LOCUS       NM_001012041            1630 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus interferon regulatory factor 9 (Irf9), mRNA.
ACCESSION   NM_001012041 XM_224190
VERSION     NM_001012041.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1630)
  AUTHORS   Liu Y, Sun Y, Xue BH, Wang XD and Yu WL.
  TITLE     Negative Regulation of SIRT1 by IRF9 Involved in Hyperlipidemia
            Acute Pancreatitis Associated with Kidney Injury
  JOURNAL   Dig Dis Sci 66 (4), 1063-1071 (2021)
   PUBMED   32462510
REFERENCE   2  (bases 1 to 1630)
  AUTHORS   Xue BH, Liu Y, Chen H, Sun Y and Yu WL.
  TITLE     A novel function of IRF9 in acute pancreatitis by modulating cell
            apoptosis, proliferation, migration, and suppressing SIRT1-p53
  JOURNAL   Mol Cell Biochem 472 (1-2), 125-134 (2020)
   PUBMED   32577948
  REMARK    GeneRIF: A novel function of IRF9 in acute pancreatitis by
            modulating cell apoptosis, proliferation, migration, and
            suppressing SIRT1-p53.
REFERENCE   3  (bases 1 to 1630)
  AUTHORS   Wan W, Ding Y, Xie Z, Li Q, Yan F, Budbazar E, Pearce WJ, Hartman
            R, Obenaus A, Zhang JH, Jiang Y and Tang J.
  TITLE     PDGFR-beta modulates vascular smooth muscle cell phenotype via
            IRF-9/SIRT-1/NF-kappaB pathway in subarachnoid hemorrhage rats
  JOURNAL   J Cereb Blood Flow Metab 39 (7), 1369-1380 (2019)
   PUBMED   29480757
  REMARK    GeneRIF: study shows that Platelet-derived growth factor
            receptor-beta/interferon regulatory factor 9/sirtuin 1/NF-kappaB
            signaling played a role in the vascular smooth muscle cell
            phenotypic transformation after subarachnoid hemorrhage
REFERENCE   4  (bases 1 to 1630)
  AUTHORS   Huber M, Suprunenko T, Ashhurst T, Marbach F, Raifer H, Wolff S,
            Strecker T, Viengkhou B, Jung SR, Obermann HL, Bauer S, Xu HC, Lang
            PA, Tom A, Lang KS, King NJC, Campbell IL and Hofer MJ.
  TITLE     IRF9 Prevents CD8+ T Cell Exhaustion in an Extrinsic Manner during
            Acute Lymphocytic Choriomeningitis Virus Infection
  JOURNAL   J Virol 91 (22), e01219-17 (2017)
   PUBMED   28878077
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1630)
  AUTHORS   Lee AJ, Chen B, Chew MV, Barra NG, Shenouda MM, Nham T, van Rooijen
            N, Jordana M, Mossman KL, Schreiber RD, Mack M and Ashkar AA.
  TITLE     Inflammatory monocytes require type I interferon receptor signaling
            to activate NK cells via IL-18 during a mucosal viral infection
  JOURNAL   J Exp Med 214 (4), 1153-1167 (2017)
   PUBMED   28264883
REFERENCE   6  (bases 1 to 1630)
  AUTHORS   Li W, Hofer MJ, Jung SR, Lim SL and Campbell IL.
  TITLE     IRF7-dependent type I interferon production induces lethal
            immune-mediated disease in STAT1 knockout mice infected with
            lymphocytic choriomeningitis virus
  JOURNAL   J Virol 88 (13), 7578-7588 (2014)
   PUBMED   24760883
REFERENCE   7  (bases 1 to 1630)
  AUTHORS   Rajsbaum R, Versteeg GA, Schmid S, Maestre AM, Belicha-Villanueva
            A, Martinez-Romero C, Patel JR, Morrison J, Pisanelli G, Miorin L,
            Laurent-Rolle M, Moulton HM, Stein DA, Fernandez-Sesma A, tenOever
            BR and Garcia-Sastre A.
  TITLE     Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin
            ligase TRIM6 stimulates the interferon-IKKepsilon kinase-mediated
            antiviral response
  JOURNAL   Immunity 40 (6), 880-895 (2014)
   PUBMED   24882218
REFERENCE   8  (bases 1 to 1630)
  AUTHORS   Jiang DS, Luo YX, Zhang R, Zhang XD, Chen HZ, Zhang Y, Chen K,
            Zhang SM, Fan GC, Liu PP, Liu DP and Li H.
  TITLE     Interferon regulatory factor 9 protects against cardiac hypertrophy
            by targeting myocardin
  JOURNAL   Hypertension 63 (1), 119-127 (2014)
   PUBMED   24144649
REFERENCE   9  (bases 1 to 1630)
  AUTHORS   Hofer MJ, Li W, Manders P, Terry R, Lim SL, King NJ and Campbell
            IL.
  TITLE     Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+
            T-cell-mediated disease following infection with lymphocytic
            choriomeningitis virus
  JOURNAL   J Virol 86 (12), 6932-6946 (2012)
   PUBMED   22496215
REFERENCE   10 (bases 1 to 1630)
  AUTHORS   Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada
            N, Ohba Y, Takaoka A, Yoshida N and Taniguchi T.
  TITLE     IRF-7 is the master regulator of type-I interferon-dependent immune
            responses
  JOURNAL   Nature 434 (7034), 772-777 (2005)
   PUBMED   15800576
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079454.1.
