LOCUS       NP_001100261             461 aa            linear   ROD 30-MAR-2024
DEFINITION  interleukin-1 receptor-associated kinase 4 [Rattus norvegicus].
ACCESSION   NP_001100261 XP_001058330 XP_217026
VERSION     NP_001100261.2
DBSOURCE    REFSEQ: accession NM_001106791.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 461)
  AUTHORS   Wu,R., Liu,J., Vu,J., Huang,Y., Dietz,D.M. and Li,J.X.
  TITLE     Interleukin-1 receptor-associated kinase 4 (IRAK4) in the nucleus
            accumbens regulates opioid-seeking behavior in male rats
  JOURNAL   Brain Behav Immun 101, 37-48 (2022)
   PUBMED   34958862
  REMARK    GeneRIF: Interleukin-1 receptor-associated kinase 4 (IRAK4) in the
            nucleus accumbens regulates opioid-seeking behavior in male rats.
REFERENCE   2  (residues 1 to 461)
  AUTHORS   Bai,S., Li,D., Zhou,Z., Cao,J., Xu,T., Zhang,X., Wang,Y., Guo,J.
            and Zhang,Y.
  TITLE     Interleukin-1 Receptor-Associated Kinase 1/4 as a Novel Target for
            Inhibiting Neointimal Formation After Carotid Balloon Injury
  JOURNAL   J Atheroscler Thromb 22 (12), 1317-1337 (2015)
   PUBMED   26310493
  REMARK    GeneRIF: IRAK1/4 could serve as a potential therapeutic target to
            suppress neointimal formation in carotid arteries after balloon
            injury through the TLR4/NFkappaB signaling pathway
REFERENCE   3  (residues 1 to 461)
  AUTHORS   Dzietko,M., Hahnemann,M., Polley,O., Sifringer,M.,
            Felderhoff-Mueser,U. and Buhrer,C.
  TITLE     Effects of PMA (PHORBOL-12-MYRISTATE-13-ACETATE) on the Developing
            Rodent Brain
  JOURNAL   Biomed Res Int 2015, 318306 (2015)
   PUBMED   25918710
  REMARK    GeneRIF: PMA treatment during a vulnerable period can alter brain
            development. IL-18 and IRAK-4 appear to be important for the
            development of PMA induced injury.
REFERENCE   4  (residues 1 to 461)
  AUTHORS   Chen,H., Zhu,W., Feng,J. and Li,S.
  TITLE     Protective effect of diallyl trisulfide on liver in rats with
            sepsis and the mechanism
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 32 (5), 657-662 (2012)
   PUBMED   23073793
REFERENCE   5  (residues 1 to 461)
  AUTHORS   Sun,K., Chen,Y., Liang,S.Y., Liu,Z.J., Liao,W.Y., Ou,Z.B., Tu,B.
            and Gong,J.P.
  TITLE     Effect of taurine on IRAK4 and NF-kappa B in Kupffer cells from rat
            liver grafts after ischemia-reperfusion injury
  JOURNAL   Am J Surg 204 (3), 389-395 (2012)
   PUBMED   22771449
  REMARK    GeneRIF: Data suggest that taurine could protect against hepatic
            ischemia/reperfusion injury after liver transplantation, and the
            protective effects may be through downregulation of IRAK-4 in
            Kupffer cells.
REFERENCE   6  (residues 1 to 461)
  AUTHORS   Chandrasekar,B., Mummidi,S., Valente,A.J., Patel,D.N., Bailey,S.R.,
            Freeman,G.L., Hatano,M., Tokuhisa,T. and Jensen,L.E.
  TITLE     The pro-atherogenic cytokine interleukin-18 induces CXCL16
            expression in rat aortic smooth muscle cells via MyD88,
            interleukin-1 receptor-associated kinase, tumor necrosis factor
            receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase,
            Akt, c-Jun N-terminal kinase, and activator protein-1 signaling
  JOURNAL   J Biol Chem 280 (28), 26263-26277 (2005)
   PUBMED   15890643
  REMARK    GeneRIF: IL-18 induces CXCL16 expression via a MyD88,
            IRAK1-IRAK4-TRAF6, c-Src, PI3K, Akt, JNK, AP-1 pathway
REFERENCE   7  (residues 1 to 461)
  AUTHORS   Felderhoff-Mueser,U., Sifringer,M., Polley,O., Dzietko,M.,
            Leineweber,B., Mahler,L., Baier,M., Bittigau,P., Obladen,M.,
            Ikonomidou,C. and Buhrer,C.
