LOCUS       NM_001168633            6301 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus insulin receptor substrate 2 (Irs2), mRNA.
ACCESSION   NM_001168633 XM_573948
VERSION     NM_001168633.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6301)
  AUTHORS   Nakahara,M., Ito,H., Skinner,J.T., Lin,Q., Tamosiuniene,R.,
            Nicolls,M.R., Keegan,A.D., Johns,R.A. and Yamaji-Kegan,K.
  TITLE     The inflammatory role of dysregulated IRS2 in pulmonary vascular
            remodeling under hypoxic conditions
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 321 (2), L416-L428 (2021)
   PUBMED   34189964
  REMARK    GeneRIF: The inflammatory role of dysregulated IRS2 in pulmonary
            vascular remodeling under hypoxic conditions.
REFERENCE   2  (bases 1 to 6301)
  AUTHORS   Toyoshima,Y., Nakamura,K., Tokita,R., Teramoto,N., Sugihara,H.,
            Kato,H., Yamanouchi,K. and Minami,S.
  TITLE     Disruption of insulin receptor substrate-2 impairs growth but not
            insulin function in rats
  JOURNAL   J Biol Chem 295 (33), 11914-11927 (2020)
   PUBMED   32631952
  REMARK    GeneRIF: Disruption of insulin receptor substrate-2 impairs growth
            but not insulin function in rats.
REFERENCE   3  (bases 1 to 6301)
  AUTHORS   Elhafiz,M., Zhao,G., Ismail,M., Xu,D., Das,D., Fan,S., Cheng,N.,
            Yousef,B.A., Jiang,Z. and Zhang,L.
  TITLE     Imbalanced insulin substrate-1 and insulin substrate-2 signaling
            trigger hepatic steatosis in vitamin D deficient rats:
            8-methoxypsoralen, a vitamin D receptor ligand with a promising
            anti-steatotic action
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1865 (6), 158657 (2020)
   PUBMED   32045698
  REMARK    GeneRIF: Imbalanced insulin substrate-1 and insulin substrate-2
            signaling trigger hepatic steatosis in vitamin D deficient rats:
            8-methoxypsoralen, a vitamin D receptor ligand with a promising
            anti-steatotic action.
REFERENCE   4  (bases 1 to 6301)
  AUTHORS   Hao,C.L., Lin,H.L., Ke,L.Y., Yen,H.W. and Shen,K.P.
  TITLE     Pre-germinated brown rice extract ameliorates high-fat diet-induced
            metabolic syndrome
  JOURNAL   J Food Biochem 43 (3), e12769 (2019)
   PUBMED   31353547
REFERENCE   5  (bases 1 to 6301)
  AUTHORS   Manu,M.S., Rachana,K.S. and Advirao,G.M.
  TITLE     Altered expression of IRS2 and GRB2 in demyelination of peripheral
            neurons: Implications in diabetic neuropathy
  JOURNAL   Neuropeptides 62, 71-79 (2017)
   PUBMED   28065675
  REMARK    GeneRIF: a radical increase in the phosphorylation of IRS2 at
            serine 731 prevents the recruitment of GRB2 adaptor protein which
            may fail further to connect the Ras and other pathways required to
            the cell for its survival and to maintain integrity
REFERENCE   6  (bases 1 to 6301)
  AUTHORS   Kitamura,T., Nakae,J., Kitamura,Y., Kido,Y., Biggs,W.H. 3rd,
            Wright,C.V., White,M.F., Arden,K.C. and Accili,D.
  TITLE     The forkhead transcription factor Foxo1 links insulin signaling to
            Pdx1 regulation of pancreatic beta cell growth
  JOURNAL   J Clin Invest 110 (12), 1839-1847 (2002)
   PUBMED   12488434
REFERENCE   7  (bases 1 to 6301)
  AUTHORS   Anderwald,C., Muller,G., Koca,G., Furnsinn,C., Waldhausl,W. and
            Roden,M.
  TITLE     Short-term leptin-dependent inhibition of hepatic gluconeogenesis
            is mediated by insulin receptor substrate-2
  JOURNAL   Mol Endocrinol 16 (7), 1612-1628 (2002)
   PUBMED   12089355
  REMARK    GeneRIF: leptin both alone and in combination with insulin reduces
            hepatic glucose production by decreasing the synthesis of the key
            enzyme of gluconeogenesis, PEPCK, which results mainly from the
            stimulation of the IRS-2 pathway.
