LOCUS       NM_001034130            3058 bp    mRNA    linear   ROD 14-APR-2024
DEFINITION  Rattus norvegicus IQ motif and ubiquitin domain containing (Iqub),
            mRNA.
ACCESSION   NM_001034130 XM_342648
VERSION     NM_001034130.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3058)
  AUTHORS   Lai,C.K., Gupta,N., Wen,X., Rangell,L., Chih,B., Peterson,A.S.,
            Bazan,J.F., Li,L. and Scales,S.J.
  TITLE     Functional characterization of putative cilia genes by high-content
            analysis
  JOURNAL   Mol Biol Cell 22 (7), 1104-1119 (2011)
   PUBMED   21289087
REFERENCE   2  (bases 1 to 3058)
  AUTHORS   Shi,Y.Q., Li,Y.C., Hu,X.Q., Liu,T., Liao,S.Y., Guo,J., Huang,L.,
            Hu,Z.Y., Tang,A.Y., Lee,K.F., Yeung,W.S., Han,C.S. and Liu,Y.X.
  TITLE     Male germ cell-specific protein Trs4 binds to multiple proteins
  JOURNAL   Biochem Biophys Res Commun 388 (3), 583-588 (2009)
   PUBMED   19706271
  REMARK    GeneRIF: These results suggested that Trs4 might be involved in
            diverse processes of spermiogenesis and/or fertilization through
            interactions with its multiple binding partners.
REFERENCE   3  (bases 1 to 3058)
  AUTHORS   Shin,N., Lee,S., Ahn,N., Kim,S.A., Ahn,S.G., YongPark,Z. and
            Chang,S.
  TITLE     Sorting nexin 9 interacts with dynamin 1 and N-WASP and coordinates
            synaptic vesicle endocytosis
  JOURNAL   J Biol Chem 282 (39), 28939-28950 (2007)
   PUBMED   17681954
  REMARK    GeneRIF: SNX9 interacts with dynamin-1 and N-WASP in presynaptic
            terminals, where it links actin dynamics and synaptic vesicle
            endocytosis.
REFERENCE   4  (bases 1 to 3058)
  AUTHORS   Pommereit,D. and Wouters,F.S.
  TITLE     An NGF-induced Exo70-TC10 complex locally antagonises
            Cdc42-mediated activation of N-WASP to modulate neurite outgrowth
  JOURNAL   J Cell Sci 120 (Pt 15), 2694-2705 (2007)
   PUBMED   17635999
  REMARK    GeneRIF: findings confirm that the Exo70-TC10 complex mainly
            targets the NGF-induced Cdc42-dependent activation of N-WASP
REFERENCE   5  (bases 1 to 3058)
  AUTHORS   Fukuoka,M., Miki,H. and Takenawa,T.
  TITLE     Identification of N-WASP homologs in human and rat brain
  JOURNAL   Gene 196 (1-2), 43-48 (1997)
   PUBMED   9322739
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099086.1.
            
            On Oct 14, 2005 this sequence version replaced XM_342648.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099086.1, DQ132434.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3058
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..3058
                     /gene="Iqub"
                     /gene_synonym="RGD1562359; Trs4"
                     /note="IQ motif and ubiquitin domain containing"
                     /db_xref="GeneID:296936"
                     /db_xref="RGD:4145674"
     exon            1..45
                     /gene="Iqub"
                     /gene_synonym="RGD1562359; Trs4"
                     /inference="alignment:Splign:2.1.0"
     exon            46..440
                     /gene="Iqub"
                     /gene_synonym="RGD1562359; Trs4"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..2422
                     /gene="Iqub"
                     /gene_synonym="RGD1562359; Trs4"
                     /note="IQ and ubiquitin-like domain-containing protein"
                     /codon_start=1
