LOCUS       NM_001106108            4803 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus interferon regulatory factor 4 (Irf4), mRNA.
ACCESSION   NM_001106108 XM_001061610 XM_225283
VERSION     NM_001106108.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4803)
  AUTHORS   Wang,B., Li,X., Dong,T., Gao,F., Li,Z. and Ma,Z.
  TITLE     Expression of interferon regulatory factor 4 and inflammation in
            secondary injury of intracerebral haemorrhage
  JOURNAL   Folia Neuropathol 59 (3), 291-297 (2021)
   PUBMED   34628795
  REMARK    GeneRIF: Expression of interferon regulatory factor 4 and
            inflammation in secondary injury of intracerebral haemorrhage.
REFERENCE   2  (bases 1 to 4803)
  AUTHORS   Cheng,W.L., She,Z.G., Qin,J.J., Guo,J.H., Gong,F.H., Zhang,P.,
            Fang,C., Tian,S., Zhu,X.Y., Gong,J., Wang,Z.H., Huang,Z. and Li,H.
  TITLE     Interferon Regulatory Factor 4 Inhibits Neointima Formation by
            Engaging Kruppel-Like Factor 4 Signaling
  JOURNAL   Circulation 136 (15), 1412-1433 (2017)
   PUBMED   28851732
  REMARK    GeneRIF: IRF4 protects arteries against neointima formation by
            promoting the expression of KLF4 by directly binding to its
            promoter.
REFERENCE   3  (bases 1 to 4803)
  AUTHORS   Lin,Y., Zhang,L., Dai,Y., Li,H., Wang,Y., Zhang,B., Chen,S. and
            Lu,Z.
  TITLE     Expression of interleukin-9 and its upstream stimulating factors in
            rats with ischemic stroke
  JOURNAL   Neurol Sci 36 (6), 913-920 (2015)
   PUBMED   25652434
REFERENCE   4  (bases 1 to 4803)
  AUTHORS   So,A.Y., Sookram,R., Chaudhuri,A.A., Minisandram,A., Cheng,D.,
            Xie,C., Lim,E.L., Flores,Y.G., Jiang,S., Kim,J.T., Keown,C.,
            Ramakrishnan,P. and Baltimore,D.
  TITLE     Dual mechanisms by which miR-125b represses IRF4 to induce myeloid
            and B-cell leukemias
  JOURNAL   Blood 124 (9), 1502-1512 (2014)
   PUBMED   25006123
REFERENCE   5  (bases 1 to 4803)
  AUTHORS   Kong,X., Banks,A., Liu,T., Kazak,L., Rao,R.R., Cohen,P., Wang,X.,
            Yu,S., Lo,J.C., Tseng,Y.H., Cypess,A.M., Xue,R., Kleiner,S.,
            Kang,S., Spiegelman,B.M. and Rosen,E.D.
  TITLE     IRF4 is a key thermogenic transcriptional partner of PGC-1alpha
  JOURNAL   Cell 158 (1), 69-83 (2014)
   PUBMED   24995979
REFERENCE   6  (bases 1 to 4803)
  AUTHORS   Hu,C.M., Jang,S.Y., Fanzo,J.C. and Pernis,A.B.
  TITLE     Modulation of T cell cytokine production by interferon regulatory
            factor-4
  JOURNAL   J Biol Chem 277 (51), 49238-49246 (2002)
   PUBMED   12374808
REFERENCE   7  (bases 1 to 4803)
  AUTHORS   Chang,C.C., Lorek,J., Sabath,D.E., Li,Y., Chitambar,C.R., Logan,B.,
            Kampalath,B. and Cleveland,R.P.
  TITLE     Expression of MUM1/IRF4 correlates with clinical outcome in
            patients with B-cell chronic lymphocytic leukemia
  JOURNAL   Blood 100 (13), 4671-4675 (2002)
   PUBMED   12393648
REFERENCE   8  (bases 1 to 4803)
  AUTHORS   Ito,M., Iida,S., Inagaki,H., Tsuboi,K., Komatsu,H., Yamaguchi,M.,
            Nakamura,N., Suzuki,R., Seto,M., Nakamura,S., Morishima,Y. and
            Ueda,R.
