LOCUS       NM_001127555            2749 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus interleukin-1 receptor-associated kinase 1
            (Irak1), mRNA.
ACCESSION   NM_001127555 XM_001057078 XM_343844
VERSION     NM_001127555.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2749)
  AUTHORS   Zhang Q and Wang SF.
  TITLE     miR-330 alleviates dextran sodium sulfate-induced ulcerative
            colitis through targeting IRAK1 in rats
  JOURNAL   Kaohsiung J Med Sci 37 (6), 497-504 (2021)
   PUBMED   33508876
  REMARK    GeneRIF: miR-330 alleviates dextran sodium sulfate-induced
            ulcerative colitis through targeting IRAK1 in rats.
REFERENCE   2  (bases 1 to 2749)
  AUTHORS   Wang H, Hao P, Zhang H, Xu C and Zhao J.
  TITLE     MicroRNA-223 inhibits lipopolysaccharide-induced inflammatory
            response by directly targeting Irak1 in the nucleus pulposus cells
            of intervertebral disc
  JOURNAL   IUBMB Life 70 (6), 479-490 (2018)
   PUBMED   29707878
  REMARK    GeneRIF: High IRAK1 expression is associated with inflammation.
REFERENCE   3  (bases 1 to 2749)
  AUTHORS   Wei J, Wang J, Zhou Y, Yan S, Li K and Lin H.
  TITLE     MicroRNA-146a Contributes to SCI Recovery via Regulating TRAF6 and
            IRAK1 Expression
  JOURNAL   Biomed Res Int 2016, 4013487 (2016)
   PUBMED   27830143
  REMARK    GeneRIF: As a negative feedback element, miRNA-146a could make sure
            that the expression of IRAK1- and TRAF6-mediated genes was under
            tight control. Thus, miRNA-146a may serve as a novel therapeutic
            target for SCI interventions.
REFERENCE   4  (bases 1 to 2749)
  AUTHORS   Eftekhar,E., Doustaki Zaboli,M., Katebi,M. and Soufi,F.G.
  TITLE     MicroRNA-146a and its adapter proteins are affected by diabetes in
            rat's heart
  JOURNAL   Bratisl Lek Listy 117 (3), 166-170 (2016)
   PUBMED   26925748
  REMARK    GeneRIF: increased in the heart of diabetic rats
REFERENCE   5  (bases 1 to 2749)
  AUTHORS   Bai S, Li D, Zhou Z, Cao J, Xu T, Zhang X, Wang Y, Guo J and Zhang
            Y.
  TITLE     Interleukin-1 Receptor-Associated Kinase 1/4 as a Novel Target for
            Inhibiting Neointimal Formation After Carotid Balloon Injury
  JOURNAL   J Atheroscler Thromb 22 (12), 1317-1337 (2015)
   PUBMED   26310493
  REMARK    GeneRIF: IRAK1/4 could serve as a potential therapeutic target to
            suppress neointimal formation in carotid arteries after balloon
            injury through the TLR4/NFkappaB signaling pathway
REFERENCE   6  (bases 1 to 2749)
  AUTHORS   Li S, Strelow A, Fontana EJ and Wesche H.
  TITLE     IRAK-4: a novel member of the IRAK family with the properties of an
            IRAK-kinase
  JOURNAL   Proc Natl Acad Sci U S A 99 (8), 5567-5572 (2002)
   PUBMED   11960013
REFERENCE   7  (bases 1 to 2749)
  AUTHORS   Jensen LE and Whitehead AS.
  TITLE     IRAK1b, a novel alternative splice variant of interleukin-1
            receptor-associated kinase (IRAK), mediates interleukin-1 signaling
            and has prolonged stability
  JOURNAL   J Biol Chem 276 (31), 29037-29044 (2001)
   PUBMED   11397809
REFERENCE   8  (bases 1 to 2749)
  AUTHORS   Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera
            B, Lewis A, Ray K, Tschopp J and Volpe F.
  TITLE     Tollip, a new component of the IL-1RI pathway, links IRAK to the
            IL-1 receptor
  JOURNAL   Nat Cell Biol 2 (6), 346-351 (2000)
   PUBMED   10854325
REFERENCE   9  (bases 1 to 2749)
  AUTHORS   Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda
            K and Akira S.
  TITLE     Differential roles of TLR2 and TLR4 in recognition of gram-negative
            and gram-positive bacterial cell wall components
  JOURNAL   Immunity 11 (4), 443-451 (1999)
   PUBMED   10549626
REFERENCE   10 (bases 1 to 2749)
  AUTHORS   Wesche H, Gao X, Li X, Kirschning CJ, Stark GR and Cao Z.
