LOCUS       NM_001012007            2240 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus immunity-related GTPase M (Irgm), mRNA.
ACCESSION   NM_001012007 XM_220360
VERSION     NM_001012007.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2240)
  AUTHORS   Hansen,M.D., Johnsen,I.B., Stiberg,K.A., Sherstova,T., Wakita,T.,
            Richard,G.M., Kandasamy,R.K., Meurs,E.F. and Anthonsen,M.W.
  TITLE     Hepatitis C virus triggers Golgi fragmentation and autophagy
            through the immunity-related GTPase M
  JOURNAL   Proc Natl Acad Sci U S A 114 (17), E3462-E3471 (2017)
   PUBMED   28389568
REFERENCE   2  (bases 1 to 2240)
  AUTHORS   Chauhan,S., Mandell,M.A. and Deretic,V.
  TITLE     IRGM governs the core autophagy machinery to conduct antimicrobial
            defense
  JOURNAL   Mol Cell 58 (3), 507-521 (2015)
   PUBMED   25891078
REFERENCE   3  (bases 1 to 2240)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian
            interferon-gamma-inducible GTPases
  JOURNAL   Funct Integr Genomics 12 (4), 599-607 (2012)
   PUBMED   22892676
  REMARK    Review article
REFERENCE   4  (bases 1 to 2240)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   5  (bases 1 to 2240)
  AUTHORS   Zhao,Y.O., Konen-Waisman,S., Taylor,G.A., Martens,S. and
            Howard,J.C.
  TITLE     Localisation and mislocalisation of the interferon-inducible
            immunity-related GTPase, Irgm1 (LRG-47) in mouse cells
  JOURNAL   PLoS One 5 (1), e8648 (2010)
   PUBMED   20072621
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2240)
  AUTHORS   Trost,M., English,L., Lemieux,S., Courcelles,M., Desjardins,M. and
            Thibault,P.
  TITLE     The phagosomal proteome in interferon-gamma-activated macrophages
  JOURNAL   Immunity 30 (1), 143-154 (2009)
   PUBMED   19144319
REFERENCE   7  (bases 1 to 2240)
  AUTHORS   Singh,S.B., Davis,A.S., Taylor,G.A. and Deretic,V.
  TITLE     Human IRGM induces autophagy to eliminate intracellular
            mycobacteria
  JOURNAL   Science 313 (5792), 1438-1441 (2006)
   PUBMED   16888103
REFERENCE   8  (bases 1 to 2240)
  AUTHORS   Collazo,C.M., Yap,G.S., Sempowski,G.D., Lusby,K.C., Tessarollo,L.,
            Vande Woude,G.F., Sher,A. and Taylor,G.A.
  TITLE     Inactivation of LRG-47 and IRG-47 reveals a family of interferon
            gamma-inducible genes with essential, pathogen-specific roles in
            resistance to infection
  JOURNAL   J Exp Med 194 (2), 181-188 (2001)
   PUBMED   11457893
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079106.1.
            
            On Feb 11, 2005 this sequence version replaced XM_220360.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079106.1, CK476330.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2240
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..2240
                     /gene="Irgm"
                     /gene_synonym="Ifggd3; Ifi1"
                     /note="immunity-related GTPase M"
                     /db_xref="GeneID:303090"
                     /db_xref="RGD:1305163"
     exon            1..293
                     /gene="Irgm"
                     /gene_synonym="Ifggd3; Ifi1"
                     /inference="alignment:Splign:2.1.0"
     exon            294..518
                     /gene="Irgm"
                     /gene_synonym="Ifggd3; Ifi1"
                     /inference="alignment:Splign:2.1.0"
     CDS             492..1727
                     /gene="Irgm"
                     /gene_synonym="Ifggd3; Ifi1"
                     /note="interferon inducible protein 1;
                     interferon-gamma-inducible GTPase Ifggd3 protein;
                     immunity-related GTPase family, M"
                     /codon_start=1
                     /product="immunity-related GTPase family M protein"
