LOCUS       NM_001108859            4044 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus interferon regulatory factor 6 (Irf6), mRNA.
ACCESSION   NM_001108859 XM_001067431 XM_344194
VERSION     NM_001108859.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4044)
  AUTHORS   Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S,
            Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A,
            Ginno PA, Domcke S, Yan J, Schubeler D, Vinson C and Taipale J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   2  (bases 1 to 4044)
  AUTHORS   Lin Y, Xu D, Li X, Liu C, Liu X, Huang S, Huang Y and Liu X.
  TITLE     Upregulation of Interferon Regulatory Factor 6 Promotes Neuronal
            Apoptosis After Traumatic Brain Injury in Adult Rats
  JOURNAL   Cell Mol Neurobiol 36 (1), 27-36 (2016)
   PUBMED   26077898
  REMARK    GeneRIF: IRF6 might promote neuronal apoptosis by inhibiting Akt
            phosphorylation after Traumatic Brain Injury.
REFERENCE   3  (bases 1 to 4044)
  AUTHORS   Botti E, Spallone G, Moretti F, Marinari B, Pinetti V, Galanti S,
            De Meo PD, De Nicola F, Ganci F, Castrignano T, Pesole G, Chimenti
            S, Guerrini L, Fanciulli M, Blandino G, Karin M and Costanzo A.
  TITLE     Developmental factor IRF6 exhibits tumor suppressor activity in
            squamous cell carcinomas
  JOURNAL   Proc Natl Acad Sci U S A 108 (33), 13710-13715 (2011)
   PUBMED   21807998
REFERENCE   4  (bases 1 to 4044)
  AUTHORS   Stottmann RW, Moran JL, Turbe-Doan A, Driver E, Kelley M and Beier
            DR.
  TITLE     Focusing forward genetics: a tripartite ENU screen for
            neurodevelopmental mutations in the mouse
  JOURNAL   Genetics 188 (3), 615-624 (2011)
   PUBMED   21515572
REFERENCE   5  (bases 1 to 4044)
  AUTHORS   Nikopensius T, Jagomagi T, Krjutskov K, Tammekivi V, Saag M, Prane
            I, Piekuse L, Akota I, Barkane B, Krumina A, Ambrozaityte L,
            Matuleviciene A, Kucinskiene ZA, Lace B, Kucinskas V and Metspalu
            A.
  TITLE     Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to
            nonsyndromic cleft palate
  JOURNAL   Birth Defects Res A Clin Mol Teratol 88 (9), 748-756 (2010)
   PUBMED   20672350
REFERENCE   6  (bases 1 to 4044)
  AUTHORS   Bailey CM, Abbott DE, Margaryan NV, Khalkhali-Ellis Z and Hendrix
            MJ.
  TITLE     Interferon regulatory factor 6 promotes cell cycle arrest and is
            regulated by the proteasome in a cell cycle-dependent manner
  JOURNAL   Mol Cell Biol 28 (7), 2235-2243 (2008)
   PUBMED   18212048
REFERENCE   7  (bases 1 to 4044)
  AUTHORS   Richardson RJ, Dixon J, Malhotra S, Hardman MJ, Knowles L,
            Boot-Handford RP, Shore P, Whitmarsh A and Dixon MJ.
  TITLE     Irf6 is a key determinant of the keratinocyte
            proliferation-differentiation switch
  JOURNAL   Nat Genet 38 (11), 1329-1334 (2006)
   PUBMED   17041603
REFERENCE   8  (bases 1 to 4044)
  AUTHORS   Ingraham CR, Kinoshita A, Kondo S, Yang B, Sajan S, Trout KJ, Malik
            MI, Dunnwald M, Goudy SL, Lovett M, Murray JC and Schutte BC.
  TITLE     Abnormal skin, limb and craniofacial morphogenesis in mice
            deficient for interferon regulatory factor 6 (Irf6)
  JOURNAL   Nat Genet 38 (11), 1335-1340 (2006)
   PUBMED   17041601
REFERENCE   9  (bases 1 to 4044)
  AUTHORS   Bailey CM, Khalkhali-Ellis Z, Kondo S, Margaryan NV, Seftor RE,
            Wheaton WW, Amir S, Pins MR, Schutte BC and Hendrix MJ.
  TITLE     Mammary serine protease inhibitor (Maspin) binds directly to
            interferon regulatory factor 6: identification of a novel serpin
            partnership
  JOURNAL   J Biol Chem 280 (40), 34210-34217 (2005)
   PUBMED   16049006
REFERENCE   10 (bases 1 to 4044)
  AUTHORS   Kondo S, Schutte BC, Richardson RJ, Bjork BC, Knight AS, Watanabe
            Y, Howard E, de Lima RL, Daack-Hirsch S, Sander A, McDonald-McGinn
            DM, Zackai EH, Lammer EJ, Aylsworth AS, Ardinger HH, Lidral AC,
            Pober BR, Moreno L, Arcos-Burgos M, Valencia C, Houdayer C, Bahuau
            M, Moretti-Ferreira D, Richieri-Costa A, Dixon MJ and Murray JC.
