LOCUS       NP_001102329             467 aa            linear   ROD 20-MAR-2023
DEFINITION  interferon regulatory factor 6 [Rattus norvegicus].
ACCESSION   NP_001102329 XP_001067431 XP_344195
VERSION     NP_001102329.1
DBSOURCE    REFSEQ: accession NM_001108859.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 467)
  AUTHORS   Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S,
            Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A,
            Ginno PA, Domcke S, Yan J, Schubeler D, Vinson C and Taipale J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   2  (residues 1 to 467)
  AUTHORS   Lin Y, Xu D, Li X, Liu C, Liu X, Huang S, Huang Y and Liu X.
  TITLE     Upregulation of Interferon Regulatory Factor 6 Promotes Neuronal
            Apoptosis After Traumatic Brain Injury in Adult Rats
  JOURNAL   Cell Mol Neurobiol 36 (1), 27-36 (2016)
   PUBMED   26077898
  REMARK    GeneRIF: IRF6 might promote neuronal apoptosis by inhibiting Akt
            phosphorylation after Traumatic Brain Injury.
REFERENCE   3  (residues 1 to 467)
  AUTHORS   Botti E, Spallone G, Moretti F, Marinari B, Pinetti V, Galanti S,
            De Meo PD, De Nicola F, Ganci F, Castrignano T, Pesole G, Chimenti
            S, Guerrini L, Fanciulli M, Blandino G, Karin M and Costanzo A.
  TITLE     Developmental factor IRF6 exhibits tumor suppressor activity in
            squamous cell carcinomas
  JOURNAL   Proc Natl Acad Sci U S A 108 (33), 13710-13715 (2011)
   PUBMED   21807998
REFERENCE   4  (residues 1 to 467)
  AUTHORS   Stottmann RW, Moran JL, Turbe-Doan A, Driver E, Kelley M and Beier
            DR.
  TITLE     Focusing forward genetics: a tripartite ENU screen for
            neurodevelopmental mutations in the mouse
  JOURNAL   Genetics 188 (3), 615-624 (2011)
   PUBMED   21515572
REFERENCE   5  (residues 1 to 467)
  AUTHORS   Nikopensius T, Jagomagi T, Krjutskov K, Tammekivi V, Saag M, Prane
            I, Piekuse L, Akota I, Barkane B, Krumina A, Ambrozaityte L,
            Matuleviciene A, Kucinskiene ZA, Lace B, Kucinskas V and Metspalu
            A.
  TITLE     Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to
            nonsyndromic cleft palate
  JOURNAL   Birth Defects Res A Clin Mol Teratol 88 (9), 748-756 (2010)
   PUBMED   20672350
REFERENCE   6  (residues 1 to 467)
  AUTHORS   Bailey CM, Abbott DE, Margaryan NV, Khalkhali-Ellis Z and Hendrix
            MJ.
  TITLE     Interferon regulatory factor 6 promotes cell cycle arrest and is
            regulated by the proteasome in a cell cycle-dependent manner
  JOURNAL   Mol Cell Biol 28 (7), 2235-2243 (2008)
   PUBMED   18212048
REFERENCE   7  (residues 1 to 467)
  AUTHORS   Richardson RJ, Dixon J, Malhotra S, Hardman MJ, Knowles L,
            Boot-Handford RP, Shore P, Whitmarsh A and Dixon MJ.
  TITLE     Irf6 is a key determinant of the keratinocyte
            proliferation-differentiation switch
  JOURNAL   Nat Genet 38 (11), 1329-1334 (2006)
   PUBMED   17041603
REFERENCE   8  (residues 1 to 467)
  AUTHORS   Ingraham CR, Kinoshita A, Kondo S, Yang B, Sajan S, Trout KJ, Malik
            MI, Dunnwald M, Goudy SL, Lovett M, Murray JC and Schutte BC.
  TITLE     Abnormal skin, limb and craniofacial morphogenesis in mice
            deficient for interferon regulatory factor 6 (Irf6)
  JOURNAL   Nat Genet 38 (11), 1335-1340 (2006)
   PUBMED   17041601
REFERENCE   9  (residues 1 to 467)
  AUTHORS   Bailey CM, Khalkhali-Ellis Z, Kondo S, Margaryan NV, Seftor RE,
            Wheaton WW, Amir S, Pins MR, Schutte BC and Hendrix MJ.
  TITLE     Mammary serine protease inhibitor (Maspin) binds directly to
            interferon regulatory factor 6: identification of a novel serpin
            partnership
  JOURNAL   J Biol Chem 280 (40), 34210-34217 (2005)
   PUBMED   16049006
REFERENCE   10 (residues 1 to 467)
  AUTHORS   Kondo S, Schutte BC, Richardson RJ, Bjork BC, Knight AS, Watanabe
            Y, Howard E, de Lima RL, Daack-Hirsch S, Sander A, McDonald-McGinn
            DM, Zackai EH, Lammer EJ, Aylsworth AS, Ardinger HH, Lidral AC,
            Pober BR, Moreno L, Arcos-Burgos M, Valencia C, Houdayer C, Bahuau
            M, Moretti-Ferreira D, Richieri-Costa A, Dixon MJ and Murray JC.
  TITLE     Mutations in IRF6 cause Van der Woude and popliteal pterygium
            syndromes
  JOURNAL   Nat Genet 32 (2), 285-289 (2002)
   PUBMED   12219090
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473985.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_344195.2, XP_001067431.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     Protein         1..467
                     /product="interferon regulatory factor 6"
                     /calculated_mol_wt=52931
     Region          9..114
                     /region_name="IRF"
                     /note="Interferon regulatory factor transcription factor;
                     pfam00605"
                     /db_xref="CDD:459863"
     Site            order(42,82,84..85,88)
                     /site_type="other"
                     /note="DNA sequence recognition sites [nucleotide
                     binding]"
                     /db_xref="CDD:238051"
     Site            order(87..88,90,93)
                     /site_type="metal-binding"
                     /db_xref="CDD:238051"
     Region          223..407
                     /region_name="IRF-3"
                     /note="Interferon-regulatory factor 3; pfam10401"
                     /db_xref="CDD:463076"
     CDS             1..467
                     /gene="Irf6"
                     /coded_by="NM_001108859.1:150..1553"
                     /db_xref="GeneID:364081"
                     /db_xref="RGD:1309645"
ORIGIN      
        1 malhprrvrl kpwlvaqvds glypgliwlh rdskrfqipw khatrhspqq eeentifkaw
       61 avetgkyqeg vddpdpakwk aqlrcalnks refnlmydgt kevpmnpvki yqvcdipqpq
      121 gsvinpgstg sapwdekdnd vdeddeedel eqsqhhvpiq dtfpflning spmapasvgn
      181 csvgncspes vwpkteplem evpqapiqpf ysspelwiss lpmtdldikf qyrgkeygqt
      241 mtvsnpqgcr lfygdlgpmp dqeelfgpvs leqvkfpgpe hitnekqklf tsklldvmdr
      301 glilevsgha iyairlcqck vywsgpcaps laapnlierq kkvklfclet flseliahqk
      361 gqiekqppfe iylcfgeewp dgkplerkli lvqvipvvar miyemfsgdf trsfdsgsvr
      421 lqistpdikd nivaqlkqly rilqtqeswq pmqpapsmql ppalpaq
//