  TITLE     MUM1/IRF4 expression is an unfavorable prognostic factor in B-cell
            chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)
  JOURNAL   Jpn J Cancer Res 93 (6), 685-694 (2002)
   PUBMED   12079517
REFERENCE   9  (bases 1 to 4803)
  AUTHORS   Yoshida,S., Nakazawa,N., Iida,S., Hayami,Y., Sato,S., Wakita,A.,
            Shimizu,S., Taniwaki,M. and Ueda,R.
  TITLE     Detection of MUM1/IRF4-IgH fusion in multiple myeloma
  JOURNAL   Leukemia 13 (11), 1812-1816 (1999)
   PUBMED   10557056
REFERENCE   10 (bases 1 to 4803)
  AUTHORS   Iida,S., Rao,P.H., Butler,M., Corradini,P., Boccadoro,M., Klein,B.,
            Chaganti,R.S. and Dalla-Favera,R.
  TITLE     Deregulation of MUM1/IRF4 by chromosomal translocation in multiple
            myeloma
  JOURNAL   Nat Genet 17 (2), 226-230 (1997)
   PUBMED   9326949
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001106108.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.19054.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                JAXUCZ010000017.1  33948698-33948730   c
            34-280              JAXUCZ010000017.1  33947227-33947473   c
            281-467             JAXUCZ010000017.1  33946149-33946335   c
            468-556             JAXUCZ010000017.1  33945196-33945284   c
            557-701             JAXUCZ010000017.1  33944386-33944530   c
            702-809             JAXUCZ010000017.1  33942701-33942808   c
            810-1163            JAXUCZ010000017.1  33940186-33940539   c
            1164-1276           JAXUCZ010000017.1  33936061-33936173   c
            1277-4803           JAXUCZ010000017.1  33930471-33933997   c
FEATURES             Location/Qualifiers
     source          1..4803
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..4803
                     /gene="Irf4"
                     /note="interferon regulatory factor 4"
                     /db_xref="GeneID:291100"
                     /db_xref="RGD:1308050"
     exon            1..33
                     /gene="Irf4"
                     /inference="alignment:Splign:2.1.0"
     exon            34..280
                     /gene="Irf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1417
                     /gene="Irf4"
                     /codon_start=1
                     /product="interferon regulatory factor 4"
                     /protein_id="NP_001099578.1"
                     /db_xref="GeneID:291100"
                     /db_xref="RGD:1308050"
                     /translation="MNLETGSRGSEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWEN
                     EEKSVFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALN
                     KSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDTQMAMGHPYPMTAPYGS
                     LPTQQVHNYMMPPHDRSWRDYAPDQSHPEIPYQCPVTFGPRGHHWQSPSCENGCQVTG
                     TFYACAPPESQAPGIPIEPSIRSAEALALSDCRLHICLYYRDILVKELTTSSPEGCRI
                     SHGHTYDVSNLDQVLFPYPDDNGQRKNIEKLLSHLERGLVLWMAPDGLYAKRLCQSRI
                     YWDGPLALSSDRPNKLERDHTCKLFDTQQFLSELQVFAHHGRPAPRFQVTLCFGEEFP
                     DPQRQRKLITAHVEPLLARQLYFFAQQNSGHFLRGYELPEHISTPDYHRSLRHSSIQE
                     "
     exon            281..467
                     /gene="Irf4"
                     /inference="alignment:Splign:2.1.0"
     exon            468..556
