LOCUS       NM_001012470            4116 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus interferon regulatory factor 2 binding
            protein-like (Irf2bpl), mRNA.
ACCESSION   NM_001012470 XM_234429
VERSION     NM_001012470.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4116)
  AUTHORS   Marcogliese,P.C., Shashi,V., Spillmann,R.C., Stong,N.,
            Rosenfeld,J.A., Koenig,M.K., Martinez-Agosto,J.A., Herzog,M.,
            Chen,A.H., Dickson,P.I., Lin,H.J., Vera,M.U., Salamon,N.,
            Graham,J.M. Jr., Ortiz,D., Infante,E., Steyaert,W., Dermaut,B.,
            Poppe,B., Chung,H.L., Zuo,Z., Lee,P.T., Kanca,O., Xia,F., Yang,Y.,
            Smith,E.C., Jasien,J., Kansagra,S., Spiridigliozzi,G., El-Dairi,M.,
            Lark,R., Riley,K., Koeberl,D.D., Golden-Grant,K., Yamamoto,S.,
            Wangler,M.F., Mirzaa,G., Hemelsoet,D., Lee,B., Nelson,S.F.,
            Goldstein,D.B., Bellen,H.J. and Pena,L.D.M.
  CONSRTM   Program for Undiagnosed Diseases (UD-PrOZA); Undiagnosed Diseases
            Network
  TITLE     IRF2BPL Is Associated with Neurological Phenotypes
  JOURNAL   Am J Hum Genet 103 (2), 245-260 (2018)
   PUBMED   30057031
  REMARK    Erratum:[Am J Hum Genet. 2018 Sep 6;103(3):456. doi:
            10.1016/j.ajhg.2018.08.010.. PMID: 30193138]
REFERENCE   2  (bases 1 to 4116)
  AUTHORS   Higashimori,A., Dong,Y., Zhang,Y., Kang,W., Nakatsu,G., Ng,S.S.M.,
            Arakawa,T., Sung,J.J.Y., Chan,F.K.L. and Yu,J.
  TITLE     Forkhead Box F2 Suppresses Gastric Cancer through a Novel
            FOXF2-IRF2BPL-beta-Catenin Signaling Axis
  JOURNAL   Cancer Res 78 (7), 1643-1656 (2018)
   PUBMED   29374064
REFERENCE   3  (bases 1 to 4116)
  AUTHORS   Li,C. and Li,P.
  TITLE     Enhanced at Puberty-1 (Eap1) Expression Critically Regulates the
            Onset of Puberty Independent of Hypothalamic Kiss1 Expression
  JOURNAL   Cell Physiol Biochem 43 (4), 1402-1412 (2017)
   PUBMED   29017168
  REMARK    GeneRIF: Eap1 expression critically regulates puberty as well as
            GnRH expression. However, Eap1-regulation of puberty may not
            necessitate KiSS1/GPR54 signaling.
REFERENCE   4  (bases 1 to 4116)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   5  (bases 1 to 4116)
  AUTHORS   Matagne,V., Mastronardi,C., Shapiro,R.A., Dorsa,D.M. and Ojeda,S.R.
  TITLE     Hypothalamic expression of Eap1 is not directly controlled by
            ovarian steroids
  JOURNAL   Endocrinology 150 (4), 1870-1878 (2009)
   PUBMED   19022886
REFERENCE   6  (bases 1 to 4116)
  AUTHORS   Heger,S., Mastronardi,C., Dissen,G.A., Lomniczi,A., Cabrera,R.,
            Roth,C.L., Jung,H., Galimi,F., Sippell,W. and Ojeda,S.R.
