LOCUS       NM_207617               7410 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus IQ motif and Sec7 domain ArfGEF 3 (Iqsec3), mRNA.
ACCESSION   NM_207617
VERSION     NM_207617.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7410)
  AUTHORS   Fruh,S., Tyagarajan,S.K., Campbell,B., Bosshard,G. and
            Fritschy,J.M.
  TITLE     The catalytic function of the gephyrin-binding protein IQSEC3
            regulates neurotransmitter-specific matching of pre- and
            post-synaptic structures in primary hippocampal cultures
  JOURNAL   J Neurochem 147 (4), 477-494 (2018)
   PUBMED   30142695
  REMARK    GeneRIF: we provide biochemical evidence to confirm gephyrin/IQSEC3
            interaction near the IQSEC3 IQ motif, which in turn binds
            calmodulin at low Ca(2+) concentrations
REFERENCE   2  (bases 1 to 7410)
  AUTHORS   Uezu,A., Kanak,D.J., Bradshaw,T.W., Soderblom,E.J., Catavero,C.M.,
            Burette,A.C., Weinberg,R.J. and Soderling,S.H.
  TITLE     Identification of an elaborate complex mediating postsynaptic
            inhibition
  JOURNAL   Science 353 (6304), 1123-1129 (2016)
   PUBMED   27609886
REFERENCE   3  (bases 1 to 7410)
  AUTHORS   Um,J.W., Choii,G., Park,D., Kim,D., Jeon,S., Kang,H., Mori,T.,
            Papadopoulos,T., Yoo,T., Lee,Y., Kim,E., Tabuchi,K. and Ko,J.
  TITLE     IQ Motif and SEC7 Domain-containing Protein 3 (IQSEC3) Interacts
            with Gephyrin to Promote Inhibitory Synapse Formation
  JOURNAL   J Biol Chem 291 (19), 10119-10130 (2016)
   PUBMED   27002143
  REMARK    GeneRIF: these data reveal that IQSEC3 acts together with gephyrin
            to regulate inhibitory synapse development.
REFERENCE   4  (bases 1 to 7410)
  AUTHORS   Fukaya,M., Kamata,A., Hara,Y., Tamaki,H., Katsumata,O., Ito,N.,
            Takeda,S., Hata,Y., Suzuki,T., Watanabe,M., Harvey,R.J. and
            Sakagami,H.
  TITLE     SynArfGEF is a guanine nucleotide exchange factor for Arf6 and
            localizes preferentially at post-synaptic specializations of
            inhibitory synapses
  JOURNAL   J Neurochem 116 (6), 1122-1137 (2011)
   PUBMED   21198641
REFERENCE   5  (bases 1 to 7410)
  AUTHORS   Inaba,Y., Tian,Q.B., Okano,A., Zhang,J.P., Sakagami,H.,
            Miyazawa,S., Li,W., Komiyama,A., Inokuchi,K., Kondo,H. and
            Suzuki,T.
  TITLE     Brain-specific potential guanine nucleotide exchange factor for
            Arf, synArfGEF (Po), is localized to postsynaptic density
  JOURNAL   J Neurochem 89 (6), 1347-1357 (2004)
   PUBMED   15189337
  REMARK    GeneRIF: cloned from a rat brain cDNA library; both the mRNA and
            the protein were localized in the postsynaptic compartments;
            results suggest a postsynaptic role of synArfGEF in the brain
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB057643.1.