                     /product="IQ motif and ubiquitin-like domain-containing
                     protein"
                     /protein_id="NP_001029302.1"
                     /db_xref="GeneID:296936"
                     /db_xref="RGD:4145674"
                     /translation="MSDTEENVLDSPASGEAAGEVISIPGPTDEAEESDISPEQEYEI
                     EGFTTESEETVEHYSDLSVSTPKSYDSKPRDEVVSLGSATDSHEQEYRLGDLGGDQRS
                     EEDEMSFLYKIKAIKENLQSSVKECIATVKIVLIPAGQEIVMPFRVDAPFRFLKEHFA
                     HLLRIPHHVLQMAYTGISVGNNESLIQYGVKPREIVQMNVFSSEPDQYPVRRIEGLSE
                     GSKIITVTIQTGIERYEEVAVEIVKSDFHKPFLGGFRHKITGLEYHNAGTQTVPKKIP
                     EKDNLFCRDTQTVFQKKKLQQTMNTTSTQMTKIGVYVSNMTDKLLTPGSYFSAAEYHA
                     RRLNAVIVIQTAYRRWHAKCYVDSLRLQKKMRLEWEKEEELKKIREKEEWIRMDYYRR
                     HNPKTTEDFELLFNALELWRQEEVTQVEQYSSEAERKAALCELLEKETQIIASIGRHR
                     YVAQLERQDVATQAFLDKCSASNTWRRPDGQTVEMDTQFTIRARELQSIYKCILLKNL
                     SQDERLDILLTLKHTVKEHECKLTQEILELIDREVDLMMRGVKSHNLEGLRKRITTLF
                     IHYIKTPLFNPEVAKHLKVPQDPLKFYDKIYFCHSCQMYLPSVEFSVSPTSHRVYRCR
                     HCINLENETQRRESFLKYKCLLQRLYFSEANYEDNSHIAYLMQLQDIKYLTENIWASQ
                     SALSAWDDLNDLVMVRWNKHVEWSPWNCILLTKDEGTAHLKLESIEKGYGRLFIHKIK
                     HKHILAKNYFSQVPVLASLILKDDEIEAIRSKYSTENPPKIIVPHGIVPN"
     exon            441..575
                     /gene="Iqub"
                     /gene_synonym="RGD1562359; Trs4"
                     /inference="alignment:Splign:2.1.0"
     exon            576..737
                     /gene="Iqub"
                     /gene_synonym="RGD1562359; Trs4"
                     /inference="alignment:Splign:2.1.0"
     exon            738..910
                     /gene="Iqub"
                     /gene_synonym="RGD1562359; Trs4"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1066
                     /gene="Iqub"
                     /gene_synonym="RGD1562359; Trs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1277
                     /gene="Iqub"
                     /gene_synonym="RGD1562359; Trs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1453
                     /gene="Iqub"
                     /gene_synonym="RGD1562359; Trs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1624
                     /gene="Iqub"
                     /gene_synonym="RGD1562359; Trs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1801
                     /gene="Iqub"
                     /gene_synonym="RGD1562359; Trs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..2050
                     /gene="Iqub"
                     /gene_synonym="RGD1562359; Trs4"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2236
                     /gene="Iqub"
                     /gene_synonym="RGD1562359; Trs4"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..3034
                     /gene="Iqub"
                     /gene_synonym="RGD1562359; Trs4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactggggaa accttttggt cggtaatagc tgttttcttg agcaggaaaa tgtccgatac
       61 ggaggagaat gtccttgact ccccggccag tggtgaagcg gccggcgaag tcatcagtat
      121 tcctggccct acagacgaag cagaagagtc agatatctca ccagagcaag aatacgaaat
      181 agagggattt accaccgaga gtgaggagac agtggagcac tacagtgatc tcagtgtttc
      241 aacccccaaa tcttacgact ccaaacccag ggacgaggtc gtgtcccttg gaagtgccac
      301 agactctcat gagcaagaat acagacttgg agatcttgga ggtgaccaga gatcagaaga
