LOCUS       NM_022863               3323 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus iron responsive element binding protein 2
            (Ireb2), mRNA.
ACCESSION   NM_022863
VERSION     NM_022863.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3323)
  AUTHORS   Li,X., Wu,L., Tian,X., Zheng,W., Yuan,M., Tian,X., Zuo,H., Song,H.
            and Shen,Z.
  TITLE     miR-29a-3p in Exosomes from Heme Oxygenase-1 Modified Bone Marrow
            Mesenchymal Stem Cells Alleviates Steatotic Liver
            Ischemia-Reperfusion Injury in Rats by Suppressing Ferroptosis via
            Iron Responsive Element Binding Protein 2
  JOURNAL   Oxid Med Cell Longev 2022, 6520789 (2022)
   PUBMED   35720183
  REMARK    GeneRIF: miR-29a-3p in Exosomes from Heme Oxygenase-1 Modified Bone
            Marrow Mesenchymal Stem Cells Alleviates Steatotic Liver
            Ischemia-Reperfusion Injury in Rats by Suppressing Ferroptosis via
            Iron Responsive Element Binding Protein 2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3323)
  AUTHORS   Costain,G., Ghosh,M.C., Maio,N., Carnevale,A., Si,Y.C.,
            Rouault,T.A. and Yoon,G.
  TITLE     Absence of iron-responsive element-binding protein 2 causes a novel
            neurodegenerative syndrome
  JOURNAL   Brain 142 (5), 1195-1202 (2019)
   PUBMED   30915432
REFERENCE   3  (bases 1 to 3323)
  AUTHORS   Li,Y., Yu,P., Chang,S.Y., Wu,Q., Yu,P., Xie,C., Wu,W., Zhao,B.,
            Gao,G. and Chang,Y.Z.
  TITLE     Hypobaric Hypoxia Regulates Brain Iron Homeostasis in Rats
  JOURNAL   J Cell Biochem 118 (6), 1596-1605 (2017)
   PUBMED   27925282
REFERENCE   4  (bases 1 to 3323)
  AUTHORS   Wang,Z.W., Yang,L.J., Ding,Y.X., Chang,Y.Z. and Cui,H.
  TITLE     Insights into the role of iron in immature rat model of
            hypoxic-ischemic brain injury
  JOURNAL   Exp Ther Med 12 (3), 1723-1731 (2016)
   PUBMED   27602087
REFERENCE   5  (bases 1 to 3323)
  AUTHORS   Zhang,Y., Sun,X., Xie,C., Shu,X., Oso,A.O., Ruan,Z., Deng,Z.Y.,
            Wu,X. and Yin,Y.
  TITLE     Effects of ferrous carbamoyl glycine on iron state and absorption
            in an iron-deficient rat model
  JOURNAL   Genes Nutr 10 (6), 54 (2015)
   PUBMED   26584806
REFERENCE   6  (bases 1 to 3323)
  AUTHORS   Guo,B., Phillips,J.D., Yu,Y. and Leibold,E.A.
  TITLE     Iron regulates the intracellular degradation of iron regulatory
            protein 2 by the proteasome
  JOURNAL   J Biol Chem 270 (37), 21645-21651 (1995)
   PUBMED   7665579
REFERENCE   7  (bases 1 to 3323)
  AUTHORS   Guo,B., Brown,F.M., Phillips,J.D., Yu,Y. and Leibold,E.A.
  TITLE     Characterization and expression of iron regulatory protein 2
            (IRP2). Presence of multiple IRP2 transcripts regulated by
            intracellular iron levels
  JOURNAL   J Biol Chem 270 (28), 16529-16535 (1995)
   PUBMED   7622457
REFERENCE   8  (bases 1 to 3323)
  AUTHORS   Samaniego,F., Chin,J., Iwai,K., Rouault,T.A. and Klausner,R.D.
  TITLE     Molecular characterization of a second iron-responsive element
            binding protein, iron regulatory protein 2. Structure, function,
            and post-translational regulation
  JOURNAL   J Biol Chem 269 (49), 30904-30910 (1994)
   PUBMED   7983023
REFERENCE   9  (bases 1 to 3323)
  AUTHORS   Guo,B., Yu,Y. and Leibold,E.A.
  TITLE     Iron regulates cytoplasmic levels of a novel iron-responsive
            element-binding protein without aconitase activity
  JOURNAL   J Biol Chem 269 (39), 24252-24260 (1994)
   PUBMED   7523370
REFERENCE   10 (bases 1 to 3323)
  AUTHORS   Henderson,B.R., Seiser,C. and Kuhn,L.C.