            
            [WARNING] On Apr 11, 2024 this sequence was replaced by
            NM_207617.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB057643.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..7410
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..7410
                     /gene="Iqsec3"
                     /gene_synonym="sag"
                     /note="IQ motif and Sec7 domain ArfGEF 3"
                     /db_xref="GeneID:404781"
                     /db_xref="RGD:1593191"
     exon            1..1179
                     /gene="Iqsec3"
                     /gene_synonym="sag"
                     /inference="alignment:Splign:2.1.0"
     CDS             644..4228
                     /gene="Iqsec3"
                     /gene_synonym="sag"
                     /note="synArfGEF; synArfGEF-Po; potential synaptic guanine
                     nucleotide exchange factor for Arf; IQ motif and Sec7
                     domain 3"
                     /codon_start=1
                     /product="IQ motif and SEC7 domain-containing protein 3"
                     /protein_id="NP_997500.1"
                     /db_xref="GeneID:404781"
                     /db_xref="RGD:1593191"
                     /translation="MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRQRIDELERRLD
                     ELSAENRSLWEHQQLLQAQPPPGLVPPPSAPLPAPAATAPAATAAQEPLQDHGQLIPA
                     TPEPPLQHHGQLLAQPQPAPSSRVQTPQSPHQHPVAPGAVADKEKERPSSCCAAAGAL
                     LQHASPAALGKGVLSRRPKNETVLHQFCCPATDTEQKPACSDLASQSDGSCAQAGGGM
                     EDSVVAAVAAGRPSAHAPKAQAPELQQEEERPGAVGSPRAGPLRAASPGQQQPALATA
                     LCSHTPAASEYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKI
                     RNSLLESRLPRRISLRKVRAPTAESLVAEKALLESCGLLGLPLGRSPSLPPTFAGSLT
                     ELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLQESGAYQLHQALHPSAGQPGLETEAA
                     REPDSGPGSGDEAGSLPQGHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQT
                     AQATAEPAAVQTEQGDAATQEVSEVPASELMDPPVEDSEAAESGAQSAHEPTVAEAVV
                     EEAVATEAEEEEEGAGQAGKGAEAEVGDNSEQLSSSSASTKSAKSGSEVSAAASKEAL
                     QAVILSLPRYHCENPASCRSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIP
                     DTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSNMELDEALRKF
                     QAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSP
                     NIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEK
                     SIVGMKTVLSMPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKK
                     SSFTYTFCKAVGLLGMRFHLFENEYYSHGITLATPLSGSEKKQVLHFCALGSDEMQKF
                     VEDLKESIAEVTELEQIRIEWELERQQGTKTLSARSAGAQGDPQSKQGSPTAKREAMA
                     GEKATESSGEVSIHNRLQTFQHSPKLGVERGAPAPSPPTSPPPPLPPDPQPSPLREQP
                     PPLPLPPPTPPGTLVQCQQIVKVIVLDKPCLARMEPLLSQALSCYASSSSDSCGSTPL
                     RGPGSPVKVIHQPPLPPPPPPYNHPHQFCPPGSLLLRRRYSSGSRSLV"
     exon            1180..1263
                     /gene="Iqsec3"
                     /gene_synonym="sag"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1534
                     /gene="Iqsec3"
                     /gene_synonym="sag"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..2640
                     /gene="Iqsec3"
                     /gene_synonym="sag"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2802
                     /gene="Iqsec3"
                     /gene_synonym="sag"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..2925
