgctg cccccttgcc tgctctgtct cttccagctg taccgcctca gaaacacctc
     1861 aggaagaagt gctccaaaga aattagactc ttaagagaaa gtactagaac atctctctgc
     1921 acccccaccc caaacccaaa caacaaacaa ataaaacacc tacagaacc
//
