LOCUS       NM_001006969            1471 bp    mRNA    linear   ROD 27-NOV-2023
DEFINITION  Rattus norvegicus interferon regulatory factor 3 (Irf3), mRNA.
ACCESSION   NM_001006969 XM_214921
VERSION     NM_001006969.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1471)
  AUTHORS   Zeng Y, Ng JPL, Wang L, Xu X, Law BYK, Chen G, Lo HH, Yang L, Yang
            J, Zhang L, Qu L, Yun X, Zhong J, Chen R, Zhang D, Wang Y, Luo W,
            Qiu C, Huang B, Liu W, Liu L and Wong VKW.
  TITLE     Mutant p53R211* ameliorates inflammatory arthritis in AIA rats via
            inhibition of TBK1-IRF3 innate immune response
  JOURNAL   Inflamm Res 72 (12), 2199-2219 (2023)
   PUBMED   37935918
  REMARK    GeneRIF: Mutant p53[R211*] ameliorates inflammatory arthritis in
            AIA rats via inhibition of TBK1-IRF3 innate immune response.
REFERENCE   2  (bases 1 to 1471)
  AUTHORS   Guo H, Chen R, Li P, Yang Q and He Y.
  TITLE     ZBP1 mediates the progression of Alzheimer's disease via pyroptosis
            by regulating IRF3
  JOURNAL   Mol Cell Biochem 478 (12), 2849-2860 (2023)
   PUBMED   36964897
  REMARK    GeneRIF: ZBP1 mediates the progression of Alzheimer's disease via
            pyroptosis by regulating IRF3.
REFERENCE   3  (bases 1 to 1471)
  AUTHORS   Shi C, Wang Y, Zhuang G, Qi Z, Li Y and Yin P.
  TITLE     Tumor necrosis factor-alpha-induced protein-8 like 2 regulates
            lipopolysaccharide-induced rat rheumatoid arthritis immune
            responses and is associated with Rac activation and interferon
            regulatory factor 3 phosphorylation
  JOURNAL   Mol Med Rep 16 (5), 6346-6353 (2017)
   PUBMED   28849230
  REMARK    GeneRIF: TIPE2 regulates lipopolysaccharide-induced rat rheumatoid
            arthritis immune responses and is associated with Rac1 activation
            and IRF3 phosphorylation.
REFERENCE   4  (bases 1 to 1471)
  AUTHORS   Li R, Wang LG, Wang Q, Li ZH, Ma YL and Guo QD.
  TITLE     Silencing of IRF3 alleviates chronic neuropathic pain following
            chronic constriction injury
  JOURNAL   Biomed Pharmacother 88, 403-408 (2017)
   PUBMED   28122305
  REMARK    GeneRIF: knockdown of IRF3 may alleviate neuropathic pain by
            inhibiting the activation of NF-kappaB signaling pathway.
REFERENCE   5  (bases 1 to 1471)
  AUTHORS   Hasan M, Gonugunta VK, Dobbs N, Ali A, Palchik G, Calvaruso MA,
            DeBerardinis RJ and Yan N.
  TITLE     Chronic innate immune activation of TBK1 suppresses mTORC1 activity
            and dysregulates cellular metabolism
  JOURNAL   Proc Natl Acad Sci U S A 114 (4), 746-751 (2017)
   PUBMED   28069950
REFERENCE   6  (bases 1 to 1471)
  AUTHORS   Hoebe K, Du X, Georgel P, Janssen E, Tabeta K, Kim SO, Goode J, Lin
            P, Mann N, Mudd S, Crozat K, Sovath S, Han J and Beutler B.
  TITLE     Identification of Lps2 as a key transducer of MyD88-independent TIR
            signalling
  JOURNAL   Nature 424 (6950), 743-748 (2003)
   PUBMED   12872135
REFERENCE   7  (bases 1 to 1471)
  AUTHORS   Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi
            O, Sugiyama M, Okabe M, Takeda K and Akira S.
  TITLE     Role of adaptor TRIF in the MyD88-independent toll-like receptor
            signaling pathway
  JOURNAL   Science 301 (5633), 640-643 (2003)
   PUBMED   12855817
REFERENCE   8  (bases 1 to 1471)
  AUTHORS   Shinobu N, Iwamura T, Yoneyama M, Yamaguchi K, Suhara W, Fukuhara
            Y, Amano F and Fujita T.
  TITLE     Involvement of TIRAP/MAL in signaling for the activation of
            interferon regulatory factor 3 by lipopolysaccharide
  JOURNAL   FEBS Lett 517 (1-3), 251-256 (2002)
   PUBMED   12062447
REFERENCE   9  (bases 1 to 1471)
  AUTHORS   Lin CH, Hare BJ, Wagner G, Harrison SC, Maniatis T and Fraenkel E.
  TITLE     A small domain of CBP/p300 binds diverse proteins: solution
            structure and functional studies
  JOURNAL   Mol Cell 8 (3), 581-590 (2001)
   PUBMED   11583620
REFERENCE   10 (bases 1 to 1471)
  AUTHORS   Wathelet MG, Lin CH, Parekh BS, Ronco LV, Howley PM and Maniatis T.
