LOCUS       NM_001108101            2972 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus interleukin-1 receptor-associated kinase 3
            (Irak3), mRNA.
ACCESSION   NM_001108101 XM_001079164 XM_235183
VERSION     NM_001108101.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2972)
  AUTHORS   Hu X and Miao H.
  TITLE     MiR-539-5p inhibits the inflammatory injury in septic H9c2 cells by
            regulating IRAK3
  JOURNAL   Mol Biol Rep 49 (1), 121-130 (2022)
   PUBMED   34757596
  REMARK    GeneRIF: MiR-539-5p inhibits the inflammatory injury in septic H9c2
            cells by regulating IRAK3.
REFERENCE   2  (bases 1 to 2972)
  AUTHORS   Paik S, Choe JH, Choi GE, Kim JE, Kim JM, Song GY and Jo EK.
  TITLE     Rg6, a rare ginsenoside, inhibits systemic inflammation through the
            induction of interleukin-10 and microRNA-146a
  JOURNAL   Sci Rep 9 (1), 4342 (2019)
   PUBMED   30867482
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2972)
  AUTHORS   Emal D, Rampanelli E, Claessen N, Bemelman FJ, Leemans JC, Florquin
            S and Dessing MC.
  TITLE     Calcineurin inhibitor Tacrolimus impairs host immune response
            against urinary tract infection
  JOURNAL   Sci Rep 9 (1), 106 (2019)
   PUBMED   30643171
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2972)
  AUTHORS   Huang Z, Yi X, Chen Y, Hou X, Wang X, Zhu P, Zhao K, Wu S, Fu N and
            Liu B.
  TITLE     Pretreatment of Pam3CSK4 attenuates inflammatory responses caused
            by systemic infection of methicillin-resistant Staphylococcus
            aureus in mice
  JOURNAL   Biomed Pharmacother 95, 1684-1692 (2017)
   PUBMED   28954388
REFERENCE   5  (bases 1 to 2972)
  AUTHORS   Xu D, Zhang H, Wang X and Chen Y.
  TITLE     Expression of IRAK-3 is associated with colitis-associated
            tumorigenesis in mice
  JOURNAL   Mol Med Rep 16 (3), 3415-3420 (2017)
   PUBMED   28713897
REFERENCE   6  (bases 1 to 2972)
  AUTHORS   Pathak SK, Basu S, Bhattacharyya A, Pathak S, Kundu M and Basu J.
  TITLE     Mycobacterium tuberculosis lipoarabinomannan-mediated IRAK-M
            induction negatively regulates Toll-like receptor-dependent
            interleukin-12 p40 production in macrophages
  JOURNAL   J Biol Chem 280 (52), 42794-42800 (2005)
   PUBMED   16263713
REFERENCE   7  (bases 1 to 2972)
  AUTHORS   del Fresno C, Otero K, Gomez-Garcia L, Gonzalez-Leon MC,
            Soler-Ranger L, Fuentes-Prior P, Escoll P, Baos R, Caveda L, Garcia
            F, Arnalich F and Lopez-Collazo E.
  TITLE     Tumor cells deactivate human monocytes by up-regulating IL-1
            receptor associated kinase-M expression via CD44 and TLR4
  JOURNAL   J Immunol 174 (5), 3032-3040 (2005)
   PUBMED   15728517
REFERENCE   8  (bases 1 to 2972)
  AUTHORS   Kobayashi K, Hernandez LD, Galan JE, Janeway CA Jr, Medzhitov R and
            Flavell RA.
  TITLE     IRAK-M is a negative regulator of Toll-like receptor signaling
  JOURNAL   Cell 110 (2), 191-202 (2002)
   PUBMED   12150927
REFERENCE   9  (bases 1 to 2972)
  AUTHORS   Rosati O and Martin MU.
  TITLE     Identification and characterization of murine IRAK-M
  JOURNAL   Biochem Biophys Res Commun 293 (5), 1472-1477 (2002)
   PUBMED   12054681
  REMARK    Erratum:[Biochem Biophys Res Commun. 2003 Apr 25;304(1):213]
REFERENCE   10 (bases 1 to 2972)
  AUTHORS   Wesche H, Gao X, Li X, Kirschning CJ, Stark GR and Cao Z.