                     /gene="Irf4"
                     /inference="alignment:Splign:2.1.0"
     exon            557..701
                     /gene="Irf4"
                     /inference="alignment:Splign:2.1.0"
     exon            702..809
                     /gene="Irf4"
                     /inference="alignment:Splign:2.1.0"
     exon            810..1163
                     /gene="Irf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1276
                     /gene="Irf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..4803
                     /gene="Irf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggacccttt gctgccctca gctcagagtg cagcgcacga gcgcggagga ggtcagcacg
       61 cgtcatgaac ttggagacgg gcagccgggg ctcagagttc ggcatgagcg cggtgagctg
      121 cggcaacggg aaactcagac agtggctgat cgaccagatc gacagcggca agtaccccgg
      181 gctggtgtgg gagaacgagg agaagagcgt cttccgcatc ccgtggaaac acgcgggcaa
      241 acaggactac aaccgggagg aggacgcagc cctcttcaag gcttgggcac tatttaaagg
      301 caagttccga gaagggattg acaagccaga tcctcctact tggaagacaa gattacgatg
      361 cgctctgaac aagagcaatg actttgagga actggtagag aggagtcagc tggatatctc
      421 cgacccatac aaggtctaca ggattgttcc agagggagcc aaaaaaggag caaagcagct
      481 cactttggaa gacacacaga tggccatggg ccacccctac cccatgacag caccttatgg
      541 ctctctgcca acccagcagg ttcataacta catgatgcca ccccatgaca ggagctggag
      601 ggattatgcc cctgaccagt cacacccaga aatcccatat caatgtcctg tgacgtttgg
      661 cccgcgcggc caccactggc aaagcccatc ttgtgaaaat ggttgccagg tgacaggaac
      721 cttttatgct tgtgccccac ctgagtccca ggctcctgga atccccattg agccaagcat
      781 aaggtctgct gaagccttgg cgctctcaga ctgccggctg catatctgcc tgtattaccg
      841 ggacatcctc gtgaaggagc tgaccacgtc cagccccgag ggctgccgga tctcccacgg
      901 acatacctat gatgttagca acctggacca agtcctgttc ccctaccccg acgacaatgg
      961 gcagaggaag aacattgaga agttgctgag ccacctggag aggggactgg tcctctggat
     1021 ggccccagat gggctttatg ccaaaagact gtgccagagc aggatctact gggatgggcc
     1081 cctggcactg tccagtgatc ggcccaacaa actagaaaga gaccacactt gcaagctctt
     1141 tgacacgcag cagtttctat cagagctaca agtgtttgct caccacggcc ggccagcacc
     1201 gagattccag gtgactctgt gctttgggga ggagtttcca gaccctcaga gacagaggaa
     1261 gctcatcaca gctcatgtgg aacctctgct agccagacaa ctgtattttt ttgctcaaca
     1321 aaacagtgga cattttctga ggggctatga attacctgaa cacattagca ctccagatta
     1381 ccaccggtcc ctccgtcatt cttccatcca agagtgagaa accaacagca ggaatgattt
     1441 catttaattg taaatactcg gacaggacag ccagttggag ctaagaagcg ggttcccact
     1501 tgaagacaaa aacatggatt cgtgaggaga aacagctgta tctgctcaac agaggagctt
     1561 ggcccagaaa agtgcttgtc atccaggtct tgacaagtgc cagtacttgg gtgactgtac
     1621 cccggcttat aactgtgaaa cttgacagtg tcgtgtttac atgtacttca atactggctt
     1681 tagcctggtg tcgatggcct ttcgcttgaa gactgaaaac ccgtgccagc ataaatccct
     1741 gataaaagac atacatatta ttggtccatt tctcagggaa cggaagtcta aaccagaaac
     1801 tactctgtcc atccacagag aagtgcactc cccagtggag taactgtagg actcctggac
     1861 catgcccact gagtgaaggg tcttggttct tagtcccagt ctaggctatc acgtcctggt
     1921 cctgcagact ctctctgagt ggaccctgta tcctgtttgc tccctcctct tgcccttctc
     1981 taaaaaccag ctggtagact cttgttgcca cacacttgag ccaaaaaagc atcagggaca
     2041 tataagatga agcagtttcg tatctcctcc aatctaacaa tgactgcaaa ctgcaaagta
     2101 ctttttgcta tctccccttt ttgttttgcc tctcattctt tagaattgtt gctttttttt