  TITLE     Virus infection induces the assembly of coordinately activated
            transcription factors on the IFN-beta enhancer in vivo
  JOURNAL   Mol Cell 1 (4), 507-518 (1998)
   PUBMED   9660935
  REMARK    Erratum:[Mol Cell 1999 Jun;3(6):813]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083776.1.
            
            On Nov 22, 2004 this sequence version replaced XM_214921.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083776.1, FQ213393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1471
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1471
                     /gene="Irf3"
                     /note="interferon regulatory factor 3"
                     /db_xref="GeneID:292892"
                     /db_xref="RGD:1549774"
     exon            1..102
                     /gene="Irf3"
                     /inference="alignment:Splign:2.1.0"
     exon            103..301
                     /gene="Irf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1402
                     /gene="Irf3"
                     /codon_start=1
                     /product="interferon regulatory factor 3"
                     /protein_id="NP_001006970.1"
                     /db_xref="GeneID:292892"
                     /db_xref="RGD:1549774"
                     /translation="MGTPKPLILPWLVSQLDLGQLKGVAWLDESRTKFRIPWKHGLRQ
                     DAQMADFGIFQAWAEASGAYTPGKDKPDLSTWKRNFRSALNRKEVLRLAEDRSKDPFD
                     PHKVYEFVTPGGARDFVHLDTSPDTNGKSSLSDHQEDLLELLDHMALGPLPDEGSSDL
                     PIASDPSQPPLSPIVNNFPNPAPQENPLRQLLAEEQWEFEVTAFYRGRQVFQQTLFCP
                     GGLRLVGSTSDNGTLPWQPVTLPDPEEFLTDRLVREYVRQVLKGLGKGLVLWRAGQCL
                     WAQRLGHSHSFWALGEELLPDSGRGPDGEVPKDKNGVVFDLRPFVADLIAFMEGSRHS
                     PRYTLWFCVGESWPQDQPWVKRLVMVKVVPTCLKELLEMAREGGASSLKTVDLHISNS
                     QPISLTSDQYKACLQDLVEDMDFQATGET"
     exon            302..473
                     /gene="Irf3"
                     /inference="alignment:Splign:2.1.0"
     exon            474..547
                     /gene="Irf3"
                     /inference="alignment:Splign:2.1.0"
     exon            548..722
                     /gene="Irf3"
                     /inference="alignment:Splign:2.1.0"
     exon            723..1103
                     /gene="Irf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1219
                     /gene="Irf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1445
                     /gene="Irf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacaaagaag ggggttgcgt ggctgcgagt ctcaactact gtttgggagc cccaaaacca
       61 gtgctgacac ccgcgcccca cgagcgcgca attcctcccc tggctcagga actgcactgt
      121 atgcgcaggc tggatcatgg gaaccccgaa accgctgatt ttgccttggc tggtgtctca
      181 gctggacctg ggacagctga aaggtgtggc ctggctggac gagagccgta caaagttcag
      241 gatcccatgg aagcatggct tacgacagga cgcacagatg gctgactttg gcatcttcca
      301 ggcctgggcg gaagccagtg gtgcctacac cccagggaag gataagccag acctgtcaac
      361 ctggaagagg aatttccggt cagccctgaa ccggaaagaa gtgttgcgat tagctgagga
      421 ccggagcaag gacccttttg accctcataa agtgtatgag tttgtgactc caggaggagc
      481 aagggacttt gtacatctgg acacctcccc tgacaccaat ggcaaaagca gtctgtctga
      541 tcaccaggaa gacctcttgg aattactcga tcacatggcc ttgggacccc tcccagatga
      601 ggggtcctca gacctgccta ttgcttctga tccttctcaa ccaccactaa gccccattgt
      661 aaacaacttc ccaaacccag caccccagga aaacccacta aggcagctgc tagctgagga
      721 acagtgggag ttcgaggtga ctgccttcta ccgaggccgc caggtcttcc agcagacact
      781 cttttgcccc gggggcctgc ggctggtggg cagcacgtct gacaacggga cactgccctg
      841 gcagccagtc accctgccag accctgagga gtttctgaca gacaggcttg tgagggagta
      901 tgtgaggcag gtactcaagg ggctgggcaa ggggctggtg ctgtggcggg cagggcagtg
      961 cctctgggcc cagcgcctag gccactcgca ttccttctgg gccctgggtg aggagctgct
     1021 tccagacagt gggagagggc ctgatggaga ggtccccaag gacaagaacg gagtcgtgtt
     1081 cgacctcagg ccctttgtgg cagatctcat tgccttcatg gaaggaagca gacattcccc
     1141 acgatacact ctgtggttct gtgtggggga atcgtggccc caggaccagc cgtgggtcaa
     1201 gaggcttgtg atggtcaagg ttgttcctac atgtcttaag gagctgttag agatggcccg
     1261 ggaaggggga gcctcatcac tgaaaaccgt ggacttgcac atctccaaca gccagccgat
     1321 ctcccttacc tctgaccagt acaaggcctg cctccaggac ttggtggaag acatggactt
     1381 ccaggccact ggagaaacct gagcccagct cagctgctcc aataaagcaa tttatgccac
     1441 catcaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
