LOCUS       NM_001106791            2323 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus interleukin-1 receptor-associated kinase 4
            (Irak4), mRNA.
ACCESSION   NM_001106791 XM_001058330 XM_217026
VERSION     NM_001106791.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2323)
  AUTHORS   Wu,R., Liu,J., Vu,J., Huang,Y., Dietz,D.M. and Li,J.X.
  TITLE     Interleukin-1 receptor-associated kinase 4 (IRAK4) in the nucleus
            accumbens regulates opioid-seeking behavior in male rats
  JOURNAL   Brain Behav Immun 101, 37-48 (2022)
   PUBMED   34958862
  REMARK    GeneRIF: Interleukin-1 receptor-associated kinase 4 (IRAK4) in the
            nucleus accumbens regulates opioid-seeking behavior in male rats.
REFERENCE   2  (bases 1 to 2323)
  AUTHORS   Bai,S., Li,D., Zhou,Z., Cao,J., Xu,T., Zhang,X., Wang,Y., Guo,J.
            and Zhang,Y.
  TITLE     Interleukin-1 Receptor-Associated Kinase 1/4 as a Novel Target for
            Inhibiting Neointimal Formation After Carotid Balloon Injury
  JOURNAL   J Atheroscler Thromb 22 (12), 1317-1337 (2015)
   PUBMED   26310493
  REMARK    GeneRIF: IRAK1/4 could serve as a potential therapeutic target to
            suppress neointimal formation in carotid arteries after balloon
            injury through the TLR4/NFkappaB signaling pathway
REFERENCE   3  (bases 1 to 2323)
  AUTHORS   Dzietko,M., Hahnemann,M., Polley,O., Sifringer,M.,
            Felderhoff-Mueser,U. and Buhrer,C.
  TITLE     Effects of PMA (PHORBOL-12-MYRISTATE-13-ACETATE) on the Developing
            Rodent Brain
  JOURNAL   Biomed Res Int 2015, 318306 (2015)
   PUBMED   25918710
  REMARK    GeneRIF: PMA treatment during a vulnerable period can alter brain
            development. IL-18 and IRAK-4 appear to be important for the
            development of PMA induced injury.
REFERENCE   4  (bases 1 to 2323)
  AUTHORS   Chen,H., Zhu,W., Feng,J. and Li,S.
  TITLE     Protective effect of diallyl trisulfide on liver in rats with
            sepsis and the mechanism
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 32 (5), 657-662 (2012)
   PUBMED   23073793
REFERENCE   5  (bases 1 to 2323)
  AUTHORS   Sun,K., Chen,Y., Liang,S.Y., Liu,Z.J., Liao,W.Y., Ou,Z.B., Tu,B.
            and Gong,J.P.
  TITLE     Effect of taurine on IRAK4 and NF-kappa B in Kupffer cells from rat
            liver grafts after ischemia-reperfusion injury
  JOURNAL   Am J Surg 204 (3), 389-395 (2012)
   PUBMED   22771449
  REMARK    GeneRIF: Data suggest that taurine could protect against hepatic
            ischemia/reperfusion injury after liver transplantation, and the
            protective effects may be through downregulation of IRAK-4 in
            Kupffer cells.
REFERENCE   6  (bases 1 to 2323)
  AUTHORS   Chandrasekar,B., Mummidi,S., Valente,A.J., Patel,D.N., Bailey,S.R.,
            Freeman,G.L., Hatano,M., Tokuhisa,T. and Jensen,L.E.
  TITLE     The pro-atherogenic cytokine interleukin-18 induces CXCL16
            expression in rat aortic smooth muscle cells via MyD88,
            interleukin-1 receptor-associated kinase, tumor necrosis factor
            receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase,
            Akt, c-Jun N-terminal kinase, and activator protein-1 signaling
  JOURNAL   J Biol Chem 280 (28), 26263-26277 (2005)
   PUBMED   15890643
  REMARK    GeneRIF: IL-18 induces CXCL16 expression via a MyD88,
            IRAK1-IRAK4-TRAF6, c-Src, PI3K, Akt, JNK, AP-1 pathway
REFERENCE   7  (bases 1 to 2323)
  AUTHORS   Felderhoff-Mueser,U., Sifringer,M., Polley,O., Dzietko,M.,
            Leineweber,B., Mahler,L., Baier,M., Bittigau,P., Obladen,M.,
            Ikonomidou,C. and Buhrer,C.
  TITLE     Caspase-1-processed interleukins in hyperoxia-induced cell death in
            the developing brain
  JOURNAL   Ann Neurol 57 (1), 50-59 (2005)
   PUBMED   15622543
REFERENCE   8  (bases 1 to 2323)
  AUTHORS   Lye,E., Mirtsos,C., Suzuki,N., Suzuki,S. and Yeh,W.C.