  TITLE     IRAK-M is a novel member of the Pelle/interleukin-1
            receptor-associated kinase (IRAK) family
  JOURNAL   J Biol Chem 274 (27), 19403-19410 (1999)
   PUBMED   10383454
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474099.1.
            
            On or before May 23, 2008 this sequence version replaced
            XM_001057078.1, XM_343844.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166780.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2749
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..2749
                     /gene="Irak1"
                     /gene_synonym="RGD1563841"
                     /note="interleukin-1 receptor-associated kinase 1"
                     /db_xref="GeneID:363520"
                     /db_xref="RGD:1563841"
     exon            1..317
                     /gene="Irak1"
                     /gene_synonym="RGD1563841"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..2314
                     /gene="Irak1"
                     /gene_synonym="RGD1563841"
                     /EC_number="2.7.1.-"
                     /codon_start=1
                     /product="interleukin-1 receptor-associated kinase 1"
                     /protein_id="NP_001121027.1"
                     /db_xref="GeneID:363520"
                     /db_xref="RGD:1563841"
                     /translation="MAGGPGPGEPVVPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQ
                     FAALIVRDQTELRLCERSEQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAW
                     HPPASVLPPSTGAPRPSSISAGSETEDWSPRKLQSSASTFLSPAFPGSQTHSESELLQ
                     VPLSDSLGPPLQSSAPSSIKPSPESPVSGLQRARPSPFCWPFCEISQGTCNFSEELRI
                     GEGGFGCVYRAVMRNTTYAVKRLKEEADLEWTVVKQSFLTEVEQLSRFRHPNIVDFAG
                     YCAESGFYCLVYGFLPNGSLEDQLHLQTQACSPLSWPQRLDILLGTARAIQFLHQDSP
                     SLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFAGANPSQSSTVARTCTVRGTLAYLP
                     EEYIKTGRLAVDTDTFSFGVVILETLAGQRAVRTQGAKTKYLKDLIEDEAEEVGVTLK
                     STQPTLWMGVATDAWTAPIAAQIYKKHLDSRPGPCPPQLGLALAQLACCCMHRRAKKR
                     PPMTQVYKRLEGLQAVPPWKLEVAGHGSPSPQENSYMSTTGSAQSGDEPWQPLVVTTR
                     APAQAAQQLQRSPNQPVESDESVPGLSATLHSWHLTPDSHPSPVSFREASCTQGGTTR
                     ESSLRSGPGFQPTTMEGSSMGSSSLLSSEPPQIIINPARQKMVQKLALYEEGVLDSLQ
                     LLSSGFFPGLDLEPEKRKRPEESDEFQS"
     exon            318..485
                     /gene="Irak1"
                     /gene_synonym="RGD1563841"
                     /inference="alignment:Splign:2.1.0"
     exon            486..617
                     /gene="Irak1"
                     /gene_synonym="RGD1563841"
                     /inference="alignment:Splign:2.1.0"
     exon            618..721
                     /gene="Irak1"
                     /gene_synonym="RGD1563841"
                     /inference="alignment:Splign:2.1.0"
     exon            722..910
                     /gene="Irak1"
                     /gene_synonym="RGD1563841"
                     /inference="alignment:Splign:2.1.0"
     exon            911..975
                     /gene="Irak1"
                     /gene_synonym="RGD1563841"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1090
                     /gene="Irak1"
                     /gene_synonym="RGD1563841"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1209
                     /gene="Irak1"
                     /gene_synonym="RGD1563841"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1417
                     /gene="Irak1"
                     /gene_synonym="RGD1563841"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1483
                     /gene="Irak1"
                     /gene_synonym="RGD1563841"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1720
                     /gene="Irak1"
                     /gene_synonym="RGD1563841"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..2102