  TITLE     Characterization of a second RNA-binding protein in rodents with
            specificity for iron-responsive elements
  JOURNAL   J Biol Chem 268 (36), 27327-27334 (1993)
   PUBMED   8262972
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081798.1.
            
            On Jun 10, 2007 this sequence version replaced NM_022863.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081798.1, U20181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3323
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3323
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /note="iron responsive element binding protein 2"
                     /db_xref="GeneID:64831"
                     /db_xref="RGD:621539"
     exon            1..125
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..2998
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /note="IRE-BP 2; iron regulatory protein 2"
                     /codon_start=1
                     /product="iron-responsive element-binding protein 2"
                     /protein_id="NP_074054.2"
                     /db_xref="GeneID:64831"
                     /db_xref="RGD:621539"
                     /translation="MDSPSAGYTFEYLIETLNGSSQKKFFNVPKLGGTKYDILPYSIR
                     VLLEAAVRNCDGFLMKKEDVINILDWKTKQSNVEVPFFPARVVLQDFTGIPAMVDFAA
                     MREAVKTLGGDPKKVHPACPTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPL
                     KVQPKKLPCRGQTTCRGSCDSGELSRNSGTFSSQIENTPVLCPFHLQPVPEPETVLKN
                     QEVEFGRNRERLQFFKWSSGAFKNVAVIPPGTGMAHQVNLEHLSRVVFEEADLLFPDS
                     VIGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVGCELTGSSNAFVTSI
                     DIVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVT
                     LRHLEHTGFDKTKLESMEEYLKAVKLFRNDENSSEPEYSQVIQINLNSIVASVSGPKR
                     PQDRVAVTDMKSDFQACLNEKVGFKGFQVAAEKQSDTVSVRYDGSEYKLSHGSVVIAA
                     VISCTNNCNPSVMLAAGLLAKKAVETGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYL
                     SKLGFEIVGYGCSTCVGNTAPLSEAILNAVKQGDLVTCGVLSGNKNFEGRLCDCVRAN
                     YLASPPLVVAYAIAGTVNIDFQTEPLGTDSTGKNIYLHDIWPSREEVHQIEEEHVILS
                     MFKALKEKVEMGNKRWNSLDAPDSVLFPWDVKSTYIRCPSFFDKLTKEPAASQPIENA
                     HVLLYLGDSVTTDHISPAGSIARSSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGT
                     FANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRD
                     WAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLEFLPGENADSLGLSGREVFSLSF
                     PEELFPGITLNIKTSTGKEFSVIAAFENDVEITLYKHGGLLNFVARKFL"
     exon            126..215
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            216..381
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            382..519
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            520..738
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            739..808
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..992
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1132
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1304
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1402
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1519
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1679
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1815
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1900
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2057
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2182
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2287
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2430
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2578
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2701
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2887
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..3297
                     /gene="Ireb2"
                     /gene_synonym="Irp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttcccact gccagtctgc cggtcttcct ccctatcttc ccggcccggc ctccccctcc
       61 ttcccccgcc ggccccctcc ccgcagggat aatatggtct ccggcgatgg actccccaag