                     /gene="Iqsec3"
                     /gene_synonym="sag"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3092
                     /gene="Iqsec3"
                     /gene_synonym="sag"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3232
                     /gene="Iqsec3"
                     /gene_synonym="sag"
                     /inference="alignment:Splign:2.1.0"
     exon            3233..3358
                     /gene="Iqsec3"
                     /gene_synonym="sag"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3458
                     /gene="Iqsec3"
                     /gene_synonym="sag"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..3620
                     /gene="Iqsec3"
                     /gene_synonym="sag"
                     /inference="alignment:Splign:2.1.0"
     exon            3621..3713
                     /gene="Iqsec3"
                     /gene_synonym="sag"
                     /inference="alignment:Splign:2.1.0"
     exon            3714..3763
                     /gene="Iqsec3"
                     /gene_synonym="sag"
                     /inference="alignment:Splign:2.1.0"
     exon            3764..7391
                     /gene="Iqsec3"
                     /gene_synonym="sag"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actaagcaac agacacacgc attgttttct agagtctatt aactgttcac agacacccca
       61 caaagcaaat tgttgagcat caaaaaggca ggtatgtcct cctcagaagg tcttaaaaat
      121 gggccctgcc tccgagttag atacaggaaa atgtgattgt gaccttttcg agctgggtgc
      181 ctatatgcct ctcttcgtca gtgccagctt cccccctcct tattcttcct ttttctcaga
      241 aggcttcctt tttgtcttcg ttccctagca ctttcccagc tcttctgctc gggttgaccg
      301 gtagaactga tctccatcct ggaatctcac agagtatctt gctcgaccga acctcttcct
      361 ctttgctctc ccttcgcccc cgcctcccct acgcccccgc gggaagcaga gttcctcacg
      421 aagcccagag gtgggaggtg ggccctggcg ccggtccgcc ccttagtgcg tgtgcgaatg
      481 cctgtgtggc ggtgacgcgc aggcgacggc gggaagggga gggagagaga gagagggagg
      541 gaggccaccg accgacagag ctgctgggct gctgggctcc tgcgcgctca cgctccccgc
      601 cgcccgccta ggcgcaggca gggcgcaggc ggcggcgggc ggcatggaga gcctgctgga
      661 gaacccggtg cgcgccgtgc tctaccttaa ggagctcacg gccatcgtgc agaaccagca
      721 aagcctcatc catacccagc gccagcgcat cgatgagctg gagcggcgtc tagacgagct
      781 gagcgcggag aaccgcagcc tgtgggaaca ccagcagctg ctgcaagccc agcctccgcc
      841 tgggctggtt cccccgccgt ctgccccact gccggctcct gcagccactg ctccggccgc
      901 cactgcggcc caggaaccgc ttcaggacca cggacagctc atacccgcca cgccggagcc
      961 gccgcttcag caccacggac agctcctggc acagccacag ccggccccca gcagcagggt
     1021 tcagactccc cagtcgcccc accagcaccc ggtggcaccc ggggccgtag ctgacaagga
     1081 gaaggagcgt ccctcgagtt gttgtgctgc cgcgggagcc ctgcttcagc acgcatcccc
     1141 cgccgccctc ggcaagggcg tcctgagcag gagacccaag aatgagaccg tgctacacca
     1201 attctgctgc cccgccactg acactgagca gaagcctgct tgctctgacc tggcttccca
     1261 aagtgatggc tcctgtgccc aggccggtgg gggcatggag gactccgtgg tggcagcggt
     1321 ggcagccggc agacccagtg cccatgcccc gaaggctcaa gccccggagc tacagcagga
     1381 ggaggagcgg ccaggggcgg tgggctcccc acgggctggc cccctccgcg cggcctcccc
     1441 tggccagcag cagcctgccc tggcgacggc gctctgctcc cacactcctg ctgcctccga
     1501 gtacgaactc tcccttgacc taaagaataa acagattgaa atgctagaac acaaatacgg
     1561 gggccacctg gtatcccgac gcgccgcgtg caccatccaa accgcttttc gccagtacca
     1621 gctcagcaag aactttgaga agatccgtaa ctcgctcctg gagagccgcc tgcctcggcg
     1681 gatctcgctg cgcaaggtga gggcgcccac agcggaaagc ctggtggcag agaaggcact
     1741 cctggagagc tgtgggctcc tggggctccc gctggggcgc tcgccctccc taccacccac
