LOCUS       NM_001025422            2977 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus interleukin-1 receptor-associated kinase 2
            (Irak2), mRNA.
ACCESSION   NM_001025422 XM_342739
VERSION     NM_001025422.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2977)
  AUTHORS   Liu,Z., Zhao,N., Zhu,H., Zhu,S., Pan,S., Xu,J., Zhang,X., Zhang,Y.
            and Wang,J.
  TITLE     Circulating interleukin-1beta promotes endoplasmic reticulum
            stress-induced myocytes apoptosis in diabetic cardiomyopathy via
            interleukin-1 receptor-associated kinase-2
  JOURNAL   Cardiovasc Diabetol 14, 125 (2015)
   PUBMED   26394923
  REMARK    GeneRIF: Elevated circulating IL-1beta contributed to promote ER
            stress- induced myocytes apoptosis by affecting IRAK-2/CHOP pathway
            in diabetic cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2977)
  AUTHORS   Kumar,H., Kawai,T. and Akira,S.
  TITLE     Pathogen recognition by the innate immune system
  JOURNAL   Int Rev Immunol 30 (1), 16-34 (2011)
   PUBMED   21235323
  REMARK    Review article
REFERENCE   3  (bases 1 to 2977)
  AUTHORS   Weber,A., Wasiliew,P. and Kracht,M.
  TITLE     Interleukin-1 (IL-1) pathway
  JOURNAL   Sci Signal 3 (105), cm1 (2010)
   PUBMED   20086235
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2977)
  AUTHORS   Bailey,M.J., Coon,S.L., Carter,D.A., Humphries,A., Kim,J.S.,
            Shi,Q., Gaildrat,P., Morin,F., Ganguly,S., Hogenesch,J.B.,
            Weller,J.L., Rath,M.F., Moller,M., Baler,R., Sugden,D.,
            Rangel,Z.G., Munson,P.J. and Klein,D.C.
  TITLE     Night/day changes in pineal expression of >600 genes: central role
            of adrenergic/cAMP signaling
  JOURNAL   J Biol Chem 284 (12), 7606-7622 (2009)
   PUBMED   19103603
  REMARK    GeneRIF: Expression of Irak2 increases ~ 15-fold at night in the
            rat pineal gland, as a result of adrenergic-cyclic AMP signalling.
            Night time levels are >15-fold greater than median expression
            levels in other tissues.
REFERENCE   5  (bases 1 to 2977)
  AUTHORS   Elzinga,B.M., Twomey,C., Powell,J.C., Harte,F. and McCarthy,J.V.
  TITLE     Interleukin-1 receptor type 1 is a substrate for
            gamma-secretase-dependent regulated intramembrane proteolysis
  JOURNAL   J Biol Chem 284 (3), 1394-1409 (2009)
   PUBMED   18996842
  REMARK    GeneRIF: TRAF6 and interleukin receptor-associated kinase 2 are
            novel binding partners for PS1, and IL-1R1 is a new substrate for
            presenilin-dependent gamma-secretase cleavage
REFERENCE   6  (bases 1 to 2977)
  AUTHORS   Hardy,M.P. and O'Neill,L.A.
  TITLE     The murine IRAK2 gene encodes four alternatively spliced isoforms,
            two of which are inhibitory
  JOURNAL   J Biol Chem 279 (26), 27699-27708 (2004)
   PUBMED   15082713
REFERENCE   7  (bases 1 to 2977)
  AUTHORS   Rosati,O. and Martin,M.U.
  TITLE     Identification and characterization of murine IRAK-2
  JOURNAL   Biochem Biophys Res Commun 297 (1), 52-58 (2002)
   PUBMED   12220507
REFERENCE   8  (bases 1 to 2977)
  AUTHORS   Mamidipudi,V., Li,X. and Wooten,M.W.
  TITLE     Identification of interleukin 1 receptor-associated kinase as a
            conserved component in the p75-neurotrophin receptor activation of
            nuclear factor-kappa B
  JOURNAL   J Biol Chem 277 (31), 28010-28018 (2002)
   PUBMED   12034707
REFERENCE   9  (bases 1 to 2977)
  AUTHORS   Wesche,H., Gao,X., Li,X., Kirschning,C.J., Stark,G.R. and Cao,Z.