      121 tgcaggatac acctttgagt accttattga aacattaaat ggcagttcac agaagaagtt
      181 cttcaatgta cctaaacttg gaggcaccaa gtatgatatt ctgccttact caatacgggt
      241 cctattggaa gctgctgtac gaaattgtga tggattttta atgaaaaagg aagatgttat
      301 aaatattttg gactggaaaa ccaaacaaag caatgttgaa gtgccctttt tccccgcccg
      361 tgttgttctt caagatttca ctggaatacc ggcaatggtg gattttgctg ctatgaggga
      421 ggcagtgaaa actcttggag gtgatcctaa gaaagtccac cctgcctgtc caacagatct
      481 cacagttgac cactctttac agattgactt cagtaaatgt gcaatacaga atgcaccaaa
      541 tcctggaggt ggtgacctac agaaagcagg aaagctctct ccacttaaag tacagcctaa
      601 gaagcttcca tgtcgaggcc agactacctg ccggggatcg tgtgattctg gagaactaag
      661 ccgaaactca ggaacatttt cttcgcagat tgagaatacg cctgtcctgt gtccctttca
      721 tttgcaacca gtgcctgaac ctgagacggt gttaaaaaat caagaagtag aatttggcag
      781 aaatcgagag aggcttcaat ttttcaagtg gagctcagga gcttttaaga atgtggcagt
      841 catccctcct ggaactggaa tggctcatca agtgaactta gaacatttgt cgagagtagt
      901 gtttgaagaa gccgacctgc tcttcccaga cagcgtaatt ggcacagatt ctcatataac
      961 catggtgaat ggattgggaa ttcttgggtg gggagttgga ggcattgaga cagaggcagt
     1021 tatgcttggc ctgccagtta ctcttacttt accagaggtg gttggatgtg agctaactgg
     1081 gtcatccaat gcttttgtta catccataga tattgtccta ggcattacaa agcacctcag
     1141 gcaagtaggc gtggctggaa agtttgttga gttctttgga agtggagttt cacaattatc
     1201 tattgtcgat agaactacta tagcaaacat gtgtcccgag tatggtgcta tcctcagctt
     1261 tttccctgtt gacaatgtga cactacgaca tttagaacat acaggttttg acaaaaccaa
     1321 acttgagtca atggaagaat accttaaagc tgtgaaattg tttcgaaatg atgagaattc
     1381 ttcagaacct gaatattctc aggtgataca gattaatctg aattcaatag ttgcatctgt
     1441 cagtggtcca aaaaggcctc aggatagagt tgctgtaaca gatatgaaaa gtgattttca
     1501 ggcttgctta aatgaaaagg ttggatttaa aggcttccaa gttgcagcag aaaaacaaag
     1561 tgatactgtc tcagttcgtt atgatggaag tgagtataag ctgtcccatg ggtccgtggt
     1621 cattgctgcg gttatcagct gtaccaataa ctgcaatcca tcggtgatgc tcgctgcagg
     1681 tcttttggct aaaaaggctg ttgaaactgg tctacgagtt aaaccttata taagaacaag
     1741 tttgtctcca ggcagtggga tggttacaca ttacctcagt tcaagtggag tgttacccta
     1801 ccttagcaag ctagggtttg aaatagttgg ctatggatgt tcaacgtgtg taggaaatac
     1861 agcaccttta tcagaagcaa ttttgaatgc agtaaaacag ggtgatttgg ttacctgtgg
     1921 agttttatct ggaaacaaaa atttcgaagg tcgtctttgt gattgtgtcc gtgctaatta
     1981 tctcgcctct ccacccttag tggtggctta cgccatagca ggcacagtga atatagattt
     2041 ccagacagag ccattaggta ctgactctac aggcaagaac atttacctgc atgacatttg
     2101 gcctagtcga gaagaagttc atcagataga agaagaacat gttattttgt ccatgtttaa
     2161 agcactgaaa gagaaagtag agatgggaaa taaacggtgg aattccttag acgctccaga
     2221 ttcagtgttg tttccatggg atgttaagtc tacttacatc agatgccctt cattttttga
     2281 taaacttacc aaagaaccag ctgcatccca gcctattgaa aatgcccatg tcctgttgta
     2341 cttgggagac tctgtcacta cagaccacat atcacctgct ggaagcattg ctaggagcag
     2401 tgctgctgct aagtacttga caaacagagg ccttactccc cgagagttca actcttatgg
     2461 agctcgaaga ggtaatgatg ctgtgatgac aagaggcacg tttgcaaaca tcaagctttt
     2521 taataagttt attgggaagc cagctcccaa aacaattcat tttccatcag gacagacgct
     2581 cgatgtattt gaagctgcag aattatacca aaaagaaggt atcccactga taattttagc
     2641 aggaaaaaaa tatggttcag gaaattcaag agactgggct gcgaaaggac cctatttgct
     2701 gggtgtaaag gctgttttgg ctgaaagcta tgaaaagata cacaaagatc atttgattgg
     2761 aattggtata gcaccacttg agttcctccc aggagaaaat gcagattcct tgggcctctc
     2821 cggcagagaa gtattttctt tatcatttcc tgaagaactc tttcctggaa ttacgttaaa
     2881 tataaagacg agcactggca aagagttcag cgtgattgca gcatttgaaa atgatgtgga
     2941 gataactttg tacaaacatg gaggattgtt aaactttgtg gctcgaaaat tcttatagta
     3001 tctactcccc atggtatctt tcatggctgg taactgcaaa gccttcttct gtgctggacc
     3061 caggaatcat tgccatggaa ctgcagatga tttcagtata cttctctcct ccatggatgt
     3121 aaatgataac gaatcaacgt agtgactaaa atgaaatctt gattttaaat aatatacgaa
     3181 tggtgctatt aacattgcta aaatcaacgt gtgaagtgtg ttgtggaaga gacctgtaag
     3241 tatggggggt atattttatg agaacatttt gtaaataaag acagaatttg aacttgtaaa
     3301 aaaaaaaaaa aaaaaaaaaa aaa
//
