LOCUS       NP_001101571             610 aa            linear   ROD 26-FEB-2024
DEFINITION  interleukin-1 receptor-associated kinase 3 [Rattus norvegicus].
ACCESSION   NP_001101571 XP_001079164 XP_235183
VERSION     NP_001101571.1
DBSOURCE    REFSEQ: accession NM_001108101.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 610)
  AUTHORS   Hu X and Miao H.
  TITLE     MiR-539-5p inhibits the inflammatory injury in septic H9c2 cells by
            regulating IRAK3
  JOURNAL   Mol Biol Rep 49 (1), 121-130 (2022)
   PUBMED   34757596
  REMARK    GeneRIF: MiR-539-5p inhibits the inflammatory injury in septic H9c2
            cells by regulating IRAK3.
REFERENCE   2  (residues 1 to 610)
  AUTHORS   Paik S, Choe JH, Choi GE, Kim JE, Kim JM, Song GY and Jo EK.
  TITLE     Rg6, a rare ginsenoside, inhibits systemic inflammation through the
            induction of interleukin-10 and microRNA-146a
  JOURNAL   Sci Rep 9 (1), 4342 (2019)
   PUBMED   30867482
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 610)
  AUTHORS   Emal D, Rampanelli E, Claessen N, Bemelman FJ, Leemans JC, Florquin
            S and Dessing MC.
  TITLE     Calcineurin inhibitor Tacrolimus impairs host immune response
            against urinary tract infection
  JOURNAL   Sci Rep 9 (1), 106 (2019)
   PUBMED   30643171
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 610)
  AUTHORS   Huang Z, Yi X, Chen Y, Hou X, Wang X, Zhu P, Zhao K, Wu S, Fu N and
            Liu B.
  TITLE     Pretreatment of Pam3CSK4 attenuates inflammatory responses caused
            by systemic infection of methicillin-resistant Staphylococcus
            aureus in mice
  JOURNAL   Biomed Pharmacother 95, 1684-1692 (2017)
   PUBMED   28954388
REFERENCE   5  (residues 1 to 610)
  AUTHORS   Xu D, Zhang H, Wang X and Chen Y.
  TITLE     Expression of IRAK-3 is associated with colitis-associated
            tumorigenesis in mice
  JOURNAL   Mol Med Rep 16 (3), 3415-3420 (2017)
   PUBMED   28713897
REFERENCE   6  (residues 1 to 610)
  AUTHORS   Pathak SK, Basu S, Bhattacharyya A, Pathak S, Kundu M and Basu J.
  TITLE     Mycobacterium tuberculosis lipoarabinomannan-mediated IRAK-M
            induction negatively regulates Toll-like receptor-dependent
            interleukin-12 p40 production in macrophages
  JOURNAL   J Biol Chem 280 (52), 42794-42800 (2005)
   PUBMED   16263713
REFERENCE   7  (residues 1 to 610)
  AUTHORS   del Fresno C, Otero K, Gomez-Garcia L, Gonzalez-Leon MC,
            Soler-Ranger L, Fuentes-Prior P, Escoll P, Baos R, Caveda L, Garcia
            F, Arnalich F and Lopez-Collazo E.
  TITLE     Tumor cells deactivate human monocytes by up-regulating IL-1
            receptor associated kinase-M expression via CD44 and TLR4
  JOURNAL   J Immunol 174 (5), 3032-3040 (2005)
   PUBMED   15728517
REFERENCE   8  (residues 1 to 610)
  AUTHORS   Kobayashi K, Hernandez LD, Galan JE, Janeway CA Jr, Medzhitov R and
            Flavell RA.
  TITLE     IRAK-M is a negative regulator of Toll-like receptor signaling
  JOURNAL   Cell 110 (2), 191-202 (2002)
   PUBMED   12150927
REFERENCE   9  (residues 1 to 610)
  AUTHORS   Rosati O and Martin MU.
  TITLE     Identification and characterization of murine IRAK-M
  JOURNAL   Biochem Biophys Res Commun 293 (5), 1472-1477 (2002)
   PUBMED   12054681
  REMARK    Erratum:[Biochem Biophys Res Commun. 2003 Apr 25;304(1):213]
REFERENCE   10 (residues 1 to 610)
  AUTHORS   Wesche H, Gao X, Li X, Kirschning CJ, Stark GR and Cao Z.
  TITLE     IRAK-M is a novel member of the Pelle/interleukin-1
            receptor-associated kinase (IRAK) family
  JOURNAL   J Biol Chem 274 (27), 19403-19410 (1999)
   PUBMED   10383454
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473960.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_235183.4, XP_001079164.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166731.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..610
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     Protein         1..610
                     /product="interleukin-1 receptor-associated kinase 3"
                     /EC_number="2.7.11.1"
                     /calculated_mol_wt=68846
     Region          15..102
                     /region_name="Death_IRAK-M"
                     /note="Death domain of Interleukin 1 Receptor Associated
                     Kinase-M; cd08796"
                     /db_xref="CDD:260062"
     Region          185..460
                     /region_name="PK_IRAK3"
                     /note="Pseudokinase domain of Interleukin-1 Receptor
                     Associated Kinase 3; cd14160"
                     /db_xref="CDD:271062"
     CDS             1..610
                     /gene="Irak3"
                     /coded_by="NM_001108101.1:140..1972"
                     /db_xref="GeneID:314870"
                     /db_xref="RGD:1308846"
ORIGIN      
        1 magpcgargt lsphsllfdl ppallgelct ildscdgplg wrglaerlsn swldvrhiek
       61 yvhqgksgtr ellwswaqkn ktigdllqvl hemghqraih limnygvnwt ppvqthhelr
      121 fpnlppnskp vcresdpgpl elanvtvdnv lvpehnergv vlhktpisfq silegtkhfh
      181 kdfligegei fevyrveirn qtyavklfkq ektmqlkkhw krflselevl llfnhphile
      241 laayftemek lclvypymsn gtlfdrlqct ngttplswhv risvligiak aiqclhntrp
      301 cavicgniss anillddqfq pkltdfaaah frphleqqss tinmtgsgrk hlwympeeyi
      361 rqgrltiktd vysfgivime vltgckvvld dpkhvqlrdl lmelvekrgl dsclsfldrk
      421 ippcprnfsa klfslagqcv atraklrptm devlntlest qpslyfaedp ptslksfrcp
      481 splfldnvps ipveddenqn nypvppkeal rtdrvtqktp fecsqsevtf lgldrnkgnr
      541 gseaacnmps ssceecwcpe laeasqdlrp tvislgsswe vpgysygskp mekrcssglf
      601 cseheqskrq
//
