LOCUS       NM_001106586            2099 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Rattus norvegicus interferon regulatory factor 5 (Irf5), mRNA.
ACCESSION   NM_001106586 XM_001064215 XM_216105
VERSION     NM_001106586.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2099)
  AUTHORS   Cao,J., Hu,C., Ding,Z., Chen,J., Liu,S. and Li,Q.
  TITLE     Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in
            CCI-induced Neuropathic Pain in Rats
  JOURNAL   Curr Mol Med 24 (7), 940-949 (2024)
   PUBMED   37622691
  REMARK    GeneRIF: Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in
            CCI-induced Neuropathic Pain in Rats.
REFERENCE   2  (bases 1 to 2099)
  AUTHORS   Liang,C., Tang,Y., Gao,X., Lei,N., Luo,Y., Chen,P., Duan,S.,
            Cao,Y., Yang,Y. and Zhang,Y.
  TITLE     Depression Exacerbates Dextran Sulfate Sodium-Induced Colitis via
            IRF5-Mediated Macrophage Polarization
  JOURNAL   Dig Dis Sci 68 (4), 1269-1279 (2023)
   PUBMED   36088512
  REMARK    GeneRIF: Depression Exacerbates Dextran Sulfate Sodium-Induced
            Colitis via IRF5-Mediated Macrophage Polarization.
REFERENCE   3  (bases 1 to 2099)
  AUTHORS   Tang,T., Guo,Y., Xu,X., Zhao,L., Shen,X., Sun,L. and Xie,P.
  TITLE     BoDV-1 infection induces neuroinflammation by activating the
            TLR4/MyD88/IRF5 signaling pathway, leading to learning and memory
            impairment in rats
  JOURNAL   J Med Virol 93 (11), 6163-6171 (2021)
   PUBMED   34260072
  REMARK    GeneRIF: BoDV-1 infection induces neuroinflammation by activating
            the TLR4/MyD88/IRF5 signaling pathway, leading to learning and
            memory impairment in rats.
REFERENCE   4  (bases 1 to 2099)
  AUTHORS   Chang,Q., Hao,Y., Wang,Y., Zhou,Y., Zhuo,H. and Zhao,G.
  TITLE     Bone marrow mesenchymal stem cell-derived exosomal microRNA-125a
            promotes M2 macrophage polarization in spinal cord injury by
            downregulating IRF5
  JOURNAL   Brain Res Bull 170, 199-210 (2021)
   PUBMED   33609602
  REMARK    GeneRIF: Bone marrow mesenchymal stem cell-derived exosomal
            microRNA-125a promotes M2 macrophage polarization in spinal cord
            injury by downregulating IRF5.
REFERENCE   5  (bases 1 to 2099)
  AUTHORS   Bo,M., Niegowska,M., Eames,H.L., Almuttaqi,H., Arru,G., Erre,G.L.,
            Passiu,G., Khoyratty,T.E., van Grinsven,E., Udalova,I.A. and
            Sechi,L.A.
  TITLE     Antibody response to homologous epitopes of Epstein-Barr virus,
            Mycobacterium avium subsp. paratuberculosis and IRF5 in patients
            with different connective tissue diseases and in mouse model of
            antigen-induced arthritis
  JOURNAL   J Transl Autoimmun 3, 100048 (2020)
   PUBMED   32743529
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2099)
  AUTHORS   Huang,Y.H., Wang,P.W., Tiao,M.M., Chou,M.H., Du,Y.Y., Huang,C.C.
            and Chuang,J.H.
  TITLE     Glucocorticoid modulates high-mobility group box 1 expression and
            Toll-like receptor activation in obstructive jaundice
  JOURNAL   J Surg Res 170 (1), e47-e55 (2011)
   PUBMED   21737101
REFERENCE   7  (bases 1 to 2099)
  AUTHORS   Vandenbroeck,K., Alloza,I., Swaminathan,B., Antiguedad,A.,
            Otaegui,D., Olascoaga,J., Barcina,M.G., de las Heras,V.,
            Bartolome,M., Fernandez-Arquero,M., Arroyo,R., Alvarez-Lafuente,R.,
            Cenit,M.C. and Urcelay,E.
