LOCUS       NM_001033691            1985 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus interferon regulatory factor 7 (Irf7), mRNA.
ACCESSION   NM_001033691 XM_215121
VERSION     NM_001033691.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1985)
  AUTHORS   Ling,X., Wei,S., Ling,D., Cao,S., Chang,R., Wang,Q. and Yuan,Z.
  TITLE     Irf7 regulates the expression of Srg3 and ferroptosis axis
            aggravated sepsis-induced acute lung injury
  JOURNAL   Cell Mol Biol Lett 28 (1), 91 (2023)
   PUBMED   37946128
  REMARK    GeneRIF: Irf7 regulates the expression of Srg3 and ferroptosis axis
            aggravated sepsis-induced acute lung injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1985)
  AUTHORS   Deng,Y., Guo,S.L., Li,J.Q., Xie,S.S., Zhou,Y.C., Wei,B., Wang,Q.
            and Wang,F.
  TITLE     Interferon regulatory factor 7 inhibits rat vascular smooth muscle
            cell proliferation and inflammation in monocrotaline-induced
            pulmonary hypertension
  JOURNAL   Life Sci 264, 118709 (2021)
   PUBMED   33152351
  REMARK    GeneRIF: Interferon regulatory factor 7 inhibits rat vascular
            smooth muscle cell proliferation and inflammation in
            monocrotaline-induced pulmonary hypertension.
REFERENCE   3  (bases 1 to 1985)
  AUTHORS   Ren,Y., Zhao,Y., Lin,D., Xu,X., Zhu,Q., Yao,J., Shu,H.B. and
            Zhong,B.
  TITLE     The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression
            of Usp25 Gene
  JOURNAL   J Biol Chem 291 (25), 13206-13215 (2016)
   PUBMED   27129230
REFERENCE   4  (bases 1 to 1985)
  AUTHORS   Li,W., Hofer,M.J., Jung,S.R., Lim,S.L. and Campbell,I.L.
  TITLE     IRF7-dependent type I interferon production induces lethal
            immune-mediated disease in STAT1 knockout mice infected with
            lymphocytic choriomeningitis virus
  JOURNAL   J Virol 88 (13), 7578-7588 (2014)
   PUBMED   24760883
REFERENCE   5  (bases 1 to 1985)
  AUTHORS   Wang,J., Yang,B., Hu,Y., Zheng,Y., Zhou,H., Wang,Y., Ma,Y., Mao,K.,
            Yang,L., Lin,G., Ji,Y., Wu,X. and Sun,B.
  TITLE     Negative regulation of Nmi on virus-triggered type I IFN production
            by targeting IRF7
  JOURNAL   J Immunol 191 (6), 3393-3399 (2013)
   PUBMED   23956435
REFERENCE   6  (bases 1 to 1985)
  AUTHORS   Takaoka,A., Wang,Z., Choi,M.K., Yanai,H., Negishi,H., Ban,T.,
            Lu,Y., Miyagishi,M., Kodama,T., Honda,K., Ohba,Y. and Taniguchi,T.
  TITLE     DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of
            innate immune response
  JOURNAL   Nature 448 (7152), 501-505 (2007)
   PUBMED   17618271
REFERENCE   7  (bases 1 to 1985)
  AUTHORS   Sgarbanti,M., Marsili,G., Remoli,A.L., Orsatti,R. and Battistini,A.
  TITLE     IRF-7: new role in the regulation of genes involved in adaptive
            immunity
  JOURNAL   Ann N Y Acad Sci 1095, 325-333 (2007)
   PUBMED   17404045
REFERENCE   8  (bases 1 to 1985)
  AUTHORS   Kawai,T., Takahashi,K., Sato,S., Coban,C., Kumar,H., Kato,H.,
            Ishii,K.J., Takeuchi,O. and Akira,S.
  TITLE     IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I
            interferon induction
  JOURNAL   Nat Immunol 6 (10), 981-988 (2005)
   PUBMED   16127453
REFERENCE   9  (bases 1 to 1985)
  AUTHORS   Honda,K., Yanai,H., Negishi,H., Asagiri,M., Sato,M., Mizutani,T.,
            Shimada,N., Ohba,Y., Takaoka,A., Yoshida,N. and Taniguchi,T.
  TITLE     IRF-7 is the master regulator of type-I interferon-dependent immune
            responses
  JOURNAL   Nature 434 (7034), 772-777 (2005)
   PUBMED   15800576
REFERENCE   10 (bases 1 to 1985)
  AUTHORS   Caillaud,A., Prakash,A., Smith,E., Masumi,A., Hovanessian,A.G.,
            Levy,D.E. and Marie,I.
  TITLE     Acetylation of interferon regulatory factor-7 by p300/CREB-binding
            protein (CBP)-associated factor (PCAF) impairs its DNA binding
  JOURNAL   J Biol Chem 277 (51), 49417-49421 (2002)
   PUBMED   12374802
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC104686.1.