  TITLE     Mutations in IRF6 cause Van der Woude and popliteal pterygium
            syndromes
  JOURNAL   Nat Genet 32 (2), 285-289 (2002)
   PUBMED   12219090
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473985.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_344194.3, XM_001067431.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4044
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     gene            1..4044
                     /gene="Irf6"
                     /note="interferon regulatory factor 6"
                     /db_xref="GeneID:364081"
                     /db_xref="RGD:1309645"
     exon            1..146
                     /gene="Irf6"
                     /inference="alignment:Splign:2.1.0"
     exon            147..323
                     /gene="Irf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1553
                     /gene="Irf6"
                     /codon_start=1
                     /product="interferon regulatory factor 6"
                     /protein_id="NP_001102329.1"
                     /db_xref="GeneID:364081"
                     /db_xref="RGD:1309645"
                     /translation="MALHPRRVRLKPWLVAQVDSGLYPGLIWLHRDSKRFQIPWKHAT
                     RHSPQQEEENTIFKAWAVETGKYQEGVDDPDPAKWKAQLRCALNKSREFNLMYDGTKE
                     VPMNPVKIYQVCDIPQPQGSVINPGSTGSAPWDEKDNDVDEDDEEDELEQSQHHVPIQ
                     DTFPFLNINGSPMAPASVGNCSVGNCSPESVWPKTEPLEMEVPQAPIQPFYSSPELWI
                     SSLPMTDLDIKFQYRGKEYGQTMTVSNPQGCRLFYGDLGPMPDQEELFGPVSLEQVKF
                     PGPEHITNEKQKLFTSKLLDVMDRGLILEVSGHAIYAIRLCQCKVYWSGPCAPSLAAP
                     NLIERQKKVKLFCLETFLSELIAHQKGQIEKQPPFEIYLCFGEEWPDGKPLERKLILV
                     QVIPVVARMIYEMFSGDFTRSFDSGSVRLQISTPDIKDNIVAQLKQLYRILQTQESWQ
                     PMQPAPSMQLPPALPAQ"
     exon            324..528
                     /gene="Irf6"
                     /inference="alignment:Splign:2.1.0"
     exon            529..657
                     /gene="Irf6"
                     /inference="alignment:Splign:2.1.0"
     exon            658..816
                     /gene="Irf6"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1209
                     /gene="Irf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1328
                     /gene="Irf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..4044
                     /gene="Irf6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accgggcacc gaggtgggca ggtgcgggcc tgtgcgggcc gcagaggagc ccgcggttcc
       61 cagccgtgcc tagccgtcgg gagagctcct gtgctgcggt ggcgagaact cctgtgcacc
      121 tgttcctgag caccgactga ggccagagca tggccctcca ccctcgaaga gtccggctga
      181 agccctggct ggtggcccag gtggacagtg gcctctaccc tggtctcatc tggctacata
      241 gagattccaa acgcttccag atcccctgga aacatgccac gcggcacagc ccccaacaag
      301 aggaagaaaa caccattttt aaggcttggg ctgtggagac tggaaagtac caggaagggg
      361 tggacgatcc tgacccagct aaatggaagg ctcagctccg atgtgctctc aacaaaagcc
      421 gggaattcaa cttgatgtat gacggcacca aggaagtgcc catgaatcct gtgaagatct
      481 atcaagtgtg tgacatcccc cagccccagg gctctgtcat taacccagga tccacagggt
      541 ctgctccttg ggatgagaaa gataatgatg tggatgaaga tgacgaggaa gatgaacttg
      601 aacagtcaca gcaccacgtc ccgatccagg acaccttccc cttcctgaac atcaatggtt
      661 ctcccatggc accagccagc gtgggcaact gcagtgtggg aaactgcagc cctgaatcag
      721 tgtggcccaa aacagaacct ctggaaatgg aagtaccgca ggcacccatt cagcccttct
      781 atagttctcc agagctgtgg atcagctccc tccccatgac tgacttggac atcaagtttc
      841 agtatcgtgg gaaggagtat gggcaaacca tgacggtgag caacccccag ggctgccggc
      901 tcttctatgg ggacctgggc cccatgcctg accaggagga gctctttggt cctgtcagcc
      961 tggagcaggt caagttcccg gggccagagc atatcaccaa tgagaagcag aagctgttca
     1021 ccagtaagct gttggatgtc atggacaggg gactgatcct ggaggtcagc ggacatgcca
