LOCUS       NM_001008722            2860 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus interferon regulatory factor 8 (Irf8), mRNA.
ACCESSION   NM_001008722 XM_006255737 XM_226538
VERSION     NM_001008722.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2860)
  AUTHORS   Lyu,C., Zhou,J., Wu,Q. and Fang,X.
  TITLE     Spinal Interferon Regulatory Factor 8 and Brain-derived
            Neurotrophic Factor in the Prefrontal Cortex are Involved in
            Pain-induced Depression Relief via Ultrasound-guided Pulsed
            Radiofrequency in a Rat Spared Nerve Injury Model
  JOURNAL   Pain Physician 26 (2), 187-196 (2023)
   PUBMED   36988364
  REMARK    GeneRIF: Spinal Interferon Regulatory Factor 8 and Brain-derived
            Neurotrophic Factor in the Prefrontal Cortex are Involved in
            Pain-induced Depression Relief via Ultrasound-guided Pulsed
            Radiofrequency in a Rat Spared Nerve Injury Model.
REFERENCE   2  (bases 1 to 2860)
  AUTHORS   Shi,G., Zhang,Z., Ma,S., Li,Y., Du,S., Chu,Y., Li,Y., Tang,X.,
            Yang,Y., Chen,Z., Wang,Z. and Wu,H.
  TITLE     Hepatic interferon regulatory factor 8 expression mediates liver
            ischemia/reperfusion injury in mice
  JOURNAL   Biochem Pharmacol 192, 114728 (2021)
   PUBMED   34400126
REFERENCE   3  (bases 1 to 2860)
  AUTHORS   Fang,X., Xu,X., Lin,X. and Liu,R.
  TITLE     Downregulated spinal IRF8 and BDNF in NAC are involved in
            neuropathic pain-induced depression relief via pulsed
            radiofrequency on dorsal root ganglion in rat SNI model
  JOURNAL   Brain Res Bull 146, 192-200 (2019)
   PUBMED   30639279
  REMARK    GeneRIF: The suppressed overexpression of the spinal IRF8 and BDNF
            in NAc may play an important role and contribute considerably to
            effectiveness of the therapy by PRF on DRG.
REFERENCE   4  (bases 1 to 2860)
  AUTHORS   Guo,C., Pei,L., Xiao,X., Wei,Q., Chen,J.K., Ding,H.F., Huang,S.,
            Fan,G., Shi,H. and Dong,Z.
  TITLE     DNA methylation protects against cisplatin-induced kidney injury by
            regulating specific genes, including interferon regulatory factor 8
  JOURNAL   Kidney Int 92 (5), 1194-1205 (2017)
   PUBMED   28709638
  REMARK    GeneRIF: DNA methylation plays a protective role in
            cisplatin-induced acute kidney injury by regulating specific genes,
            such as Irf8.
REFERENCE   5  (bases 1 to 2860)
  AUTHORS   Qiu,Y., Zhu,Y., Yu,H., Yi,S., Su,W., Cao,Q., Yuan,G., Kijlstra,A.
            and Yang,P.
  TITLE     Ocular Behcet's disease is associated with aberrant methylation of
            interferon regulatory factor 8 (IRF8) in monocyte-derived dendritic
            cells
  JOURNAL   Oncotarget 8 (31), 51277-51287 (2017)
   PUBMED   28881647
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2860)
  AUTHORS   Alter-Koltunoff,M., Goren,S., Nousbeck,J., Feng,C.G., Sher,A.,
            Ozato,K., Azriel,A. and Levi,B.Z.
  TITLE     Innate immunity to intraphagosomal pathogens is mediated by
            interferon regulatory factor 8 (IRF-8) that stimulates the
            expression of macrophage-specific Nramp1 through antagonizing
            repression by c-Myc
  JOURNAL   J Biol Chem 283 (5), 2724-2733 (2008)
   PUBMED   18045875
  REMARK    Erratum:[J Biol Chem. 2008 Aug 8;283(32):22336]
REFERENCE   7  (bases 1 to 2860)
  AUTHORS   Nakano,N., Nishiyama,C., Masuoka,N., Nishiyama,M., Yamane,H.,
            Okumura,K. and Ogawa,H.
  TITLE     Analysis of PU.1/ICSBP (IRF-8) complex formation with various PU.1
            mutants: molecular cloning of rat Icsbp (Irf-8) cDNA
  JOURNAL   Immunogenetics 56 (12), 871-877 (2005)
   PUBMED   15688197
  REMARK    GeneRIF: cloning and interaction with PU.1 mutants
REFERENCE   8  (bases 1 to 2860)
  AUTHORS   Aliberti,J., Schulz,O., Pennington,D.J., Tsujimura,H., Reis e
            Sousa,C., Ozato,K. and Sher,A.
