LOCUS       NM_012969               5354 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus insulin receptor substrate 1 (Irs1), mRNA.
ACCESSION   NM_012969
VERSION     NM_012969.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5354)
  AUTHORS   Su,X., Yang,X. and Liu,H.
  TITLE     Long Non-coding RNA SPAG5-AS1 Attenuates Diabetic Retinal Vascular
            Dysfunction by Inhibiting Human Retinal Microvascular Endothelial
            Cell Proliferation, Migration, and Tube Formation by Regulating the
            MicroRNA-1224-5p/IRS-1 Axis
  JOURNAL   Mol Biotechnol 65 (6), 904-912 (2023)
   PUBMED   36346578
  REMARK    GeneRIF: Long Non-coding RNA SPAG5-AS1 Attenuates Diabetic Retinal
            Vascular Dysfunction by Inhibiting Human Retinal Microvascular
            Endothelial Cell Proliferation, Migration, and Tube Formation by
            Regulating the MicroRNA-1224-5p/IRS-1 Axis.
REFERENCE   2  (bases 1 to 5354)
  AUTHORS   He,C.T., Lei,Y., Du,J.R., Jia,J.J., Hu,Q. and Niu,Q.
  TITLE     [Effect of miR-96-5p targeting IRS1 on apoptosis of PC12 cells
            induced by aluminum maltol]
  JOURNAL   Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 41 (5), 324-332
            (2023)
   PUBMED   37248076
  REMARK    GeneRIF: [Effect of miR-96-5p targeting IRS1 on apoptosis of PC12
            cells induced by aluminum maltol].
REFERENCE   3  (bases 1 to 5354)
  AUTHORS   Sanchez-Sarasua,S., Meseguer-Beltran,M., Garcia-Diaz,C.,
            Beltran-Bretones,M.T., ElMlili,N. and Sanchez-Perez,A.M.
  TITLE     IRS1 expression in hippocampus is age-dependent and is required for
            mature spine maintenance and neuritogenesis
  JOURNAL   Mol Cell Neurosci 118, 103693 (2022)
   PUBMED   34942345
  REMARK    GeneRIF: IRS1 expression in hippocampus is age-dependent and is
            required for mature spine maintenance and neuritogenesis.
REFERENCE   4  (bases 1 to 5354)
  AUTHORS   Cao,Q., Li,X., Xuan,X., Huang,S. and Xie,X.
  TITLE     Changes of LRP6/beta-catenin pathway in adipose tissue of rats with
            intrauterine growth restriction with catch-up growth
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 50 (6), 755-761 (2021)
   PUBMED   35347917
  REMARK    GeneRIF: Changes of LRP6/beta-catenin pathway in adipose tissue of
            rats with intrauterine growth restriction with catch-up growth.
REFERENCE   5  (bases 1 to 5354)
  AUTHORS   Tian,S., Tan,S., Jia,W., Zhao,J. and Sun,X.
  TITLE     Activation of Wnt/beta-catenin signaling restores insulin
            sensitivity in insulin resistant neurons through transcriptional
            regulation of IRS-1
  JOURNAL   J Neurochem 157 (3), 467-478 (2021)
   PUBMED   33336396
  REMARK    GeneRIF: Activation of Wnt/beta-catenin signaling restores insulin
            sensitivity in insulin resistant neurons through transcriptional
            regulation of IRS-1.
REFERENCE   6  (bases 1 to 5354)
  AUTHORS   Kharitonenkov,A., Schnekenburger,J., Chen,Z., Knyazev,P., Ali,S.,
            Zwick,E., White,M. and Ullrich,A.
  TITLE     Adapter function of protein-tyrosine phosphatase 1D in insulin
            receptor/insulin receptor substrate-1 interaction
  JOURNAL   J Biol Chem 270 (49), 29189-29193 (1995)
   PUBMED   7493946
REFERENCE   7  (bases 1 to 5354)
  AUTHORS   Sun,X.J., Crimmins,D.L., Myers,M.G. Jr., Miralpeix,M. and
            White,M.F.
  TITLE     Pleiotropic insulin signals are engaged by multisite
            phosphorylation of IRS-1
  JOURNAL   Mol Cell Biol 13 (12), 7418-7428 (1993)
   PUBMED   7504175
REFERENCE   8  (bases 1 to 5354)
  AUTHORS   Backer,J.M., Myers,M.G. Jr., Shoelson,S.E., Chin,D.J., Sun,X.J.,
            Miralpeix,M., Hu,P., Margolis,B., Skolnik,E.Y., Schlessinger,J. et
            al.