                     /protein_id="NP_001012007.1"
                     /db_xref="GeneID:303090"
                     /db_xref="RGD:1305163"
                     /translation="MKPSHKSCEAAPLLPKMPETSTHNAPLNLSFPSVPSYQIGCSSL
                     PEISRSTERALKEGKLPELVYGVKETVATLSQIPVSIFVTGDSGNGMSSFINALRIIG
                     HEEDASAPTGVVRTTQTRAEYSSSHFPNVVLWDLPGLGATAQTVENYIEEMKFSTCDL
                     FIIVASEQFSSNHVKLAKIIQSMGKRFYVIWTKLDRDLSTSVLSEVRLIQNIQENIRE
                     NLQKEGVKEVPIFLVSNLDPLLHDFPELRNTLQTDLSNIRCCEPLKTLYVIYEKIIGD
                     KVANWNQIIANGRLKSSLGVRDDDDMGECLKRYRLIFGIDDESLQQIAHGMGTVVMEY
                     KANIKSQDFHTLRRADWKLRLMTCTTVNALFCLFKFLPCLCHCFKRMRHKRMLLLVAK
                     DTKNILKKILMDAVSPPQI"
     exon            519..2209
                     /gene="Irgm"
                     /gene_synonym="Ifggd3; Ifi1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccggctggg ccctggcaaa cagatctcag atctagaaac tgcaggacaa actgcttaga
       61 gaccagaggc agaaaggaaa tccacccgat cagacctcgt cttggttcac tcctctcaga
      121 actccagacc tctgcatctc atctctaaac atccgggtct agattccagt tctgggtctc
      181 tctgtagaga acttttgccg gaggaccgca acgtttattt ctaagaaaga aggagggggt
      241 gacgttacag gaagcccact aacattgaat cacacataac tcttctggat cagggtttga
      301 ggagtattaa gtgagataag gcattcgaag gaaccaactc agattcaaga cacaggacct
      361 tcttgctgtg tgcttagagt ctaagagtgg aggaagaacc tgaggaacgg cttcctcaga
      421 gaccctaata aaaccagaga gcctcaccag ggagctgaga ggtgcccaga aagcatcaca
      481 cggatcttgt catgaaacca tcacacaagt cctgcgaggc tgctccacta ctccccaaga
      541 tgccagagac cagtacccat aatgctccac tgaacttgtc cttcccctcc gtcccttcat
      601 accaaatagg ctgtagcagt ttgcctgaga tcagtaggag cactgaaaga gctttaaaag
      661 aaggaaaact accggaactg gtctatggag tcaaggagac tgtggcaaca ttgtcccaaa
      721 tcccagtgag catcttcgtg actggggact cgggcaatgg catgtcatct ttcatcaatg
      781 cacttcgaat cattggccat gaggaagatg cctcggctcc cactggggta gtaaggacca
      841 cccagacacg ggctgagtac tcctcatccc actttcccaa tgtggtactg tgggacctac
      901 ctggattggg ggccacagcc caaaccgtag agaactatat agaagagatg aaattcagta
      961 cgtgtgactt attcatcatc gtcgcctcgg agcagttcag ctcaaatcac gtgaagctgg
     1021 ccaaaatcat ccagagcatg ggaaagaggt tctatgtcat ctggaccaag ctggaccggg
     1081 acctcagcac gagcgtccta tcagaggtcc ggctcataca gaatatccag gagaatatac
     1141 gggagaatct ccagaaggag ggagtgaagg aagttcccat attcctagta tccaatctag
     1201 accctctcct gcatgacttc ccggaactta ggaacacact tcagacagac ctgtccaaca
     1261 tcaggtgctg tgaaccctta aagacccttt atgtcattta tgagaagatc atcggtgaca
     1321 aagtagccaa ctggaaccag ataatagcca acgggcgctt gaagagttct ctcggggtca
     1381 gagatgatga tgacatgggg gagtgtctga aaaggtaccg attgatattt ggtatcgatg
     1441 atgaatcact tcagcagata gctcacggta tggggacagt agtcatggag tacaaggcca
     1501 acataaagtc ccaagacttc cacactctcc gcagagcgga ctggaaactg cggctgatga
     1561 cctgtacaac tgtgaatgca ctcttctgtt tgtttaaatt tctcccgtgc ttatgccact
     1621 gtttcaaacg catgagacat aaacgcatgc tcctcttagt tgccaaggac accaagaaca
     1681 tcctgaagaa aatcctgatg gacgctgtct ctccaccgca aatctagtgt aagggtggcc
     1741 tggtaccctt cttttcatat agagccaatt acctcttcct tagatcccta tttctccact
     1801 agaaatcaag agataaattc tttgatagga gttagtcatg atggactcat ccccccccca
     1861 cccagactct aatgtattgt tctactgagg aacagggaca agtaatgatt aaaaatcaat
     1921 gactgggggc tgacaagatg gctcactggc tgctcttcca caggtcctga gttcagttcc
     1981 cagcaaccac atggtgactc acaaccatct ttaggaaaat ctgatgcctt cttcaggcag
     2041 gcggatgtat atgcagcaga gcactcatat attaaataaa taaactttaa aaaaatcaat
     2101 gaccatgatt cttagatgga atatagacat tttgttttca gctattaagt gtgatttatg
     2161 tctaaatcaa ttttcctctg aaacaataaa gtcggttggt tcctcttcaa aaaaaaaaaa
     2221 aaaaaaaaaa aaaaaaaaaa
//