  TITLE     IRAK-M is a novel member of the Pelle/interleukin-1
            receptor-associated kinase (IRAK) family
  JOURNAL   J Biol Chem 274 (27), 19403-19410 (1999)
   PUBMED   10383454
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098060.1.
            
            On Jul 15, 2005 this sequence version replaced XM_342739.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098060.1, SRR8487227.155940.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2977
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2977
                     /gene="Irak2"
                     /note="interleukin-1 receptor-associated kinase 2"
                     /db_xref="GeneID:362418"
                     /db_xref="RGD:1309584"
     exon            1..129
                     /gene="Irak2"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1910
                     /gene="Irak2"
                     /note="IRAK-2"
                     /codon_start=1
                     /product="interleukin-1 receptor-associated kinase-like 2"
                     /protein_id="NP_001020593.1"
                     /db_xref="GeneID:362418"
                     /db_xref="RGD:1309584"
                     /translation="MACYIYQLPSWVLDDLCRNIDTLSEWDWMQFASYVITDLTQLRK
                     IKSMERVQGVSITRELLWWWSMRQATVQQLVDLLCHLELYRAAQIVLSWKPAPDSLSP
                     LSAFPEAVKPGPVATSGRNLKDDQKKGQPVKPCSFLSSGTTMAGAQQQASCQRPCEED
                     APCSLKTDVPDSLQSKYCSTSIPKQEKLLNLPGDRLFWSEADIVQATEDFDQSHRISE
                     GTFADIYRGQRNGVAFAFKRLREVTGSSPGSMDRFLQAEMQLCLRCCHPNILPLLGFC
                     TGRQFHSLIYPYMANGSLQDRLWAQGDSDMLSWPQRASICSGLLLAVEHLHSLDIIHS
                     NVKSANVLLDQHLNPKLAHPVAHPCPTNKKTKYTVMKTHLFQASAAYLPENFIRVGQL
                     TKQVDIFSCGIVLAEVLTGIPAMDKDRSPVYLKDLLLSEIPSNTSSVHSRKTSMGKVV
                     VKEICQKHLERKAGLLPEACAETWATAVSVCLRRREASLEEARVSMAGVEEQLRGQLS
                     LPWSRVSEDTGSSSNTPEETDDVDNSSLSVPSSVMVVSCARVSSPPPSMGNGTAQPST
                     SGRQEADSSSEACAGPQPPQEATETSWKIEINEAKRRLMENILLYKEEKLDSVELFGP
                     "
     exon            130..312
                     /gene="Irak2"
                     /inference="alignment:Splign:2.1.0"
     exon            313..456
                     /gene="Irak2"
                     /inference="alignment:Splign:2.1.0"
     exon            457..563
                     /gene="Irak2"
                     /inference="alignment:Splign:2.1.0"
     exon            564..758
                     /gene="Irak2"
                     /inference="alignment:Splign:2.1.0"
     exon            759..823
                     /gene="Irak2"
                     /inference="alignment:Splign:2.1.0"
     exon            824..938
                     /gene="Irak2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1048
                     /gene="Irak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1244
                     /gene="Irak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1307
                     /gene="Irak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1508
                     /gene="Irak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1797
                     /gene="Irak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..2945
                     /gene="Irak2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccgccacc ggctcagtcg ccgcgcagtc tcgccatggc ttgctacatc taccagctgc
       61 cgtcctgggt actggacgac ctgtgccgca atatcgacac gctcagtgag tgggactgga
      121 tgcagttcgc ttcctatgtg atcacagacc tgacacagct gaggaagatc aagtccatgg
