LOCUS       NM_012591               2049 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus interferon regulatory factor 1 (Irf1), mRNA.
ACCESSION   NM_012591
VERSION     NM_012591.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2049)
  AUTHORS   Wu,M., Tu,J., Huang,J., Wen,H., Zeng,Y. and Lu,Y.
  TITLE     Exosomal IRF1-loaded rat adipose-derived stem cell sheet
            contributes to wound healing in the diabetic foot ulcers
  JOURNAL   Mol Med 29 (1), 60 (2023)
   PUBMED   37098476
  REMARK    GeneRIF: Exosomal IRF1-loaded rat adipose-derived stem cell sheet
            contributes to wound healing in the diabetic foot ulcers.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2049)
  AUTHORS   Zhao,J., Chen,C., Xiao,J.R., Wei,H.F., Zhou,X.H., Mao,X.X.,
            Zhang,W.D., Qian,R., Chen,X.L., He,M.Q., Yu,X.W. and Zhao,J.
  TITLE     An Up-regulation of IRF-1 After a Spinal Cord Injury: Implications
            for Neuronal Apoptosis
  JOURNAL   J Mol Neurosci 57 (4), 595-604 (2015)
   PUBMED   26342280
  REMARK    GeneRIF: IRF-1 protein levels gradually increased after a spinal
            cord injury.  IRF-1 depletion decreases neuronal apoptosis.
            Erratum:[J Mol Neurosci. 2016 Apr;58(4):532. doi:
            10.1007/s12031-016-0718-7.. PMID: 27000775]
REFERENCE   3  (bases 1 to 2049)
  AUTHORS   Qiu,W., Zhou,J., Zhu,G., Zhao,D., He,F., Zhang,J., Lu,Y., Yu,T.,
            Liu,L. and Wang,Y.
  TITLE     Sublytic C5b-9 triggers glomerular mesangial cell apoptosis via
            XAF1 gene activation mediated by p300-dependent IRF-1 acetylation
  JOURNAL   Cell Death Dis 5 (4), e1176 (2014)
   PUBMED   24743731
  REMARK    GeneRIF: These data implicate that sublytic C5b-9 induces the
            expression of both p300 and IRF-1, as well as p300-dependent IRF-1
            acetylation that may contribute to XAF1 gene activation and
            subsequent glomerular mesangial cells apoptosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2049)
  AUTHORS   Stadler,K., Bierwirth,C., Stoenica,L., Battefeld,A., Reetz,O.,
            Mix,E., Schuchmann,S., Velmans,T., Rosenberger,K., Brauer,A.U.,
            Lehnardt,S., Nitsch,R., Budt,M., Wolff,T., Kole,M.H. and Strauss,U.
  TITLE     Elevation in type I interferons inhibits HCN1 and slows cortical
            neuronal oscillations
  JOURNAL   Cereb Cortex 24 (1), 199-210 (2014)
   PUBMED   23042740
  REMARK    GeneRIF: these findings identify HCN1 channels as a novel neural
            target for type I IFNs providing the possibility to tune neural
            responses
REFERENCE   5  (bases 1 to 2049)
  AUTHORS   Zhang,X., Liu,L., Chen,C., Chi,Y.L., Yang,X.Q., Xu,Y., Li,X.T.,
            Guo,S.L., Xiong,S.H., Shen,M.R., Sun,Y., Zhang,C.S. and Hu,K.M.
  TITLE     Interferon regulatory factor-1 together with reactive oxygen
            species promotes the acceleration of cell cycle progression by
            up-regulating the cyclin E and CDK2 genes during high
            glucose-induced proliferation of vascular smooth muscle cells
  JOURNAL   Cardiovasc Diabetol 12, 147 (2013)
   PUBMED   24119616
  REMARK    GeneRIF: The Irf-1 overexpression-induced proliferation of VSMCs,
            the up-regulation of cyclin E/CDK2 and the acceleration of cell
            cycle progression are associated with ROS/Erk1/2 signaling pathway
            under high glucose conditions.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2049)
  AUTHORS   Eason,D.D., Shepherd,A.T. and Blanck,G.