  TITLE     Validation of IRF5 as multiple sclerosis risk gene: putative role
            in interferon beta therapy and human herpes virus-6 infection
  JOURNAL   Genes Immun 12 (1), 40-45 (2011)
   PUBMED   20861862
REFERENCE   8  (bases 1 to 2099)
  AUTHORS   Dixit,E., Boulant,S., Zhang,Y., Lee,A.S., Odendall,C., Shum,B.,
            Hacohen,N., Chen,Z.J., Whelan,S.P., Fransen,M., Nibert,M.L.,
            Superti-Furga,G. and Kagan,J.C.
  TITLE     Peroxisomes are signaling platforms for antiviral innate immunity
  JOURNAL   Cell 141 (4), 668-681 (2010)
   PUBMED   20451243
REFERENCE   9  (bases 1 to 2099)
  AUTHORS   Chen,W., Lam,S.S., Srinath,H., Jiang,Z., Correia,J.J.,
            Schiffer,C.A., Fitzgerald,K.A., Lin,K. and Royer,W.E. Jr.
  TITLE     Insights into interferon regulatory factor activation from the
            crystal structure of dimeric IRF5
  JOURNAL   Nat Struct Mol Biol 15 (11), 1213-1220 (2008)
   PUBMED   18836453
REFERENCE   10 (bases 1 to 2099)
  AUTHORS   Barnes,B.J., Field,A.E. and Pitha-Rowe,P.M.
  TITLE     Virus-induced heterodimer formation between IRF-5 and IRF-7
            modulates assembly of the IFNA enhanceosome in vivo and
            transcriptional activity of IFNA genes
  JOURNAL   J Biol Chem 278 (19), 16630-16641 (2003)
   PUBMED   12600985
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473959.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_216105.4, XM_001064215.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN13663602
                              [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2099
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..2099
                     /gene="Irf5"
                     /note="interferon regulatory factor 5"
                     /db_xref="GeneID:296953"
                     /db_xref="RGD:1310447"
     exon            1..78
                     /gene="Irf5"
                     /inference="alignment:Splign:2.1.0"
     exon            79..284
                     /gene="Irf5"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1583
                     /gene="Irf5"
                     /codon_start=1
                     /product="interferon regulatory factor 5"
                     /protein_id="NP_001100056.1"
                     /db_xref="GeneID:296953"
                     /db_xref="RGD:1310447"
                     /translation="MNQSAPGIPTPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFY
                     IPWRHATRHGPSQDGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFQL
                     YYDGPRDMPPQPYKIYEVCSNGPAPTESQPTDDYVLGEEEEEEDEELQRMLPGLSITE
                     PVLPGPPIAPYSLPKEDTKWPPALQPPVGLGPPPPDPNLLAPPSGDSAGFRQLLPEVL
                     EPGPLASNQPPTEQLLPDLLISPHMLPLTDLEIKFQYRGRPPRALTISNPQGCRLFYS
                     QLEATQEQVELFGPVTLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLY
                     AIRLCQCKVFWSGPCALAHGSCPNPIQREVKTKLFSLEQFLNELILFQKGQTNTPPPF
                     EIFFCFGEEWPDLKPREKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLK
                     DHMVEQFKELHHIWQSQQRLQPMVQAPPVAGLDAGQGPWPMHPVGMQ"
     exon            285..474
                     /gene="Irf5"
                     /inference="alignment:Splign:2.1.0"