REFERENCE   8  (bases 1 to 6301)
  AUTHORS   Tsuji,Y., Kaburagi,Y., Terauchi,Y., Satoh,S., Kubota,N.,
            Tamemoto,H., Kraemer,F.B., Sekihara,H., Aizawa,S., Akanuma,Y.,
            Tobe,K., Kimura,S. and Kadowaki,T.
  TITLE     Subcellular localization of insulin receptor substrate family
            proteins associated with phosphatidylinositol 3-kinase activity and
            alterations in lipolysis in primary mouse adipocytes from IRS-1
            null mice
  JOURNAL   Diabetes 50 (6), 1455-1463 (2001)
   PUBMED   11375348
REFERENCE   9  (bases 1 to 6301)
  AUTHORS   Kessler,A., Uphues,I., Ouwens,D.M., Till,M. and Eckel,J.
  TITLE     Diversification of cardiac insulin signaling involves the p85
            alpha/beta subunits of phosphatidylinositol 3-kinase
  JOURNAL   Am J Physiol Endocrinol Metab 280 (1), E65-E74 (2001)
   PUBMED   11120660
REFERENCE   10 (bases 1 to 6301)
  AUTHORS   Mammarella,S., Romano,F., Di Valerio,A., Creati,B., Esposito,D.L.,
            Palmirotta,R., Capani,F., Vitullo,P., Volpe,G., Battista,P., Della
            Loggia,F., Mariani-Costantini,R. and Cama,A.
  TITLE     Interaction between the G1057D variant of IRS-2 and overweight in
            the pathogenesis of type 2 diabetes
  JOURNAL   Hum Mol Genet 9 (17), 2517-2521 (2000)
   PUBMED   11030756
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Dec 12, 2009 this sequence version replaced XM_573948.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1118375.1,
                                           SRR26360190.1797962.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3979              JAXUCZ010000016.1  85190310-85194288
            3980-6301           JAXUCZ010000016.1  85212222-85214543
FEATURES             Location/Qualifiers
     source          1..6301
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..6301
                     /gene="Irs2"
                     /gene_synonym="4PS; IRS-2"
                     /note="insulin receptor substrate 2"
                     /db_xref="GeneID:29376"
                     /db_xref="RGD:69316"
     CDS             1..3984
                     /gene="Irs2"
                     /gene_synonym="4PS; IRS-2"
                     /note="tyrosine kinase substrate"
                     /codon_start=1
                     /product="insulin receptor substrate 2"
                     /protein_id="NP_001162104.1"
                     /db_xref="GeneID:29376"
                     /db_xref="RGD:69316"
                     /translation="MASAPLPGPPASAGGDGPNLNNNNNNNNNHSVRKCGYLRKQKHG
                     HKRFFVLRGPGTGGEEAAAAGGSPPQPPRLEYYESEKKWKSKAGAPKRVIALDCCLNI
                     NKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEGRSGDGGSGTTGGS
                     CSASLPGALGGSAGAAGCDDNYGLVTPATAVYREVWQVNLKPKGLGQSKNLTGVYRLC
                     LSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSV
                     VAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQT
                     GLVRRSRTDSLAATPPAAKCTSCRVRTASEGDGGAAGGAGTAGGRPMSVAGSPLSPGP
                     VRAPLSRSHTLSAGCGGRPSKVALAPAGGALQHSRSMSMPVAHSPPAATSPGSLSSSS