            
            On Sep 25, 2005 this sequence version replaced XM_215121.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104686.1, SRR8487226.211659.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN06680451
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1985
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1985
                     /gene="Irf7"
                     /note="interferon regulatory factor 7"
                     /db_xref="GeneID:293624"
                     /db_xref="RGD:1307828"
     exon            1..417
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..1771
                     /gene="Irf7"
                     /codon_start=1
                     /product="interferon regulatory factor 7"
                     /protein_id="NP_001028863.1"
                     /db_xref="GeneID:293624"
                     /db_xref="RGD:1307828"
                     /translation="MAEVRGVQRVLFGDWLLGEVSSGRYEGLQWLNEAHTVFRVPWKH
                     FSRRDLDEADAQIFKAWAVARGRWPPSGVNLPPPEAEAAERRGWKTNFRCALRSTGRF
                     ILRQDNSGDPADPHKVYELSPELGSTTGPALENREEVTLSSALPTQGMSLGSFLARGN
                     AGLQTPSPLLSGDAGDLLLQVLQYSHLLDSESRADSVPPQASGQEQEHLPEEPHAAWQ
                     MEATSSPRLQHPVLMTERNLGSLDVTIMYKGRTVLQAMVGHPRCVFLYSPVGSAIRTS
                     EPQPVIFPSPAELPDQKQLHYTETLLQHVSPGLQLELRGPSLWALRMGKCKVYWEVGS
                     PMGSTNPSTPAQLLERNCHTPIFDFSTFFRELEEFRARRRQGSPHYTIYLGFGQDLSA
                     GRPKEKSLILVKLEPWLCKTHLEGVQREGVSSLDSSSLGLCLSSTNSLYDDIEHFLMD
                     LGQWA"
     exon            418..580
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
     exon            581..791
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
     exon            792..847
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1010
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1106
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1496
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1615
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1959
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagggtccag cctgtgacag cccatccagg cccggacgct ggatcaacac ctgtgacatc
       61 acatgtgcgc tcccgctgct acatctgtag tcacatctac agccaccttg gcctaggaat
      121 ccacacttaa attgggaacc taggtggcta taagttctca aacctcatct gtgaccctca
      181 acaccctaat acctgggtca cacttgtgaa acttcaattc ccacctgtga ccaacaatcc
      241 taacgtttaa aacatattta tgaaacttgg ttacactatc tgtggctaaa accataaaga
      301 cacccaaggg actcttacct tatttgtaat actgcctcag tgactgcaag tcatcagagt
      361 agtagcacct actttctccc agactgcccg tgtagaagga gcaatggccg aagtgagggg
      421 ggtccagcga gtgctgttcg gagactggct cttgggtgag gtcagtagtg gccggtacga
      481 ggggctgcag tggctgaatg aggctcacac agtcttccgt gtgccctgga agcatttcag
      541 ccgtagggat ctggatgaag ctgatgcaca gatcttcaag gcctgggctg tggcccgagg
      601 gaggtggcca cctagtggag ttaacttacc acccccagag gctgaggctg ctgagcgaag
      661 aggctggaag accaacttcc gatgtgcact ccgcagcaca gggcgcttta tcttgcgtca
      721 agacaactca ggggaccctg ctgatccgca caaggtgtat gaacttagcc cggagcttgg
      781 atctacaact ggcccagctc tggagaacag ggaagaagtg accctcagca gtgccctacc
      841 cacacagggt atgtccctag gatcattcct ggcaagagga aatgctgggt tgcaaacccc
      901 aagccctctg ctttctggtg atgctgggga cctcttgctt caggttctgc aatacagcca
      961 cctactggac tctgagtcta gggcggactc agtcccacca caggcttctg gccaggagca
     1021 agaacacctt cctgaggagc cccatgcagc atggcagatg gaagctacct ccagccccag
     1081 gcttcaacac ccagttctga tgactgagcg caaccttggg tccctggatg tgaccatcat
     1141 gtacaagggc cgcacagtgc tacaggcaat ggtggggcac cccagatgcg tgttcctgta
     1201 tagccccgtg ggctcagcaa taagaacttc agagccccag ccggtgattt ttccgagccc
     1261 cgctgagctc ccagatcaga agcagctgca ctacacagag actctcctac agcatgtgtc
     1321 tccaggcctt cagctggagc ttcgggggcc atcactatgg gccctgcgaa tgggcaagtg
     1381 caaggtgtac tgggaggtgg gcagccctat gggctccacc aacccctcca ccccagccca
     1441 gctgctggag cgcaactgcc atactcccat ctttgacttc agcactttct tccgagaact
     1501 ggaggagttc cgggcccgga ggcgacaagg atcaccacat tacaccatct acctgggttt
     1561 tgggcaagac ttgtcagcag ggaggcccaa ggagaagagc ctgatcctgg tgaagctgga
     1621 gccatggctg tgcaagacac atctggaagg cgtgcagcgt gagggtgtgt cctctctgga
     1681 cagcagcagt cttggcctgt gcttgtctag caccaatagt ctctacgatg acattgaaca
     1741 cttcctcatg gacctgggtc agtgggcttg attcagaacc ccaacttcca atagagttca
     1801 gaaccactgc tgccctggct caggcttatt ccttggctat atgtcatctc tagtggacct
     1861 tgtggagtcc cttgaaagaa ggtgaccccc cactccctac acactaggcc tcctttgtag
     1921 cactcatctt tacaataaag aattggttgg gttaccataa aaaaaaaaaa aaaaaaaaaa
     1981 aaaaa
//