  TITLE     IRAK-M is a novel member of the Pelle/interleukin-1
            receptor-associated kinase (IRAK) family
  JOURNAL   J Biol Chem 274 (27), 19403-19410 (1999)
   PUBMED   10383454
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473960.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_235183.4, XM_001079164.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166731.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2972
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2972
                     /gene="Irak3"
                     /note="interleukin-1 receptor-associated kinase 3"
                     /db_xref="GeneID:314870"
                     /db_xref="RGD:1308846"
     exon            1..272
                     /gene="Irak3"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1972
                     /gene="Irak3"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="interleukin-1 receptor-associated kinase 3"
                     /protein_id="NP_001101571.1"
                     /db_xref="GeneID:314870"
                     /db_xref="RGD:1308846"
                     /translation="MAGPCGARGTLSPHSLLFDLPPALLGELCTILDSCDGPLGWRGL
                     AERLSNSWLDVRHIEKYVHQGKSGTRELLWSWAQKNKTIGDLLQVLHEMGHQRAIHLI
                     MNYGVNWTPPVQTHHELRFPNLPPNSKPVCRESDPGPLELANVTVDNVLVPEHNERGV
                     VLHKTPISFQSILEGTKHFHKDFLIGEGEIFEVYRVEIRNQTYAVKLFKQEKTMQLKK
                     HWKRFLSELEVLLLFNHPHILELAAYFTEMEKLCLVYPYMSNGTLFDRLQCTNGTTPL
                     SWHVRISVLIGIAKAIQCLHNTRPCAVICGNISSANILLDDQFQPKLTDFAAAHFRPH
                     LEQQSSTINMTGSGRKHLWYMPEEYIRQGRLTIKTDVYSFGIVIMEVLTGCKVVLDDP
                     KHVQLRDLLMELVEKRGLDSCLSFLDRKIPPCPRNFSAKLFSLAGQCVATRAKLRPTM
                     DEVLNTLESTQPSLYFAEDPPTSLKSFRCPSPLFLDNVPSIPVEDDENQNNYPVPPKE
                     ALRTDRVTQKTPFECSQSEVTFLGLDRNKGNRGSEAACNMPSSSCEECWCPELAEASQ
                     DLRPTVISLGSSWEVPGYSYGSKPMEKRCSSGLFCSEHEQSKRQ"
     exon            273..455
                     /gene="Irak3"
                     /inference="alignment:Splign:2.1.0"
     exon            456..559
                     /gene="Irak3"
                     /inference="alignment:Splign:2.1.0"
     exon            560..614
                     /gene="Irak3"
                     /inference="alignment:Splign:2.1.0"
     exon            615..769
                     /gene="Irak3"
                     /inference="alignment:Splign:2.1.0"
     exon            770..834
                     /gene="Irak3"
                     /inference="alignment:Splign:2.1.0"
     exon            835..949
                     /gene="Irak3"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1068
                     /gene="Irak3"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1267
                     /gene="Irak3"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1330
                     /gene="Irak3"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1495
                     /gene="Irak3"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..2972
                     /gene="Irak3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggacccgc cctgcgactg cccgggcgtg gagtgttgca agctccgggc agccgtcgtg
       61 gagctgaatt tccgcggttg tgaaaggagg tggcagcggc gacgtctctg cttctcagcg
      121 tggggtccgg ggctccgcga tggccggccc gtgcggggcc cgtggtacgc tgtcgccaca
      181 ctcgctgctc ttcgacctgc cgcccgcgct gctgggcgag ctgtgcacga tcctggatag