     2161 ttttaaagaa agggggaagg gagggaggta gggagggagg gagggggaga gagagagaga
     2221 atactagaga gagattttta aaatcctgtg ccatttctct ttctatttgt tttgttggcc
     2281 atcagtagtc tccatggcaa cactggaagg gcggagcctt tgagtagttt gagaactgtc
     2341 ctggacacca gtggttcagt atacagctgc agactcagtg ggctgtttct gcttattttg
     2401 tatattagat gcttccttgt gctaataata gtttgacaga gtctcaaaat taccaggctt
     2461 ttccaacaat acattctttc actgaatcct gaagagtctc ccttgccttc ataaatggtc
     2521 tgatccctta ttttcttgtt actgttttgt ttaggtagct ttggcatgct acagaatttt
     2581 ctcctaccac aacataattt ctgtttcttc caggctcaga aagagtcaac tgtcacacac
     2641 tggcacttac ttcttttttt tgtttaacat gccactctta atatttcttc ttaagtcttt
     2701 cagcagcagc atacattcaa taagcagtgg accattgggg tgtcatctat gtttttattt
     2761 tttaaaagga gcctttgata aataatacac atcacagaaa atggaagcat gtttcataga
     2821 gaaggggaaa actgaaaagc attttgtatt tgaatcttcc ttcctagaat tagctccaag
     2881 agttcagtct gttctttaaa catgttttac ttttcaatac ttatgtatga agttgccttt
     2941 ttttagagag agacagagag acagagagac agagagagag agagagagag agagagagag
     3001 agagagagag agagaaatgt gatgacattc ttatgtaccc aagtatacag acttacctca
     3061 tctttagagt ggcgtgtgga atcccactgc agtgtgcctg ggtgcttctt agccacccgt
     3121 tatgagtgca tcccagcagt cctctgagtc tcgtggactg aagtcgctta tacatcttat
     3181 agatgcaaaa cattctgggg tatattatcc caagggaaga tgaaggcaaa attgggaagc
     3241 actcatttcc agaggcccca agccatagca gtcctaccag agtgtatcaa ccgtatcttg
     3301 tattttacca aggctctttg cctggtcttg ggtgaccatg actcttcgtc ccataagcag
     3361 atgctttgtt tcaattgccc tgtgagtttt tttttccccc attgctgtta tgctgcttaa
     3421 acagtaaagc tgacttttct gggaaatgcg tatggtttgg gcccccagtt catgtctcac
     3481 tgacagacat gcatgctgat ggcttccatc ttgagggatg ggaagatagg caaacacttc
     3541 tgacacagaa aggaacacct ccctcatccc cattgagacg aagtgggatg tacacagtag
     3601 actttcgttt gctctcactg gaagattctg ttgaagagat aggccgagga gcactgcatc
     3661 ctagggtgaa aatgggcaac gggtgcatgc tgttggtttg gctccagtgc ttgtgcaggc
     3721 attagtgtct aacttaaaac taaaagccct gaagcccctc tgttgttgtc cccggacaga
     3781 gaaggtggta gaattcacct gtaaagatcc agataaactc tgggtttgga gcaaggaggg
     3841 gcctgcctta tcgtgagaat gccaggacca cagaggcccg aatgtactgc ctgagtggct
     3901 gtgtgtatgt gtgccagaca caggaattcc agaggctgag attggtgact gactaaggca
     3961 tatgtgaggt gcccttgccc tgcagacagg ttgagtgtga gccccagcag caaaggattc
     4021 tgggagttgg ggtatcatgt cttacaaagg aagagccttc aataatgcta ttaaaactta
     4081 ctttcccatt gctgatattt tgataaaaat ccaaacaagg tttaaatgcc ctctcatccc
     4141 tctccaggca gtcttgtccg tcctgctggt gaatactttt attgctgttg ttgttgttgt
     4201 tgctgttgtt attggtgaaa attgtgaaat tgttaagatc tctgtttttg ttatttatct
     4261 ccttaaactg cacagctact gtgtacagtg cagtgttgcc acgagtctgc cgtgccacac
     4321 acatcttttt gcaagtcact tcttcactca ctgaaacccg agctgtaagt gaaattcact
     4381 cattccttgc ctacggcagt tcactgtcac atgaacacag gccaggctgg ttttcctgga
     4441 ctcactttca acatgtctcc agagtatatt gaagtagaag atgcgtttgg aaagccagtt
     4501 cttattagac actgctacat gtgtcacact caagtggacc cacctcaagt tgaagggcat
     4561 cagtgccctt ctgctccatg gcctgtgcac ccactttcat agtgaaagac ctgctgggga
     4621 ccaggacaca gagatctctg gcttaagagc ttgtcctttg gatgtctgcc aagtctaagt
     4681 ccaacaggaa agcaggtacc atcctgcctg cagtgctgga gggatagctc atggattttg
     4741 ctgtaaactt gcttcatgag gaaagccgtg tgttttaaaa tatttgataa ataaaggatt
     4801 tct
//