  TITLE     The role of interleukin 1 receptor-associated kinase-4 (IRAK-4)
            kinase activity in IRAK-4-mediated signaling
  JOURNAL   J Biol Chem 279 (39), 40653-40658 (2004)
   PUBMED   15292196
REFERENCE   9  (bases 1 to 2323)
  AUTHORS   Picard,C., Puel,A., Bonnet,M., Ku,C.L., Bustamante,J., Yang,K.,
            Soudais,C., Dupuis,S., Feinberg,J., Fieschi,C., Elbim,C.,
            Hitchcock,R., Lammas,D., Davies,G., Al-Ghonaium,A., Al-Rayes,H.,
            Al-Jumaah,S., Al-Hajjar,S., Al-Mohsen,I.Z., Frayha,H.H., Rucker,R.,
            Hawn,T.R., Aderem,A., Tufenkeji,H., Haraguchi,S., Day,N.K.,
            Good,R.A., Gougerot-Pocidalo,M.A., Ozinsky,A. and Casanova,J.L.
  TITLE     Pyogenic bacterial infections in humans with IRAK-4 deficiency
  JOURNAL   Science 299 (5615), 2076-2079 (2003)
   PUBMED   12637671
REFERENCE   10 (bases 1 to 2323)
  AUTHORS   Li,S., Strelow,A., Fontana,E.J. and Wesche,H.
  TITLE     IRAK-4: a novel member of the IRAK family with the properties of an
            IRAK-kinase
  JOURNAL   Proc Natl Acad Sci U S A 99 (8), 5567-5572 (2002)
   PUBMED   11960013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Feb 18, 2009 this sequence version replaced NM_001106791.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.24263.1,
                                           SRR26360190.1756710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               JAXUCZ010000007.1  127561777-127561935
            160-327             JAXUCZ010000007.1  127567189-127567356
            328-473             JAXUCZ010000007.1  127570314-127570459
            474-662             JAXUCZ010000007.1  127573026-127573214
            663-823             JAXUCZ010000007.1  127573864-127574024
            824-888             JAXUCZ010000007.1  127575811-127575875
            889-1003            JAXUCZ010000007.1  127577568-127577682
            1004-1113           JAXUCZ010000007.1  127578055-127578164
            1114-1297           JAXUCZ010000007.1  127582486-127582669
            1298-1360           JAXUCZ010000007.1  127583538-127583600
            1361-1519           JAXUCZ010000007.1  127586492-127586650
            1520-2323           JAXUCZ010000007.1  127586766-127587569
FEATURES             Location/Qualifiers
     source          1..2323
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q35"
     gene            1..2323
                     /gene="Irak4"
                     /note="interleukin-1 receptor-associated kinase 4"
                     /db_xref="GeneID:300177"
                     /db_xref="RGD:1305303"
     exon            1..159
                     /gene="Irak4"
                     /inference="alignment:Splign:2.1.0"
     exon            160..327
                     /gene="Irak4"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1552
                     /gene="Irak4"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="interleukin-1 receptor-associated kinase 4"
                     /protein_id="NP_001100261.2"
                     /db_xref="GeneID:300177"
                     /db_xref="RGD:1305303"
                     /translation="MSKPLTPSTYVRSLNVGILRKLSDFIDPQEGWKKLAVAIKKPSG
                     DDRYNQFHIRRFEALLQTGKSPTCELLFDWGTTNCTVGDLVDLLIQIELFAPATLLLP
                     DAVPQAVHSLPPREAATVAQAHRPCQEKNRTTVTPALAQKLEPSCELPDSSSPGHQSV
                     EFSDTRFHSFSFYELKSITNDFDERPVSIGGNRMGEGGFGVVYKGCVNNTTVAVKKLG
                     AMVEISTEELKQQFDQEIKVMAKCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRL
                     SCLDGTPPLSWHMRCKIARGAANGIRFLHENHHIHRDIKSANILLDQDFTAKISDFGL
                     ARASAKLAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLELITGLAAVDEN
                     REPQLLLDIKEEIEDKEKTIEDCTDEKMSDADPASVEAMYSVASQCLHEKKNRRPDIA
                     KVQQLLQETSA"
     exon            328..473
                     /gene="Irak4"