      181 agagggttca gggggtgagc atcacccggg agctgctgtg gtggtggtcc atgcggcagg
      241 ccactgtcca gcagctggtg gacctcctgt gtcacctgga actctaccga gctgcccaga
      301 ttgtcctgag ctggaagccg gctcctgaca gcttgtctcc cctctcggcc ttcccagagg
      361 ctgtgaagcc aggtcctgtg gctacttctg gaagaaacct caaggatgac cagaagaagg
      421 gccagcctgt gaaaccatgc tcctttctga gctcagggac caccatggct ggcgcccagc
      481 agcaggcctc atgccaacgt ccatgcgagg aggatgcccc ttgttccctg aaaactgatg
      541 tacctgactc tctccaatct aagtattgta gcacgtccat ccccaagcag gaaaagcttt
      601 tgaatttgcc cggagacagg cttttctgga gtgaagcaga tatcgttcaa gcaactgagg
      661 actttgacca aagccaccga atcagtgagg ggacctttgc cgatatctac cggggacaaa
      721 ggaatggcgt ggcctttgcc ttcaagaggc tcagggaggt gactggctca agtccagggt
      781 ccatggacag attcctgcag gcggagatgc agctctgcct cagatgctgc caccccaaca
      841 tcctacctct gctgggcttc tgcactggaa gacagttcca cagcctcatc tacccctaca
      901 tggccaatgg ctctctgcag gacagactct gggctcaggg cgactcagac atgttgtcct
      961 ggccacagcg tgccagcatc tgctcagggc ttcttctagc tgtggaacac ctgcatagcc
     1021 tggatatcat ccacagtaat gtgaagagtg ccaacgtttt gctggaccag catcttaacc
     1081 ccaagctagc ccatccagta gctcacccgt gtcccaccaa taaaaagacc aaatatactg
     1141 taatgaagac tcacctgttc caggcctcag ctgcgtatct gcctgaaaac ttcatccgag
     1201 tgggacagct caccaagcaa gtagacatct tcagctgtgg aattgtattg gccgaggttc
     1261 tcaccggcat ccctgcaatg gacaaggacc gcagtccagt ttacctgaag gatttgcttc
     1321 tcagtgagat tcccagcaat acttcctcag tccactccag gaagaccagc atggggaagg
     1381 tggtggtgaa agagatctgc cagaagcact tggagaggaa ggcagggcta ctgcctgagg
     1441 cctgcgcgga aacctgggcc accgctgtga gcgtctgcct gcggagacgg gaggccagcc
     1501 tggaggaggc acgagtctcc atggctgggg tagaggagca gctcagaggg cagctgtccc
     1561 tcccctggag cagggtttct gaggatacgg gctcatcttc taatacccca gaggaaacgg
     1621 atgacgttga caattccagc ctcagtgtcc cctcttctgt tatggtggtg tcatgtgcaa
     1681 gggtttcctc ccctccacca tccatgggaa atgggacagc acagccatct accagtggga
     1741 ggcaggaggc tgactcctcc tccgaggctt gtgcaggccc acagccacct caggaagcta
     1801 cagagacttc atggaaaatt gagatcaatg aggccaaaag gagactgatg gagaacatcc
     1861 tactgtataa agaagagaaa ctggacagcg ttgagctttt tggaccctga tgaccagagc
     1921 acatctgaag acccttattc tcaactggat agacaaatgt ccagtcaagg aagaggtctt
     1981 tgactgccca agttcggttg agatccatac aacccaaatg tcagcctgaa cagaaggaaa
     2041 cattgtttca tcagagtcaa gttgcaggga ggggggcagg gggacatcaa cttacacaga
     2101 caccaaactc caggaagtac tcctcctctt tgagactgct tagtcagagg gctatgaagt
     2161 ggaacatctt gtacgtgacc caaggatttg ggtggttttg tggttccaga gagcccgtgt
     2221 tgattaccac cctaagagat gcttgcccca aaagctttta ttcctccaca acggacaaag
     2281 gggtatagca cccatggtgt tttccagagt tatcatctgt cagtcatatt tgcagacagt
     2341 tttctacaaa tttccacttc ttaaaagacc ttcagccagt gtctcagcaa tgcttgactc
     2401 atctctcaag ttcaggacta cagaggcaag acagttggca aaggactcct taggcttact
     2461 ccttcagttg gagatcttgt aagccactgg tatttgggaa ctgcttgctt ttcaccttcg
     2521 ccctcctgtc atacctatgt ttattttaat gaagactccg aggttgtatg ttatttataa
     2581 ctaggtgaag aagcatgaga aacagtctca tgtttgattc tgctgctagt aaagtcagtc
     2641 actcagtggc ggtaactcag tttccttgta agatgacccc tcttctattc agagctgttc
     2701 tattcagctt ttgggaggtg aggtgcagtg gctatagaag cactttgaaa atgtatctgt
     2761 tctgttttat aaattaagta aaaggtattt agttcatgtt tctgccctgt agaaaatgtt
     2821 tatgaagtga atatattttt gaaaagtcat gttgcaaacc ttttttgtaa aagaaactat
     2881 ttctaattca ctatttaaaa ataattccac tatagtgaca aaataaaaat gtttgttatc
     2941 tagcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