  TITLE     Phosphatidylinositol 3'-kinase is activated by association with
            IRS-1 during insulin stimulation
  JOURNAL   EMBO J 11 (9), 3469-3479 (1992)
   PUBMED   1380456
REFERENCE   9  (bases 1 to 5354)
  AUTHORS   Sun,X.J., Rothenberg,P., Kahn,C.R., Backer,J.M., Araki,E.,
            Wilden,P.A., Cahill,D.A., Goldstein,B.J. and White,M.F.
  TITLE     Structure of the insulin receptor substrate IRS-1 defines a unique
            signal transduction protein
  JOURNAL   Nature 352 (6330), 73-77 (1991)
   PUBMED   1648180
REFERENCE   10 (bases 1 to 5354)
  AUTHORS   Rothenberg,P.L., Lane,W.S., Karasik,A., Backer,J., White,M. and
            Kahn,C.R.
  TITLE     Purification and partial sequence analysis of pp185, the major
            cellular substrate of the insulin receptor tyrosine kinase
  JOURNAL   J Biol Chem 266 (13), 8302-8311 (1991)
   PUBMED   2022647
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012969.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X58375.1, SRR26643296.24734.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984017 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4309              JAXUCZ010000009.1  91049651-91053959   c
            4310-5354           JAXUCZ010000009.1  91001137-91002181   c
FEATURES             Location/Qualifiers
     source          1..5354
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q34"
     gene            1..5354
                     /gene="Irs1"
                     /gene_synonym="IRS1IRM"
                     /note="insulin receptor substrate 1"
                     /db_xref="GeneID:25467"
                     /db_xref="RGD:2922"
     exon            1..4309
                     /gene="Irs1"
                     /gene_synonym="IRS1IRM"
                     /inference="alignment:Splign:2.1.0"
     CDS             581..4288
                     /gene="Irs1"
                     /gene_synonym="IRS1IRM"
                     /note="IRS-1; pp185"
                     /codon_start=1
                     /product="insulin receptor substrate 1"
                     /protein_id="NP_037101.2"
                     /db_xref="GeneID:25467"
                     /db_xref="RGD:2922"
                     /translation="MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARL
                     EYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAE
                     QDSWYQALLQLHNRAKAHHDGAGGGCGGSCSGSSGVGEAGEDLSYDTGPGPAFKEVWQ
                     VILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFI
                     EVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSSCSNPIS
                     VPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRP
                     ASVDGSPVSPSTNRTHAHRHRGSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSST
                     SGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPP
                     ARGEEELSNYICMGGKGASTLTAPNGHYILSRGGNGHRYIPGATMGTSPALTGDEAAG
                     AADLDNRFRKRTHSAGTSPTISHQKTPSQSSVVSIEEYTEMMPAAYPPGGGSGGRLPG
                     YRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDSSNLHTDDGYMPMSPGVAPVPSNRKG
                     NGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGSCSPDIGGGSCSSSSIS
                     AAPSGSSYGKPWTNGVGGHHTHALPHAKPPVESGGGKLLPCTGDYMNMSPVGDSNTSS
                     PSECYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSSSSGRLRYTAT
                     AEDSSSSTSSDSLGGGYCGARPESSVTHPHHHALQPHLPRKVDTAAQTNSRLARPTRL
                     SLGDPKASTLPRVREQQQQQQQQQQSSLHPPEPKSPGEYVNIEFGSGQPGYLAGPATS
                     RSSPSVRCLPQLHPAPREETGSEEYMNMDLGPGRRATWQESGGVELGRVGPAPPGAAS