  TITLE     Essential role for ICSBP in the in vivo development of murine
            CD8alpha + dendritic cells
  JOURNAL   Blood 101 (1), 305-310 (2003)
   PUBMED   12393690
REFERENCE   9  (bases 1 to 2860)
  AUTHORS   Scharton-Kersten,T., Contursi,C., Masumi,A., Sher,A. and Ozato,K.
  TITLE     Interferon consensus sequence binding protein-deficient mice
            display impaired resistance to intracellular infection due to a
            primary defect in interleukin 12 p40 induction
  JOURNAL   J Exp Med 186 (9), 1523-1534 (1997)
   PUBMED   9348310
REFERENCE   10 (bases 1 to 2860)
  AUTHORS   Weisz,A., Marx,P., Sharf,R., Appella,E., Driggers,P.H., Ozato,K.
            and Levi,B.Z.
  TITLE     Human interferon consensus sequence binding protein is a negative
            regulator of enhancer elements common to interferon-inducible genes
  JOURNAL   J Biol Chem 267 (35), 25589-25596 (1992)
   PUBMED   1460054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On or before Sep 13, 2022 this sequence version replaced
            XM_006255737.4, NM_001008722.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.76786.1,
                                           SRR26643290.53237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000019.1  65699284-65699333
            51-225              JAXUCZ010000019.1  65702889-65703063
            226-409             JAXUCZ010000019.1  65706805-65706988
            410-498             JAXUCZ010000019.1  65708668-65708756
            499-604             JAXUCZ010000019.1  65710251-65710356
            605-652             JAXUCZ010000019.1  65711391-65711438
            653-1033            JAXUCZ010000019.1  65716505-65716885
            1034-1149           JAXUCZ010000019.1  65718726-65718841
            1150-2860           JAXUCZ010000019.1  65719356-65721066
FEATURES             Location/Qualifiers
     source          1..2860
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2860
                     /gene="Irf8"
                     /gene_synonym="ICSBP; Icsbp1"
                     /note="interferon regulatory factor 8"
                     /db_xref="GeneID:292060"
                     /db_xref="RGD:1312024"
     exon            1..50
                     /gene="Irf8"
                     /gene_synonym="ICSBP; Icsbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            51..225
                     /gene="Irf8"
                     /gene_synonym="ICSBP; Icsbp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1326
                     /gene="Irf8"
                     /gene_synonym="ICSBP; Icsbp1"
                     /note="transcription factor ICSBP; interferon consensus
                     sequence binding protein 1"
                     /codon_start=1
                     /product="interferon regulatory factor 8"
                     /protein_id="NP_001008722.1"
                     /db_xref="GeneID:292060"
                     /db_xref="RGD:1312024"
                     /translation="MCDRNGGRRLRQWLIEQIDSSMYPGLIWESEEKTLFRIPWKHAG
                     KQDYNQEVDASIFKAWAVFKGKFKEGDKAEPATWKTRLRCALNKSPDFEEVTDRSQLD
                     ISEPYKVYRIVPEEEQKCKLGVAPAGCMSDVTEMECGRSEIEELIKEPSVDEYMGIAK
                     RSPSPPEACRSQILPDWWAQQPNAGLPLVTGYTAYDAHHSALSQMVINFYYGGKLVGQ
                     ATTTSLEGCRLSLSQPGLPKLYGPDGLEPVCFPAADTIPSERQRQVTRKLFGHLERGV
                     LLHSNRKGVFVKRLCQGRVFCSGNAVVCKGRPNKLERDEVVQVFDTNMFLRDLQQFYA
                     TQSRLPDSRVVLCFGEEFPDTAPLRSKLILVQVEQLYARQMVEEAGKSCGAGSLMPAL
                     EEPQPDQAFRMFPDICTSHQRPFFRENQQITV"
     exon            226..409
                     /gene="Irf8"
                     /gene_synonym="ICSBP; Icsbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            410..498
                     /gene="Irf8"
                     /gene_synonym="ICSBP; Icsbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..604
                     /gene="Irf8"
                     /gene_synonym="ICSBP; Icsbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..652
                     /gene="Irf8"