                     GHGSGSYPLPPGSHPHLPHPLHHPQCQRPSSGSASASGSPSDPGFMSLDEYGSSPGDL
                     RAFSSHRSNTPESIAETPPARDGSGGELYGYMSMDRPLSHCGRPYRRVSGDGAQDLDR
                     GLRKRTYSLTTPARQRQVPQPSSASLDEYTLMRATFSGSSGRLCPSLPASSPKVAYNP
                     YPEDYGDIEIGSHKSSSSNLGADDGYMPMTPGAALRSGGPNSCKSDDYMPMSPTSVSA
                     PKQILQPRSAAALPPSGAAVPAPPSGAGRTFPVNGGGYKASSPAESSPEDSGYMRMWC
                     GSKLSMENPDPKLLPNGDYLNMSPSEAGTAGTPPDFFSAALRPGGEALKGVPGHCYSS
                     LPRSYKAPCTCGGGDNDQYVLMSSPVGRILEEERLEPQATPGAGTFGAAGGSHTQPHH
                     SAVPSSMRPSGIVGRPEGFLGQRCRAVRPTRLSLEGLQTLPSMQEYPLPTEPKSPGEY
                     INIDFGEGGTRLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSDSRQRSPLSD
                     YMNLDFSSPKSPKPSTRSGDTVGSIDGLLSPEASSPYPPLPPRPSASPSSLQQPLPPA
                     PGDLYRLPPATAATSQGPTAGSSMSSEPGDNGDYTEMAFGVAATPPQPIAAPPKPEGA
                     RVTSPTSGLKRLSLMDQVSGVEAFLQVSQPPDPHRGAKVIRADPQGGRRRHSSETFSS
                     TTTVTPVSPSFAHNSKRHNSASVENVSLRKSSEGNSILGGSDEPSTSPGQAQPSAGVP
                     PAPQARPWNPGQPGALIGCPGGSSSPMRRETSVGFQNGLNYIAIDVRGEQGSLAQSQP
                     QHPQPGDKNSWGRTRSLGGLLGTVGGSGTSGVCGGPGTGALPSASTYASIDFLSHHLK
                     EATVVKE"
     exon            1..3979
                     /gene="Irs2"
                     /gene_synonym="4PS; IRS-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3980..6301
                     /gene="Irs2"
                     /gene_synonym="4PS; IRS-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggctagcg cgcccctgcc tgggcccccc gcgtcggcgg gcggggacgg cccgaacctc
       61 aataacaaca acaacaacaa caacaaccac agcgtgcgca agtgcggcta cctgcgcaag
      121 cagaagcacg gccacaagcg cttcttcgtg ctgcgcggcc cgggcaccgg cggcgaggag
      181 gcagccgcgg ctggggggtc gccgccgcag cctccgcggc tggagtacta tgagagcgag
      241 aagaagtgga agagcaaggc gggcgcgccg aagcgagtga tcgcgctcga ctgctgtctg
      301 aacatcaaca agcgcgcgga cgccaagcac aagtacctga tcgccctcta caccaaggac
      361 gagtacttcg ccgtagcggc ggagaacgag caggagcagg agggctggta ccgcgcactc
      421 accgacttgg tcagcgaagg ccgctctggc gatgggggct ccggcaccac gggcggctct
      481 tgcagcgcct ctctcccggg ggccctgggc ggctcggcgg gcgccgctgg ctgcgatgac
      541 aactacgggc tcgtgacgcc cgccacggca gtctaccgcg aggtgtggca ggtgaacctg
      601 aagcctaagg gactgggcca gagcaagaac ctgaccggtg tataccgcct atgcctgtct
      661 gcgcgcacca tcggcttcgt gaagctcaat tgcgaacagc cgtcggtgac gctgcagctt
      721 atgaacattc gccgctgcgg ccactcggac agcttcttct tcatcgaggt gggccgttca
      781 gccgtcaccg gtcccggcga gctgtggatg caagccgatg actcggtggt ggcgcagaac
      841 atccatgaga ccatcctgga ggccatgaag gcactcaagg agctcttcga gttccggcct
      901 cgcagcaaga gtcagtcgtc tgggtcgtct gccacgcacc ccatcagcgt accgggcgcg
      961 cgccgccacc accacctagt caacctaccc cctagccaga cgggcctggt gcgccgctct
     1021 cgcactgata gcctggcggc caccccgcca gcagccaagt gcacttcgtg ccgggttcgt
     1081 acagccagcg agggtgacgg cggcgcggca ggcggagccg ggacggcagg aggcaggccg
     1141 atgtcggtgg cagggagccc cctgagtccc gggccggtgc gcgcgcccct tagccgctcg
     1201 cacaccctga gcgccggctg cggaggccgc ccgagcaaag tggctctggc gccggcaggg
     1261 ggagccctac aacacagccg ctccatgtcc atgcccgtgg cgcactcgcc gcctgcagcc