      361 ggacgagatg tcatttcttt ataaaatcaa agctataaag gagaacttgc agtcgtcagt
      421 gaaagagtgt atagccacag taaaaattgt acttattcct gcaggccagg aaattgtaat
      481 gcctttcaga gttgatgctc catttagatt cctcaaggag cactttgcac acttattacg
      541 tatcccccat catgtattgc aaatggccta tacaggaatc agtgttggga ataatgagtc
      601 cctgatacaa tatggagtca aaccacggga aatcgttcaa atgaatgtat tttcctcaga
      661 acccgaccaa tatccagtca gaagaataga gggcttgagt gagggctcca agatcataac
      721 ggtcaccatt cagaccggca tcgaacgcta cgaggaggta gctgtggaga tagtaaaatc
      781 tgacttccac aagccatttc ttggtggatt tagacataaa ataacaggac tagaatacca
      841 caatgctggg acacaaactg tacccaagaa gattccggaa aaagacaatc tgttctgtag
      901 ggacacccag acagtttttc agaaaaagaa gctgcaacaa actatgaata ccacctccac
      961 tcagatgact aaaatcggtg tatacgtatc aaacatgact gataaactgc tcacgccagg
     1021 aagttacttt tcagctgcag agtaccacgc tcgaaggttg aacgcggtga tagtgattca
     1081 gactgcctac aggcgatggc acgctaagtg ctatgtcgac agcctaagac tacaaaagaa
     1141 aatgaggttg gagtgggaaa aagaggaaga acttaagaag atccgagaga aggaagaatg
     1201 gatacgaatg gactattacc ggaggcacaa tcctaaaaca accgaagact ttgagctcct
     1261 tttcaatgct ctagaacttt ggcgtcaaga agaagtcaca caagttgagc aatattcaag
     1321 tgaggctgaa aggaaagctg ctctgtgcga gcttttggaa aaagagacgc agataattgc
     1381 ttccatcggg agacatagat acgttgctca gttggagaga caggatgtag ctacacaagc
     1441 ttttctggat aagtgttcag cttcaaatac ctggagaaga cctgatggac aaaccgttga
     1501 aatggacaca cagttcacaa taagagccag agagctgcaa agcatctaca agtgtatcct
     1561 gctgaaaaac ctctctcaag atgagaggct ggatatactc ctgacactga agcacactgt
     1621 gaaggaacat gagtgtaaac tgacccaaga aatcctagaa ttgattgaca gagaagttga
     1681 ccttatgatg agaggagtta aatctcataa tctcgaagga ctcaggaaaa gaatcacaac
     1741 actctttatt cactatatca aaactcctct gtttaaccca gaagtcgcaa aacaccttaa
     1801 ggtccctcaa gacccactga agttttatga taagatttac ttctgccaca gttgccaaat
     1861 gtatttgcct tctgtcgagt tttccgtctc acccacctcg catcgtgtgt accgctgccg
     1921 gcactgcata aacctggaga atgagactca gaggcgggaa tcatttttga aatacaagtg
     1981 tttacttcag cggctctact tctcagaagc caattatgag gataactccc acattgctta
     2041 tctaatgcag cttcaggata ttaagtactt gacagagaac atctgggcat cgcagtcggc
     2101 cctcagcgcc tgggatgacc tcaatgacct ggtcatggtc aggtggaaca aacacgtgga
     2161 gtggtcgccc tggaactgca ttctgctcac caaggatgaa ggcacagctc atctcaagct
     2221 agagagcatc gagaagggat atggacgcct ttttattcac aagatcaagc acaaacatat
     2281 cttggctaaa aactattttt cacaggtccc agtgctggct tcacttatac ttaaggatga
     2341 tgaaatagaa gctatcagaa gtaaatactc cacagagaat cctcctaaaa tcatagtacc
     2401 ccatgggatt gtacctaatt agagtcagga atgttgattt gatgatgagc atttttgttc
     2461 tctacgaaga gaataataca aaggtcatga acaaggaaaa ccacctatga atttttattt
     2521 ctattatata ttttactcac aatattttgt tatatgaaga gaaaacatcc gtatacaaga
     2581 acccgtgtta ggtggtttgg agtctataaa tttgatacta agattaatag ttaaagagaa
     2641 cacttttatt tttatccatt ttcatttgag gaaaagtgct ctatagtcaa aatacatcag
     2701 tgaaacaaaa ccttggctta atcttctgtg aaagtaattt acttatttaa catatatttt
     2761 atgagtataa tcactctata cgtaagcctg tattttgaga taagtagttg aatattttac
     2821 ttttattgtc tacttttacc tgttaactgc ataatacaag aaaagaaact gtaacagata
     2881 agcataaatc tgcatcgcac gccatgaaac aaggcaaaca gtggaaatgt cacgttacat
     2941 gcttcctccg gggaagtgtt gagattctgt aagaagcata aacttgataa atcaactgtc
     3001 cactgcttct caataaagta agcaataact ctgaaaaaaa aaaaaaaaaa aaaaaaaa
//
