LOCUS       NM_001277425            6022 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus IQ motif and Sec7 domain ArfGEF 2 (Iqsec2),
            transcript variant 1, mRNA.
ACCESSION   NM_001277425 XM_002727537 XM_002727538 XM_002730218 XM_003754753
VERSION     NM_001277425.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6022)
  AUTHORS   Elagabani,M.N., Brisevac,D., Kintscher,M., Pohle,J., Kohr,G.,
            Schmitz,D. and Kornau,H.C.
  TITLE     Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling
            through Brefeldin A-resistant Arf Guanine Nucleotide Exchange
            Factors BRAG1 and BRAG2 during Synapse Maturation
  JOURNAL   J Biol Chem 291 (17), 9105-9118 (2016)
   PUBMED   26884337
  REMARK    GeneRIF: both Arf6 activation through GluN2B-BRAG1 during early
            development and the transition from BRAG1- to BRAG2-dependent Arf6
            signaling induced by the GluN2 subunit switch are critical for the
            development of mature glutamatergic synapses.
REFERENCE   2  (bases 1 to 6022)
  AUTHORS   Brown,J.C., Petersen,A., Zhong,L., Himelright,M.L., Murphy,J.A.,
            Walikonis,R.S. and Gerges,N.Z.
  TITLE     Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2
            and its requirement in long-term depression
  JOURNAL   Nat Commun 7, 11080 (2016)
   PUBMED   27009485
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6022)
  AUTHORS   Kalscheuer,V.M., James,V.M., Himelright,M.L., Long,P., Oegema,R.,
            Jensen,C., Bienek,M., Hu,H., Haas,S.A., Topf,M., Hoogeboom,A.J.,
            Harvey,K., Walikonis,R. and Harvey,R.J.
  TITLE     Novel Missense Mutation A789V in IQSEC2 Underlies X-Linked
            Intellectual Disability in the MRX78 Family
  JOURNAL   Front Mol Neurosci 8, 85 (2016)
   PUBMED   26793055
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6022)
  AUTHORS   Katsumata,O., Ohara,N., Tamaki,H., Niimura,T., Naganuma,H.,
            Watanabe,M. and Sakagami,H.
  TITLE     IQ-ArfGEF/BRAG1 is associated with synaptic ribbons in the mouse
            retina
  JOURNAL   Eur J Neurosci 30 (8), 1509-1516 (2009)
   PUBMED   19811534
REFERENCE   5  (bases 1 to 6022)
  AUTHORS   Sakagami,H., Sanda,M., Fukaya,M., Miyazaki,T., Sukegawa,J.,
            Yanagisawa,T., Suzuki,T., Fukunaga,K., Watanabe,M. and Kondo,H.
  TITLE     IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6
            that interacts with PSD-95 at postsynaptic density of excitatory
            synapses
  JOURNAL   Neurosci Res 60 (2), 199-212 (2008)
   PUBMED   18164504
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Mar 9, 2021 this sequence version replaced NM_001277425.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-922               JAXUCZ010000021.1  24734246-24735167
            923-952             JAXUCZ010000021.1  24757035-24757064
            953-1214            JAXUCZ010000021.1  24792940-24793201
            1215-1616           JAXUCZ010000021.1  24794139-24794540
            1617-2512           JAXUCZ010000021.1  24799370-24800265
            2513-2674           JAXUCZ010000021.1  24801806-24801967
            2675-2797           JAXUCZ010000021.1  24802448-24802570
            2798-2964           JAXUCZ010000021.1  24803760-24803926
            2965-3104           JAXUCZ010000021.1  24806911-24807050
            3105-3230           JAXUCZ010000021.1  24807716-24807841
            3231-3330           JAXUCZ010000021.1  24810246-24810345
            3331-3492           JAXUCZ010000021.1  24811117-24811278
            3493-3666           JAXUCZ010000021.1  24812981-24813154
            3667-3716           JAXUCZ010000021.1  24813624-24813673
            3717-6022           JAXUCZ010000021.1  24814261-24816566
FEATURES             Location/Qualifiers
     source          1..6022
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..6022
                     /gene="Iqsec2"
                     /gene_synonym="RGD1562109"
                     /note="IQ motif and Sec7 domain ArfGEF 2"
                     /db_xref="GeneID:685244"
                     /db_xref="RGD:1596452"
     exon            1..922