                     /inference="alignment:Splign:2.1.0"
     exon            474..662
                     /gene="Irak4"
                     /inference="alignment:Splign:2.1.0"
     exon            663..823
                     /gene="Irak4"
                     /inference="alignment:Splign:2.1.0"
     exon            824..888
                     /gene="Irak4"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1003
                     /gene="Irak4"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1113
                     /gene="Irak4"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1297
                     /gene="Irak4"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1360
                     /gene="Irak4"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1519
                     /gene="Irak4"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..2323
                     /gene="Irak4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcccacaga aggatttggt acccggtggc ccgcatcatc cggatcgcag gcaatctgaa
       61 gtcccctcgt ggccctgtgt cctccactcc cgagtcctcg cgggaccgtg gcggggcgcc
      121 gatcgccttg tgcaggaagc gaggaacgtc agagaggaag tagaagatga gcaagccttt
      181 gacaccgtca acgtacgtac gcagcctcaa tgttggaatc ctcaggaagc tgtcggattt
      241 tattgatccc caagaaggct ggaagaaact agcagtagct attaaaaagc catcgggtga
      301 tgacagatac aatcagttcc atataaggag attcgaagcc ctacttcaga ctggaaagag
      361 ccccacttgt gaactgctgt ttgactgggg caccacgaac tgcacagtgg gcgaccttgt
      421 ggatcttctg atccagattg agctgtttgc ccctgccact ctcctgctgc cagatgctgt
      481 tccccaagcc gtccacagcc tacctcctag agaagcagca acagtggcgc aggcacacag
      541 gccctgccag gaaaagaaca ggacaaccgt aacgcctgcg cttgcgcaga agctagaacc
      601 cagctgtgag ctgcccgact cctccagtcc aggccatcaa agtgtagaat ttagcgacac
      661 tcgatttcac agtttctcat tttatgaact gaagagcatc acgaatgact tcgacgagcg
      721 acctgtgtct atcgggggca accgaatggg agagggggga tttggagtgg tgtacaaagg
      781 ctgtgtgaac aacacaaccg tagcggtgaa gaagcttgga gcaatggtgg aaatcagtac
      841 tgaagaacta aagcaacagt ttgaccaaga aattaaagta atggccaagt gtcagcacga
      901 aaacctggtg gagctgctgg gcttctcgag cgacagtgac aacctgtgct tagtgtatgc
      961 ttacatgccc aatggttcct tgctagacag actgtcctgc ctggacggaa cgccaccact
     1021 ttcctggcac atgagatgca agattgctcg gggtgcagca aacggcatcc gttttttgca
     1081 tgaaaatcat catattcaca gagatattaa aagtgcaaat atcttactag accaagactt
     1141 tactgccaaa atatctgact ttgggcttgc acgggcttcc gcgaagcttg cacaaacggt
     1201 catgaccagc cgaattgtgg gcacaacggc ttatatggca cctgaagctt tgcgaggaga
     1261 aataacaccc aaatctgaca tctacagctt cggtgtggtt ttattggagc tgataaccgg
     1321 acttgcggct gtggatgaaa accgcgaacc tcaactacta ctggatatta aagaagagat
     1381 tgaagacaag gagaagacga tcgaagattg cacagacgag aagatgagcg atgcggaccc
     1441 tgcgtcggtc gaggcgatgt actctgttgc tagccagtgt ctgcacgaga agaaaaacag
     1501 acggccagac attgcaaagg ttcaacagct gctacaagag acctctgcat aaaactaatg
     1561 aagtaaacat agacgttttt acttcgtggt cctggagacc ggaaaagcac tttgacactg
     1621 agctgcatca cttgcctatt gtttgcgttt gtttttgttt ttcctgaacg tgctttgtct
     1681 ttaacaaggc agcatggtgc gatgtactgg ttagttgatg aatgtgtcgg cctggggcag
     1741 aagtggcggt tgcatggtag cacttggccc cgcccactta gtacggagct catttcaaca
     1801 ttaccagtgt acagtgaact aaagattcag gaaatcagcc ctgtgcttta cagagatcct
     1861 agggttactg gggagtggag gaggtgaggt aagacagggt ttctctgtgt acccctgaat
     1921 gtcctggaac ttgctctgta gaccaggctg gccttgaact cagcaatctg cctgcctctg
     1981 cctacttcat gttgggattg aaggtgtgtg ccaccacctt ccagctgggg atcgaggttt
     2041 gaagctcagc aaaccccact agtaatttcc tgcaaagctt tggaccagct cttagctacc
     2101 ataagcctta gttttggctt ttgttttttg ttatgaactc tgtgctcctg taaataactc
     2161 ctcacctatg tccctgtaag gaacctctcc ccacagtccc tataacccca actaaactcg
     2221 ttggttcaac catgtagact tgggtggaat ctactcttca gtctgttacc ggggtcctat
     2281 tttgaatgaa tagatgtttg cttatctccc ccagaaacat tca
//