            
            On Feb 11, 2005 this sequence version replaced XM_224190.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079454.1, SRR8487227.186255.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1630
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..1630
                     /gene="Irf9"
                     /gene_synonym="Isgf3g"
                     /note="interferon regulatory factor 9"
                     /db_xref="GeneID:305896"
                     /db_xref="RGD:1308766"
     exon            1..21
                     /gene="Irf9"
                     /gene_synonym="Isgf3g"
                     /inference="alignment:Splign:2.1.0"
     exon            22..202
                     /gene="Irf9"
                     /gene_synonym="Isgf3g"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1219
                     /gene="Irf9"
                     /gene_synonym="Isgf3g"
                     /note="interferon dependent positive acting transcription
                     factor 3 gamma"
                     /codon_start=1
                     /product="interferon regulatory factor 9"
                     /protein_id="NP_001012041.1"
                     /db_xref="GeneID:305896"
                     /db_xref="RGD:1308766"
                     /translation="MATGKARCTRKLRNWIVEQVESGQFPGVCWDDAAKTMFRIPWKH
                     AGKQDFREDQDAAIFKAWALFKEKHKDGDIGNPAVWKTRLRCALNKSSEFEEVPERGR
                     MDVAEPYKVYRILPAGTLPTQPRNQKSPFKRSISSVSPERGECKENGIVSHSDSGSNV
                     CGGGSNGGGSSDSCGSTSSSELEEGAGTTEATVQEDPVFMENPLPPNSDYSLLLTFIY
                     GGRVVHEIQVHSLDCRLVAEPSDPESSMVQQVVFPRPDPLEPTQSLLNQLERGILVAS
                     NSRGLFVQRLCPIPISWNAPEAPPGPGPHLLPSNKCVELFSTTYFCRDLAQYFQGQGP
                     LPKYQATLHFWDRSPSSSYTQENLITVRMEQAFARNLLEKIPEEEKAALFLVQHTEHQ
                     PATLAL"
     exon            203..386
                     /gene="Irf9"
                     /gene_synonym="Isgf3g"
                     /inference="alignment:Splign:2.1.0"
     exon            387..460
                     /gene="Irf9"
                     /gene_synonym="Isgf3g"
                     /inference="alignment:Splign:2.1.0"
     exon            461..575
                     /gene="Irf9"
                     /gene_synonym="Isgf3g"
                     /inference="alignment:Splign:2.1.0"
     exon            576..647
                     /gene="Irf9"
                     /gene_synonym="Isgf3g"
                     /inference="alignment:Splign:2.1.0"
     exon            648..992
                     /gene="Irf9"
                     /gene_synonym="Isgf3g"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1108
                     /gene="Irf9"
                     /gene_synonym="Isgf3g"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1599
                     /gene="Irf9"
                     /gene_synonym="Isgf3g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtacatcct cggtcgctca ggatggccac aggcaaagca cgctgtaccc gaaagctccg
       61 gaactggata gtggaacagg tggaaagtgg gcagttccca ggggtgtgct gggacgacgc
      121 agccaagacc atgttccgga ttccctggaa gcacgcaggc aagcaagact tccgagaaga
      181 ccaggatgct gccatattca aggcctgggc actgtttaag gaaaagcaca aagacgggga
      241 cataggaaac cctgctgtct ggaagactcg cctacgctgt gccctcaaca agagttccga
      301 atttgaggag gttcccgaga gaggccggat ggatgttgca gaaccctaca aagtatatcg
      361 aatactgcca gcaggaaccc tccccaccca accaagaaac cagaaatcgc cattcaagcg
      421 aagtatcagt tctgtgtcac ctgagagggg agagtgtaag gaaaatggga ttgtaagcca
      481 ctcagacagc ggcagcaatg tctgtggtgg tggcagcaac ggtggcggca gcagtgacag
      541 ctgtggcagc accagcagct ctgagctaga ggaaggagct ggcacaactg aagccaccgt
      601 tcaagaggac ccagtgttca tggagaatcc gcttcctccg aactcagact actcgctgct
      661 gctcaccttc atctatggcg ggcgcgtggt gcatgagatc caggtgcaca gcctagactg
      721 tcggcttgtg gctgagccct cagacccgga gagcagcatg gtgcagcagg tggtgtttcc
      781 cagacctgac ccactggagc ccacccagag cctgctgaat cagctcgaga gaggcatcct
      841 ggtggccagc aattccagag gcctctttgt tcagcgcctc tgccccatcc ccatctcctg
      901 gaacgcaccc gaggccccac ctgggcctgg gcctcatctg ctgcccagca ataagtgtgt
      961 ggagctcttc agtaccacat acttctgtag agatttggcc cagtacttcc agggccaggg
     1021 acctctaccc aagtaccaag caacactgca tttctgggac aggagtccta gctctagcta
     1081 tacccaagag aatcttatca cggtgcggat ggagcaggcc tttgcccgaa atttactaga
     1141 gaagattcca gaagaggaga aagctgcctt gttcctggta cagcacacag agcaccaacc
     1201 tgccactctc gcactctgat cctcgggtcc ccgttgaaat agacttgttc tccacaccgt
     1261 tggtctgcct gctttcgtga tgattcttat cactgtgggc tttccaatgt ggccaagaga
     1321 aagtgcaagg ataactttta tcttcaaaaa ctattctgag agccagactc gttggtggat
     1381 attcataatc tcagcactgg attatgagtt caaggacaac ctgggggaga cttctatttc
     1441 ctttttctaa agctatatct tctttcattt ctaagaaact ggaaagttcc aaagggtgtg
     1501 atctcagagg aaattttgct atcctcccaa tccctaactc taaacctaag ctgtatgtat
     1561 gtgtgtatgt atatatataa atatatattt cccccctcaa aaaaaaaaaa aaaaaaaaaa
     1621 aaaaaaaaaa
//