     exon            475..533
                     /gene="Irf5"
                     /inference="alignment:Splign:2.1.0"
     exon            534..567
                     /gene="Irf5"
                     /inference="alignment:Splign:2.1.0"
     exon            568..825
                     /gene="Irf5"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1218
                     /gene="Irf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1337
                     /gene="Irf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..2099
                     /gene="Irf5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcagctcg gcgagagctc agctcggccg cagcgccagg ccggggctcc aggctccccg
       61 cgggcgcacc gcagacagag ccctttgcca tgaaccagtc agccccaggg attcccacac
      121 caccccgccg tgtgaggctg aagccctggc tggtggccca ggtgaacagc tgccagtacc
      181 cagggctcca gtgggtcaac ggggaaaaga aactcttcta tatcccctgg cgccatgcta
      241 caaggcacgg tcccagccag gatggagaca acaccatctt caaggcctgg gctaaagaga
      301 cagggaagta cacggagggc gtggatgagg ctgacccagc caaatggaag gccaacctgc
      361 gctgtgccct taacaaaagc cgtgacttcc agctgtacta tgatggccct cgagacatgc
      421 cacctcagcc ctacaagatc tacgaggtct gctccaatgg ccctgctccc acagagtccc
      481 agcccacaga tgattacgtt ctgggagaag aggaggaaga ggaagatgaa gagctccaga
      541 gaatgctacc aggcctgagt atcacagaac ctgtgctacc tgggcctccc atagcaccct
      601 attccttacc caaagaagac accaagtggc cacctgctct ccagccacct gtagggctgg
      661 gtccccctcc cccagaccca aatctcctgg cccctccctc tggagattct gctggcttta
      721 ggcagcttct ccctgaggtc ctggagcctg gacccctggc ttccaaccag ccccctacag
      781 aacaactctt gcctgacctg ctcatcagcc cccacatgct gcctttgact gacctagaga
      841 tcaagttcca gtaccgggga cgtccaccgc gggccctcac catcagcaac ccacaaggct
      901 gcaggctctt ctatagccag ctagaggcta cccaggagca agtggaactc tttggccctg
      961 tgaccctgga gcaagttcgc ttccctagcc cagaggatat ccccagtgac aagcagcgct
     1021 tctatacgaa ccagctgctg gatgtcctgg accgagggct catcctgcag ctgcagggcc
     1081 aggacctgta tgccatccgt ctgtgccagt gtaaggtgtt ctggagtggg ccctgtgcct
     1141 tggcccatgg ttcctgcccc aaccccatcc agcgggaagt caagacaaag ctctttagcc
     1201 tagagcagtt tctcaatgaa ctcatcctgt tccagaaggg ccaaaccaat accccaccac
     1261 cttttgagat cttcttttgc tttggagaag aatggcctga cctcaaaccc cgagagaaga
     1321 agctcattac tgtacaggtg gtacctgtcg cagcccggtt gctgctggag atgttctcag
     1381 gagagctttc ttggtcagca gacagcattc ggctgcagat ctcaaacccg gatctcaaag
     1441 accacatggt agagcagttc aaagagctcc atcacatctg gcagtcccag cagcgcttgc
     1501 agcccatggt ccaggcccct cctgtggcag gccttgatgc tggccagggg ccctggccca
     1561 tgcacccagt tggcatgcaa tagtgaggtt acagatggtg gctgacttgg acttccttgg
     1621 gcagctgtgt agactgacat agcaatgtag tagccccagc aggcctggct ggctgcagga
     1681 ttctcagtct ccagaagaaa ggcctggggt tgcattttcc ctaaacattt tctatttgaa
     1741 cactgcctta tggtgatttc tctaatatgc ctgtctctga agaaataaag tcagcagccc
     1801 cagtgggagg caggaaacac actagtctga ggccttcaat acacaggtcc agttaccaca
     1861 gggcagtcaa cttttaaggt tccaccaatt cctccagcaa aacctgccaa ggagtgttgt
     1921 ggggcttctg cagagaatgg gcctgatttg ggggttccct agtttgaacc tttctcatca
     1981 tccttaggac agggatttca ccaggcattt gggctggcag ctaccctcct tctgagtcta
     2041 agaagctggg gcagaaagaa gaatttaaaa tatttttgga ttaataaatg ttaaaagca
//