                     /gene="Iqsec2"
                     /gene_synonym="RGD1562109"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..4682
                     /gene="Iqsec2"
                     /gene_synonym="RGD1562109"
                     /note="isoform 1 is encoded by transcript variant 1; IQ
                     motif and SEC7 domain-containing protein 2; IQ motif and
                     Sec7 domain 2"
                     /codon_start=1
                     /product="IQ motif and SEC7 domain-containing protein 2
                     isoform 1"
                     /protein_id="NP_001264354.2"
                     /db_xref="GeneID:685244"
                     /db_xref="RGD:1596452"
                     /translation="MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRI
                     EELEGQLDQLTQENRDLREESQLHRGELHRDPLGARDSPGRESQYQNLRETQFHHREL
                     RESQFHQASRDVGYPNRDGAYQNREAIYRDKEREASYQLQDTTGYTARERDVAQCHLH
                     HENPALGRERGGREAGPAHPGREKEAGYSAAVGVGQRPPRERGQLSRGASRSSSPGAG
                     GGHSTSTSTSPATTLQRKSDGENSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPP
                     TSSHMGGPPAGVGLPWSQRARLQPASVALRKQEEEEIKRSKALSDSYELSTDLQDKKV
                     EMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQF
                     SFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTS
                     GEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDS
                     SATSFSDLPLYLDDPVPPPSPERLPSTEPPPQGRPEFWAPAPLPPVPPPMPPGTREDG
                     SREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEAD
                     GCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLG
                     KCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRH
                     SWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGL
                     SRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERL
                     IEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKN
                     LRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRL
                     VCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEM
                     HMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEK
                     YRVESELEKQKGMMRPNASQPGGAKDSVNGTLARSSLEDTYGAGDGLKRGALSSSLRD
                     LSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSF
                     LGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQS
                     KLQALHAQYCQGPGPAPPPYLPPQQPPLPPPPQQPPPLPQLGSIPPPPASAPPVGPHR
                     HFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHP
                     PAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPS
                     YPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV"
     exon            923..952
                     /gene="Iqsec2"
                     /gene_synonym="RGD1562109"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1214
                     /gene="Iqsec2"
                     /gene_synonym="RGD1562109"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1616
                     /gene="Iqsec2"
                     /gene_synonym="RGD1562109"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..2512
                     /gene="Iqsec2"
                     /gene_synonym="RGD1562109"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2674
                     /gene="Iqsec2"
                     /gene_synonym="RGD1562109"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2797
                     /gene="Iqsec2"
                     /gene_synonym="RGD1562109"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2964
                     /gene="Iqsec2"
                     /gene_synonym="RGD1562109"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3104
                     /gene="Iqsec2"
                     /gene_synonym="RGD1562109"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3230
                     /gene="Iqsec2"
                     /gene_synonym="RGD1562109"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3330
                     /gene="Iqsec2"
                     /gene_synonym="RGD1562109"