                     ICRPTRSVPNSRGDYMTMQIGCPRQSYVDTSPVAPVSYADMRTGIAAEKVSLPRTTGA
                     APPPSSTASASASVTPQGAAEQAAHSSLLGGPQGPGGMSAFTRVNLSPNHNQSAKVIR
                     ADTQGCRRRHSSETFSAPTRAGNTVSFGAGAAGGGSGGGSEDVKRHSSASFENVWLRP
                     GDLGGASKESAPGYGAAGGLEKSLNYIDLDLVKDVKQHPQDCPSQQQSLPPPPPHQPL
                     GSNEGSSPRRSSEDLSTYASINFQKQPEDRQ"
     exon            4310..5354
                     /gene="Irs1"
                     /gene_synonym="IRS1IRM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggtatttg ggcggctggt ggcggcgggg actgttggag ggtgggagga ggcagaggag
       61 gaggaggaga aggaggagga gggagaaccc cgtgcaacgt tgggacttgg cagcccgcct
      121 ccccctgccc aaggatattt aatttgcctg gggaatcgct acttccagag gggaactcgg
      181 gagggaagga gcgcgcgcct ggagggccaa gcggggactc ctccggtcgt ctctgcctcc
      241 ctgcatcgga ctctaccagg ggcggcaagg gatgcaccat agctccttct ctgctgcaag
      301 gactggggga gacttagtcc tcggaagatt gcggctgcac tcaccctaga cccactgcct
      361 ttccctctgg gcatgaaacg cccttaaact cggatcaggc tatcttcctt tggcgcagct
      421 acctcgtcct tcggctgccc ctccccagcg ccaggaacgg cgtgaatttc ggagtcaggg
      481 tttctgcttg cttcctccag cccggagtgc atgtgcgggg ccgcaccgag aagccacccc
      541 tcacccagtt tttcgacacc tccctctgct ccgcagcagc atggcgagcc ctccggatac
      601 cgatggcttc tcagacgtgc gcaaggtggg ttacctgcgc aaacccaaga gtatgcataa
      661 gcgctttttc gtgctgcggg cggccagcga ggccgggggc ccggcgcgcc tggagtatta
      721 tgagaacgag aagaagtggc ggcacaagtc gagcgccccc aaacgctcga tccccctcga
      781 gagctgtttc aacatcaaca agcgggctga ctccaagaac aagcacctgg tggctctcta
      841 cacccgagac gaacactttg ccattgcggc ggatagcgag gctgaacaag acagctggta
      901 ccaggctctt ctgcagctgc ataatcgggc aaaggcccac catgacgggg ctggaggagg
      961 ctgcggtggt agctgcagcg gcagctctgg cgtcggagag gcaggggagg acttgagcta
     1021 tgacacgggc ccaggacccg cgttcaagga ggtctggcag gttatcctga aacccaaggg
     1081 cttaggtcag acaaagaact tgattggtat ctaccgcctc tgcctgacca gcaagaccat
     1141 cagctttgtg aagctcaact ctgaggctgc cgctgtggtg ctgcagctga tgaacatcag
     1201 acgctgtggc cactcagaga acttcttctt catcgaggtg gggcggtcag ctgtgaccgg
     1261 gcccggcgag ttctggatgc aagtggatga ctccgtggtg gcccagaaca tgcatgagac
     1321 cattctagag gccatgcggg ccatgagcga tgagtttcgc ccgcgcagca aaagccaatc
     1381 ttcatccagt tgctccaacc ccatcagtgt tcccctgcgc aggcaccatc tcaacaatcc
     1441 tccgcccagc caagtggggc tgactcggag atctcgaact gagagcatca ctgccacctc
     1501 ccctgccagt atggtgggtg ggaaaccagg ttccttcagg gtgcgtgcct ccagcgatgg
     1561 cgaaggcacc atgtcccgtc cagcatcagt ggatggcagt cctgtgagcc ctagcaccaa
     1621 caggacccac gcccatcggc atcgaggcag ctccaggttg caccccccac tcaaccacag
     1681 ccgctccatc cctatgcctt cttcacgatg ctccccttca gccaccagcc cagtgagcct
     1741 gtcatccagt agtaccagtg gccacggctc cacttcagac tgtctcttcc cgaggcgctc
     1801 tagtgcttcc gtgtccggtt ctcctagcga tggcggtttc atctcttctg atgagtatgg
     1861 ctctagtccc tgcgatttcc gaagttcctt ccgcagtgtc accccagatt ccctgggcca
     1921 caccccacca gccaggggtg aggaggagct gagcaactat atctgcatgg gtggcaaggg
     1981 agcctccacc ttgacagctc ccaatggtca ctacattttg tctaggggtg gcaacggcca
     2041 tcgctacatc ccaggtgcta ccatggggac aagcccggcg ctgactggag acgaagccgc
     2101 tggtgcagca gatctggata accggtttcg gaagagaact cactcggctg gcacgtcccc
     2161 caccatatcc caccagaaga ccccctcgca gtcctcagtg gtttctattg aggaatatac
     2221 agagatgatg cccgctgcct acccaccagg aggtggcagt ggaggccgac tgcccggcta
     2281 ccggcattcc gccttcgtgc ccacccactc ctatcccgag gagggtctag agatgcacca
     2341 cttggaacgt cgtgggggcc accaccgtcc agactcctcc aacctccaca ccgatgatgg
     2401 ctacatgccc atgtctcccg gagtggctcc agtgcccagc aaccgcaaag gaaatgggga