     1801 cttcgcaggc tctctcaccg agctggagga ctcctttacc gagcaggtgc agtccctggc
     1861 caagtccata gacgacgccc tcagcacctg gagcctcaag accatgtgct cgctgcagga
     1921 gagtggcgcg taccagctcc accaggcgct gcaccctagt gccgggcagc caggtctgga
     1981 gaccgaggcg gcgcgggagc cggacagcgg cccagggtca ggagatgagg ccggtagcct
     2041 gcctcagggt cacagcggta ccctcatgat ggctttccgg gacgtcacgg tgcagatcgc
     2101 taaccagaac atctctgttt cctcctccac cgccctgtct gtggctaact gtctgggcgc
     2161 acagaccgct caggccacag ccgagcctgc agccgttcaa accgaacaag gggacgctgc
     2221 gactcaggag gtctcggaag tcccagcctc ggaactgatg gacccacccg ttgaggactc
     2281 agaggcggcg gagagcggcg cccagagcgc acacgaaccc acggtggccg aggccgtggt
     2341 ggaggaggca gtggctacag aagcagaaga ggaagaagaa ggggccgggc aggcagggaa
     2401 aggggcggag gctgaggtgg gcgacaactc tgagcagttg agcagcagca gcgcatccac
     2461 caagtccgcc aaatctggct cagaggtctc tgccgctgcc tccaaggagg ccctgcaggc
     2521 ggtgatcctg agcttgcctc gctaccactg cgagaaccca gccagctgca ggtcccccac
     2581 gctctccaca gacaccctgc gcaagcggct ataccgcata ggcctcaacc tcttcaatat
     2641 aaatccggac aagggcatcc agttcctgat ctcccgtggc ttcatccccg acacccccat
     2701 cggtgtggcc cacttcctcc tccagcgcaa aggcctcagc cgccagatga taggagagtt
     2761 tctgggcaat agcaagaagc agttcaaccg ggacgtgcta gactgcgtgg tggatgagat
     2821 ggacttttcc aacatggagc tggatgaagc cctgaggaag tttcaagcgc acatccgagt
     2881 gcaaggggaa gcccagaagg tagagcgact catagaagct ttcagccaac gctactgcat
     2941 gtgcaatcct gaggtggtgc aacaattcca caacccagac actatcttca tcctggcctt
     3001 cgccatcatc ctcctcaaca ccgacatgta cagccccaac atcaagcctg accggaagat
     3061 gatgctggaa gattttatcc ggaacctccg aggtgtggat gacggcgctg acatccccag
     3121 ggagctggtg gtaggcatct atgaaaggat ccagcagaag gagctcaagt ccaatgagga
     3181 ccatgtcaca tatgtcacca aggtggagaa gtccatcgtg ggcatgaaga cggtgctgtc
     3241 catgccacat cgccgcctgg tctgctgtag ccggctcttc gaggtgaccg atgtgaacaa
     3301 gttacagaaa caagccgccc accagagaga agtgttcctc ttcaacgatc tgctggtgat
     3361 tctcaagctg tgtccaaaga agaagagctc cttcacatac accttctgca aagcggtcgg
     3421 cctgttaggc atgcgattcc acctctttga gaacgagtat tactctcatg gtatcaccct
     3481 ggcgaccccg ctctcgggct ccgagaagaa gcaggtgctg cacttctgcg ccctgggctc
     3541 cgacgagatg cagaagttcg tggaagacct gaaggagtcc atcgccgagg tgacagagct
     3601 ggagcagatt cggatagaat gggaactgga gaggcagcag ggaacaaaga cactctctgc
     3661 aaggtctgct ggagcccagg gggacccaca gtcaaagcaa ggatcaccca cagccaagag
     3721 ggaagcgatg gcaggagaga aagcgacgga gagctcgggg gaggtgtcaa ttcacaacag
     3781 gcttcaaacg ttccagcaca gccccaagtt gggggtcgag aggggagcgc cagcaccatc
     3841 accaccaaca tcaccaccac caccgttgcc accagaccca cagcctagtc ccctgaggga
     3901 gcagcccccg ccactgccac tgccaccacc cacaccccca ggcaccctgg tacagtgcca
     3961 gcaaattgtc aaggtcattg tcctggataa accctgcttg gcccgcatgg agcccctgct
     4021 gagccaggct ctgtcctgct atgcctcatc ctcctcagac tcctgtggct ccacaccttt
     4081 gcgtggtccg ggctccccag ttaaggtcat ccaccagcct ccactgcccc cacccccacc
     4141 cccatacaac caccctcacc agttctgccc accaggctct ctgctactcc ggcgccgcta
     4201 ctccagtggc tccaggagcc tggtgtagac ccttagcacc ccgatgttcc agtgggttgt
     4261 ccttcaggaa tctgggctgc tccttggcac tcctcacatc ttggcataat gccttcctgg
     4321 ccactggtca ctgtcgtgaa aagagaatgc cctggcaaga tggtttgctt gacccaacca
     4381 tccttcacta cgtgatttga gtacctcacc acaaacatac cactttctca ctctctccag
     4441 gggtgccaca tggccagatg ggccttctcc tctgtgttca ccatgctccc ctaattagat
     4501 tgtacatcga aggagccaag gggcctgtgg ggctgatggg ctgaccatct tggtctacta
     4561 gtgtccatgt cttgggccag tggacaagag caaaaggctg gacctgccag cagcacaccc