                     /inference="alignment:Splign:2.1.0"
     exon            3331..3492
                     /gene="Iqsec2"
                     /gene_synonym="RGD1562109"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3666
                     /gene="Iqsec2"
                     /gene_synonym="RGD1562109"
                     /inference="alignment:Splign:2.1.0"
     exon            3667..3716
                     /gene="Iqsec2"
                     /gene_synonym="RGD1562109"
                     /inference="alignment:Splign:2.1.0"
     exon            3717..6022
                     /gene="Iqsec2"
                     /gene_synonym="RGD1562109"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcggcg gcggcggtag cctcagctcc tgcgccccgt gccgccggcc ccagcgctgt
       61 ctcccgggcc ccctagggcc cccgggcccc cgagcccggt gcgcgccctt gcgtcccgcc
      121 ggccccctcc cccggctggg cccgggggag ggtggcgccg tgagcgagcg gggactgggc
      181 tctcctgccc gttcccctgt ccctgggccg ccaggatgga ggcggggtcc ggtcctccgg
      241 gtggcccggg atctgagagc cccaaccggg cggtggagta cctgctggag ctgaacaaca
      301 tcatcgagag tcagcagcag ctgttggaga cccagcggcg gcgcatagaa gagctggagg
      361 gccagttgga ccagctcacc caggagaacc gcgacctgcg ggaggagagc cagctgcacc
      421 gtggggaact gcaccgggac ccccttggcg cgcgggatag tcctggccgc gagagccagt
      481 accagaacct gcgtgagacc cagttccacc accgcgagct gcgggagagc cagttccacc
      541 aggcgtcccg ggacgtgggc tacccgaacc gggatggcgc ttaccagaac cgggaagcta
      601 tctatcggga taaggagcga gaagcttcct atcagctcca ggacactacc ggttacacag
      661 cccgcgagcg cgacgtggcc cagtgccacc tgcaccatga gaacccagcc ctgggtcgcg
      721 agcgtggcgg gagggaggct gggccagcgc acccgggccg cgagaaggaa gccggctatt
      781 ccgcggcggt gggcgtgggg cagcggccac cgcgggagcg gggccagttg agccgtggcg
      841 catccagaag ctccagccct ggcgcgggcg gaggtcacag caccagtacc agcaccagcc
      901 ctgctacaac cctccagaga aaatctgatg gtgagaattc cagaacagtc agtgtggagg
      961 gtgatgcccc aggcagtgac ctgagcacag cggttgatag tcctgggagc caacccccct
     1021 accggctgag ccaactgccc ccaaccagca gccacatggg gggcccccct gctggcgtgg
     1081 gcctaccttg gtctcagagg gctcgcctcc agccagccag tgtcgccctg aggaagcagg
     1141 aggaggagga gataaagcgc tccaaggccc tgtcagacag ctatgaactc tccacagacc
     1201 tacaggacaa gaaggtggaa atgctggaga ggaagtatgg gggctccttc ctgagccgca
     1261 gggctgccag gaccatccag acagcctttc gccagtatcg tatgaataag aactttgagc
     1321 gactgcgcag ctcggcttca gagagccgca tgtcccgccg catcatcttg tccaacatgc
     1381 ggatgcagtt ctcctttgag gagtacgaga aagcacagaa ccctgcatac ttcgaaggca
     1441 agcctgcctc attggatgag ggtgcaatgg ctggagcccg gagccaccgg cttgaacggg
     1501 gcctccccta tggaggctcc tgtggtgggg gcatcgatgg tggtggaagt tcagtcacca
     1561 catctggaga gttttctaat gacatcacag agctcgagga ctccttctcc aaacaggtaa
     1621 agtctctggc tgaatccatt gatgaggcct tgaactgcca cccatcaggg cctatgtctg
     1681 aggagccagg gtcagcccaa ctggagaagc gggaatcaaa ggaacagcaa gaagacagct
     1741 cagccacatc cttcagtgac ctccccctct acttggatga cccagttcct cctccatcac
     1801 ctgagcgact gcccagcaca gagcccccac cccaaggccg ccctgagttc tgggcaccag
     1861 ctcccctccc accagttcct ccaccaatgc caccagggac ccgggaagat ggtagccgtg
     1921 aggaaggcac tcgaaggggt cctgggtgct tggagtgccg ggatttccgg ctccgggctg
     1981 cacacctccc cctcctcacc attgagcctc ccagtgacag ttctgtagac ctgagtgacc
     2041 gctcagatcg cggctctgtc caccgccagc tggtgtatga ggctgatggc tgcagccccc
     2101 atgggaccct gaagcacaag gggccaccag gcagggcccc aatcccacac cgccactacc
     2161 ctgcccctga gggtccagct ccagccccac cagggcccct gccaccagcc cccaatagtg
     2221 gtactgggcc cagtggtgtg gctggaggtc ggaggttggg aaagtgtgag gcagcaggtg
     2281 agaactctga tggtggagac aatgagagcc ttgagagctc cagcaactct aatgagacca
     2341 tcaactgcag ctctggctcc tcctctcggg atagcctgag ggaacctcca gccactggcc
     2401 tgtgcaagca gacttaccag cgggagacaa ggcacagctg ggactcgcca gccttcaaca
     2461 atgacgtggt acaaagaagg cattacagaa ttggcctcaa cctcttcaat aagaagccag
     2521 agaagggtat ccagtatttg atcgagcgag gcttcctgtc agacactcct gtgggggtgg
     2581 ctcacttcat cctggagcgg aaaggcctga gtcggcagat gataggggaa ttcctgggga
     2641 atcgacagaa gcagttcaac agagatgtgt tggactgtgt ggtggatgag atggacttct
     2701 cctctatgga tttggacgat gcactcagga agttccaatc ccatatccga gttcagggtg