     2461 ctatatgccc atgagcccca agagtgtatc tgccccccag cagatcatta accccatcag
     2521 gcgccaccca cagagagtgg accccaatgg ctacatgatg atgtctccca gtggtagttg
     2581 ctctcctgac attggaggtg ggtcttgcag cagtagcagc atcagcgcag ccccttctgg
     2641 gagcagctat gggaagccat ggacaaacgg agtagggggg caccataccc atgcccttcc
     2701 ccatgccaaa cctcctgttg agagcggtgg tggtaagctc ttgccttgca ctggtgacta
     2761 catgaacatg tcgccagtgg gagattccaa caccagcagc ccctcagaat gctactatgg
     2821 cccagaagat ccccagcaca agcctgtcct ctcctactac tcattaccaa ggtcctttaa
     2881 gcacacccag cgccctgggg agccagagga gggtgccagg caccagcatc ttcgtctctc
     2941 ttcaagctct ggacgccttc gctataccgc aactgccgaa gattcctcct cttccaccag
     3001 cagcgacagc ctgggtgggg gttactgtgg ggctaggcca gagtctagcg tcacacatcc
     3061 ccaccaccat gccttgcagc cccatctgcc tcgaaaggta gacacagctg cacagaccaa
     3121 cagccgcctg gctcgaccca caaggctgtc cttgggggat cccaaggcaa gcactttacc
     3181 ccgggtacga gagcaacagc agcagcagca acagcagcag cagtcttccc tgcaccctcc
     3241 cgagcccaaa agcccaggag aatatgtgaa tattgaattc gggagtggcc agccaggcta
     3301 tttagctggc cctgcaactt cccgtagctc cccttcagtt cgatgtctac cccagctcca
     3361 cccagctccc agagaagaga ctggctcgga agagtacatg aacatggact tggggccagg
     3421 ccggagggca acctggcagg agagtggtgg agttgagttg ggcagagtag gccctgcacc
     3481 tccaggggct gcttccattt gtaggccaac ccggtcggtg ccaaatagcc gtggtgatta
     3541 catgaccatg cagataggtt gtcctcgtca aagctatgtg gatacctcac cagtggcccc
     3601 agtcagctat gctgacatgc ggacaggcat tgctgcagag aaggtgagcc tgcccagaac
     3661 cacaggagct gccccccctc catcctccac agcctctgct tctgcttctg ttacacctca
     3721 aggggccgct gagcaggccg ctcactcttc cttgctggga ggccctcagg gacctggggg
     3781 catgagcgca ttcaccaggg tgaacctaag tcccaaccat aaccagagtg ccaaagtgat
     3841 tcgtgcagac actcaaggct gccggaggag gcacagctcc gagaccttct cggcgcctac
     3901 gcgggctggc aacacagtgt cttttggagc aggggctgca ggagggggca gcggtggtgg
     3961 cagtgaggat gtgaaacgcc acagctctgc atcctttgag aatgtgtggc tgagacccgg
     4021 ggatctaggg ggagcatcca aggagtcggc tccagggtac ggggctgccg ggggattgga
     4081 gaagagtctt aactatatag acttggattt ggtcaaggat gttaagcagc accctcaaga
     4141 ctgcccctct caacagcagt ccctgccacc ccctccccct caccaaccct taggcagcaa
     4201 tgagggcagc tccccaagac gctccagtga ggatttaagc acctatgcca gcatcaactt
     4261 ccagaagcaa ccagaggacc gtcaatagct taactggacg tcacagcaga atgaagacct
     4321 aaatgacctc agcaatcctc ctttttaact catgggtacc cagactcgaa ctctttcacg
     4381 attcacaacc aggacctcac gtcttcctcc tcagtagatg gtacgatgca tcccttacag
     4441 tttgtttact ttgtacaatc ctcaggagtt cattgactga actgcacgtt ctttattgtg
     4501 ccaagcaaca agaaagcact gtgacaccgg aacaatgagt gtgcataaac ttcatcttga
     4561 actttaagga cagctggcca cgaagagcca gtgtgctccc tgccacgccg aaagaggatg
     4621 ggtttactct cgtcaaattt acaagcatac ggttcctcta ctctgaaacc gtgttccatg
     4681 acacgccgct gtaaattatt tcatatggaa ctgttcgcgt tgggtggaga gagtattaaa
     4741 tatttaacat aggtcttgat ttatatatgt aattttttaa tgaaaatgta actttcctca
     4801 cagcacattt tttttttctc ttggaatgtg gaactgaggt attcaatgtt ttgttttaaa
     4861 gagtgggaag aatacttaaa acaaggctaa aaagagtaga ctaggagatg atccttgttt
     4921 taagattcta attcagaaaa ataatataat atgaatcata gtgccataga aggttctgga
     4981 ctgtatagtt gtacttgctg atgctgtctc ttgtaatata aacttgatgt cgagctgagt
     5041 tccttttaag aattaagctt agttttgtaa tttttttttt ttccaaaccg aaggaggatg
     5101 tattctactg gggtgttttc aagtgtcggc ttagaattgg aagttgaatg gaagcaaagt
     5161 tcaacaaaga gaggaagcca cagacttcca ttgtaaatac tgtagagaga gacatgagcg
     5221 atcccttcaa gtcaaaaatc tctctttgga atgaagaatg tgggtgttta taaattctga
     5281 aaatgtcttt ctgttcataa taaactagac actgttggtc cctccccacc cccacttcta
     5341 taagcctttc cccc
//