     1321 accagcccag gcagcctgtc ctccagcagt gggcatggct caggctccta cccgctgcct
     1381 cctggttccc acccgcacct gcctcatccg ctccatcacc cccaatgcca acgtccgtcc
     1441 agcggaagtg cctccgcctc gggctccccc agcgacccgg gtttcatgtc ccttgacgag
     1501 tatggctcca gccctggtga cctgagagcc ttcagtagcc acaggagcaa cacacctgag
     1561 tccatcgcgg agaccccgcc agccagggac ggcagtgggg gcgagctcta tgggtatatg
     1621 agcatggata ggcccctgag ccactgtggc cgcccttacc gtagggtctc tggggatggg
     1681 gcccaggatc tggacagagg actgaggaag aggacttact ccctaaccac gcctgcccgg
     1741 cagcggcagg ttcctcagcc ttcctctgcc tctctagacg aatacactct catgcgggcc
     1801 accttctctg gcagttcagg tcgcctctgc ccatccctcc ctgcgtcctc tcccaaagtg
     1861 gcctacaacc cttacccaga ggactatgga gacattgaga ttggttctca caagagttcc
     1921 agcagtaacc tgggggcaga tgatggctac atgcccatga cccctggggc agccctcagg
     1981 agtggtggcc ccaatagctg caagagcgat gactacatgc ccatgagccc caccagcgtg
     2041 tctgccccta agcagatcct gcaaccacgt tcggcagcgg ccttgccccc ctctggagca
     2101 gccgtgccag cacccccttc aggggcgggc aggactttcc cagtgaacgg aggcggctac
     2161 aaagccagct ccccagcgga gagctcccca gaagatagcg ggtacatgcg aatgtggtgt
     2221 ggctccaagc tgtccatgga gaacccagac cctaagctgc tccccaatgg ggactacctc
     2281 aacatgtccc ccagtgaggc aggcaccgca gggaccccac ctgacttctt ctcagcagct
     2341 ttgcgtccag gcggtgaggc cctcaaaggc gtccctggcc actgctacag ctctttgccc
     2401 cgctcttaca aggctccctg tacttgcggt ggtggagaca acgaccagta cgtgctcatg
     2461 agctcccctg tgggtcggat tttggaagag gagagactgg agccccaggc caccccaggg
     2521 gctggcacat ttggggcagc tggtggtagt catacccagc ctcatcactc agcagtgcct
     2581 tcctccatga gaccaagtgg catcgttggc cgacctgagg gcttcctggg ccagcgctgt
     2641 cgggcagtgc ggcccacacg cctttcgcta gagggactgc agacccttcc cagcatgcaa
     2701 gagtaccctc tacccactga gcccaagagc cctggcgagt acatcaacat tgactttggt
     2761 gaagggggta cccgtctgtc tccgcctgct cccccactac tggcatcagc ggcctcctcc
     2821 tcttcactgc tctcagccag tagtcctgct tcatccctgg gttcaggtac cccaggcacc
     2881 agcagtgaca gccggcagcg ctctccgctc tctgactata tgaacctgga cttcagttct
     2941 cccaagtccc ctaagcctag cacccgcagt ggggacacag tgggctccat cgatggcctt
     3001 ctctctccag aagcctcatc cccataccca ccgctgcccc cgcgtccttc tgcttcccct
     3061 tcctccttac agcagcctct gccacctgcc ccaggagacc tataccgcct gcctccagca
     3121 acagctgcca catcccaggg tcccactgct ggctcctcaa tgtcctctga gcctggggat
     3181 aatggtgact ataccgagat ggcctttggt gtggctgcta ccccgccaca acctattgcg
     3241 gcacccccga agccagaagg tgcccgagtg accagtccca catcaggctt gaagcggcta
     3301 agtctcatgg atcaggtatc tggggtagag gccttccttc aagtcagcca gccccctgat
     3361 ccccaccggg gcgctaaggt catccgtgca gacccgcagg ggggacgtcg tcgccacagt
     3421 tcagagacct tctcctctac caccactgtc accccagtgt ccccatcctt tgctcacaat
     3481 tccaagcgcc acaattcggc ctctgtggaa aacgtctctc tcaggaaaag cagtgaaggc
     3541 aacagcatcc tgggaggaag tgatgagcca tccacatccc caggacaggc acagccctcg
     3601 gcaggtgtgc ccccagcgcc acaggctagg ccatggaacc ccggtcagcc tggagctttg
     3661 attggctgtc ctggaggcag cagttctccc atgcgcagag agacctccgt gggtttccag
     3721 aacggcctca actatatcgc catcgatgtg agaggtgagc aggggtcctt ggcgcagtct
     3781 cagcctcagc atccacagcc aggagacaag aactcctggg gccggacccg tagccttggg