  TITLE     Interferon regulatory factor 1 tryptophan 11 to arginine point
            mutation abolishes DNA binding
  JOURNAL   Biochim Biophys Acta 1446 (1-2), 140-144 (1999)
   PUBMED   10395927
REFERENCE   7  (bases 1 to 2049)
  AUTHORS   Sampath,D., Castro,M., Look,D.C. and Holtzman,M.J.
  TITLE     Constitutive activation of an epithelial signal transducer and
            activator of transcription (STAT) pathway in asthma
  JOURNAL   J Clin Invest 103 (9), 1353-1361 (1999)
   PUBMED   10225979
REFERENCE   8  (bases 1 to 2049)
  AUTHORS   Nozawa,H., Oda,E., Ueda,S., Tamura,G., Maesawa,C., Muto,T.,
            Taniguchi,T. and Tanaka,N.
  TITLE     Functionally inactivating point mutation in the tumor-suppressor
            IRF-1 gene identified in human gastric cancer
  JOURNAL   Int J Cancer 77 (4), 522-527 (1998)
   PUBMED   9679752
REFERENCE   9  (bases 1 to 2049)
  AUTHORS   Le Stunff,C. and Rotwein,P.
  TITLE     Growth hormone stimulates interferon regulatory factor-1 gene
            expression in the liver
  JOURNAL   Endocrinology 139 (3), 859-866 (1998)
   PUBMED   9492014
REFERENCE   10 (bases 1 to 2049)
  AUTHORS   Yu-Lee,L.Y., Hrachovy,J.A., Stevens,A.M. and Schwarz,L.A.
  TITLE     Interferon-regulatory factor 1 is an immediate-early gene under
            transcriptional regulation by prolactin in Nb2 T cells
  JOURNAL   Mol Cell Biol 10 (6), 3087-3094 (1990)
   PUBMED   2342469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM058778.1 and BC076382.1.
            
            On Nov 20, 2020 this sequence version replaced NM_012591.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076382.1, M34253.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                FM058778.1         1-84
            85-2049             BC076382.1         1-1965
FEATURES             Location/Qualifiers
     source          1..2049
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..2049
                     /gene="Irf1"
                     /note="interferon regulatory factor 1"
                     /db_xref="GeneID:24508"
                     /db_xref="RGD:2920"
     exon            1..189
                     /gene="Irf1"
                     /inference="alignment:Splign:2.1.0"
     exon            190..281
                     /gene="Irf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1181
                     /gene="Irf1"
                     /note="IRF-1"
                     /codon_start=1
                     /product="interferon regulatory factor 1"
                     /protein_id="NP_036723.2"
                     /db_xref="GeneID:24508"
                     /db_xref="RGD:2920"
                     /translation="MPITRMRMRPWLEMQINSNQIPGLSWINKEEMIFQIPWKHAAKH
                     GWDINKDACLFRSWAIHTGRYKAGEKEPDPKTWKANFRCAMNSLPDIEEVKDQSRNKG
                     SSAVRVYRMLPPLTKNQRKERKSKSSRDTKSKTKRKLCGDSSPDTLSDGLSSSTLPDD
                     HSSYTAQGYLGQDLDMDRDITPALSPCVVSSSLSEWHMQMDIMPDSTTDLYNLQVSPM
                     PSTSEAATDEDEEGKLPEDIMKLFEQSEWQPTHVDGKGYLLNEPGAQLSTVYGDFSCK
                     EEPEIDSPGGDIEIGIQRVFTEMKNMDPVMWMDTLLGNSTRPPSIQAIPCAP"
     exon            282..381
                     /gene="Irf1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..608