     1081 tttatgccat ccggctgtgc cagtgcaaag tgtactggtc ggggccgtgt gccccctcac
     1141 ttgctgctcc taacctgatt gagaggcaga agaaggtcaa gttgttttgt ctggaaacat
     1201 tcctgagtga gctcattgcc catcagaaag ggcagataga gaagcagcca cctttcgaga
     1261 tttacttatg cttcggggaa gaatggccag atggaaagcc cctggagagg aagctcatct
     1321 tggtccaggt cattccagtg gtggctcgca tgatctatga gatgttttct ggtgatttca
     1381 cccggtcctt tgacagtggc agtgttcgcc tgcagatttc cactccagac atcaaagata
     1441 acatcgtcgc tcagctcaag cagctgtacc gcatccttca aacccaggag agctggcagc
     1501 ccatgcagcc tgcccccagc atgcagctgc cgcctgccct gcctgcccag tgacccagac
     1561 tcctgtgcat gtcctcttct ctcctctctc ttgttttttt atattgtata taaggatttt
     1621 ttaaaaattc agatttagtc aacttttaat ctcctttcta taacatcatt agaagtctga
     1681 ggctttccaa atatgcctag ttttataagt tcctctaact tatcaagata tcatcctctg
     1741 agggggttcc ttttagatct tccatggttg gtgtaggaga aatttgattt ggaagtttag
     1801 acacgaggac tctagctgtt tccatctgac tttagataga tcatttaact ggagggggtc
     1861 agatgcatca ctcataaata aaaaaaaggt ttggaatgat gcccaaaatt gtattcagcc
     1921 ttaaaactca actattttcc tatacttgta taagacataa ctgcctggaa caggactctt
     1981 ctgcattgtt cttagaccac tttttccccc ttctttcatc caagttcctt gagcactgat
     2041 ctgatctgaa ctgagttctg tttgacctgt tctgctagta gtcagctggc tccctgctgg
     2101 gggaagtgag agaggagctg attggttgcc tagcaaccag tcttgatatc taaatagaga
     2161 tggtgccaag gtctgaaagt cacccaacct gtgtgtggag taaaagctca taaagtgaat
     2221 gtcgaagggg aagctggtga cacggaaggc tgaaggattc catgagagaa tggttgccag
     2281 cggaggggtt ccatgggagc atcgtcatca gccatgtacc tcatcaccac tcacgccacc
     2341 tagtatttgg gttttgatga gcagctgtga ctccatgtgt ctcacggcaa acactcttct
     2401 cttcctcatt tttttctcaa agacgaatct ggagggagtc aggcatctag gatatgctct
     2461 gacaacaaaa tggatggttt ttgggcagag acttccaggg gtcttcctga catttggatt
     2521 tttccatttg tgaaaaatta ggtgttgcgt atgttaaagg tctggacggt gctcttccag
     2581 gaaaggctca aacttgctta gatcactagc tgtgagcaac ggagacagtg aagaacagtg
     2641 cagctatgtc ttacagagtg tcggccccag tcccttctca gaatttgagt tccaagactt
     2701 ggatgaaaag caaaattcgt ctctctggtt atagccccca atcctcttga gtactggtat
     2761 ctatttgttt tatgtcacag ggaccatgcc cccctgtacg gtctgctgcc cttacactaa
     2821 gggtagcatc ttctgctttt caagccaccg aaagttggga tgcatttgaa gtctaaaagc
     2881 tcaacctaat cttgggtgac agtgagactt acttaggatg cttaagcttt ggtttgaagt
     2941 tctcttagag attgttaaaa ggaagaccaa gagacatctg agtgagttaa gacaggcagg
     3001 tgtctgtgtg aataagagca aagtacaatt gtatacccat agccatagta tgaaaatgtc
     3061 agagtaatta taaatgtttg aagagaagtt taggtaaaag tttaaaagct ggacttttat
     3121 agaccaggaa acatgcaagg cctacggact ttattctttt tttttggagg aatgagtagc
     3181 gtcatttggt gagatgaagt gagggagtct tggtatgggg atgcttcatc tggaagttca
     3241 aagttaaaaa taatccatta tagagaaagt ggaagggcag ctgtggaata ggggacatct
     3301 ccttcccctt ctgtgaaatg tcagcaggct atgaggaaca gccagacaac aggacctggt
     3361 aaagaaaatt gaaaattaga actaagggct atgtattgag tttttagtgt gtgactggaa
     3421 tgaaaagttg acaaatctgt cgggatgatg aatgattttg tgtgctccta actagacagt
     3481 ccagttcctt ccttgttttg catcgttttc ggaatgctgg gaccacacac tgcatgcagg
     3541 gtcttctcta gtcatcttca gcaatctctc tctggttttg gtggatacca ggtcccttcc
     3601 tttttaggag cgataagttt tctgatgttc ccattcactc cccagctgtc ttcttcttcc
     3661 ttgccttcat ctgaagactc agaagggagg aggatttccc cagtttcctc ctttttctta
     3721 cagtgcactc cagataaacg ccaatgttaa aagaaccact acagataaac cgggaaggca
     3781 gatttgaatc tggtctcctc tccacaatga agtccttggt tgtatgttcc tgtagcacct
     3841 taaactttca gaataactgt gtcatttgaa aagggctccg catctatgtc ctgcttgacc
     3901 gactgcaaac ttggaaagtg gaaactgttt gtcttagatt tactgccagg tcttttctga
     3961 tacagtgtgt tctgagatat ttgtgctgta ataaatgaac taagcctttt gtttggagat
     4021 ttattgctaa ctaccatggg aatg
//