                     /gene="Irak1"
                     /gene_synonym="RGD1563841"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2252
                     /gene="Irak1"
                     /gene_synonym="RGD1563841"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2749
                     /gene="Irak1"
                     /gene_synonym="RGD1563841"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaggccgc ggagggcaag atggcggcgg gccgagcgcc gcctcttccg cctgccgggt
       61 gtcgcacgag gccggcttga aggggaagtg agtcagtgtt tgtggaccgg gctggctaag
      121 gcccgcgccc gccgaggccc ggagaggcct cggcccggcg gcgggggcgg cggcaacggt
      181 catggccggg ggcccgggcc ccggggagcc tgtggttccc ggcgcccagc atttcttgta
      241 cgaggtgcct ccctgggtta tgtgccgttt ctacaaagtg atggacgccc tggagcccgc
      301 cgactggtgc cagttcgcgg ccttgatcgt gcgcgaccag acagagctgc ggctgtgtga
      361 gcgctccgag cagcgcacgg ccagtgtcct gtggccctgg atcaaccgca acgcgcgtgt
      421 ggctgacctc gttcacatcc tcacgcacct gcagctgctg cgtgcgcggg acatcattac
      481 agcctggcac cctcctgcct ctgttctgcc cccaagcacc ggtgccccaa ggcccagcag
      541 catctctgca ggctctgaga ctgaggactg gagcccccgg aaattgcagt cctctgcctc
      601 caccttcctc tccccagctt ttccaggctc ccagacccat tctgagtcag agctcctcca
      661 ggttccactc tctgattccc tcgggccacc actacaatct tcagccccct cctccatcaa
      721 gccaagccca gagagcccag tgtctggcct ccaaagagct cgtccctccc cattttgctg
      781 gcccttctgt gagatttccc aaggcacttg caacttctct gaagaactca ggattggaga
      841 gggtggtttt gggtgtgtgt accgagcagt aatgagaaat actacatatg ctgtgaagag
      901 actgaaggag gaggctgacc tagagtggac tgtggtgaaa cagagcttcc taacagaggt
      961 ggaacagcta tcaaggtttc gtcacccaaa tatcgtggac tttgctggct actgtgcaga
     1021 gagtggcttc tactgccttg tttatggctt cctgcccaat ggctccttag aggatcagct
     1081 tcaccttcag acccaagcct gctccccact ttcctggcct caacgactgg acattcttct
     1141 gggcacagcc cgggctattc agtttttaca tcaggacagc cccagcctta tccatggaga
     1201 catcaagagt tctaatgtgc ttctggatga gagactgatg cccaagctgg gagactttgg
     1261 tctggctcgt ttcagccgct ttgcaggggc caacccaagc cagagcagta ctgtggcccg
     1321 gacttgcaca gttcgaggta ccctcgccta cctgcctgag gagtacatca agacaggccg
     1381 gctggctgtg gacaccgata ccttcagctt tggggtggta atactggaga cccttgctgg
     1441 tcagagggct gtgaggacac aaggtgcaaa aaccaaatat ctgaaagacc tgattgaaga
     1501 tgaggctgaa gaggtgggag tgaccttaaa aagcacccag cctactttgt ggatgggtgt
     1561 agccacggat gcttggactg ctccaattgc tgcccagatc tataagaagc acctggactc
     1621 cagacctggg ccctgcccac cccagttggg cctggccctg gctcaactag cttgctgctg
     1681 catgcaccgt cgggccaaga agaggccacc catgacccag gtatacaaga gactagaagg
     1741 gcttcaggca gtacctccct ggaagctaga ggttgccggc catggctctc cttccccaca
     1801 ggagaactcc tacatgtcca ccactggcag tgcccagagt ggggatgaac catggcagcc
     1861 tctggtagtg accacaagag ctccagccca ggctgcccag caactccaga gaagtcccaa
     1921 ccagccagtg gagagtgatg agagtgttcc tggcctctct gctaccctgc attcctggca
     1981 cttgactcca gattcccacc caagccctgt gtccttcaga gaggctagct gtacacaagg
     2041 aggcactacc agagaatcaa gtttgaggag tggcccaggc ttccagccta cgaccatgga
     2101 aggctcatcg atgggcagtt catccctgct gtcatcagag ccaccacaga tcatcatcaa
     2161 cccagcccga cagaagatgg tacaaaagct ggccctgtat gaagaggggg tcttggatag
     2221 cctgcaactg ctgtcatcag gctttttccc aggcttggat ttagaacctg aaaagagaaa
     2281 gagacctgaa gaaagtgatg aattccagag ctgatttatt cactcagact cagatgtcaa
     2341 agttctcatt gttggaagtt ctcatggtgt acaaactcct cagtacccca aaggcatcag
     2401 gtgtggtggc ccaccctggc aaaggagaga gggtggtgga ccctgttatt ctcataatgt
     2461 aagcacagac aaggccagcc aaagaacctg atagaagctg ataaggctgg cagtgttggg
     2521 ccagcatttg tgagcaaggc aagcagagca cctaagggat tgggtagtat ataacagaag
     2581 actgctagct acacaggccc agaggacgca agtgggtctg tttctatggt ggagctggct
     2641 cccctgagag ctagacagaa tatctgcagc ctaactatga atccattcct atgaacttcc
     2701 ctagaacccc aagagaaaga agctattgtg cttttaaaat gcaaataat
//