     3841 gggctcctcg gtaccgttgg aggctctggc accagtggag tgtgtggggg tccaggcact
     3901 ggagccttac cctctgccag cacctacgca agcatcgact tcttgtccca tcacttgaaa
     3961 gaagccaccg tggtgaaaga gtaaagtgct gcgggctcct tcgccacctc gtcgaagact
     4021 ctgaatccat tctgaggaga tgcttagcat gtttccaacc aacgctgctc actttccttc
     4081 caacgggagc aattctacat tttgagactt ctgtgaattg tattagataa ggaaccaaga
     4141 ggcagggctt gcctctccgc tgtccccaca cacctgtcct cattgcccgg tttgcgttgc
     4201 atttcatttc ctttgtaaac taacgggctg atggagtaca ctccgggaga ttggacgttt
     4261 ccggcctcgt cagccttcat aagtcctggc cattgctgtc atttctcctg ttactttgat
     4321 tttggcaaag cggattaatc cctcagcatg caaggaaatg ctgtaataca catggaagtg
     4381 gtcaaatctg gtatttactg gcttacagtc aaaactacca cagtcctacc tcagttcagg
     4441 gtgaagccgg attgttcggc agggtacagg gcagctctgc cccaggatca catgctgacc
     4501 tccgtctctc tgttaagtag atgtggactc cagtccaggt acctaaaacg tttacctacg
     4561 cacagagcct ggtgtgggac tgacaattgt ccatgagatt ggactcaaag atggattaat
     4621 cctgataatt cctaaatgtg actggagcag cctcctttta gagatcatca gccgtatttg
     4681 ggggtctggg tggggaaggg tggatctttc tttgtatctt ttaacaggct tgttgactcc
     4741 tctctgtaga tgttcatgta agtacttcag attgcaaaag ccttttctcc cctccacaag
     4801 cctcctgtct ctgaatctta gctcgcattc ctcaaaccaa aaactcatca taggcatgct
     4861 cacagctcaa gtttggcttg ggtttttgtt tttttaaata tattatctct gacacaatgt
     4921 tacttcattg gccaacaagg ttgccctgaa caggagggga ggcattccag cagttgtact
     4981 atgaagggca aaagaagaaa gccatctctc tcccctacac ttgctcctca accgttcttg
     5041 acagagactg gttctgttgt cagtgttctg gaaatgtcag tgttgtggaa ttgtttccta
     5101 tgtcacctag aagggctgag cttgccggca gaaccgccat gaccttgctg ctccgtcaca
     5161 gggctggagg ccctgcctcc ctgaccccta acttcccagt gcctgtctcc atagtcctgt
     5221 agaggctaca ctaactcttg gaaatgtgag ttgctggctt attttttaat cgttgttttg
     5281 tttttatttg ggagaatata tatatatata tataaatata tagatatata tcactataga
     5341 gtaatgcatt ggtaaggtaa gaaggggctt ttagaggacg accaaaaaaa ttccatgtct
     5401 taaaaaaata tatttaatgg caatgcagct gtcttcctgc ttccattgct gagcttgtag
     5461 aagaaggttg tattgtaaga cacagttgaa tgtaaattga cccccaccct gcgagaactc
     5521 tcaaggtttc ccttcctgca gctacacatc ctagcggtcc acaggccaca cagcactagg
     5581 gcggaagtct gttcgggtgt gtgctatact tagagatgtt aaagggtctc ctgaaacctt
     5641 acacagtgtt gacgaggaac ctgcactgtg tttgctgtgt aactgaatcc cccagggaca
     5701 gtagggccga tctgctgact gcagcacact gaggcagatg tgacacaccc tccatgctgg
     5761 gaacggtcac cacaggacac agatgccacg tgtccctgat gcagctgaca tgagcaaaaa
     5821 agagaaatgg agaatacact aaactccccc tcccccatcc tgtacatttc aagaagagca
     5881 ggcatatgca atatttacgt ccttaattta gtttacagaa tggaaccaaa atgtgtaagt
     5941 gttacgtttg ccacacttca tgctgtatat tgggtctttg tacattttgc ttgacttaat
     6001 cttaaattta aactattttt tgctatataa actttaacag ttattaaaca gtgttttctt
     6061 tgggtacatg tttcctggat atcaagatgt taaatatatt tctcgctatt gtgtttcaaa
     6121 aagagactca ccctccctgt tgtcttccgc tgtgcgtgct gtatataggg gtcacatgat
     6181 gccgctgaag acaagaataa actggagtag tttagtatgc tgtgtttagt ctgtattgac
     6241 cgtggatgcc ctccttaata gccatatgca ataaaataaa atacattatt tatgaaatga
     6301 a
//