     4621 taggacgggg caggctaccc cagcataagg tgtatctatg accaagctga atcaaggaat
     4681 gctatccctg gctccctgga gaggtctaaa catagtagga gaagggagct ttgtctgctg
     4741 tgtcctgtta tccaaaccta cagtcaggaa actcgttctt agctccccag ggacattggc
     4801 tcccttaacc atgtctgctc tcctgcctcc cctagaccca ggaaagatcc aagaaagaga
     4861 aggaattggg gtattcaggt ttatctgggt cagttcaaca tggccctgaa acggtgaggt
     4921 catgtctgca aagtgcactt tttaagaaca tttcttggtt ctctagcctt aaacacttgg
     4981 ccagtactga gtgtacacag gcagttatcc ataaacacat gtgagaacca ggttgatgac
     5041 ttccttgtgg aaccagaagc aaagggaatg acatgctggt ttggccaaca gaggtgtgac
     5101 tgggcctgga gcaggacttc ctggtgtacg actctgcggc ctctgtgtac acagacaagg
     5161 caaagcagtg gggttccaga gtcactctgc cacccctgtt gccctaccct tgaaacattt
     5221 cctccctgga aaatgtacgc tggcttccag caggggtggc ctagacttcc tggaccttcc
     5281 aaactgcaga cagagctgag cagggagagc ttgtcggctt gccaggtctg ctagcacagg
     5341 tagccctggc cctacagagc cccagacaga tgaggcagcc ccagagtcag acttcagggg
     5401 tgatatcatg ggctgtcacc ttcatgctgt tttcagggac cacctgtcac aagccaggcc
     5461 agtctccttt gtcctgtgcc aacagcaatc tctgaccatc ctcaagatgt cctcctcctc
     5521 aaagcctgtt tttaaagttt cccaagaggc tacaggcaca gtgaacgtgg ccatagtcaa
     5581 aagtaaattg aggggctggg aatttagctc agtggtagag cgcttaccta ggaagcgcaa
     5641 ggccctgggt tcggtcccca gctccgaaaa aaagaaccaa aaaaaagaaa aaaattgact
     5701 tttcctggtc cctactatcc accccgagat tcagtaccct gaaccagata ggaggctttt
     5761 agaggggcca aatgtcccca tttcacatgc atgcatgtat gtgcatgtat gtgaatgaat
     5821 gtgtatgcgt gtgcgttttc atccagaggt cattatgacg acacccagga tgtttctgtc
     5881 ctattcctgt aactcttggc caatataata tttcctcaga ggctccctgc ctgtattttt
     5941 ctgagttggc tgccttgggc cctcctggag cacccatatt tcagaaaatc atcagaatct
     6001 gtcagactgg aacagctgac agataggtgc cgtgcttaga catctcaccc atctgggctg
     6061 gagaacaaag gttcgagact aggtaaagca caaagctttg attgtgattg gagggcactg
     6121 aaatagaggg gaattcatgg ctaataagga ggacgtgggg tatgaaggag tgtaagttat
     6181 agatgtgtct aagcatgttt ctggagtaga ggccgtggtg tcaagggctg ataaaaggga
     6241 catagccctg gatagcccag ttcccattgc caagccctgc tccctgctca cacctggctt
     6301 cctgctaaca gtgccctctg tccctcccac ctcagctgaa gcccgacttt tcagatgagc
     6361 tctcagatga gctccagcat cagcagaggt ttgggggctg gcccacctgt gcaggctctg
     6421 agaacccaga gtctcagcac tgtgtacctt tcctccaggc agaggcttag ctcgctaggg
     6481 ttgctacagt agttcaccca ctccctgcta ggcagagcaa agtcctgcac aggaagccac
     6541 gctgcttggg gtcctagcat ggagcaaccc tgagctgtca gggttttgag ccccaatagc
     6601 ccagagcagg aaggaactgg cccaccttac tggtcaggtg aacttagagt ccctgtgtgt
     6661 gttgcatcag ccaaccttca aatggtggaa ttcacctgta tcttagtccc tagagacctg
     6721 ggagaaaaat cctcccaccc gccgtggcag ggcctccatt ttttggtaga ggcccagaaa
     6781 gaggctcttg agactccagt tgtctcaaaa ttaagggagc agtggagtgc tagctaagct
     6841 cccagatcca agctccctaa gatgccccgg tctatcagct ctctaggcct tattttgggg
     6901 agcctgggcc cctcttccgg tttgtccatt tggccccaac tccaggatca agagggaggt
     6961 gaaaccagat tccttacctc cttttaggca atcccaccta aagtagtcct gtcttggcag
     7021 cctttcccgg gagctggcct gtctgtcttt tcgtctgcaa agatgtcttg ctcccacaaa
     7081 tatgtattag tcctgggtct ttgattcccc caccccaatg tccaaagtgt gccaggatgt
     7141 ctctgttacc cagtagaggt tcctgatgtc atccatctgt ccgtccctgc atcagctgtc
     7201 catcttccag aggtacctct cctccctgct tacccctcac cagatggagt gacagctctc
     7261 tggggacagg cagggtggcc gcactcagta actaatccaa atggcaaata ttttgtaaca
     7321 aaatagccca gaggtatttt atctgttcaa ttcctagagt tttagagatt ttattgaact
     7381 gtgtcacttg accgaaaaaa aaaaaaaaaa
//