      241 ctgcgatggt ccgctgggct ggcggggcct ggcggagcga ctttcaaaca gctggctgga
      301 tgttcgtcat attgaaaaat atgtacacca aggtaaaagt ggaacaagag aattgctgtg
      361 gtcctgggcg cagaaaaaca agaccattgg cgacctttta caggttctcc acgagatggg
      421 gcatcaacga gctatccatc taatcatgaa ctatggagta aactggactc ctccagtgca
      481 gactcatcac gagcttcgat ttcccaactt accacctaac tcgaagcctg tgtgcagaga
      541 aagtgacccc ggacctctgg agctagccaa tgtcacagtg gataatgttc ttgttcctga
      601 acataatgaa agaggagtag tactgcataa gacccctatc agcttccaaa gtatcctaga
      661 aggaaccaaa catttccaca aagacttcct aattggagaa ggggagatat ttgaagtata
      721 cagagtggag attagaaacc aaacatacgc cgttaaatta tttaaacagg agaaaacaat
      781 gcagcttaag aagcactgga agaggttttt gtcggaactg gaagttttac tcctgttcaa
      841 tcacccccac atactagagc tggctgcata tttcacagag atggagaaac tttgtctggt
      901 ttatccctat atgagcaatg ggacactttt cgacagatta cagtgcacaa atggcacaac
      961 cccactttcc tggcacgttc gaatcagtgt gttgatagga atagccaaag ccatccagtg
     1021 cttgcacaac acccggccgt gtgccgtcat ctgtggcaac atttccagtg caaacatact
     1081 cttggatgac cagttccaac ccaaactaac cgattttgcc gcggcgcact tccgacccca
     1141 cctagagcag cagagttcta ccataaatat gaccggcagc ggcaggaagc atctgtggta
     1201 catgccggaa gaatacatca gacagggaag actcaccatt aaaacggacg tctacagctt
     1261 tggaatcgtg atcatggaag ttctaacggg ctgcaaagtg gtgctggatg atccaaaaca
     1321 tgttcagctg agggacctcc tcatggaact ggtggagaag agaggcctag actcctgcct
     1381 ctcgttcttg gacaggaaga taccgccctg tcctcggaac ttctctgcca agctcttctc
     1441 tctggcgggc cagtgtgtgg caactcgggc caagttaaga cccacgatgg acgaagtcct
     1501 gaacactctg gagagcacac agcctagctt gtattttgca gaagaccctc ccacttcctt
     1561 gaagtccttc aggtgtcctt ctcctctgtt cttggataat gttccaagta ttccagtaga
     1621 agatgatgaa aaccagaata actatccagt acctcccaag gaagctttga ggacagatag
     1681 agtgacacag aaaaccccct ttgaatgcag ccagtctgag gtcacctttc tgggcttgga
     1741 tcgaaacaaa gggaacaggg gaagtgaagc tgcttgcaac atgcccagtt cttcttgtga
     1801 ggaatgctgg tgcccagagc ttgcggaagc atcccaggac ttaaggccta ctgtgatcag
     1861 tttggggtct tcttgggaag taccaggcta ttcttatggg agcaagccaa tggagaagag
     1921 gtgttcctct ggactctttt gcagtgagca cgaacagtcc aaaaggcagt gaattcacca
     1981 gaagataaag cacatatcgc taaaggcacc tgagcaaaca gcgttacatc accgtggaaa
     2041 gacagggggt ctgagctctg tgagtaaggc caagggacca acgggtggag aatttgaata
     2101 gtgcagatta gcagcaagga agtttgtttc ttctccaaac agaatgtcaa gagatgtttt
     2161 attcgggtga cgtctctcag tcaaatccaa gctaaactgg agtcgatctg agttatccaa
     2221 gattttgggt tctgactgtc gaaacctatc aaagagtggc aggaacctta agtcgctctg
     2281 tcatcatctg agtgagacct ttgtgtaggc gaccagagaa ccacccacat tccagaacca
     2341 ggttctcccc aagccctctc caagtaaaca gccagtcgtt taccgacagc caaatgtgat
     2401 acagtgccat tcttcctctg cgcatgcgcc atgcccttta taaaaccgag gtcttcagcc
     2461 ccaccctctt tctgttccat cctcgctcaa aggcagcctt tgggcctact gggaggccac
     2521 ctcaataaat ctcccacatg aggtctattg catggtgtga cttagcatca cttggtcctc
     2581 agatcgtttc cacaaaagct aaggaataaa caacaacaaa aactcaccat cgttgccacc
     2641 agcactcagt cagtctttct actagggatt ggatggtcta ttggcttccc acagtcacag
     2701 gaaacgttgc tcacatggaa aggtgtagga aatgtctaat ttgtaagtgg tgacaggagc
     2761 cttttgaaag aattgtgatt ttaagttgct tctcttttgt tgatcgctgg ttaacccgtc
     2821 aatctggaag tgagccaagt cacccttgct acggcatgtt ctgtgtggag agggaattcc
     2881 agtccaaagt ctgcatttct gtacttacat tcttagaaga gttacccgcg ttatgccaat
     2941 tgttataaaa actatattta aaaaaacaca gc
//