     2761 aggcccagaa agtggagcga ctcattgaag ctttcagcca gcggtactgt gtctgtaacc
     2821 ctgccctcgt acgacagttc cggaacccag acactatctt catccttgct tttgccatca
     2881 tcctcctcaa taccgatatg tacagcccca gtgtcaaggc tgaacgcaag atgaagctgg
     2941 atgacttcat taagaacctg agaggagttg acaatggtga agacatcccc cgagacctcc
     3001 tagtaggcat ctaccagcgc atccaaggtc gtgaactaag gaccaacgat gaccatgtgt
     3061 cccaggtgca ggctgtggag cgcatgattg ttggcaagaa accggtcctg tcgctccctc
     3121 accgtcgact ggtttgctgc tgccagctct atgaggtgcc agatccaaat cgcccccaaa
     3181 ggctggggct gcatcagcgg gaggtcttcc tcttcaatga cctccttgtg gtcaccaaaa
     3241 ttttccagaa gaagaagatc ttggtgacat acagcttccg tcagtccttt cccctggtgg
     3301 aaatgcatat gcagctcttc cagaattcat attatcagtt tggaatcaag ttactatctg
     3361 cggtacctgg aggggaacga aaagttctca ttatctttaa tgctcctagc ctccaagaca
     3421 ggctacgctt tacctctgac ctgcgggagt ccattgctga ggtgcaggag atggagaagt
     3481 accgtgtgga atcggagctg gagaagcaga aaggtatgat gcggcctaat gcctcacaac
     3541 ctggaggagc caaggactca gtgaatggga ctctggcccg cagtagtctg gaggacactt
     3601 atggggcagg cgatgggctc aagcggggtg cactcagtag ttccctgcga gacctctctg
     3661 atgcagggaa gcgggggcgg cgtaacagcg tgggatcgct ggacagcacc atcgaagggt
     3721 ctgttattag cagtccacgc cctcaccaga ggatgccacc tccgccccca cccccgccgc
     3781 cagaggagta caagagccag aggccagtct ccaactcctc atctttcctg ggctccctat
     3841 ttggaagcaa gagaggcaaa gggcccttcc agatgccacc accgccaaca ggccaggcct
     3901 ctgcctcgtc ttcatctgct tcctccaccc accaccacca tcaccaccac caccatggtc
     3961 acagccatgg tggcctgggg gtgctacctg atgggcagtc caagctccag gccctgcatg
     4021 cccagtattg ccaaggaccg ggccctgccc caccacccta cctcccaccc cagcaacccc
     4081 ctctgcctcc accccctcag cagcctccac ccctgcccca gctgggctcc attccaccac
     4141 cacctgcctc agccccacct gtggggccac atcgacactt ccatgcccat ggcccagttc
     4201 caggacccca gcattatacc ttgggccggc caggcagagc cccaagacga ggggctggag
     4261 gacaccctca gtttgctcca catggccgcc accccttgca ccagcccaca tccccgttac
     4321 ccctgtacag tcctgctcca cagcaccctc ctgcccataa acagggcccc aagcacttca
     4381 tcttcagtca ccacccacag atgatgccag cagcaggtgc agctgggggc cctgggtccc
     4441 ggccaccagg gggatcctac tcccaccctc accaccccca atcaccactg tccccacact
     4501 cacccatccc acctcacccc tcctacccgc ccctgccccc accctcacct cacactccac
     4561 attcacccct accacccacc tccccccatg gcccactgca cgcctctggg ccccctggca
     4621 cggctaatcc acccagtgca aaccccaagg ccaagccaag ccggatcagc actgtggtct
     4681 gaggaatggg atgagtgtac tggggaacag gatagtctgg ggaaatccac aggagaggga
     4741 ccttgcccct cacttcttcc tcgttttttt caaaatatat atacactcag cagtgtcctt
     4801 cttcccactt cctccatatc tccagaccct tcttccaacc cccagcagtt gccatggggt
     4861 ctcctttcag attggagggc ccttgccact cgcagcctga gcatagggca ctgcagtgct
     4921 gggaagcggt aagggcctct cagcagccct cgtcctcccg ttcctgtctt cctctcctct
     4981 ttcttgtccc tggaggtcta gttggtgacc tcagacctct ggacaaatgt gagcttcctt
     5041 gcaagctgat ggagaaggca ggcttctgga gctgcagagg tgaaggcttt ccccagagct
     5101 cctctggctg tgtggggcta ggagagagct ctgtagagct gtggccaaac ctcagctggc
     5161 tcagccctct gacctcaggg cctagccaca cacctccatg tgtctttctg cctgctggag
     5221 gacacataga ccgtcagtca gtgcactccg tgggtggaac cccgcttgtg ctggccccca
     5281 atgagggcag tgcttcctct cttgagccag tctgtgccct ctctcctaat aggccccagc
     5341 ccagacctct ttggcttcag gaacttgcct tgccctgcaa tgttcttatc ctgatcaaag
     5401 tccagacagg tttttacttt ggaggcgggg gagggggggg ctcaggtctg ggatgagaag
     5461 ggtactgccc tccctcaccc atattgcatg cccccccttc cttcttttcc caccttcaac
     5521 tgaagacaat gcactttaca gataccaccc acacatatct cactggggca gggcacccag
     5581 catcagccct ggggaaagac tcccagagga ccaccctgag cccaagatgt ccttcctgag
     5641 gcagagattg aagccatcag agcaggggct gcgagccaga atgcccaagc ccctcttgtt
     5701 catcaaaatc tccactgcct cgccagccct tctgcaccct gtttatttat tataaatata
     5761 ttttttacaa gtcccagctc ctcttcttgc cctacattca gctcctttca cagtccctgc
     5821 ctttctctcc cctgtccagt atgggctgca atacagacag acagatggac cctctatgtc
     5881 aaagggtccc tggggcttgg ggttgtggga gggtgttggt gggagggact tatggagagg
     5941 agctggggtt cagacattgt ctttttccct ccttgtatat aagaatgtat atttgatgcc
     6001 tcataaaaga ccttgtgctc ac
//