  TITLE     Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of
            the female neuroendocrine reproductive axis
  JOURNAL   J Clin Invest 117 (8), 2145-2154 (2007)
   PUBMED   17627301
  REMARK    GeneRIF: EAP1 is a transcriptional regulator that, acting within
            the neuroendocrine brain, contributes to controlling female
            reproductive function.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Dec 7, 2020 this sequence version replaced NM_001012470.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR21887623.711755.1,
                                        SRR26360186.1527481.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4116              JAXUCZ010000006.1  112258149-112262264 c
FEATURES             Location/Qualifiers
     source          1..4116
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..4116
                     /gene="Irf2bpl"
                     /gene_synonym="Eap1; Pqcp; RGD1310994"
                     /note="interferon regulatory factor 2 binding
                     protein-like"
                     /db_xref="GeneID:314329"
                     /db_xref="RGD:1310994"
     exon            1..4116
                     /gene="Irf2bpl"
                     /gene_synonym="Eap1; Pqcp; RGD1310994"
                     /inference="alignment:Splign:2.1.0"
     CDS             894..3242
                     /gene="Irf2bpl"
                     /gene_synonym="Eap1; Pqcp; RGD1310994"
                     /EC_number="2.3.2.27"
                     /note="enhanced at puberty protein 1;
                     polyglutamine-containing protein"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase IRF2BPL"
                     /protein_id="NP_001012488.2"
                     /db_xref="GeneID:314329"
                     /db_xref="RGD:1310994"
                     /translation="MSAAQVSSSRRQSCYLCDLPRMPWAMIWDFSEPVCRGCVNYEGA
                     DRIEFVIETARQLKRAHGCFQDGRSPGPPPPVGVKTVALSAKEAAAAAAAAQQQQQQQ
                     QQQQQQQQQPQQLNHVDGSTKPAVLPAPSGLERYGLSAAAAAAAAAAAAVEQRSRFEY
                     PPPPVSLGSSSHAARLPNGLGGPNGFPKPAPEEGPPELNRQSPNSSSAATSVASRRGT
                     HSGLVTGLPNPGGGGGPQLTVPPNLLPQTLLNGPASAAVLPPPHGLGGSRGPPTPAPP
                     GAPGGPACLGGPPGVSATVSSAPSSTSSTVAEVGVGAAGKRPGSVSSTDQERELKEKQ
                     RNAEALAELSESLRNRAEEWANKPKMVRDTLLTLAGCTPYEVRFKKDHSLLGRVFAFD
                     AVSKPGMDYELKLFIEYPTGSGNVYSSASGVAKQMYQDCMKDFGRGLSSGFKYLEYEK
                     KHGSGDWRLLGDLLPEAVRFFKEGVPGADMLPQPYLDASCPMLPTALVSLSRAPSAPP
                     GTGALPPAAPTGRGAAASLRKRKASPEPPDSAESALKLGEEQQRQQWMANQSEALKLT
                     MSAGGFAAPGHAAGGPPPPPPPLGPHSNRTTPPESAPQNGPSPMAALMSVADTLGTAH
                     SPKDGSSVHSTTASARRNSSSPVSPASVPGQRRLASRNGDLNLQVAPPPPSAHPGMDQ
                     VHPQNIPDSPMANSGPLCCTICHERLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATG
                     EVYCPSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKKERDP"
ORIGIN      
        1 ggggacagcg cgagccgcag ccggagcagg agcgctgaga cgcgcctccg gaacgtagag
       61 taacaatcac aaccccacat tccaggcgag cgcgagcggg aagggatgcg acccgggtgg
      121 aggcgccgag cgagcgccct gcagccaacg tgagcgccgc cagcctctgt ggccggagag
      181 gtggtcaggc cagggggtgg tgggagcctg cgtgcgtgcg ctcctctcct ctgctctcgt
      241 gtgtcttgga aacggtggcc gcagctgctc tctccggcgt gcaaacccag gcgccgccag
      301 cgcaacggcc gtcgctgcgg aagggaaacg ctcctctttt ggcagccacc tcctcccccg
      361 gccctcccgg ggaatcagcg gcttcagcaa gattggacct gggcaccggg tggcaaaacc
      421 ttctaaccct ctccccgggg cgcctggcgt agagaagact cagatcgtag ggaggacccc
      481 cttcgcgttc cacgcttcaa tcactccggg gagggggcca agaggccact ggcggtcggc
      541 cccggacacc ctagccccct ccccccaggc ccggagctcg cagccctgat ccgccgcacc
      601 aggaagaagg cacccggtgc tctgctctgg acaagacagc cgcagtagga ggtgggggcg
      661 aggagcgtgc ggaacccgtc ggtcgcctgg gcggtggagc ccccgccgag aggcactact
      721 gcgccggcag tggagactcg cgctccctcc agcccctggg gcagaacttt ctcgcccccc
      781 tcctctcccc tcccccgcag ccggactcct tccccagcca gctagtcctc ccgaaggaga
      841 aagcgccgcg gagacagccc gggcgggggc ctaccttccc cgaggctggc atcatgtcgg