                     /gene_synonym="ICSBP; Icsbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..1033
                     /gene="Irf8"
                     /gene_synonym="ICSBP; Icsbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1149
                     /gene="Irf8"
                     /gene_synonym="ICSBP; Icsbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..2860
                     /gene="Irf8"
                     /gene_synonym="ICSBP; Icsbp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcccgcgg ccggtcgcgg aggcgcgggc agcgtgggaa ccggtggcag gatgtgtgac
       61 cggaatggcg ggcggcggct gcgacagtgg ctgatcgaac agattgacag cagcatgtac
      121 ccggggctga tctgggagag tgaggagaag accctgttcc gcatcccctg gaaacacgca
      181 ggcaagcaag actacaacca ggaagtggac gcttcaatct tcaaggcctg ggcagttttt
      241 aaagggaagt ttaaagaggg agacaaagct gagccagcca cgtggaagac acggttacgc
      301 tgcgctctga acaagagccc ggattttgaa gaggtgaccg accggtccca gctggacatt
      361 tccgagccat acaaagttta ccgaatcgtc cccgaggaag agcaaaaatg caagctgggc
      421 gtggcacctg cgggctgcat gagcgacgtc acggagatgg agtgtggccg ttcagagatc
      481 gaggagctga tcaaggagcc ttctgtggat gaatacatgg gaatagccaa aaggagccca
      541 tcccctccag aggcctgcag gagccagatc ctccctgact ggtgggccca gcagcccaac
      601 gcaggcctgc cactggtgac tgggtatact gcctatgacg cacaccattc agccttatcc
      661 cagatggtga tcaactttta ctacgggggc aagctggtgg gccaggccac caccacctcc
      721 cttgagggct gccgcctatc cctgagccag ccggggctgc cgaagctgta tgggccggac
      781 ggcctggagc ccgtgtgctt cccggcggcg gacaccatcc ccagtgagcg gcagaggcag
      841 gtgacccgga agctgtttgg acacctggag cgcggcgtgc tcctgcacag caaccgcaag
      901 ggtgtgttcg tgaagcggct gtgccagggc cgcgtgttct gcagcggcaa cgcggtggtg
      961 tgcaagggta gacccaacaa gctggagcgg gatgaggtgg tgcaggtctt tgacaccaac
     1021 atgttcctcc gagacctgca gcagttctac gccacccaga gccgcctgcc tgatagcagg
     1081 gtggttctgt gctttgggga ggagtttcca gacacagcgc ccttgcgctc caaactcatt
     1141 ctggtgcagg tagagcagct gtatgccagg cagatggtgg aggaagcggg caagagctgt
     1201 ggggcaggct ccctgatgcc agccctggag gaaccccagc cagaccaggc ctttcggatg
     1261 tttccagata tctgtacctc acaccagaga ccctttttca gagaaaatca acagatcacc
     1321 gtctaagcct caatccgggc accccacctc acccaagctc aagtttcaag attctgtgac
     1381 taagagaatt ctggatggac gtggacccct ctgactgggc tgggcgggtg tcctcagagg
     1441 ggcctcagga agctcacaga tggacaagct cttgctcagg caggagtcag aagcttgcag
     1501 gggcagtggt cagaacctgt gatcaaagca ttcctttcct gcatttaccc ccttcaccat
     1561 tagtggctgg ccttctttct gcatgctgag gtctttgtca catggtgatg gctctaatca
     1621 tctggtgaca gcagatctgc ctttgtcctt ttctggttga gggtaaaaat gtatgacttt
     1681 ctctgcttga ttgtagacaa agagacttta ctgttcaggc cttttctttt agtttttggt
     1741 ccgaagtctg agaaaataag ttgacaatat tttttccccc aaatgggttt caattttaaa
     1801 atggtttcac actctctacc gtaaatcact ttaggccttt cctgtgaagt ggggtcgatt
     1861 gtaaatatgg gtgtggacac tgtgagcttc gcaggaattt tggttgcggc tcatcgattc
     1921 ccatgactct gtgtcagctg acagggctgt atggggcatc gtaggaccag gcactgtgga
     1981 gaggagtgtg ccgttcactg gcatctcacc ctttccttgt cctgctccac acccagtcct
     2041 aagacccagt gaaaagcaat atccaaactg ctctgggctc agaagtgcct gtccatgtac
     2101 cagggaaagg gtatgcatcc tacaaagcag actcagagcg gaaaacccac cctcagcccg
     2161 gtttgcgccc ccaatctgac tgtccaatct aaatcggtga ctgcagtcct gcctaaggga
     2221 cactttctgt aggagtccct gtcaagggtt tagtttgcat cagtacacag caggtacaga
     2281 ggccaagcag atgtggggac agggaacatc attatctcct tttgtgtgag gacaggagag
     2341 accttttcta tttgttctac tctgtaacca acctgggtta caggctcagt gcagttagag
     2401 gagcctctaa tgtgctcagc attccctggg gaagggcagg gaacgcctta acctgttgac
     2461 tgttgttctg agaagtgggg agaagcagga gggtgtggaa gacagtccgg tgcagctacg
     2521 agtgataggc cacaccttac aacctgaaaa gttaaggacg ttggtgacat tcatggtgaa
     2581 tggtgctggg tgtgggtcct gttccacagt cagggtcacc atagtatgtg actcatgaaa
     2641 acagaatcct ggggtctgct tctccccact cagccaaagc aggaacatct cttccaaagc
     2701 caggacgacc tgttcactgg ccccttgtca cacgccacgc cccccacctg cctcacagag
     2761 tacaagtgtg cccaactctg taatccaaat atttattttt gtattcactt aaaaagtatt
     2821 gttctcatct tttattaaaa caagttgctt tttcataaaa
//