  TITLE     Caspase-1-processed interleukins in hyperoxia-induced cell death in
            the developing brain
  JOURNAL   Ann Neurol 57 (1), 50-59 (2005)
   PUBMED   15622543
REFERENCE   8  (residues 1 to 461)
  AUTHORS   Lye,E., Mirtsos,C., Suzuki,N., Suzuki,S. and Yeh,W.C.
  TITLE     The role of interleukin 1 receptor-associated kinase-4 (IRAK-4)
            kinase activity in IRAK-4-mediated signaling
  JOURNAL   J Biol Chem 279 (39), 40653-40658 (2004)
   PUBMED   15292196
REFERENCE   9  (residues 1 to 461)
  AUTHORS   Picard,C., Puel,A., Bonnet,M., Ku,C.L., Bustamante,J., Yang,K.,
            Soudais,C., Dupuis,S., Feinberg,J., Fieschi,C., Elbim,C.,
            Hitchcock,R., Lammas,D., Davies,G., Al-Ghonaium,A., Al-Rayes,H.,
            Al-Jumaah,S., Al-Hajjar,S., Al-Mohsen,I.Z., Frayha,H.H., Rucker,R.,
            Hawn,T.R., Aderem,A., Tufenkeji,H., Haraguchi,S., Day,N.K.,
            Good,R.A., Gougerot-Pocidalo,M.A., Ozinsky,A. and Casanova,J.L.
  TITLE     Pyogenic bacterial infections in humans with IRAK-4 deficiency
  JOURNAL   Science 299 (5615), 2076-2079 (2003)
   PUBMED   12637671
REFERENCE   10 (residues 1 to 461)
  AUTHORS   Li,S., Strelow,A., Fontana,E.J. and Wesche,H.
  TITLE     IRAK-4: a novel member of the IRAK family with the properties of an
            IRAK-kinase
  JOURNAL   Proc Natl Acad Sci U S A 99 (8), 5567-5572 (2002)
   PUBMED   11960013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Feb 18, 2009 this sequence version replaced NP_001100261.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.24263.1,
                                           SRR26360190.1756710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q35"
     Protein         1..461
                     /product="interleukin-1 receptor-associated kinase 4"
                     /EC_number="2.7.11.1"
                     /calculated_mol_wt=50937
     Region          9..108
                     /region_name="Death_IRAK4"
                     /note="Death domain of Interleukin-1 Receptor-Associated
                     Kinase 4; cd08793"
                     /db_xref="CDD:260060"
     Site            order(12,14,16..17,20,47..48,52,55..56,59,69,72..73,76,78)
                     /site_type="other"
                     /note="IRAK4-MyD88 interaction site [polypeptide binding]"
                     /db_xref="CDD:260060"
     Site            order(25,28..30,34,37,46,50,54,92..96,98,108)
                     /site_type="other"
                     /note="IRAK4-IRAK2 interaction site [polypeptide binding]"
                     /db_xref="CDD:260060"
     Region          172..458
                     /region_name="STKc_IRAK4"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Interleukin-1 Receptor Associated Kinase 4; cd14158"
                     /db_xref="CDD:271060"
     Site            order(194..198,202,213,215,248,264..267,271,273,313,315,
                     317..318,320,331,334,352..355)
                     /site_type="active"
                     /db_xref="CDD:271060"
     Site            order(194..198,202,213,215,248,264..267,271,313,315,
                     317..318,320,331)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271060"
     Site            order(198,271,273,313,315,317,334,352..355)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271060"
     Site            order(330..342,344..355)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271060"
     CDS             1..461
                     /gene="Irak4"
                     /coded_by="NM_001106791.2:167..1552"
                     /db_xref="GeneID:300177"
                     /db_xref="RGD:1305303"
ORIGIN      
        1 mskpltpsty vrslnvgilr klsdfidpqe gwkklavaik kpsgddrynq fhirrfeall
       61 qtgksptcel lfdwgttnct vgdlvdlliq ielfapatll lpdavpqavh slppreaatv
      121 aqahrpcqek nrttvtpala qklepscelp dssspghqsv efsdtrfhsf sfyelksitn
      181 dfderpvsig gnrmgeggfg vvykgcvnnt tvavkklgam veisteelkq qfdqeikvma
      241 kcqhenlvel lgfssdsdnl clvyaympng slldrlscld gtpplswhmr ckiargaang
      301 irflhenhhi hrdiksanil ldqdftakis dfglarasak laqtvmtsri vgttaymape
      361 alrgeitpks diysfgvvll elitglaavd enrepqllld ikeeiedkek tiedctdekm
      421 sdadpasvea mysvasqclh ekknrrpdia kvqqllqets a
//