                     /gene="Irf1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..741
                     /gene="Irf1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..864
                     /gene="Irf1"
                     /inference="alignment:Splign:2.1.0"
     exon            865..914
                     /gene="Irf1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1050
                     /gene="Irf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..2049
                     /gene="Irf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcgtcgagg taggacgagc tctcactgtc tgagccaaac cgaaccgggc cgagctgagc
       61 cgaggtcagc ggtggccaga ggaacccagc atctcgggca tcattcgctc cgtgcacgca
      121 tcgtgtacct acaccgcaac tccgtgcctc attcccgggt accctctgtg actcgctcct
      181 gcagcaaagc caccatgcct atcactcgga tgcgaatgag accctggcta gagatgcaga
      241 ttaattccaa ccaaattcca gggctgagct ggatcaataa agaagagatg atcttccaga
      301 tcccatggaa gcatgctgcc aagcacggtt gggacatcaa caaggatgcc tgtctgttcc
      361 ggagctgggc cattcacaca ggccgataca aagcagggga aaaagagcca gatcccaaga
      421 cttggaaggc aaacttccgg tgtgccatga actccctacc agacatcgag gaagtgaagg
      481 accagagcag gaacaagggc agctctgctg tacgcgtgta ccggatgctg ccacccctca
      541 ccaagaacca gaggaaagag agaaagtcca agtccagccg tgacactaag agcaaaacca
      601 agaggaagct gtgcggagat tctagccctg acaccttatc tgacggactg agcagctcta
      661 ctctgcctga tgaccacagc agttacacag ctcagggata cctgggtcag gacttggaca
      721 tggacaggga cattacccca gctctgtcac cgtgcgtcgt cagcagcagt ctctctgagt
      781 ggcatatgca gatggacatc atgccagaca gcaccactga tctgtacaac ttgcaggtgt
      841 cgcccatgcc ctccacctct gaagctgcaa cagatgagga tgaggaaggg aagttacctg
      901 aggacatcat gaagctcttt gaacagtctg agtggcagcc gacgcacgtg gatggcaagg
      961 gatacttgct caatgaacca ggagcccaac tctctactgt ctatggagac ttcagctgca
     1021 aggaggaacc agagatcgac agccctggag gggacatcga gataggcata cagcgtgtct
     1081 tcacagagat gaagaatatg gaccccgtca tgtggatgga caccctgctg ggcaactcta
     1141 ccaggccgcc ctccattcag gctattcctt gtgcaccata atttgggtcc ctgacccgtt
     1201 cttgccctcc tgagtgagct aggtccagca tcatggtggc tgtgatacaa cataaagcta
     1261 aacttccgtg gaccccttga tgtggcaaaa cataatccca ttgccaagca gggaagggac
     1321 caaaccatcc tccttgggtc agtggactga ctcttcagag cttaggaggc agggtctaag
     1381 tttttcaagc tggtcctgac tcctaggaag atggattggc gttctgaggt tagtgtgagg
     1441 cagaggacct ggacggaagt taccttctag ctctttgaaa gcttcattgc ttagagaggg
     1501 tctcaccact gggctggccc tgggggaata gaccagcgcc cacagaagag cattgcactg
     1561 gccttagggc tggctccaca ctgggagaca attgcactaa gtcctattcc caaagaactg
     1621 ctgcccttcc caaccgagcc ctgggatggt tctagagcca gtgaaatgtg aaggaaaaaa
     1681 tggggtcctg tgagggttgt ctcccttagc ctcagaggga ttctgcctca ctccctgctc
     1741 cagctgtggg gctcaggaaa aaaaaatggc actttctctg tggactttgc cacatttctg
     1801 atcagaagtg tacactaaca tttctcccca agtcttggcc tttgcattta tttatatagt
     1861 gccttgccct gtgcctgctg tctctcctca ggcctcagca gtcctcagca ggcccaggga
     1921 gggggttgtg agcgccttgg cgtgactctg aacattggaa acgccaccta actactaagt
     1981 tgtgtctgat ctcgtgtgga tctgtgtaaa tatgtatatt catcttttta taaaaaccta
     2041 agttgttta
//