      901 cggcgcaggt gtcctcgtcc cggagacagt cttgctacct gtgcgacctg cctcgcatgc
      961 cctgggccat gatctgggac ttctccgaac ccgtatgccg tggttgcgtc aattacgaag
     1021 gcgccgaccg catagaattc gtgatcgaga cagcacgcca gctgaagcgg gcgcacggtt
     1081 gcttccaaga cggccgctcc cccgggccgc cgccgccagt cggggtcaag acagtggcct
     1141 tgtccgccaa ggaagcggca gcagcagctg ccgccgctca gcaacagcag cagcaacaac
     1201 aacagcagca gcagcagcag cagcagccac agcagctcaa ccacgtcgat ggctctacca
     1261 agcctgcagt gttgcccgcc ccgtccggtc tggagcgcta tggcctgagc gcagcggccg
     1321 ccgcggctgc tgccgccgcc gccgcggttg aacaacgcag ccgtttcgag tacccgcctc
     1381 ccccggtgag tctggggagc agcagccacg ccgcccggct gcccaacggc ctgggaggtc
     1441 ccaacggctt ccccaagccg gcaccagagg agggtccccc ggagctgaac cgccagagcc
     1501 ccaactcatc ctcagcggca acatcggtgg cttctcggcg tgggactcat agtgggctgg
     1561 tgaccgggct gcccaacccg ggtggtggcg ggggacccca gctcaccgtg ccccccaacc
     1621 tattgccgca gacgctgctt aatggcccgg ccagcgccgc ggtactgcct ccgccccatg
     1681 ggctgggggg aagccgaggg cccccgactc cagcacctcc gggtgctcct ggggggcccg
     1741 cctgtctcgg gggtcccccg ggtgtgtcgg ccactgtatc ctctgctccg tcatcgacct
     1801 cgtcgacagt ggcagaggtg ggcgtgggtg ctgctggtaa gaggcctgga tcggtgtcga
     1861 gcacagacca ggagcgtgag ctaaaggaaa agcagcgcaa cgctgaggcc ttggccgagc
     1921 tgagcgagag cctgcgcaac cgcgcggagg agtgggctaa caagcccaag atggtccgtg
     1981 acacgctgct cacgctggct ggctgcacgc cctacgaggt gcgcttcaag aaggaccatt
     2041 cgctgttggg tcgtgtcttt gccttcgacg cggtctctaa gcccggcatg gactacgagc
     2101 tgaagctgtt cattgagtat cccacgggct ccggcaatgt gtactccagc gcgtctgggg
     2161 tggccaaaca gatgtaccag gattgcatga aggactttgg ccggggtctg tcctctggct
     2221 tcaaatacct ggagtacgag aaaaagcatg gctctggcga ctggcgcctt cttggggacc
     2281 tactgcccga agctgtgcgc ttcttcaagg agggcgtgcc cggcgcggac atgctgcccc
     2341 agccctacct agatgccagt tgtcccatgc tacccacggc gctggtgagt ctcagccgcg
     2401 cccccagcgc acctccagga actggagcct tgccacccgc ggcgcccacg ggccggggtg
     2461 cagcagccag cctgcgcaaa aggaaggcat ccccggagcc tccagactca gctgaaagcg
     2521 cactgaagct cggtgaggag cagcagaggc agcagtggat ggcaaaccag agcgaggcgc
     2581 tgaagctcac tatgtccgcg gggggctttg cggcgccggg acacgcagca gggggaccgc
     2641 ctccaccccc tccacctctg ggacctcatt ccaatcggac caccccgccc gagtcagccc
     2701 cccagaacgg tccgtccccc atggccgcgc tcatgtcagt agcagacact ttgggcacag
     2761 cgcattcgcc caaggatggc agttcagtgc actccaccac tgcatctgct aggcgaaaca
     2821 gcagcagccc ggtgtcgcct gcctccgtgc cggggcagcg tcgcctggca tcacgcaatg
     2881 gggacctgaa tttacaggtg gcacccccac cgcctagcgc ccacccgggc atggaccaag
     2941 tgcaccccca aaacattccg gattccccta tggccaacag cgggcccctc tgctgtacca
     3001 tttgccacga acgtttggag gacactcatt tcgttcagtg tccatccgtc cctagccaca
     3061 aattttgttt cccttgttct agagagagta tcaaagccca gggggccaca ggtgaggtgt
     3121 attgccccag cggagagaaa tgccccctag tcgggtctaa tgtaccttgg gccttcatgc
     3181 agggcgaaat cgcaactatc ttagctgggg atgttaaagt gaaaaaagag agagaccctt
     3241 gaaccgcgca gggcagcgac ctcctttgcc ctagaccacc tcctcttcag tctggagggc
     3301 ccttccccca cctgcctcca ccttccctat ccaccaagat gtagaattgt gaataaaact
     3361 gcaaaaagtt agtcttatgt atagacatta ttttcgtcgg tatgtttcta tattttgaaa
     3421 caggtatgta acttcttcat ttgaaggata agccgatttg tgttaagcag tataatattg
     3481 attgggtctt tcgcatcata ttcgttagca tttatttggt ggcagaatgt ttgcctaggt
     3541 acagaattaa tagcccttag caacgactgc tgctggtgtg tgtgtatttt tgtaaatgtt
     3601 atgcactctg aaaggataaa acacacaaaa gaaaaagatt ttgttgtttt tgttttgcca
     3661 aggccagtgt tgctgcctaa aaaaaaaaaa aaaaacaaaa aacaaaaaac aaacaaaaaa
     3721 caaaaaaaaa atttgatgct ataaaatggt aaaagcttct ttctaaacag ccccaagtgt
     3781 tgaagtcttc acttaatttt gttctgtttt gtttttctgt tttgtttgca aaatggtaag
     3841 gggggtgttg ggaggggatg ggtgtttttt tgttgcaagt ttgtgaaggg ggtaaaaatg
     3901 ttttggtttg tttctactga cctgaatgtg ttggatcttc acgtgttgtt ttgttttggc
     3961 tttattgatg cacggatgct tttgaacagt agagcgaaat gctagacatg gagaacttgc
     4021 tctgtttgtc ctttatacat ttctgtagtt aacagaacac tgtaatgtgc cttggagctt
     4081 agtaacttgt aataaattca attgatatta attctg
//
